Editorial Material
Computer Science, Information Systems
Rafael Capilla, Miroslaw Staron
Summary: SEAA is an international forum for discussing the latest trends and innovations in software engineering and advanced applications. This special issue highlights the use of systematic reviews, deep learning, and cloud computing in software engineering.
INFORMATION AND SOFTWARE TECHNOLOGY
(2021)
Editorial Material
Engineering, Biomedical
Alison Burdett, Pedram Mohseni, Maysam Ghovanloo, Roman Genov
Summary: The papers in this special section were presented at the 2021 IEEE International Solid-State Circuits Conference.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2021)
Review
Agriculture, Dairy & Animal Science
W. Jean Dodds
Summary: Animal models of human and animal diseases have been extensively studied in both experimental and clinical research, leading to advancements in the management and therapy of these disorders. Molecular and genomic research has allowed for the gene editing and gene therapies of an increasing number of heritable human and animal bleeding diseases.
Review
Behavioral Sciences
Eliza Bliss-Moreau, Peter H. Rudebeck
Summary: Moods play a crucial role in shaping human experience, yet their neurobiological mechanisms remain poorly understood. Animal models, especially nonhuman primates, are essential for investigating the origins of mood and validating mood-like states due to limitations in methods and data interpretation in humans.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Clinical Neurology
Sarinnapha M. Vasunilashorn, Nadia Lunardi, John C. Newman, Gregory Crosby, Leah Acker, Ted Abel, Seema Bhatnagar, Colm Cunningham, Rafael de Cabo, Laura Dugan, Joseph A. Hippensteel, Yumiko Ishizawa, Shouri Lahiri, Edward R. Marcantonio, Zhongcong Xie, Sharon K. Inouye, Niccolo Terrando, Roderic G. Eckenhoff
Summary: Delirium is a common, morbid, and costly syndrome closely associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). While human studies have improved our understanding of delirium in terms of incidence, risk factors, outcomes, and management, limited knowledge exists about the neurobiology of delirium. This article discusses the use of preclinical and translational animal models to advance our understanding of delirium neurobiology and develop new prevention and treatment strategies. Recommendations for the development and validation of these models are provided to enhance awareness in this important field.
ALZHEIMERS & DEMENTIA
(2023)
Review
Pharmacology & Pharmacy
Katarzyna Trzos, Natalia Pydyn, Jolanta Jura, Jerzy Kotlinowski
Summary: This review discusses the etiology, risk factors, and murine models of autoimmune liver diseases, providing important references for studying their development mechanisms and testing new treatment strategies.
PHARMACOLOGICAL REPORTS
(2022)
Review
Cell Biology
Simona D'Agnelli, Giada Amodeo, Silvia Franchi, Benedetta Verduci, Marco Baciarello, Alberto Emilio Panerai, Elena Giovanna Bignami, Paola Sacerdote
Summary: The hypothesis that pain may contribute to the development of frailty has been investigated in recent clinical studies, but further research is needed to understand the shared mechanisms between pain and frailty, particularly in genetics, epigenetics, and inflammation. Current evidence is preliminary, with observational clinical studies and a lack of investigation into the impact of pain treatment on frailty progression. Specific research on the pain-frailty relationship is necessary to uncover potential intervention strategies.
AGEING RESEARCH REVIEWS
(2022)
Review
Genetics & Heredity
Siyuan Kong, Rongrong Li, Yunhan Tian, Yaqiu Zhang, Yuhui Lu, Qiaoer Ou, Peiwen Gao, Kui Li, Yubo Zhang
Summary: With the advancement of high-throughput single-cell sequencing technology, single-cell omics has become a powerful tool for understanding the molecular basis of cellular mechanisms and improving our understanding of different cell states. It reveals heterogeneity at different genetic levels and their associations through multiple omics analysis, providing a comprehensive genetic map of biological regulatory networks. After GWAS, single-cell omics will further elucidate the molecular biological mechanisms influencing human diseases. This review summarizes the development and trends of single-cell omics, including technologies, data integration methods, applications in human organs and diseases, laboratory cell lines, and animal disease models. It provides perspectives on understanding human diseases and constructing animal models.
