Article
Biochemistry & Molecular Biology
Yu-Jing Wang, Hong-Yan Wang, Qiang-Ming Li, Xue-Qiang Zha, Jian-Ping Luo
Summary: In this study, the intervention effect of Dendrobium fimbriatum Hook polysaccharide (cDFPW1) on ulcerative colitis (UC) was confirmed through experiments on mice. The results showed that cDFPW1 significantly alleviated UC symptoms and promoted the proliferation of intestinal epithelial cells. Furthermore, cDFPW1 directly improved intestinal organoid damage and increased the number of epithelial cells, promoting stem cell-mediated intestinal epithelial regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Yasuka Matsunaga, Trevon Clark, Alanna G. Wanek, Jacob P. Bitoun, Qingqing Gong, Misty Good, Jay K. Kolls
Summary: Type 17 cytokines, particularly IL-17, play crucial roles in mucosal immunity by regulating the production of antimicrobial peptides and controlling the generation of pathogen-specific IgA(+) antibody-secreting cells in the intestine.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Conor J. McGrath, Edgaras Laveckis, Andrew Bell, Emmanuelle Crost, Nathalie Juge, Stephanie Schuller
Summary: The gut microbiota plays a crucial role in protecting against enteric infection, but the underlying mechanisms are largely unknown. Researchers developed a new experimental model and optimized the culture medium to study bacterial growth in mucus-producing intestinal cells. They found that L. reuteri and R. gnavus have different effects on EPEC infection and can reduce the secretion of inflammatory factors.
DISEASE MODELS & MECHANISMS
(2022)
Article
Cell & Tissue Engineering
Putianqi Wang, Noelyn Kljavin, Thi Thu Thao Nguyen, Elaine E. Storm, Bryan Marsh, Jian Jiang, William Lin, Hari Menon, Robert Piskol, Frederic J. de Sauvage
Summary: Neurons play a crucial role in regulating the regeneration of intestinal epithelial cells, as they stimulate the production of IL-22 from ILC3s to promote epithelial repair. This adrenergic-ILC3 axis is essential for intestinal regeneration.
Article
Cell Biology
Elena Layunta, Sofia Javerfelt, Brendan Dolan, Liisa Arike, Thaher Pelaseyed
Summary: The intestine is constantly exposed to chemicals, antigens, and microorganisms, but a glycocalyx forms an epithelial barrier preventing the entry of exogenous molecules and live bacteria into the brush-border membrane. Muc17 is identified as a major membrane mucin in the glycocalyx, upregulated by IL-22 during weaning to enhance the epithelial defense repertoire.
Article
Immunology
Ruichao Yue, Xiaoyuan Wei, Liuyi Hao, Haibo Dong, Wei Guo, Xinguo Sun, Jiangchao Zhao, Zhanxiang Zhou, Wei Zhong
Summary: The study found that IL-22 has not only a protective effect on the liver, but also many benefits on the intestine, including regulating the expression of antimicrobial peptides (AMPs), microbiota, and gut barrier function. This is crucial for improving alcohol-induced translocation of gut-derived bacterial pathogens and liver inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Kaijun Wang, Miao Zhou, Hongbin Si, Jie Ma
Summary: Low-grade chronic inflammation, also known as metabolic inflammation, promotes the development of metabolic diseases. Changes in gut microbes and metabolites can reduce inflammation via IL-22, highlighting the potential of IL-22 as a therapeutic target for the management of metabolic inflammation and related diseases.
Article
Cell Biology
Lisa Perruzza, Francesco Strati, Matteo Raneri, Hai Li, Giorgio Gargari, Tanja Rezzonico-Jost, Martina Palatella, Ivo Kwee, Diego Morone, Frauke Seehusen, Paolo Sonego, Claudio Donati, Pietro Franceschi, Andrew J. Macpherson, Simone Guglielmetti, Victor Greiff, Fabio Grassi
Summary: This study demonstrates that hydrolysis of extracellular ATP by apyrase results in amplification of the SIgA repertoire, influencing the distribution of bacteria and gene expression in the intestinal epithelium in mice. Apyrase-induced SIgA improves intestinal homeostasis, attenuating barrier impairment and susceptibility to infection.
