Article
Plant Sciences
Petra Borotova, Lucia Galovicova, Nenad L. Vukovic, Milena Vukic, Eva Tvrda, Miroslava Kacaniova
Summary: The tea tree essential oil from Slovakia is characterized by its chemical composition, with terpinen-4-ol as the dominant component. It demonstrates antioxidant and antimicrobial activities, inhibiting the growth of various bacteria and yeasts, while also showing resistance against biofilm-forming bacteria.
Article
Chemistry, Medicinal
Anne-Sophie M. W. Bekhof, Florence P. A. M. van Hunsel, Sonja van de Koppel, Herman J. Woerdenbag
Summary: Tea tree essential oil, mainly consisting of monoterpenes, is commonly used as an antiseptic. This study reviewed safety data and analyzed cases of adverse reactions reported to the WHO. The findings suggest that oral administration of tea tree oil can lead to central nervous system depression and pneumonitis, while topical application may cause skin disorders. Properly stored tea tree oil within its expiration date is considered safe for non-serious inflammatory skin conditions, but the occurrence of adverse reactions is difficult to predict.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Simge Varlik, Gulsen Bayrak, Selen Ozturk, Aysun Kilic Suloglu, Isik Percin, Adil Denizli
Summary: In this study, gelatin-based cryogels containing tea tree oil were synthesized and their antibacterial activity and biocompatibility were evaluated. The cryogels showed antibacterial effectiveness against E. coli and S. aureus and no toxic effects on human keratinocyte cells, indicating potential for application in skin injury and wound healing.
Article
Biochemistry & Molecular Biology
Federico Iacovelli, Alice Romeo, Patrizio Lattanzio, Serena Ammendola, Andrea Battistoni, Simone La Frazia, Giulia Vindigni, Valeria Unida, Silvia Biocca, Roberta Gaziano, Maurizio Divizia, Mattia Falconi
Summary: Tea Tree Oil (TTO) is a beneficial essential oil used in antimicrobial preparations and cosmetic products, containing compounds such as terpinen-4-ol, γ-terpinene, and 1,8-cineole. This study evaluated the antimicrobial activity of TTO and its major components against fungi, bacteria, and viruses, and proposed atomic-level explanations for their mechanisms of action through molecular dynamics simulations. The results suggest that TTO's strong antimicrobial activity is attributed to its components incorporating into lipid bilayers, altering membrane functionality, and potentially altering the structural properties of viral capsids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Lana Kairey, Tamara Agnew, Esther Joy Bowles, Bronwyn J. Barkla, Jon Wardle, Romy Lauche
Summary: This review evaluates the therapeutic efficacy and safety of tea tree oil in clinical trials. The results suggest that mouthwashes with tea tree oil can reduce dental plaque, gels with tea tree oil can aid in the treatment of periodontitis, and topical tea tree oil regimens show similar efficacy to standard treatments for methicillin-resistant Staphylococcus aureus decolonization. Tea tree oil with added iodine may be effective in treating molluscum contagiosum lesions.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaoning Zhang, Silin Chen, Ye Zhang, Yufei Xiao, Yufeng Qin, Qing Li, Li Liu, Buming Liu, Ling Chai, Hong Yang, Hailong Liu
Summary: In this study, the whole genome of Melaleuca alternifolia, a commercially important medicinal tea tree native to Australia, was investigated using next-generation sequencing. A draft genome size of about 595 Mb was obtained, including 44,369 protein-coding genes. These findings provide a reference for future functional and comparative genomics analyses.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Thuy-Vi Vo, Thi-Huyen Truong, Bing-Hung Chen
Summary: The use of surfactants can enhance the extraction of tea tree oil, improving both the yield and rate of extraction. The response surface methodology (RSM) is a useful tool for determining the optimal extraction parameters for tea tree oil.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2022)
Article
Plant Sciences
Julia Voelker, Ramil Mauleon, Mervyn Shepherd
Summary: Leaf oil terpenes in tea tree exhibit discrete phenotypes of adaptive and economic significance, and a genome-wide association study revealed that a supergene accounts for the chemotypes in Melaleuca alternifolia. A cluster of monoterpene synthase genes explained the variation in key monoterpenes, and chemotype-dependent null alleles provided an explanation for the genetic architecture underlying the chemotypes. This genetic model with three haplotypes explains the six terpene chemotypes and is supported by available cross-segregation data.