FRONTIERS IN GENETICS
(2023)
Review
Virology
Shengle Qin, Runfeng Li, Zhaoguang Zheng, Xuxin Zeng, Yutao Wang, Xinhua Wang
Summary: The increasing cases of the novel coronavirus pneumonia have led to the need for virus research. Animal models can help evaluate the efficacy of drugs and vaccines, and provide insights into the transmission and clinical features of the virus. This review compares and analyzes the current animal models of respiratory coronavirus infection, providing important information for disease management and control.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Immunology
Yinxi Zhou, Jinghua Xia, Shuonan Xu, Tao She, Yanning Zhang, Ying Sun, Miaomiao Wen, Tao Jiang, Yanlu Xiong, Jie Lei
Summary: The development and growth of tumors pose a significant and ongoing threat to human life globally. Despite the remarkable progress achieved by advanced therapeutic strategies such as immune checkpoint therapy and CAR-T in treating solid and hematological malignancies, the malignant initiation and progression of cancer remains controversial and requires further research. Experimental animal models not only have great advantages in simulating tumor occurrence, development, and malignant transformation mechanisms, but also can be used to evaluate the therapeutic effects of diverse clinical interventions, gradually becoming indispensable in cancer research. This paper reviews recent research progress in mouse and rat models, focusing on spontaneous, induced, transgenic, and transplantable tumor models, aiming to provide guidance for future studies on malignant mechanisms and tumor prevention.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Veterinary Sciences
Rachel Layton, Daniel Layton, David Beggs, Andrew Fisher, Peter Mansell, Kelly J. Stanger
Summary: The impact of stress and general anesthesia on the organism's response to infectious diseases is essential in understanding and mitigating these diseases. Optimizing animal welfare in disease research is crucial due to increasing societal scrutiny. Utilizing appropriate animal monitoring strategies is imperative to better understand the effects of stress and anesthesia on disease study and welfare outcomes.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Veterinary Sciences
Alexander Kappes, Takesure Tozooneyi, Golam Shakil, Ashley F. Railey, K. Marie Mcintyre, Dianne E. Mayberry, Jonathan Rushton, Dustin L. Pendell, Thomas L. Marsh
Summary: Animal diseases can have negative impacts on consumers, producers, and economies as a whole. Understanding the burden and distribution of animal disease is crucial for policy-making, efficient investment, and protecting animal health.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Behavioral Sciences
Fabiano Costa, Konstantin N. Zabegalov, Tatiana O. Kolesnikova, Murilo S. de Abreu, Maria M. Kotova, Elena Petersen, Allan Kalueff
Summary: This study discusses the advantages and limitations of rodent and zebrafish models in studying cortical malformations, highlighting the importance of gaining translational insights into the pathogenesis of cortical malformations from animal models.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Behavioral Sciences
Yefeng Yang, Malcolm Macleod, Jinming Pan, Malgorzata Lagisz, Shinichi Nakagawa
Summary: Meta-analytic techniques have been widely used in synthesizing data from animal models of human diseases. However, these analyses often face statistical challenges due to the complex nature of animal data. In this study, we propose a meta-analytic framework based on multilevel models to address these challenges and introduce advanced techniques for delivering robust inferences and novel insights.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Microbiology
Gabriele Meroni, Alexios Tsikopoulos, Konstantinos Tsikopoulos, Francesca Allemanno, Piera Anna Martino, Joel Fernando Soares Filipe
Summary: Osteomyelitis is a bone infection that can spread through hematogenous, contiguous, or direct inoculation routes. Animal models can be used to study osteomyelitis, and different species are chosen for research. The clinical manifestation of hematogenous osteomyelitis varies due to multiple factors, but these variables can be controlled and tested through animal models.
