Journal
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
Volume 32, Issue 3, Pages 239-250Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compmedimag.2007.12.004
Keywords
cardiac; small animal imaging; micro-CT; phenotyping; segmentation; volume measurement
Funding
- NCI NIH HHS [R21 CA124584-02, R21 CA124584-01, R21 CA124584, U24 CA092656, U24 CA092656-08, R24 CA092656] Funding Source: Medline
- NCRR NIH HHS [P41 RR005959, P41 RR006009-13S10011, P41 RR005959-18, P41 RR006009] Funding Source: Medline
- NLM NIH HHS [N01-LM-9-3531] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [U24CA092656, R21CA124584, R24CA092656] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR005959, P41RR006009] Funding Source: NIH RePORTER
- NATIONAL LIBRARY OF MEDICINE [N01LM093531] Funding Source: NIH RePORTER
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Micro-CT-based cardiac function estimation in small animals requires measurement of left ventricle (LV) volume at multiple time points during the cardiac cycle. Measurement accuracy depends on the image resolution, its signal and noise properties, and the analysis procedure. This work compares the accuracy of the Otsu thresholding and a region sampled binary mixture approach, for live mouse LV volume measurement using 100 mu m resolution datasets. We evaluate both analysis methods after varying the volume of injected contrast agent and the number of projections used for CT reconstruction with a goal of permitting reduced levels of both X-ray and contrast agent doses. (C) 2007 Elsevier Ltd. All rights reserved.
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