Journal
COMPTES RENDUS CHIMIE
Volume 11, Issue 11-12, Pages 1483-1522Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crci.2008.07.003
Keywords
Ansamycin; Anticancer antibiotics; Geldanamycin; Ansatrienin
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Funding
- NIH [CA56304]
- Novartis Graduate Fellowship
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Ansamycin antibiotics are a class of microbial metabolites that exhibit an array of biological activities. This review covers the synthetic chemistry and biological activity of benzenic ansamycins from 1989 to 2007. In the first section, synthetic approaches to the C15-benzene ansamycins (geldanamycin and related) are discussed. Access to the C17-benzene ansamycins (or ansatrienins) is disclosed in the second half of this article. To cite this article: Iwona E. Wrona et al., C. R. Chimie 11 (2,908). (C) 2008 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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