Article
Engineering, Electrical & Electronic
Tuan Ngoc Anh Vo, Pin-Chuan Chen
Summary: Polydimethylsiloxane (PDMS) and polymethylmethacrylate (PMMA) have wide applications in microfluidics due to their biocompatibility, optical transparency, and ease of fabrication. This paper proposes a systematic approach to enhance the interfacial bonding strength between PDMS and PMMA, and successfully fabricates microfluidic devices capable of withstanding high pressure and flow rates.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Chemistry, Analytical
Chia-Wen Tsao, Chang-Yen Chang, Po-Yen Chien
Summary: This paper presents a microwave-assisted solvent bonding method for sealing thermoplastic substrates using organic solvent. The method is simple and does not require expensive facilities or complex procedures. The bonding performance of the method is evaluated and compared with other heating methods, showing high bonding yield and strength without microchannel distortion.
Article
Optics
Shashi Prakash, Subrata Kumar
Summary: The article introduces different strategies for fabricating microchannels using CO2 lasers and conducts experimental studies to compare them in terms of surface quality, cross-sectional profile, and other parameters.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Polymer Science
Anthony Tony, Ildiko Badea, Chun Yang, Yuyi Liu, Kemin Wang, Shih-Mo Yang, Wenjun Zhang
Summary: This study presents a simple and effective method to enhance the bonding strength between polydimethylsiloxane (PDMS) and PDMS using isopropyl alcohol (IPA). The results showed that our method significantly improved the irreversible bonding strength of PDMS-to-PDMS, up to 3.060 MPa for natural-cured PDMS and 1.373 MPa for heat-cured PDMS, while the best bonding strength with the existing method in literature is 1.9 MPa.
Article
Chemistry, Analytical
Yuanyuan Wei, Tianle Wang, Yuye Wang, Shuwen Zeng, Yi-Ping Ho, Ho-Pui Ho
Summary: In this paper, a simple, rapid, low-cost, biocompatible, and detachable microfluidic chip fabrication method based on Parafilm(R) is reported. The Parafilm(R) acts as both a bonding agent and a functional membrane, allowing the fabrication of 3D structured microfluidic chips within 2 hours with high ultimate tensile stress and high shear stress. The fabricated chips demonstrate better stability, reliability, and high performance for practical actuation devices. Moreover, the Parafilm(R)-based microfluidic devices show excellent biocompatibility and can be used for biochemical applications and point-of-care diagnostics.
Article
Engineering, Biomedical
Pinak Samal, Jay Rabindra Kumar Samal, Hoon Suk Rho, Denis van Beurden, Clemens van Blitterswijk, Roman Truckenmuller, Stefan Giselbrecht
Summary: This paper presents a novel method for fabricating subcellular structures in the commonly available material PMMA, and discusses the effects of different developers. It also highlights the fabrication of 3D curvilinear surfaces with microstructures and the production of multilayered microfluidic chips. The method can be used for selectively exposing stem cells to soluble factors by replicating microstructures.
MATERIALS TODAY BIO
(2023)
Article
Nanoscience & Nanotechnology
Yusheng Li, Xiaoyang Wang, Shuo Yang, Jing Liu, Qi Zhang, Yiqiang Fan
Summary: A low-cost, rapid, and low-residue reversible bonding method using freeze-release adhesive was proposed in this study. The poly(butyl methacrylate)-based adhesive achieved high bonding strength between thermoplastic plates with gentle compression force and/or thermal treatment. The plates could be detached by storing the bonded chip in the refrigerator or using freeze spray. The proposed method is simple, rapid, low residue, and harmless to biological samples inside the microfluidic chip.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Review
Chemistry, Physical
Amid Shakeri, Shadman Khan, Noor Abu Jarad, Tohid F. Didar
Summary: This review provides a comprehensive discussion of recent developments in thermoplastic microfluidic device fabrication, highlighting both existing and emerging approaches. It also discusses how specific approaches induce physical and/or chemical properties that are optimally suited for real-world applications.
Article
Nanoscience & Nanotechnology
Yin Yao, Lu Li, Jiaxi Jiang, Yajun Zhang, Guohua Chen, Yiqiang Fan
Summary: A novel reversible bonding method using UV curable release tape is proposed in this study, which offers a higher bonding strength and can be easily debonded with a simple UV exposure process.
MICROFLUIDICS AND NANOFLUIDICS
(2022)
Article
Energy & Fuels
Laura Jasinska, Krzysztof Szostak, Mateusz Czok, Karol Malecha, Piotr Slobodzian
Summary: The paper presents preliminary results on the development of an integrated stripline-based microwave-microfluidic module, with measurements conducted in the frequency range of 300 MHz to 12 GHz. Due to higher-than-expected losses in transmittance, the module was further examined through cross-sections along its length, and possible causes and areas for further investigation were highlighted and described.