Editorial Material
Genetics & Heredity
Katherine M. Buckley, Jeffrey A. Yoder
Review
Genetics & Heredity
Alex Dornburg, Jeffrey A. Yoder
Summary: This article discusses the origin and evolutionary relationships of genomic loci that form the jawed vertebrate adaptive immune response. The study finds that a RAG-like transposon invaded an ancient innate immune receptor exon, leading to the diversity of Ig and TCR loci in jawed vertebrates. Additionally, other non-recombining innate immune receptors are introduced, and the research progress on VJ-containing novel immune-type receptors in ray-finned fishes is discussed in detail.
Article
Biodiversity Conservation
Kara B. Carlson, Dustin J. Wcisel, Hayley D. Ackerman, Jessica Romanet, Emily F. Christiansen, Jennifer N. Niemuth, Christina Williams, Matthew Breen, Michael K. Stoskopf, Alex Dornburg, Jeffrey A. Yoder
Summary: The future of the Wyoming toad relies on captive breeding to supplement the dwindling wild population. Investigating the diversity of key receptor families involved in the host immune response is essential for conservation efforts. The reduced immunogenetic diversity in the Wyoming toad may increase its vulnerability to infectious diseases. The findings provide a foundation for future studies to evaluate genetic diversity, identify biomarkers for disease outcomes, and guide breeding strategies.
CONSERVATION GENETICS
(2022)
Article
Genetics & Heredity
Dustin J. Wcisel, Alex Dornburg, Sean C. McConnell, Kyle M. Hernandez, Jorge Andrade, Jill L. O. de Jong, Gary W. Litman, Jeffrey A. Yoder
Summary: Multiple novel immunoglobulin-like transcripts (NILTs) have been identified in salmon, trout, and carp, but a definitive framework of NILT diversity is still lacking. In this study, the researchers identified five NILT loci in the Atlantic salmon genome, defined 86 NILT Ig domains in zebrafish chromosome 1, and described 41 NILT Ig domains in an alternative haplotype for the same genomic region. They found an unprecedented diversity of Ig domain sequences and combinations for NILTs within a single species. The results suggest that this gene family likely plays multiple roles in host immunity.
Article
Biochemistry & Molecular Biology
Jessica L. Romanet, Katherine L. Cupo, Jeffrey A. Yoder
Summary: Lipopolysaccharide (LPS)-induced signaling through Toll-like receptor 4 (TLR4) is mediated by phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P-2] and its derivatives. TMEM150A regulates the production of PI(4,5)P-2 by modifying the composition of the phosphatidylinositol 4-kinase enzyme complex. Knockdown of TMEM150A results in increased cytokine secretion and transcript levels in LPS-stimulated cells, indicating its importance in TLR4 signaling and cellular homeostasis.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2022)
Article
Toxicology
AtLee T. D. Watson, Aldo Carmona Baez, Dereje Jima, David Reif, Jun Ding, Reade Roberts, Seth W. Kullman
Summary: This study aims to investigate the regulatory mechanisms of osteoblast differentiation through global transcriptomic analysis of human bone-derived mesenchymal stem cells (hBMSCs) exposed to TCDD. The results show that TCDD exposure attenuates osteoblast differentiation of hBMSCs and leads to altered gene expression.
TOXICOLOGICAL SCIENCES
(2023)
Article
Toxicology
Drake W. Phelps, Anika I. Palekar, Haleigh E. Conley, Giuliano Ferrero, Jacob H. Driggers, Keith E. Linder, Seth W. Kullman, David M. Reif, M. Katie Sheats, Jamie C. DeWitt, Jeffrey A. Yoder
Summary: This report investigates the impact of nine environmentally-relevant PFASs on the respiratory burst, and finds that PFHxA and GenX can suppress the respiratory burst. The study demonstrates for the first time that these PFASs can suppress neutrophil function, and supports the use of zebrafish larvae and a human cell line as screening tools for identifying chemicals that may suppress human immune function.
