Journal
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
Volume 35, Issue 1, Pages 23-30Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cimid.2011.09.006
Keywords
Escherichia coli F18; Post-weaning piglet; SLA-1; SLA-3
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Funding
- Genetically Modified Organisms Technology Major Project [2009ZX08006-004B]
- National Natural Science Funds [31172183, 31140027]
- Jiangsu Province Science and Technology Supporting Project (Agriculture) [BE2009330-2, BE2010371]
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Porcine post-weaning diarrhea and edema disease are principally caused by Escherichia colt strains that produce F18 adhesin. FUT1 genotyping and receptor binding studies divided piglets into E. coli F18-resistant and -sensitive groups, and the roles of SLA-1 and SLA-3 were investigated. SLA-1 and SLA-3 expression was detected in 11 pig tissues, with higher levels of SLA-1 in lung, immune tissues and gastrointestinal tract, and higher levels of SLA-3 also in lung and lymphoid tissues. Both genes were expressed higher in F18-resistant piglets, and their expression was positively correlated in different tissues; a negative correlation was observed in some tissues of F18-sensitive group, particularly in lung and lymphatic samples. Gene ontology and pathway analyses showed that SLA-1 and SLA-3 were involved in 37 biological processes, including nine pathways related to immune functions. These observations help to elucidate the relationship between SLA class I genes and E. coli F18-related porcine gastrointestinal tract diseases. (C) 2011 Elsevier Ltd. All rights reserved.
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