Article
Environmental Sciences
Lauris Evariste, Antoine Mottier, Eric Pinelli, Emmanuel Flahaut, Laury Gauthier, Florence Mouchet
Summary: The interest in graphene-based nanomaterials (GBMs) is increasing globally due to their innovative applications, but concerns about their potential adverse effects on the environment and endocrine disruption potential are also growing. A study found that graphene oxide (GO) and reduced graphene oxide (rGO) have different effects on amphibian endocrine systems, with GBMs potentially increasing the bioavailability and toxicity of other pollutants through hormone adsorption. This highlights the need for further research on the environmental impact and potential risks associated with GBMs.
Review
Oncology
Chao Xu, Zhao He, Yongfeng Song, Shanshan Shao, Guang Yang, Jiajun Zhao
Summary: It has been traditionally believed that pituitary hormones act on their cognate receptors in classical target glands to carry out their various functions. However, recent studies have revealed that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs. This article summarizes the additional biological functions of pituitary hormones (thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin) when they act on non-classical organs, defining them as part of an atypical pituitary hormone-target tissue axis. This novel concept provides insight into the mechanisms behind metabolic diseases and offers potential novel therapeutic targets.
FRONTIERS OF MEDICINE
(2023)
Review
Endocrinology & Metabolism
Yun-Bo Shi
Summary: Thyroid hormone T3 plays a critical role in organ function, metabolism, and animal development, especially during the neonatal period in mammals. Studies on anuran metamorphosis in amphibians have shed light on how T3 regulates vertebrate development. The absence of T3 receptors in tadpoles leads to premature development of adult tissues and eventually lethality, highlighting the importance of TRs in mediating T3 effects.
Article
Multidisciplinary Sciences
Ningping Gong, Diogo Ferreira-Martins, Jessica L. Norstog, Stephen D. McCormick, Mark A. Sheridan
Summary: This study investigated the early evolution and function of the growth hormone (GH)/prolactin (PRL) family using a representative of one of the oldest vertebrate lineages. A second member of the GH/PRL family, prolactin-like (PRL-L), was identified in the sea lamprey. The findings provide insights into the origin and divergence of GH/PRL family genes in early vertebrates. The lamprey PRL-L plays a role in osmoregulation and is comparable to the function of PRLs in jawed vertebrates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Bidisha Paul, Zachary R. Sterner, Daniel R. Buchholz, Yun-Bo Shi, Laurent M. Sachs
Summary: Development in multicellular organisms relies on the integration of communication systems, particularly the neuroendocrine axes. The hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal/interrenal axes play central roles in coordinating body morphogenesis. Thyroid hormones and corticosteroids have critical functions in metamorphosis of anuran amphibians and are involved in the developmental transition seen in vertebrates.
Review
Oncology
Alessio Basolo, Antonio Matrone, Rossella Elisei, Ferruccio Santini
Summary: The increasing knowledge of molecular mechanisms in cell signaling pathways has led to the discovery of tyrosine kinases, which can be targeted for anticancer therapy. Tyrosine kinase inhibitors block enzyme activity and inhibit the growth and spread of cancer, but can also cause thyroid dysfunction.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Rikke Poulsen, Shireen H. Jackman, Martin Hansen, Caren C. Helbing
Summary: Anuran metamorphosis is associated with changes in thyroid hormone levels and gene expression. New technology allows for measuring TH levels and gene transcription during metamorphosis. The concentration profile of T2 during metamorphosis suggests its role in anuran development.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Environmental Sciences
ZhiChao Dang
Summary: Both AMA and LAGDA are used to detect thyroid-mediated modality and adversity based on morphological changes during thyroid hormone-dependent metamorphosis. The EU Guidance recommends their use for investigating the effects of thyroid hormone system disrupting chemicals. However, there is debate over the necessity of using LAGDA as a follow-up to positive AMA results. This study analyzes the similarities, differences, and sensitivity of these two assays in detecting TDCs.
ENVIRONMENTAL POLLUTION
(2022)
Article
Toxicology
Douglas J. Fort, M. Annegaaike Leopold, Jeffrey C. Wolf, Kevin J. Todhunter, Peter J. J. M. Weterings
Summary: The present study evaluated the impact of dietary quality on the effects of chemical stressors on premetamorphic development and metamorphosis in tadpoles. The results showed that suboptimal dietary quality negatively affected both growth and metamorphic development, and iodine supplementation only partially compensated for the effects on metamorphosis.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Yuji Shimizu, Shin-Ya Kawashiri, Yuko Noguchi, Yasuhiro Nagata, Takahiro Maeda, Naomi Hayashida
Summary: Anti-thyroid peroxidase antibody (TPO-Ab) is inversely associated with thyroid cysts, possibly indicating latent thyroid damage. The association between HbA1c and thyroid cysts showed an inverse correlation in participants with subclinical hypothyroidism.