JOURNAL OF IMMUNOTOXICOLOGY
(2023)
Article
Medicine, General & Internal
Jana Block, Christina Rashkova, Irinka Castanon, Samaneh Zoghi, Jessica Platon, Rico C. Ardy, Mitsuhiro Fujiwara, Beatriz Chaves, Rouven Schoppmeyer, Caspar I. van der Made, Raul Jimenez Heredia, Frederike L. Harms, Samin Alavi, Laia Alsina, Paula Sanchez Moreno, Rainiero Avila Polo, Rocio Cabrera-Perez, Sevgi Kostel Bal, Laurene Pfajfer, Bernhard Ransmayr, Anna-Katharina Mautner, Ryohei Kondo, Anna Tinnacher, Michael Caldera, Michael Schuster, Cecilia Dominguez Conde, Rene Platzer, Elisabeth Salzer, Thomas Boyer, Han G. Brunner, Judith E. Nooitgedagt-Frons, Estibaliz Iglesias, Angela Deya-Martinez, Marisol Camacho-Lovillo, Joerg Menche, Christoph Bock, Johannes B. Huppa, Winfried F. Pickl, Martin Distel, Jeffrey A. Yoder, David Traver, Karin R. Engelhardt, Tobias Linden, Leo Kager, J. Thomas Hannich, Alexander Hoischen, Sophie Hambleton, Sabine Illsinger, Lydie Da Costa, Kerstin Kutsche, Zahra Chavoshzadeh, Jaap D. van Buul, Jordi Anton, Joan Calzada-Hernandez, Olaf Neth, Julien Viaud, Akihiko Nishikimi, Loic Dupre, Kaan Boztug
Summary: This study reveals that DOCK11 regulates T-cell shape and migration as well as erythroid development. Inherited loss-of-function variants in DOCK11 resulted in early-onset severe immune dysregulation and normocytic anemia.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemical Research Methods
Mary F. Wang, Morgan M. Ritter, Seth W. Kullman, David C. Muddiman
Summary: In this study, the feasibility of sucrose-embedding with paraformaldehyde fixation as an alternative matrix for IR-MALDESI analysis in whole-body zebrafish samples was investigated. The results demonstrated that sucrose-embedding method obtained more lipid annotation information compared to the conventional fresh-frozen sample preparation. This is important for studying and analyzing disease states in whole-body zebrafish.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Genetics & Heredity
Kara B. Carlson, Cameron Nguyen, Dustin J. Wcisel, Jeffrey A. Yoder, Alex Dornburg
Summary: Understanding the evolution of the vertebrate RAG-mediated adaptive immune response has been a major focus for researchers, but less attention has been given to the impact of this evolutionary novelty on the diversity of receptors associated with the innate immune response. In this study, we investigate the diversification of toll-like receptors (TLRs), an ancient and conserved innate immune receptor family, using genomic and transcriptomic data. Our findings reveal TLR sequences that reflect major subfamilies as well as phylogenetically distinct TLR clades. We also observe gene gain during the rise of the RAG-mediated immune response, followed by gene loss during the Cretaceous period.
Article
Biochemical Research Methods
Alena N. Joignant, Morgan M. Ritter, Kevan T. Knizner, Kenneth P. Garrard, Seth W. Kullman, David C. Muddiman
Summary: This study proposes a novel method of mass spectrometry imaging (MSI) to reduce the acquisition time of MSI data using nested regions of interest (nROIs). By utilizing nROIs, a smaller region of interest can be imaged at higher spatial resolution nested within a larger region of interest at lower spatial resolution, conserving maximal spatial and chemical information while decreasing acquisition time. The nROI method was characterized on mouse liver and applied to top-hat MSI of zebrafish, resulting in significant improvements in acquisition time and spatial detail. The nROI method can be applied to any method where acquiring larger high-resolution ROIs poses a practical challenge.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Article
Genetics & Heredity
Rittika Mallik, Kara B. Carlson, Dustin J. Wcisel, Michael Fisk, Jeffrey A. Yoder, Alex Dornburg
Summary: This study introduces the importance of Holosteans as a means to connect teleost models to other vertebrate genomes. However, only three species of Holosteans have been genome-sequenced, and more species are needed to understand holostean genome evolution. The researchers report the first high quality reference genome assembly and annotation of the longnose gar, providing a critical reference for comparative genomic studies.
