Article
Obstetrics & Gynecology
Andrea R. Thurman, Thomas R. Moench, Marshall Hoke, Joseph A. Politch, Howard Cabral, Emilie Mausser, Ellena Nador, Josh Morton, Krystal Hamorsky, Kelsi Swope, Barry Bratcher, Deborah J. Anderson, Kevin J. Whaley
Summary: ZB-06, a vaginal film containing a human contraceptive antibody, was found to be safe and effective in reducing the number of motile sperm in ovulatory cervical mucus when used before intercourse. Further development and testing of ZB-06 as a viable contraceptive candidate is warranted.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gene Chong, Alexander D. MacKerell
Summary: Molecular modeling and dynamics simulations were used to generate structures of Fc gamma RIIIa-Fc epsilon RI gamma complexes and study how ITAM signaling is triggered. Different spatial orientations of ITAMs upon clustering were predicted to lead to ITAM phosphorylation by Lck and subsequent Syk activity, facilitating downstream signaling.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoyu Gu, Zixuan Guo, Maolin Cai, Yan Shi, Shoukun Wang, Fei Xie
Summary: The objective of this study was to develop a reliable diaphragm pacing system and evaluate its effectiveness through hardware testing and animal experiments. A DP system with bidirectional constant current was designed, manufactured, and tested. The effects of a wide range of stimulus amplitudes and frequencies on airflow and inspired volume were investigated, and differences in airflow characteristics under various stimulation parameters were evaluated. The study found that increasing stimulus frequency and amplitude resulted in different degrees of increase in inspired volume, and the developed DP system caused less diaphragm fatigue with increased stimulation duration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Sport Sciences
Yuka Shimozawa, Toshiyuki Kurihara, Yuki Kusagawa, Miyuki Hori, Shun Numasawa, Takashi Sugiyama, Takahiro Tanaka, Tadashi Suga, Ryoko S. Terada, Tadao Isaka, Masafumi Terada
Summary: This study examined the prevalence of dysfunctional and diaphragmatic breathing patterns among athletic populations and found that 90.6% of athletes had dysfunctional breathing patterns, while only 9.4% exhibited diaphragmatic breathing patterns. These findings suggest that clinicians may need to consider screening and implementing intervention programs to improve the efficiency of breathing patterns in athletes.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2023)
Article
Physiology
Bai-Ting He, Ying-Mei Luo, Li-shuang Wang, Yong-Yi Chen, Caroline Jolley, Joerg Steier, John Moxham, Michael L. Polkey, Yuanming Luo
Summary: The EMGdi-c/VT ratio can be used as an alternative method to assess bronchial hyperactivity and airway reversibility, allowing differentiation between patients with asthma and healthy subjects.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Sandeep Somani, Sunhwan Jo, Renuka Thirumangalathu, Danika Rodrigues, Laura M. Tanenbaum, Ketan Amin, Alexander D. MacKerell, Santosh Thakkar
Summary: The study introduces a novel in silico approach, SILCS-Biologics, for structure-based modeling of protein formulations, predicting potential hotspot regions on the protein surface for interactions among different components of a formulation. Experiments on a Fab domain of a monoclonal antibody showed that arginine increased viscosity, lysine reduced viscosity, and proline had no impact on viscosity. Efforts are now focused on further validating this computational framework and expanding its application to model full mAb and other protein therapeutics.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Physical
Abhishek A. Kognole, Anthony Hazel, Alexander D. MacKerell
Summary: RNA molecules can be potential drug targets in various diseases due to their dysregulated expression or misfolding. Noncoding RNAs, which account for a large part of the human genome, have complex structures and can be targeted by small molecules. The SILCS computational approach, termed SILCS-RNA, was extended to target RNA in this study and evaluated against seven RNA targets. The method provides detailed functional group affinity patterns and facilitates the identification of new potential binding sites and ligand design.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2022)
Article
Medicine, General & Internal
Danilo Buonsenso, Francesco Mariani, Rosa Morello, Gianmaria Cammarota, Cristina De Rose, Piero Valentini, Anna Camporesi, Luigi Vetrugno
Summary: This prospective observational study aims to define normal diaphragm ultrasound characteristics in healthy infants. Measurements of diaphragm thickness and thickening function were taken at different time points. The study provides data on normal values for these parameters in healthy infants.
Article
Anesthesiology
Takeshi Yoshida, Doreen Engelberts, Han Chen, Xuehan Li, Bhushan H. Katira, Gail Otulakowski, Yuji Fujino
Summary: This study investigates the impact of prone position on lung injury. The results show that in the prone position, there is a more even distribution of lung stress and inflation, along with reduced spontaneous effort, resulting in less lung injury.
