Article
Oncology
Amelia Barcellini, Giulia Fontana, Daria Maria Filippini, Sara Ronchi, Maria Bonora, Barbara Vischioni, Rossana Ingargiola, Anna Maria Camarda, Pierre Loap, Nadia Facchinetti, Lisa Licitra, Guido Baroni, Ester Orlandi
Summary: This study assesses the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and blood chemistry in head and neck adenoid cystic carcinoma (ACC) patients treated with carbon ion radiotherapy (CIRT). The results suggest that pre-treatment NLR and hemoglobin values may serve as independent prognostic factors for clinical outcomes in ACC patients.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Otorhinolaryngology
Antoine Yanni, Thibaut Buset, Cyril Bouland, Isabelle Loeb, Jerome R. Lechien, Alexandra Rodriguez, Fabrice Journe, Sven Saussez, Didier Dequanter
Summary: This study quantified the prognostic impact of the neutrophil-to-lymphocyte ratio (NLR) on HNSCC patients with lung metastasis. The results showed that a higher NLR was associated with shorter overall survival in the subgroup without lung metastasis, but not in the subgroup with lung metastasis. However, an elevated NLR was found to be a prognostic factor of poor lung metastasis-free survival in both subgroups.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Environmental Sciences
Yu Meng, Kan Wang, Tuanwei Wang, Yuting Tu, Shiyang Gong, Yunxia Zhang, Guanghui Zhang, William Au, David C. Christiani, Zhao-lin Xia
Summary: The study systematically assessed the effects of occupational lead exposure on leukocyte ratios and genotoxicity, finding that lead exposure increased NLR and induced genotoxicity. Elevated NLR was positively associated with DNA damage, and % tail DNA mediated part of the effect of lead on increasing NLR, suggesting potential mechanistic involvement of inflammation in the elevation of NLR caused by lead exposure.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Immunology
Pauline Jacob, Julie Bonnefoy, Stephanie Ghislin, Jean-Pol Frippiat
Summary: This study evaluated the relevance of two easily-implemented biomarkers for monitoring immune system in astronauts and suggested using neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) to assess long-lasting immune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Iwona Homa-Mlak, Anna Brzozowska, Radoslaw Mlak, Aneta Szudy-Szczyrek, Teresa Malecka-Massalska
Summary: The study revealed a positive correlation between NLR and the severity of OM, with higher NLR values associated with an increased risk of more severe OM. Additionally, higher TNM stage and NLR values were identified as independent prognostic factors for survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Ruilin Pan, Yaning Ren, Qingqing Li, Xuming Zhu, Jian Zhang, Yubao Cui, Hao Yin
Summary: This study evaluated the associations between neutrophil-lymphocyte ratio (NLR), NLR-alanine aminotransferase ratio (NAR), and NLR-albumin ratio (NBR) with the diagnosis of childhood asthma. The combination of NLR + NAR + NBR was found to distinguish asthmatic children with exacerbation from healthy children. Therefore, our results suggest that NLR + NAR + NBR could be used as a clinical biomarker for asthma in children.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2023)
Review
Oncology
Mate Naszai, Alina Kurjan, Timothy S. Maughan
Summary: Inflammation is closely related to cancer, and NLR from routine blood testing serves as an easily accessible prognostic biomarker, aiding in assessing clinical outcomes in colorectal cancer patients. Combining results from numerous studies, high NLR was found to be associated with poor clinical outcomes, despite limitations in some studies, it should be routinely collected in clinical trials.
Article
Immunology
E. Weijian, Zhixin Wang, Mingquan Pang, Yongliang Lu, Haining Fan
Summary: The NLR and PLR of AE patients were higher than those of CE patients, and the high inflammation of CE patients may be correlated to the reproductive mode of Echinococcus multilocularis. PLR and NLR have certain diagnostic values for disease classification, but PLR has higher specificity when compared with NLR.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
Ebru Yuce
Summary: The role of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting spontaneous preterm birth was investigated. Retrospective data collected from hospital records between February 2018 and November 2022 showed that NLR and PLR values can predict preterm birth with high sensitivity and specificity. Predicting preterm birth allows for sensitive and smooth management of the pregnancy process.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Efsun Somay, Busra Yilmaz, Erkan Topkan, Ahmet Kucuk, Berrin Pehlivan, Ugur Selek
Summary: This study investigated the association between pretreatment neutrophil-to-lymphocyte ratio (NLR) and the incidence of radiation-induced trismus (RIT) in patients with parotid gland cancers (PGC) after postoperative radiotherapy (PORT). The results showed that high pretreatment NLR levels were an independent predictor of significantly elevated rates of RIT.