Article
Engineering, Chemical
Thuy-Vi Vo, Bing-Hung Chen
Summary: The purpose of this study was to develop a colloidal formulation of tea tree oil using a sustainable and biocompatible surfactant. The researchers established a phase diagram and conducted various tests to determine the rheological properties and stability of the formulation. The results showed that the formulation exhibited gel-like behavior and remained stable for over a month.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Medicine, General & Internal
Francesca Ambrogio, Caterina Foti, Gerardo Cazzato, Edoardo Mortato, Stella Mazzoccoli, Anna Paola De Caro, Nicoletta Cassano, Gino Antonio Vena, Gianfranco Calogiuri, Paolo Romita
Summary: This case report describes a young man who developed severe allergic contact dermatitis to tea tree oil after applying a lotion containing the oil. The dermatitis resolved after discontinuing the lotion and using topical corticosteroid therapy. This case further highlights the potential for allergic reactions to natural ingredient-based products.
MEDICINA-LITHUANIA
(2022)
Article
Spectroscopy
Joel B. Johnson, Parbat Raj Thani, Janice S. Mani, Daniel Cozzolino, Mani Naiker
Summary: This study investigated the use of mid-infrared (MIR) spectroscopy combined with chemometric regression analysis to detect and quantify the adulteration of eucalyptus oil in tea tree oil. The results showed that this method can accurately predict the level of eucalyptus oil adulteration in tea tree oil samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Food Science & Technology
Xiaokang Lv, Liang Chen, Chuanshe Zhou, Yibing Guo, Guijie Zhang, Jinhe Kang, Zhiliang Tan, Shaoxun Tang, Zixin Liu
Summary: This study investigated the effects of tea tree oil (TTO) on intestinal amino acid transport and immune function in goats. The results showed that TTO enhanced the transport of serine and arginine in intestinal mucosa and improved intestinal immunity.
FOOD SCIENCE & NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Janelle J. Schafer, Ian A. Southwell, Lei Liu
Summary: By studying the non-volatile components of tea tree seedling leaves, four new compounds were discovered and their structures were identified.
CHEMISTRY & BIODIVERSITY
(2022)
Review
Biochemistry & Molecular Biology
Md Atiar Rahman, Abida Sultana, Mohammad Forhad Khan, Rachasak Boonhok, Sharmin Afroz
Summary: Complementary and alternative treatments, including tea tree oil, have gained popularity worldwide. This systematic review examines the anti-inflammatory effects and immunomodulatory potential of tea tree oil, focusing on its neuroprotective mechanisms. The study analyzes data from scientific databases and discusses the prospects of tea tree oil as a neuroprotective agent.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Review
Pharmacology & Pharmacy
Mariana Alves Battisti, Thiago Caon, Angela Machado de Campos
Summary: Tea tree oil (TTO) has potential antiviral, antibacterial, antimycobacterial, and antifungal properties, but its solubility, volatility, and oxidation issues can be addressed by incorporating it into micro- or nanoparticles. These systems can enhance interactions with microorganisms and improve efficacy, especially when combined with silver nanoparticles. Additionally, nano- and microparticulate systems can help avoid bacterial biofilm formation and resistant microorganisms.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Dermatology
Jart A. F. Oosterhaven, Lotte S. Spekhorst, Junfen Zhang, Angelique N. Voorberg, Geertruida L. E. Romeijn, Celeste M. Boesjes, Marlies de Graaf, Marjolein S. de Bruin-Weller, Marie L. A. Schuttelaar
Summary: The study found that AD patients treated with dupilumab had high treatment satisfaction, but there may be challenges in interpreting eczema control based on the ADCT.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Angelique N. Voorberg, Laura Loman, Marie L. A. Schuttelaar