Article
Engineering, Civil
Francisco Avila, Peter Dechent, Alexander Opazo
Summary: The increase in the number of tall CLT buildings worldwide in recent years has raised discussions about wood seismic design parameters; a hybrid building using both CLT and concrete cores was found to have fewer restrictions in high-rise wood utilization. Analysis of four hybrid buildings with different configurations demonstrated oscillating seismic behavior between semi-rigid and flexible, emphasizing the importance of correct diaphragm classification in reducing wall demand.
ENGINEERING STRUCTURES
(2021)
Article
Engineering, Biomedical
Tobias Kratz, Roman Ruff, Timo Koch, Anne-Sophie Kronberg, Johannes Breuer, Boulos Asfour, Ulrike Herberg, Benjamin Bierbach
Summary: The accelerometer is a valid method for detecting diaphragmatic excursion and can be used as a trigger for a unilateral diaphragmatic pacemaker.
BIOMEDICAL ENGINEERING ONLINE
(2023)
Review
Acoustics
Vincenzo Rizza, Francesco Maranta, Lorenzo Cianfanelli, Iside Cartella, Ottavio Alfieri, Domenico Cianflone
Summary: Diaphragm dysfunction is a common complication after cardiac surgery, with variable clinical impact and potential negative effects on prognosis and mortality. Ultrasonography is a valuable tool for evaluating diaphragmatic impairment and predicting successful weaning from mechanical ventilation. This review aims to describe the pathophysiology, diagnostic techniques, and potential applications of diaphragm ultrasound in post-cardiac surgery patients.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Construction & Building Technology
Abdul Rahman El Zein, Yannick Vanhove, Chafika Djelal, Olivier Madec, Philippe Gotteland
Summary: This study investigates the movement of water in concrete using soil mechanics theory, different water-cement ratios, and oedometric tests. The results show a good correlation between water movement in concrete and time, depth, and stress levels.
MATERIALS AND STRUCTURES
(2021)
Article
Acoustics
Aylin Tanriverdi, Sema Savci, Melike Mese, Naciye Sinem Gezer, Buse Ozcan Kahraman, Can Sevinc
Summary: In patients with non-CF bronchiectasis, diaphragm thickness is related to disease severity, pulmonary function, and physical activity, while diaphragm mobility is related to disease severity and pulmonary function.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Surgery
Uyen-Thao Le, Laurin Titze, Petar Hundeshagen, Bernward Passlick, Severin Schmid
Summary: In this study, perioperative data of patients undergoing RATS or VATS diaphragm plication were retrospectively analyzed. The results showed that RATS diaphragm plication has advantages in terms of surgical time and improvement in pulmonary function, and it is a safe approach. Further research is needed to elucidate its advantages over VATS or open approaches.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Obstetrics & Gynecology
Bruce R. Carr, Michael A. Thomas, Angelina Gangestad, David L. Eisenberg, Andrea Olariu, Mitchell D. Creinin
Summary: The study evaluated reproductive function in nulligravid and gravid women after discontinuation of the levonorgestrel 52 mg intrauterine system (IUS). It found that women had rapid return of fertility in the year post-removal, with fertility rates not varying based on gravidity, parity, age at discontinuation, or duration of IUS use.
Article
Obstetrics & Gynecology
Suji Uhm, Melissa J. Chen, Erika D. Cutler, Mitchell D. Creinin
Summary: After changing the default dispensing quantity in electronic medical record orders from one month to 12 months, providers prescribed a 12-month supply of contraceptive pills, patches, and rings more frequently. Providers at the medical center campus increased 12-month prescriptions after the change, while non-obstetrics/gynecology providers at community clinics also increased 12-month prescriptions, but obstetrics/gynecology providers did not.
Editorial Material
Obstetrics & Gynecology
Mitchell D. Creinin, Hailee Tougas, Machelle Wilson, Melissa C. Matulich
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Melissa L. Gilliam, Jeffrey T. Jensen, David L. Eisenberg, Michael A. Thomas, Andrea Olariu, Mitchell D. Creinin
Summary: This study aimed to assess the relationship between parity and prior route of delivery to levonorgestrel 52 mg intrauterine system expulsion. Results showed that IUS expulsion occurs in less than 4% of users over the first 6 years of use, mostly during the first year, and is more likely among obese and parous women.