Article
Polymer Science
Wei-Ting Du, Shiao-Wei Kuo
Summary: In this study, we synthesized a series of random copolymers of methyl methacrylate (MMA) and N-hydroxyphenylmaleimide (HPMI) using free radical copolymerization. These copolymers exhibited high glass transition temperatures (T-g) due to the strong intermolecular hydrogen bonding between the PMMA and PHPMI segments. The results from various analytical techniques confirmed the chemical structures, thermal properties, hydrogen bonding interactions, and sequence distributions of these copolymers.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Engineering, Chemical
Chia-Wen Tsao, Chang-Yen Chang, Wei-Wen Hu, Yun-Shan Tian
Summary: We propose a water-assisted microwave bonding (H2O-μWave bonding) process for sealing thermoplastic microfluidic devices. Water is used as the bonding reagent to assist the formation of covalent bonds after surface activation and water evaporation procedures. The effects of UV/Ozone and O2 plasma surface treatments on the surface properties of a PMMA substrate in H2O-μWave bonding are examined. Bonding strength, coverage, stability, and multilayer bonding are further evaluated.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2023)
Article
Chemistry, Analytical
Zhaokun Xian, Peng Dai, Wenyun Su, Cuimin Sun, Liming Liu, Hui You, Ying Liu
Summary: We have designed a novel microfluidics pump-free PMMA/paper hybrid immunosensor for quantitative and ultrasensitive detection of alpha-fetoprotein (AFP). By improving the 2D planar structure of the plastic microfluidic chip to a 3D spatial structure, the capture antibody immobilization and the cross-section area of the intercepted target protein are increased. PMMA channels efficiently transport target proteins. The paper-based, three-dimensional detection area increases the amount of immobilized captured antibody and improves the contact probability between the captured antibody and the target protein, greatly improving the efficiency of immune binding. The immunosensor achieves ultra-sensitive detection of AFP in the range of 0.01 ng/mL to 100 ng/mL with a limit of quantitation as low as 4.5 pg/mL, under optimal conditions. The recoveries for AFP range from 96.6% to 101.5%, indicating the reliability and potential of the hybrid microfluidics chip for early screening.
MICROCHEMICAL JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Lu Li, Yafeng Huang, Yiqiang Fan
Summary: This study proposes a low-cost PMMA-based microfluidic chip bonding method using blue diode laser transmission welding. Compared with traditional bonding methods, this method achieves higher bonding strength without contaminating the microchannel.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Chemistry, Analytical
Henrik Persson, Siwan Park, Michael Mohan, Ka Kit Cheung, Craig A. Simmons, Edmond W. K. Young
Summary: This study presents a method to bond poly(methylmethacrylate) layers to a polyethylene terephthalate porous membrane for creating membrane-based microfluidic devices. The bonding method allows for rapid fabrication of devices without adverse effects on the membrane structure. The bonded devices support long term cell culture and experiments related to barrier and endothelial function.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Nanoscience & Nanotechnology
Qihui Zhou, Thomas R. Jones, Hamid Moghadas, Mojgan Daneshmand
Article
Engineering, Electrical & Electronic
M. Benlamri, S. Deif, N. Mahdi, M. Baghelani, M. H. Zarifi, D. W. Barlage, K. Shankar, M. Daneshmand
SEMICONDUCTOR SCIENCE AND TECHNOLOGY
(2020)
Review
Clinical Neurology
Calvin W. Howard, Amirali Toossi, Vivian K. Mushahwar
Summary: This paper discusses the potential impact mechanisms of noise on neuronal function, including channel resonance, stochastic resonance, and high conductance states. It also explores how noise can enhance the theoretical and evidence base for electrical stimulation of the nervous system.
Article
Multidisciplinary Sciences
Amirali Toossi, Bradley Bergin, Maedeh Marefatallah, Behdad Parhizi, Neil Tyreman, Dirk G. Everaert, Sabereh Rezaei, Peter Seres, J. Christopher Gatenby, Steve I. Perlmutter, Vivian K. Mushahwar
Summary: The overall goal was to create a high-resolution MRI atlas of the lumbosacral enlargement of the spinal cord in different species and compare the sizes and locations of gray and white matter. Pigs and humans were found to have the largest and most similar enlargements, followed by monkeys and cats, and finally rats.
SCIENTIFIC REPORTS
(2021)
Article
Physics, Applied
S. S. Olokede, M. L. Neyestana, Marco Chu, M. Daneshmand, H. E. Naguib
Summary: A cylindrical dual-mode planar microwave ring resonator designed for a permanent moisture sensor shows stability and accuracy through optimization and experimental validation.