Summary: There is limited data on chronic hand eczema and its severity in the general population. This cross-sectional study investigated the prevalence and severity of hand eczema in the Dutch population through a questionnaire. The results showed that the lifetime prevalence of hand eczema was 15.0%, the 1-year prevalence was 7.3%, and the self-reported physician-diagnosed prevalence was 6.1%. The study also found that the majority of subjects with hand eczema had almost clear symptoms at their worst, and the prevalence of severe to very severe hand eczema in the general population was 1.9%. The study suggests that future epidemiological research should include data on chronic hand eczema and its severity to gain a better understanding of the burden of hand eczema.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Allergy
Manon M. Sloot, Laura Loman, Geertruida L. E. Romeijn, Fieke M. Rosenberg, Bernd W. M. Arents, Marie L. A. Schuttelaar
Summary: This study explored the patient perspective on the care process for hand eczema (HE) through focus group discussions. The findings revealed that patients valued time, attention, and being listened to and understood by healthcare professionals. Additionally, clear diagnoses and follow-up, more psychosocial support, and consistent healthcare providers were important to patients. The study highlights the importance of providing explanations about the causes and diagnoses of HE, addressing the impact of treatment on patients, and offering psychosocial and peer support. The role of specialized nurses in integrated care was also emphasized.
CONTACT DERMATITIS
(2022)
Article
Allergy
Marjolein J. Brands, Laura Loman, Marie L. A. Schuttelaar
Summary: The study aimed to investigate the association between hand eczema (HE) and occupational and non-occupational wet exposure and work-related factors in the Dutch general population. The results showed that both occupational and non-occupational wet exposure were positively associated with HE in the past year. Positive associations were also found for high-risk and non-high-risk occupations, as well as higher levels of education. Therefore, preventive strategies for HE should focus on avoiding all exposure to wet activities, regardless of origin, and job tasks should be considered when counseling patients with hand eczema.
CONTACT DERMATITIS
(2022)
Article
Allergy
Laura Loman, Marie L. A. Schuttelaar
Summary: This study investigated the possible association between hand eczema (HE) and lifestyle factors, including smoking, alcohol consumption, stress, body mass index (BMI), waist circumference, physical activity, diet, and amount of sleep in the Dutch general population. The results indicated that smoking, chronic stress, high BMI, and large waist circumference were positively associated with HE in the past year. Further research should focus on the relationship between lifestyle factors and the severity and prognosis of HE.
CONTACT DERMATITIS
(2022)
Editorial Material
Allergy
Fieke M. Rosenberg, Laura Loman, Marie L. A. Schuttelaar
CONTACT DERMATITIS
(2022)
Article
Allergy
Jacob P. Thyssen, Marie L. A. Schuttelaar, Jose H. Alfonso, Klaus E. Andersen, Irena Angelova-Fischer, Bernd W. M. Arents, Andrea Bauer, Richard Brans, Alicia Cannavo, Wianda A. Christoffers, Marie-Noelle Crepy, Peter Elsner, Manige Fartasch, Francesca Larese Filon, Ana M. Gimenez-Arnau, Margarida Goncalo, Maria G. Guzman-Perera, Carsten R. Hamann, Wolfram Hoetzenecker, Jeanne Duus Johansen, Swen M. John, Amalia C. M. Kunkeler, Suzana Ljubojevic Hadzavdic, Sonja Molin, Rosemary Nixon, Jart A. F. Oosterhaven, Thomas Rustemeyer, Esther Serra-Baldrich, Mili Shah, Dagmar Simon, Christoph Skudlik, Radoslaw Spiewak, Skaidra Valiukeviciene, Angelique N. Voorberg, Elke Weisshaar, Tove Agner
Summary: Hand eczema is a common inflammatory skin disorder. This article aims to update the European Society of Contact Dermatitis guideline on the diagnosis, prevention, and treatment of hand eczema. Consensus was reached for several statements and management strategies through analysis of evidence for therapeutic and preventive interventions using a structured method of developing consensus. The updated guideline should improve the management of hand eczema.