Article
Obstetrics & Gynecology
Katherine C. Whitehouse, Bianca M. Stifani, James M. N. Duffy, Caron R. Kim, Mitchell D. Creinin, Teresa DePineres, Beverly Winikoff, Kristina Gemzell-Danielsson, Jennifer Blum, Renee Bracey Sherman, Antonella F. Lavelanet, Dalia Brahmi, Daniel Grossman, Anand Tamang, Hailemichael Gebreselassie, Rodolfo Gomez Ponce de Leon, Bela Ganatra
Summary: By using consensus methods, a core outcome set for future abortion research has been developed, consisting of 15 outcomes that can standardize research, decrease trial heterogeneity, and enhance the quality of systematic reviews and clinical guidelines. Researchers are encouraged to select, collect, and report these core outcomes in future abortion trials, while journal editors should promote the reporting of core outcome sets.
Article
Obstetrics & Gynecology
Suji Uhm, Namrata Mastey, Courtney C. Baker, Melissa J. Chen, Melissa C. Matulich, Melody Y. Hou, Juliana Melo, Susan F. Wilson, Mitchell D. Creinin
Summary: This study aimed to evaluate the impact of mifepristone given 18 to 24 hours before osmotic dilator placement on procedural outcomes. The results showed that mifepristone increased the initial cervical dilation but did not significantly affect the proportion of participants requiring additional dilators. The subjective perception of the procedure and complication rates were similar between the mifepristone and placebo groups.
Article
Pharmacology & Pharmacy
Shelly Kaller, Natalie Morris, M. Antonia Biggs, C. Finley Baba, Sally Ra, Tina R. Raine-Bennett, Mitchell D. Creinin, Erin Berry, Elizabeth A. Micks, Karen R. Meckstroth, Sarah Averbach, Daniel Grossman
Summary: The study aimed to assess the feasibility of pharmacists dispensing mifepristone. Results showed that most pharmacists were willing to be trained, dispensed mifepristone with few challenges, were satisfied with the model, and had higher knowledge levels at follow-up.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2021)
Article
Health Care Sciences & Services
Alison Edelman, Agnes Hemon, Mitchell Creinin, Pascale Borensztein, Bruno Scherrer, Anna Glasier
Summary: This study aims to determine the cervical mucus characteristics following a 6-hour delayed pill intake or after one missed pill compared to typical daily use of norgestrel 75 mcg. The study has successfully enrolled 52 subjects and the analysis of the results is pending. The protocol was approved by a central review board and the study procedures were executed successfully.
JMIR RESEARCH PROTOCOLS
(2021)
Editorial Material
Obstetrics & Gynecology
Mitchell Creinin, Julia E. Kohn, Jennifer H. Tang, Tania Basu Serna
Article
Obstetrics & Gynecology
Mitchell D. Creinin, Courtney A. Schreiber, David K. Turok, Carrie Cwiak, Beatrice A. Chen, Andrea Olariu
Summary: This study aimed to evaluate the efficacy and safety of the levonorgestrel 52 mg intrauterine system during years 7 and 8 of use. The results showed that the system is highly effective and safe over an 8-year period of use, with low pregnancy rates and high user satisfaction.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Britany R. Lundberg, Angel Tabuyo-Martin, Matthew D. Ponzini, Machelle D. Wilson, Mitchell D. Creinin
Summary: This study investigated changes in contraceptive method plans before, during, and after abortion among patients. The results showed that most patients received the method they initially identified at the telephone intake, especially those planning to use an IUD or implant. Undecided patients were open to discussing various options.
Editorial Material
Obstetrics & Gynecology
Mitchell D. Creinin, Carolina Sales Vieira, Carolyn L. Westhoff, Diana J. A. Mansour
Summary: This study aims to address limitations in existing definitions of menstrual bleeding changes associated with contraceptive methods and proposes new recommendations for standardized bleeding data analyses. The study suggests three criteria for assessing bleeding outcomes: pattern, flow, and duration, and provides descriptors for each criterion based on the predictability of bleeding patterns. Standardizing outcomes allows for better comparison between studies and improved understanding of differences between contraceptive products for both clinicians and patients.
Letter
Health Care Sciences & Services
Mitchell D. Creinin, Melody Y. Hou
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Cassandra M. Gilbert, Melissa C. Matulich, Matthew D. Ponzini, Machelle D. Wilson, Mitchell D. Creinin
Summary: This study aimed to assess the correlation between quantitative blood loss (QBL) and clinically relevant outcomes or hemorrhage in dilation and evacuation (D&E) procedures. The findings showed that the majority of patients (75%) with clinically relevant bleeding outcomes had a QBL of 500mL or less. Therefore, the need for clinical interventions should be used to define hemorrhage in D&E procedures, rather than a specific amount of blood loss.
Letter
Obstetrics & Gynecology
Mitchell D. Creinin, Jeffrey T. Jensen
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)