Drug-drug plasma protein binding interactions of ivacaftor

Antibacterial properties of the CFTR potentiator ivacaftor

(2014) Leah R. Reznikov et al.   Journal of Cystic Fibrosis

Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle

(2013) Kang-Yang Jih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescent Dye Cocktail for Multiplex Drug-Site Mapping on Human Serum Albumin

(2013) Jun Cheng Er et al.   ACS Combinatorial Science

Structure–activity relationships for the binding of polymyxins with human α-1-acid glycoprotein

(2012) Mohammad A.K. Azad et al.   BIOCHEMICAL PHARMACOLOGY

Ivacaftor in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation

(2012) Patrick A. Flume et al.   CHEST

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner

(2012) Paul D. W. Eckford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the regulation of CFTR channels

(2011) Paul D.W. Eckford et al.   BIOCHEMICAL JOURNAL

Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy

(2011) Patrick Kim Chiaw et al.   Essays in Biochemistry

Structural Insights into Differences in Drug-binding Selectivity between Two Forms of Human α1-Acid Glycoprotein Genetic Variants, the A and F1*S Forms

(2011) Koji Nishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A CFTR Potentiator in Patients with Cystic Fibrosis and theG551DMutation

(2011) Bonnie W. Ramsey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin

(2010) Ali J. Ryan et al.   JOURNAL OF STRUCTURAL BIOLOGY

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

(2009) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Protein Binding on the Pharmacological Activity of Highly Bound Antibiotics

(2008) S. Schmidt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular basis for the ATPase activity of CFTR

(2008) Joanne C. Cheung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biliverdin is the endogenous ligand of human serum α1-acid glycoprotein

(2008) Ferenc Zsila et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The intact CFTR protein mediates ATPase rather than adenylate kinase activity

(2008) Mohabir Ramjeesingh et al.   BIOCHEMICAL JOURNAL

The 1.8-Å Crystal Structure of α1-Acid Glycoprotein (Orosomucoid) Solved by UV RIP Reveals the Broad Drug-Binding Activity of This Human Plasma Lipocalin

(2008) Dorian L. Schönfeld et al.   JOURNAL OF MOLECULAR BIOLOGY