Article
Cell Biology
Yuki Shibata, Yuta Tanizaki, Hongen Zhang, Hangnoh Lee, Mary Dasso, Yun-Bo Shi
Summary: Research shows that TR genes play crucial roles in larval epithelial cell death and adult stem cell formation during anuran metamorphosis. Lack of these processes in TRDKO tadpoles results in inhibition of metamorphosis progression.
Review
Medicine, Research & Experimental
Wenxiu Tian, Huimin Qi, Zhimei Wang, Sen Qiao, Ping Wang, Junhong Dong, Hongmei Wang
Summary: This article summarizes the functions of female-associated hormones in tumors and investigates the mechanisms underlying female hormone-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Chemistry, Analytical
Qiyong Cai, Shuiling Jin, Hong Zong, Lu Pei, Ke Cao, Lingbo Qu, Zhaohui Li
Summary: This study developed a quadruplex ultrasensitive immunoassay for simultaneous assessment of four reproductive hormone proteins in various biofluid samples. The assay exhibited good performance and consistency with clinical test results, allowing for rapid and accurate diagnosis of reproductive endocrine disorders.
ANALYTICAL CHEMISTRY
(2023)
Review
Ecology
Karine Rousseau, Sylvie Dufour, Laurent M. M. Sachs
Summary: This review focuses on the metamorphoses and developmental transitions in vertebrates, highlighting the important roles played by neuroendocrine axes in regulating these life transitions. It also discusses the impact of global climate change and environmental factors on developmental processes.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Cell Biology
Sakae Kikuyama, Itaru Hasunuma, Reiko Okada
Summary: The review article discusses the embryonic origins of the adenohypophysis and hypothalamus in amphibians, as well as the development of the hypothalamo-hypophyseal system for metamorphosis completion. The interaction of thyroid hormone and adrenal cortico-steroids plays a key role in metamorphosis, with different releasing factors involved compared to mammals. Prolactin, modulated by TRH, has a dual function in regulating metamorphic speed and organ development for adult life.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gabriela Maressa Machado Baesso, Amanda Vitoria Venancio, Livia Costa Varela Barca, Pepita Fernanda Peppi, Caique Aparecido Faria, Joao Pedro Cosmo Machado, Luiz David Solis Murgas, Alvaro Jose de Almeida Bicudo, Eduardo Mauricio Mendes de Lima, Andre Rodrigues da Cunha Barreto-Vianna
Summary: This study evaluated the effects of eugenol, menthol, and lidocaine as anesthetics on glucose levels and recovery times in zebrafish. The results showed that eugenol and menthol did not affect glucose levels, while lidocaine caused non-concentration-dependent hyperglycemia. Recovery times were similar for eugenol and menthol, but concentration-dependent for lidocaine. Eugenol and menthol were deemed safe and satisfactory for glucose analysis in zebrafish research, while lidocaine could introduce biases and safety concerns. Researchers should carefully consider the selection of anesthetics for reliable results in zebrafish assessments.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaoxue Li, Tangsong Feng, Weiqun Lu
Summary: This study reveals that exposure to VPA induces ASD-like phenotypes and behaviors, including gene transcription changes, social interaction deficit, decreased aggression, increased anxiety behavior, and elevated cortisol levels. The aggression behavior assay is a better predictor of neurotoxicology behavior of VPA.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: In this study, we investigated the hepatotoxicity and mechanism of action of pyridaben using zebrafish and ZFL cells. Pyridaben caused liver size reduction and apoptosis, and these effects were associated with uncontrolled intracellular calcium flow and downregulation of the PI3K/Akt signaling cascade.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Md Alamgir Kabir, Md. Golam Rabbane, Marco R. Hernandez, Md Aftab Ali Shaikh, Mohammad Moniruzzaman, Xuexiu Chang
Summary: This study investigated the toxicity of high concentrations of cadmium (Cd) on intestinal immunity and microbial diversity in common carp. The results showed that high Cd concentration caused intestinal inflammation, immunosuppression, and changes in the gut microbiome, leading to detrimental effects on the intestinal homeostasis and health status of the fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Anuradha Batabyal, Veronica Rivi, Cristina Benatti, Johanna M. C. Blom, Fabio Tascedda, Ken Lukowiak