G3-GENES GENOMES GENETICS
(2023)
Article
Hematology
Saara Laukkanen, Alexandra Veloso, Chuan Yan, Laura Oksa, Eric J. Alpert, Daniel Do, Noora Hyvarinen, Karin McCarthy, Abhinav Adhikari, Qiqi Yang, Sowmya Iyer, Sara P. Garcia, Annukka Pello, Tanja Ruokoranta, Sanni Moisio, Sadiksha Adhikari, Jeffrey A. Yoder, Kayleigh Gallagher, Lauren Whelton, James R. Allen, Alex H. Jin, Siebe Loontiens, Merja Heinaniemi, Michelle Kelliher, Caroline A. Heckman, Olli Lohi, David M. Langenau
Summary: This study identified a drug combination of AKT/mTORC1 inhibitors and dasatinib that effectively kills T-cell acute lymphoblastic leukemia (T-ALL) in zebrafish, including relapse and dexamethasone-resistant cases. Clinical trials have shown promising results, indicating that this combination could be an effective therapy for T-ALL in humans.
Review
Genetics & Heredity
Alex Dornburg, Rittika Mallik, Zheng Wang, Moises A. Bernal, Brian Thompson, Elspeth A. Bruford, Daniel W. Nebert, Vasilis Vasiliou, Laurel R. Yohe, Jeffrey A. Yoder, Jeffrey P. Townsend
Summary: This review highlights the importance of comparative genomics in understanding the evolution of human gene families, focusing on gene expression analysis and the role of homology in revealing similarities among species. The article also discusses methodological tools and limitations, and explores the potential of comparative genomics in gaining insights into gene family evolution across living organisms.
Article
Biochemistry & Molecular Biology
Gabriela Maressa Machado Baesso, Amanda Vitoria Venancio, Livia Costa Varela Barca, Pepita Fernanda Peppi, Caique Aparecido Faria, Joao Pedro Cosmo Machado, Luiz David Solis Murgas, Alvaro Jose de Almeida Bicudo, Eduardo Mauricio Mendes de Lima, Andre Rodrigues da Cunha Barreto-Vianna
Summary: This study evaluated the effects of eugenol, menthol, and lidocaine as anesthetics on glucose levels and recovery times in zebrafish. The results showed that eugenol and menthol did not affect glucose levels, while lidocaine caused non-concentration-dependent hyperglycemia. Recovery times were similar for eugenol and menthol, but concentration-dependent for lidocaine. Eugenol and menthol were deemed safe and satisfactory for glucose analysis in zebrafish research, while lidocaine could introduce biases and safety concerns. Researchers should carefully consider the selection of anesthetics for reliable results in zebrafish assessments.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaoxue Li, Tangsong Feng, Weiqun Lu
Summary: This study reveals that exposure to VPA induces ASD-like phenotypes and behaviors, including gene transcription changes, social interaction deficit, decreased aggression, increased anxiety behavior, and elevated cortisol levels. The aggression behavior assay is a better predictor of neurotoxicology behavior of VPA.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: In this study, we investigated the hepatotoxicity and mechanism of action of pyridaben using zebrafish and ZFL cells. Pyridaben caused liver size reduction and apoptosis, and these effects were associated with uncontrolled intracellular calcium flow and downregulation of the PI3K/Akt signaling cascade.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Md Alamgir Kabir, Md. Golam Rabbane, Marco R. Hernandez, Md Aftab Ali Shaikh, Mohammad Moniruzzaman, Xuexiu Chang
Summary: This study investigated the toxicity of high concentrations of cadmium (Cd) on intestinal immunity and microbial diversity in common carp. The results showed that high Cd concentration caused intestinal inflammation, immunosuppression, and changes in the gut microbiome, leading to detrimental effects on the intestinal homeostasis and health status of the fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Anuradha Batabyal, Veronica Rivi, Cristina Benatti, Johanna M. C. Blom, Fabio Tascedda, Ken Lukowiak
Summary: This study found that exposure to heat shock stressors and bacterial lipopolysaccharide can induce the Garcia effect in pond snails. Additionally, aspirin can prevent the formation of the Garcia effect. However, unexpectedly, exposure to crushed aspirin and heat shock stressors together leads to long-lasting feeding suppression and molecular changes in the snails' serotoninergic system and neuroplasticity genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Li-Yih Lin, Chieh-An Cheng, Sian-Tai Liu, Jiun-Lin Horng
