Article
Immunology
Huijuan Ma, Qi Shu, Zhiming Li, Xiaodong Song, Huan Xu
Summary: Formaldehyde exacerbates inflammatory responses in allergic contact dermatitis by facilitating NLRP3 inflammasome activation in macrophages. These findings not only demonstrate that formaldehyde can aggravate inflammatory responses by promoting NLRP3 inflammasome activation in macrophages, but also suggest that NLRP3 may be a therapeutic target for alleviating formaldehyde-induced inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Allergy
Kate Dear, Amanda Palmer, Rosemary L. Nixon
Summary: The study investigated contact allergy to PFR2 in a single tertiary dermatology centre, and found that even in a selected population of patients, contact allergy to PFR2 is uncommon. The research recommends routine patch testing to a plastics and glues series containing PFR2 for patients exposed to plastics and glues, or who work with wood products.
CONTACT DERMATITIS
(2021)
Article
Allergy
Waranya Boonchai, Chutipon Pruksaeakanan, Supisara Wongdama, Monthathip Bunyavaree, Titinun Kumpangsin, Chayada Chaiyabutr
Summary: This study aimed to determine the prevalence and trends of contact allergies to formaldehyde and formaldehyde releasers (FRs) in Thailand, as well as analyze the frequency of formaldehyde and FRs mentioned on product labels. The results showed that while contact allergy trends were decreasing, the proportion of products containing FRs remained high.
CONTACT DERMATITIS
(2023)
Review
Allergy
Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan
Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Environmental Sciences
Marielis C. Zambrano, Joel J. Pawlak, Jesse Daystar, Mary Ankeny, Richard A. Venditti
Summary: This study evaluated the influence of common textile finishes on the biodegradation of cotton fibers in an aquatic environment, finding that durable press and water repellent finishing treatments decreased the rate of biodegradation. Despite the impact of finishing treatments on the initial rates of biodegradation, the cellulosic material maintained its biodegradability.
MARINE POLLUTION BULLETIN
(2021)
Article
Dermatology
Holly Neale, Anna Cristina Garza-Mayers, Idy Tam, JiaDe Yu
Summary: ACD is a delayed hypersensitivity skin reaction to environmental allergens that affects children and adults similarly. However, pediatric patch testing for ACD is less common due to challenges such as smaller surface area for testing and difficulty in cooperation, particularly with younger children. Clinical suspicion guided by patient presentation and history is key in diagnosing ACD in children.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Ebru Celik, Kubra Esin Korkmaz, Asena Cigdem Dogramaci
Summary: Brazilian keratin treatment (BKT) is a popular hair straightening method, but may result in severe issues such as allergic contact dermatitis during use.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Allergy
Morgan Nguyen, Slaton Case, Nina Botto, Walter Liszewski
Summary: This study identified discussions about allergic contact dermatitis (ACD) across various social media platforms, including content created by patients, physicians, professional organizations, and companies. Instagram had the most content, while Facebook had patient support groups. However, YouTube videos presented poor quality medical information.
CONTACT DERMATITIS
(2022)
Review
Allergy
An Goossens, Olivier Aerts
Summary: This review provides an update on the role of formaldehyde and its releasers in contact allergy and allergic contact dermatitis, highlighting the need for proper diagnosis and avoidance strategies to manage dermatitis caused by these ubiquitous preservatives.
CONTACT DERMATITIS
(2022)
Review
Allergy
Sander Vandeweege, Britt Debaene, Hilde Lapeere, Hans Verstraelen
Summary: This study reviewed the literature on vulvar allergic contact dermatitis (vACD) and irritative contact dermatitis (vICD), providing a comprehensive reference list of potential vulvar allergens and irritants, and emphasizing the importance of patch testing for identifying causal allergens. Multiple allergens were identified, but not all positive reactions were relevant to the disease. Additional testing methods and late readings should be considered in standard practice. Limited information was found on irritants, highlighting the need for further research.
CONTACT DERMATITIS
(2023)
Review
Dermatology
Alix Danoy, Howard Maibach
Summary: The study found enantiospecificity in allergic reactions to certain chemicals, and proposed a link between one chemical and chronic actinic dermatitis. However, there was no clear evidence of enantio-stereospecificity in inducing allergic reactions. Future research combining modern analytical chemistry and new immunological knowledge is needed to gain clearer insights into the mechanism of allergens.
Article
Chemistry, Multidisciplinary
Zheng Liu, Zhan Fan, Jinxin Liu, Jialu Wang, Mengli Xu, Xinlin Li, Yilun Xu, Yafang Lu, Chenlu Han, Zhihong Zhang
Summary: An immunomodulatory approach based on lipid nanoparticles carrying alpha-helical configurational melittin is developed to treat allergic contact dermatitis and atopic dermatitis by suppressing T cell-mediated inflammatory reactions.
Article
Biochemistry & Molecular Biology
Jinhong Xu, Hui Xiong, Zhongqiu Zhao, Miao Luo, Yankun Ju, Guangzhong Yang, Zhinan Mei
Summary: Genistein shows strong antipruritic and anti-inflammatory effects in ACD mice by inhibiting the production of pro-inflammatory cytokines and intracellular MAP2K2/ERK cell signaling, making it a potential valuable candidate for the treatment of skin conditions and systemic syndromes in the setting of contact dermatitis.
Review
Dermatology
Rebecca S. Kimyon, Jamie P. Schlarbaum, Yujie Linda Liou, Sara A. Hylwa, Erin M. Warshaw
Summary: This article discusses allergy to topical anesthetics, provides detailed information on pramoxine, and describes characteristics of multiple patients with positive, relevant reactions to pramoxine.
Article
Biochemistry & Molecular Biology
Keisuke Nasu, Kenichi Kumagai, Takamasa Yoshizawa, Kazutaka Kitaura, Ryota Matsubara, Motoaki Suzuki, Ryuji Suzuki, Yoshiki Hamada
Summary: In this study, a novel murine model of Pd-induced allergies in the oral mucosa was established, and the immune response of cytokine profiles and T cell diversity in terms of the T cell receptor were explored. The model demonstrated that a Pd-specific T cell population with Th2 type response tendencies may be involved in the Pd-induced intraoral metal contact allergy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
