Journal
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
Volume 34, Issue 2, Pages 157-161Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cimid.2010.06.005
Keywords
Allergens; CpG; Pollen; IgE
Categories
Funding
- Ministry of Health, Labor, and Welfare of Japan
- Promotion and Mutual Aid Corporation for Private Schools of Japan
- Azabu University Research Services Division
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We determined whether a major Japanese cedar pollen allergen (Cry j 1) conjugated with CpG oligodeoxynucleotide would enhance allergen-specific Th1 responses in mice. Cry j 1 conjugated with CpG (Cry j 1-CpG) induced IL-12 in the spleen cells of naive mice. Cry j 1-CpG immunization of BALB/c mice suppressed anti-Cry j 1 IgE response and enhanced anti-Cry j 1 IgG(2a) to subsequent Cry j 1 and alum adjuvant injection. CD4(+)T cells isolated from the spleens in mice immunized with Cry j 1-CpG produced higher IFN-gamma levels than did CD4(+)T cells obtained from mice as negative controls. Our results suggested that Cry j 1-CpG immunization can induce Cry j 1-specific Th1 immune responses, thereby inhibiting IgE response to the pollen allergen. (C) 2010 Elsevier Ltd. All rights reserved.
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