Journal
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
Volume 2012, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2012/192618
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Funding
- Academy of Finland [125415, 140730, 218038]
- Sigrid Juselius Foundation, Finland
- European Research Council (ERC)
- National Doctoral Programme of Musculoskeletal Disorders and Biomaterials, Finland
- Academy of Finland (AKA) [218038, 125415, 140730, 125415, 140730, 218038] Funding Source: Academy of Finland (AKA)
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Micropipette aspiration (MA) technique has been widely used to measure the viscoelastic properties of different cell types. Cells experience nonlinear large deformations during the aspiration procedure. Neo-Hookean viscohyperelastic (NHVH) incompressible and compressible models were used to simulate the creep behavior of cells in MA, particularly accounting for the effect of compressibility, bulk relaxation, and hardening phenomena under large strain. In order to find optimal material parameters, the models were fitted to the experimental data available for mesenchymal stem cells. Finally, through Neo-Hookean porohyperelastic (NHPH) material model for the cell, the influence of fluid flow on the aspiration length of the cell was studied. Based on the results, we suggest that the compressibility and bulk relaxation/fluid flow play a significant role in the deformation behavior of single cells and should be taken into account in the analysis of the mechanics of cells.
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