Journal
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
Volume 151, Issue 4, Pages 447-454Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpc.2010.01.010
Keywords
Energy deficit; Glucocorticoids; Intramyocellular lipid; Uptake; Utilization
Funding
- Shandong Science Fund for Distinguished Youth Scholars
- National Basic Research Program of China [2004CB117507]
- National Natural Science Foundation of China [30771573]
- Doctoral Program of Higher Education
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Effects of dexamethasone (DEX) and mild feed restriction on the uptake and utilization of fatty acids in skeletal muscle of broiler chicks (Gallus gallus domesticus) were investigated Male Arbor Acres chicks (7-days old, n = 30) were injected with DEX or saline for 3 days, and a feed restriction group was included DEX enhanced circulating very low density lipoprotein (VLDL) level and the lipid accumulation in both adipose and skeletal muscle tissues Compared with the control, liver-carnitine palmitoyltransferase 1 (L-CPT1) and AMP-activated protein kinase (AMPK) alpha 2 mRNA level of M biceps lemons (BF) were down-regulated significantly by DEX, while mRNA expression of lipoprotein lipase (LPL), fatty acid transport protein 1 (FATP1), heart-fatty acid binding protein (H-FABP), long-chain acyl-CoA dehydrogenase (LCAD). activities of LPL and AMPK in both skeletal muscles were not obviously affected Feed restriction increased the mRNA expression of LPL. L-CPT1 and LCAD of M pectoral's major (PM), and FATP1. H-FABP, L-CPT1 and LCAD of BF In conclusion, DEX retards the growth of body mass but facilitates lipid accumulation in both adipose and skeletal muscle tissues In contrast to the favorable effect of mild feed restriction, DEX did not alter the uptake of fatty acids in the skeletal muscle. The result suggests that DEX may promote intramyocellular lipid accumulation by suppressed fatty acid oxidation while mild feed restriction improved fatty acid oxidation in skeletal muscle, especially in red muscle Glucocorticoids (GCs) regulated muscle fatty acid metabolism in a different way from energy deficit caused by mild feed restriction. (C) 2010 Elsevier Inc All rights reserved.
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