APPLIED PHYSICS LETTERS
(2021)
Article
Engineering, Electrical & Electronic
Masoud Baghelani, Omid Hasan-Nejad, Mojgan Daneshmand
Summary: One of the key characteristics of planar microwave resonator-based sensors is their sensitivity, which is described by the shift in resonance frequency versus variation in dielectric constant. While these sensors offer moderate sensitivity levels for various applications, they face limitations in detecting material variations in sub-percent or ppm range. This study explores the reasons behind limited sensitivity in these sensors and proposes a measurement structure capable of detecting extremely low concentrations of water contamination in mineral oil samples, showing high sensitivity with 30 kHz frequency shift for detecting water concentrations as low as 50 ppm.
IEEE SENSORS JOURNAL
(2021)
Article
Engineering, Electrical & Electronic
Mohammad Abdolrazzaghi, Nir Katchinskiy, Abdulhakem Y. Elezzabi, Peter E. Light, Mojgan Daneshmand
Summary: The study demonstrates the use of microwave sensors for monitoring glucose concentration in serum with high sensitivity and resolution, capable of detecting lower concentrations of glucose. This technique could be valuable for developing noninvasive glucose sensors for real-time monitoring in biomedical applications.
IEEE SENSORS JOURNAL
(2021)
Article
Automation & Control Systems
Masoud Baghelani, Navid Hosseini, Mojgan Daneshmand
Summary: A new approach for analyzing the volumetric fraction of different components in biofuel samples is proposed, using new independent features extracted based on multiharmonics measurement of frequency and amplitude variations of the transmission response of a resonator. The experiment shows that the sensor is capable of selectively analyzing all the components of a multivariable mixture simultaneously, achieving an average relative error in determining the water concentration in the biofuel samples as low as 0.09%.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2021)
Article
Engineering, Biomedical
Soroush Mirkiani, David A. Roszko, Carly L. O'Sullivan, Pouria Faridi, David S. Hu, Daniel Fang, Dirk G. Everaert, Amirali Toossi, Peter E. Konrad, Kevin Robinson, Vivian K. Mushahwar
Summary: This study assessed the gait biomechanics and the effect of overground walking speed on gait parameters, kinematics, and electromyographic activity in Yucatan minipigs. Increases in speed led to decreases in stride duration, stance and swing times, and an increase in stride length. The range of motion of the knee and ankle joints increased at higher speeds, and the onset of muscle activity occurred earlier in the gait cycle with increasing speed. These findings provide valuable insights for future interventions in Yucatan minipigs.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Chemistry, Analytical
Milad Alizadeh-Meghrazi, Gurjant Sidhu, Saransh Jain, Michael Stone, Ladan Eskandarian, Amirali Toossi, Milos R. Popovic
Summary: This study developed textile electrodes as an alternative to traditional gel electrodes for recording electromyography (EMG) signals, and compared their performance and washability. The results showed that the textile electrodes performed comparably to gel electrodes in signal recording, and were able to successfully control a myoelectric prosthetic hand.
Article
Materials Science, Multidisciplinary
Ladan Eskandarian, Amirali Toossi, Farah Nassif, Sahar Golmohammadi Rostami, Siting Ni, Amin Mahnam, Milad Alizadeh Meghrazi, Wataru Takarada, Takeshi Kikutani, Hani E. Naguib
Summary: This paper proposes flexible, breathable, and washable dry textile electrodes made of conductive elastomeric filaments (CEFs) to address the limitations of wearables for continuous monitoring. The CEF electrodes are found to have comparable fidelity to gold standard gel electrodes and are resistant to repeated wash and dry cycles. Smart undergarments with these textile electrodes successfully perform long-term continuous ECG monitoring.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Engineering, Biomedical
Masoud Baghelani, Zahra Abbasi, Mojgan Daneshmand, Peter E. Light
Summary: Monitoring lactate levels in a non-invasive and real-time manner is important in critical care and sports. A new chipless tag resonator has been developed, which can be taped on the skin and coupled to a reader for electromagnetic detection. This technology allows accurate and reproducible measurement of lactate concentrations and has the potential for monitoring lactate in specific working muscle groups.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Review
Materials Science, Multidisciplinary
Ladan Eskandarian, Elmira Pajootan, Amirali Toossi, Hani E. Naguib
Summary: Long-term continuous health care monitoring using wearable technologies is gaining attention for its significant contribution to disease diagnosis and health condition identification. Fiber-based electrodes, integrated into smart textiles and wearables, offer advantages such as breathability, flexibility, and durability for continuous biosignal monitoring. This review summarizes recent breakthroughs in the design and manufacturing of dry fiber-based electrodes for electrophysiology applications, with a focus on electrocardiography, electromyography, and electroencephalography. Current limitations and future development prospects, including electroactive fiber materials, fiber processing, electrode fabrication, scaled-up manufacturing, and standardization of testing and performance criteria, are also discussed.
ADVANCED FIBER MATERIALS
(2023)
Article
Surgery
[Anonymous]
CANADIAN JOURNAL OF SURGERY
(2020)
Article
Computer Science, Information Systems
Thomas R. Jones, Mojgan Daneshmand