CONTACT DERMATITIS
(2022)
Editorial Material
Dermatology
Marie L. A. Schuttelaar
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Editorial Material
Dermatology
Junfen Zhang, Marie L. A. Schuttelaar
Summary: This is an invited commentary letter discussing the association between domestic hard water and eczema in adults from the UK Biobank cohort study, published in the recent issue of BJD.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Allergy
Esme Kamphuis, Laura Loman, Henry L. Han, Geertruida L. E. Romeijn, Klaziena Politiek, Marie L. A. Schuttelaar
Summary: This prospective observational cohort study evaluated the effectiveness and safety of upadacitinib on atopic dermatitis (AD) and hand eczema (HE) in patients with AD. The results showed that upadacitinib can be an effective treatment for AD and concomitant HE. Future studies should focus on the effectiveness of upadacitinib on chronic HE, especially on the different etiological subtypes of HE, including HE in non-atopic individuals.
CONTACT DERMATITIS
(2023)
Article
Allergy
Junfen Zhang, Laura Loman, Marie L. A. Schuttelaar
Summary: This study aimed to estimate the proportion of adults with multiple atopic diseases in the Dutch general population and evaluate the prevalence of limited health literacy, as well as its association with socioeconomic status, lifestyle factors, and health-related quality of life. The study found that 11.8% of the overall study population reported having multiple atopic diseases, and 23.6% of them had limited functional health literacy, with a higher prevalence among those with a low socioeconomic status.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Letter
Dermatology
Aviel Ragamin, Ron A. Tupker, Marlies de Graaf, Thomas Rustemeyer, Suzanne G. M. A. Pasmans, Renske Schappin, Marie L. A. Schuttelaar
Summary: This study developed and validated an Investigator Global Assessment (IGA) scale for evaluating the severity of impetiginization in patients with atopic dermatitis (AD).
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Sri Awalia Febriana, Yohanes Ridora, Niken Indrastuti, Kusuma Dewi, Katharina Oginawati, Ikeu Tanziha, Cita Rosita Sigit Prakoeswa, Fajar Waskito, Marie-Louise Schuttelaar
Summary: This study aimed to identify potential health hazards and investigate the prevalence of occupational skin diseases (OSD) in the traditional batik industry in Indonesia. The workers were exposed to substances that act as irritants and potential contact allergens during each step of the batik manufacturing process. The study found a high prevalence of OSD, especially contact dermatitis, among the employees.
SCIENTIFIC REPORTS
(2023)
Article
Dermatology
Junfen Zhang, Laura Loman, Jantje M. Oldhoff, Marie L. A. Schuttelaar
Summary: This study found that there is a lack of knowledge about loneliness and psychiatric disorders other than anxiety and depression in patients with atopic dermatitis. It was revealed that atopic dermatitis is positively associated with chronic fatigue syndrome, burnout, depression, social phobia, panic disorder, attention deficit hyperactivity disorder, and eating disorder. Moreover, individuals with atopic dermatitis are more likely to experience loneliness. This study highlights the importance of recognizing and addressing the psychiatric and social aspects of atopic dermatitis.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Allergy
Fieke M. Rosenberg, Rene Wardenaar, Angelique N. Voorberg, Diana C. J. Spierings, Marie-Louise A. Schuttelaar
Summary: This study re-analyzed the transcriptome data of vesicular hand eczema (VHE) and atopic dermatitis (AD), and found that interferon signaling and necroptosis were significantly increased in VHE compared to AD, as well as some downregulated genes unique to VHE.
CONTACT DERMATITIS
(2023)