Article
Fisheries
Lei Zhu, Yiming Kong, Xulu Chang, Junchang Feng, Xinru Wang, Libo Hou, Xianliang Zhao, Chao Pei, Xianghui Kong
Summary: The study demonstrated that fish-derived probiotics can improve the growth performance, immune response, intestinal microbiota diversity, and pathogen resistance of crayfish, suggesting their potential as feed additives in aquaculture.
Article
Chemistry, Applied
Wei Wu, Jiawei Zhou, Rongrong Xuan, Juanjuan Chen, Hui Han, Jingwangwei Liu, Tingting Niu, Haimin Chen, Feng Wang
Summary: Research suggests that kappa-CGN may not directly cause inflammation, but rather creates an environment that promotes inflammation by altering gut microbiota composition, leading to a decrease in short-chain fatty acids and thinning of the mucus layer. In the presence of pathogenic bacteria, the inflammation and mucosal damage are aggravated. Fecal transplantation from kappa-CGN-fed mice can reproduce these symptoms, which can be partially reversed by administering probiotics.
CARBOHYDRATE POLYMERS
(2022)
Review
Microbiology
Mehreen Anjum, Arja Laitila, Arthur C. Ouwehand, Sofia D. Forssten
Summary: There are various models available to study the interaction between probiotics and pathogens in the gastrointestinal tract, with in vitro methods being faster, cost-effective, and ethically superior. The selection of the optimal model depends on the research question.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chao Liu, Wei Liu, Yanhong Liu, Hongxia Duan, Liqing Chen, Xintong Zhang, Mingji Jin, Minhu Cui, Xiuquan Quan, Libin Pan, Jiachun Hu, Zhonggao Gao, Yan Wang, Wei Huang
Summary: A high-density PEGylation-based glycocholic acid-decorated micelle (PTX@GNPs) was constructed to overcome the obstacles in the gastrointestinal environment. This micelle possesses mucus trapping escape ability and excellent intestine epithelium targeting, enhancing the oral bioavailability of paclitaxel (PTX) and exhibiting similar antitumor efficacy compared to intravenous injection. Furthermore, it can increase in vivo retention time of PTX and remodel the immune microenvironment, enhancing oral chemotherapy efficacy.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Immunology
Jean-Claude Lecron, Sandrine Charreau, Jean-Francois Jegou, Nadjet Salhi, Isabelle Petit-Paris, Emmanuel Guignouard, Christophe Burucoa, Laure Favot-Laforge, Charles Bodet, Anne Barra, Vincent Huguier, Jiad Mcheik, Laure Dumoutier, Julien Garnier, Francois-Xavier Bernard, Bernhard Ryffel, Franck Morel
Summary: This study found that the proinflammatory cytokines IL-22 and IL-17 induced by bacterial infection delay the healing process of skin wounds, regardless of the presence of bacteria. This discovery reveals the underlying mechanisms of bacterial infection on wound healing.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Hung-Yu Chiang, Hsueh-Han Lu, Janaki N. Sudhakar, Yu-Wen Chen, Nien-Shin Shih, Yi-Ting Weng, Jr-Wen Shui
Summary: IL-22 induces IL-18 expression by intestinal epithelial cells, and IL-18 plays an important role in host defense against intestinal infection and inflammation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Xinyue Wang, Sisi Lin, Lu Wang, Zhenping Cao, Mengmeng Zhang, Yifan Zhang, Rui Liu, Jinyao Liu
Summary: Outer membrane vesicles (OMVs) released by Akkermansia muciniphila can restore gut microbiota balance, stimulate mucosal immunoglobulin A response, and maintain intestinal barrier integrity by entering intestinal epithelial cells. Transplanting gut microbiota-derived OMVs can alleviate colitis and enhance anti-PD-1 therapy against colorectal cancer. This study highlights the important role of gut microbiota-derived OMVs in intestinal ecology and provides a new target for disease intervention and treatment.
Article
Biochemistry & Molecular Biology
Ankita Chadda, Alexander G. Kozlov, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt
Summary: In this study, it was found that the DNA damage response in Mycobacterium tuberculosis differs from well-studied model bacteria. The DNA repair helicase UvrD1 in Mtb is activated through a redox-dependent process and is closely associated with the homo-dimeric Ku protein. Additionally, Ku protein is shown to stimulate the helicase activity of UvrD1.
JOURNAL OF MOLECULAR BIOLOGY
(2024)