Summary: This study found that exposure to heat shock stressors and bacterial lipopolysaccharide can induce the Garcia effect in pond snails. Additionally, aspirin can prevent the formation of the Garcia effect. However, unexpectedly, exposure to crushed aspirin and heat shock stressors together leads to long-lasting feeding suppression and molecular changes in the snails' serotoninergic system and neuroplasticity genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Li-Yih Lin, Chieh-An Cheng, Sian-Tai Liu, Jiun-Lin Horng
Summary: This study reveals that ammonia exposure impairs ion regulation in zebrafish embryos by inducing oxidative stress, mitochondrial dysfunction, and cell death. The findings suggest that ammonia is toxic to aquatic animals and can lead to the death of embryos.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Antonio Durate Pagano, Natieli Machado Goncalves, William Borges Domingues, Tony Leandro Rezende da Silveira, Mateus Tavares Kutter, Antonio Sergio Varela Jr, Carine Dahl Corcini, Mariana Cavalcanti Nascimento, Luana Ferreira Viana dos Reis, Patricia Gomes Costa, Adalto Bianchini, Matheus Vieira Volcan, Mariana Harter Remia, Vinicius Farias Campos
Summary: This study analyzed the toxic effects of Roundup Transorb (R) on the endangered Neotropical annual killifish Austrolebias charrua by evaluating molecular and biochemical biomarkers. The findings showed that exposure to Roundup significantly increased the production of reactive oxygen species, lipid peroxidation, and DNA damage in the fish's blood cells. It also decreased membrane fluidity. Gene expression analysis revealed alterations in genes associated with oxidative stress and antioxidant defense. This study provides new insights into adaptive mechanisms of A. charrua in response to Roundup, and it has important implications for environmental monitoring and aquatic toxicology assessment.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaochan Gao, Hongtao Ren, Yong Huang, Yimin Li, Jiaqi Shen
Summary: The influence of multi-walled carbon nanotubes (MWCNTs) on the toxicity of zinc oxide nanoparticles (ZnONPs) in the intestine of common carp was investigated. The study found that the concentration and concentration ratio of the mixture played a role in the toxicity of ZnONPs. The presence of MWCNTs significantly decreased intercellular zinc accumulation and altered the microbial community diversity and composition of the gut microbiota.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Guangchao Yang, Qian Yang, Trust Beta, Qin Liu, Zhenzhu Zhu, Fei Shen
Summary: The study found that black garlic MLDs have alleviative effects on ZEN-induced toxicity, and exert their effects through antioxidative, anti-apoptotic, and inhibitory mechanisms on ZEN absorption.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tuul Sepp, Ciara Baines, Randel Kreitsberg, Joern Peter Scharsack, Pedro Nogueira, Thomas Lang, Jerome Fort, Elin Sild, John T. Clarke, Arvo Tuvikene, Richard Meitern
Summary: Environmental factors can cause cancer in both wild animals and humans. The use of polluted habitats provides opportunities to study cancer defense mechanisms, which can be influenced by genetic variation and natural selection. Flatfish species, specifically flounders, show higher resistance to pollution-induced cancer compared to dabs, with elevated pollutant metabolism and stronger tumor suppression mechanisms in their liver tissue. This suggests a potential hormetic upregulation of tumor suppression or stronger natural selection pressure for cancer resistance in flounders. Wild species offer valuable insights into understanding the nature and evolution of natural cancer defense mechanisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Regan A. Moss, Kaitlyn M. Murphy, Steven T. Gardner, Madison M. Watkins, John W. Finger Finger Jr, Meghan D. Kelley, Ruth M. Elsey, Daniel A. Warner, Mary T. Mendonca
Summary: The study explored the impact of environmentally relevant concentrations of E2 on the immune system and hormone levels of hatchling American alligators. Results showed that exposure to environmental estrogen can alter plasma hormone concentrations but have little to no impact on morphology and immune responses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ye Liang, Zihao Li, Jing Yuan, Yiwen Zhou, Meng Li, Haifeng Gu
Summary: This study investigated the toxicity mechanism of homo-YTX and NH3-N on the survival of abalone. The results showed that homo-YTX and NH3-N enhanced oxidative stress and lipid peroxidation reactions, inhibited energy supply, disrupted metabolic and immune physiological functions, and activated apoptosis in the gills of abalone.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)