Summary: This study reveals that ammonia exposure impairs ion regulation in zebrafish embryos by inducing oxidative stress, mitochondrial dysfunction, and cell death. The findings suggest that ammonia is toxic to aquatic animals and can lead to the death of embryos.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Antonio Durate Pagano, Natieli Machado Goncalves, William Borges Domingues, Tony Leandro Rezende da Silveira, Mateus Tavares Kutter, Antonio Sergio Varela Jr, Carine Dahl Corcini, Mariana Cavalcanti Nascimento, Luana Ferreira Viana dos Reis, Patricia Gomes Costa, Adalto Bianchini, Matheus Vieira Volcan, Mariana Harter Remia, Vinicius Farias Campos
Summary: This study analyzed the toxic effects of Roundup Transorb (R) on the endangered Neotropical annual killifish Austrolebias charrua by evaluating molecular and biochemical biomarkers. The findings showed that exposure to Roundup significantly increased the production of reactive oxygen species, lipid peroxidation, and DNA damage in the fish's blood cells. It also decreased membrane fluidity. Gene expression analysis revealed alterations in genes associated with oxidative stress and antioxidant defense. This study provides new insights into adaptive mechanisms of A. charrua in response to Roundup, and it has important implications for environmental monitoring and aquatic toxicology assessment.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaochan Gao, Hongtao Ren, Yong Huang, Yimin Li, Jiaqi Shen
Summary: The influence of multi-walled carbon nanotubes (MWCNTs) on the toxicity of zinc oxide nanoparticles (ZnONPs) in the intestine of common carp was investigated. The study found that the concentration and concentration ratio of the mixture played a role in the toxicity of ZnONPs. The presence of MWCNTs significantly decreased intercellular zinc accumulation and altered the microbial community diversity and composition of the gut microbiota.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Guangchao Yang, Qian Yang, Trust Beta, Qin Liu, Zhenzhu Zhu, Fei Shen
Summary: The study found that black garlic MLDs have alleviative effects on ZEN-induced toxicity, and exert their effects through antioxidative, anti-apoptotic, and inhibitory mechanisms on ZEN absorption.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tuul Sepp, Ciara Baines, Randel Kreitsberg, Joern Peter Scharsack, Pedro Nogueira, Thomas Lang, Jerome Fort, Elin Sild, John T. Clarke, Arvo Tuvikene, Richard Meitern
Summary: Environmental factors can cause cancer in both wild animals and humans. The use of polluted habitats provides opportunities to study cancer defense mechanisms, which can be influenced by genetic variation and natural selection. Flatfish species, specifically flounders, show higher resistance to pollution-induced cancer compared to dabs, with elevated pollutant metabolism and stronger tumor suppression mechanisms in their liver tissue. This suggests a potential hormetic upregulation of tumor suppression or stronger natural selection pressure for cancer resistance in flounders. Wild species offer valuable insights into understanding the nature and evolution of natural cancer defense mechanisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Regan A. Moss, Kaitlyn M. Murphy, Steven T. Gardner, Madison M. Watkins, John W. Finger Finger Jr, Meghan D. Kelley, Ruth M. Elsey, Daniel A. Warner, Mary T. Mendonca
Summary: The study explored the impact of environmentally relevant concentrations of E2 on the immune system and hormone levels of hatchling American alligators. Results showed that exposure to environmental estrogen can alter plasma hormone concentrations but have little to no impact on morphology and immune responses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ye Liang, Zihao Li, Jing Yuan, Yiwen Zhou, Meng Li, Haifeng Gu
Summary: This study investigated the toxicity mechanism of homo-YTX and NH3-N on the survival of abalone. The results showed that homo-YTX and NH3-N enhanced oxidative stress and lipid peroxidation reactions, inhibited energy supply, disrupted metabolic and immune physiological functions, and activated apoptosis in the gills of abalone.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