Article
Oncology
Mengli Zhao, Zhongrong Gao, Xiaowei Gu, Xiaojing Yang, Shanshan Wang, Jie Fu
Summary: The research focuses on analyzing the prognostic significance of minimum count of lymphocytes (LY) and the corresponding ratio of neutrophil-to-lymphocyte (NLR) in cervical cancer patients receiving radiotherapy. The study found that patients with higher LY levels and lower NLR values during radiotherapy had better survival prognosis. Factors such as FIGO stage I, absence of lymph node metastasis, and lower NLR values were associated with poorer overall survival and progression-free survival.
Article
Medicine, General & Internal
Sho Yasui, Tomoaki Takata, Yu Kamitani, Yukari Mae, Hiroki Kurumi, Yuichiro Ikebuchi, Akira Yoshida, Koichiro Kawaguchi, Kazuo Yashima, Hajime Isomoto
Summary: The study demonstrates an association between NLR and PLR with the histological diagnosis of gastric cancer, suggesting that NLR could be a useful marker for assessing early gastric cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Eleonora Gori, Alessio Pierini, Ilaria Lippi, George Lubas, Veronica Marchetti
Summary: Feline sepsis is a life-threatening syndrome with limited hematological markers, but neutrophil-to-lymphocyte ratio (NLR) has been shown as a prognostic marker in sick cats. This study investigated differences in leukocyte ratios between healthy, SIRS, and septic cats, with NLR > 4.53 indicating a significant chance of SIRS or sepsis and BLR and BNLR showing promise in differentiation.
Article
Immunology
Shaodi Wen, Yuzhong Chen, Chupeng Hu, Xiaoyue Du, Jingwei Xia, Xin Wang, Wei Zhu, Qingbo Wang, Miaolin Zhu, Yun Chen, Bo Shen
Summary: This study investigates the feasibility of combining tertiary lymphoid structure (TLS) and systemic inflammation parameters as prognosis indicators for hepatocellular carcinoma (HCC) patients. The results show a positive correlation between TLS density and patient survival, although the predictive power of TLS density alone is limited. However, combining TLS density with neutrophil-to-lymphocyte ratio (NLR) and other parameters improves survival prediction for HCC patients. A nomogram is also developed to provide a reproducible approach for survival prediction in HCC clinical practice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jonas Werner, Klaus Strobel, Dirk Lehnick, Gunesh P. Rajan
Summary: The study found a significant correlation between NLR and metabolic markers of the primary tumor in head and neck cancer patients, with NLR showing less correlation with metabolic activity markers in nodal metastases. In nodal positive cancer patients, increased NLR and SUVmax of lymph node metastasis were independently predictive of disease-specific survival. High NLR had a negative prognostic value for overall survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nutrition & Dietetics
David L. Chan, Stephen J. Clarke, Alexander Engel, Connie I. Diakos, Nick Pavlakis, Paul J. Roach, Dale L. Bailey, Judith Bauer, Merran Findlay
Summary: The study found that sarcopenia and myosteatosis are common in NEN patients but were not associated with worsened survival outcomes in this study.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Letter
Oncology
Nyan Y. Khin, Madhawa De Silva, Stephen Clarke, Nick Pavlakis, Chris M. Rogan, Kevin Ho-Shon, Rodney J. Lane
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Derrick Ho Wai Siu, Arwa Ali, Angelina Tjokrowidjaja, Madhawa De Silva, Joanna Lee, Philip R. Clingan, Morteza Aghmesheh, Daniel Brungs, Cristina Mapagu, David Goldstein, Siobhan O'Neill, Winston S. Liauw, Katrin M. Sjoquist, David Thomas, Nick Pavlakis, Stephen J. Clarke, Connie Diakos, Lorraine A. Chantrill
Summary: This study aimed to determine the demographic, histopathological and molecular characteristics of patients with early-onset colorectal cancer (EO-CRC) in Australia, as well as their survival. The results showed that some patients already presented with metastatic disease, and pathological risk factors and molecular mutations affected the survival of the patients.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Melanie R. Lovell, Jane L. Phillips, Tim Luckett, Lawrence Lam, Frances M. Boyle, Patricia M. Davidson, Seong L. Cheah, Nicola McCaffrey, David C. Currow, Tim Shaw, Annmarie Hosie, Bogda Koczwara, Stephen Clarke, Jessica Lee, Martin R. Stockler, Caitlin Sheehan, Odette Spruijt, Katherine Allsopp, Alexandra Clinch, Katherine Clark, Alison Read, Meera Agar
Summary: This study evaluated the effectiveness of three cancer pain guideline implementation strategies on improving pain outcomes for patients in oncology and palliative care outpatient services. The results showed that these strategies had limited impact on pain-related outcomes and further evaluation and improvement are needed.
Review
Oncology
Keenan Whittle, Steven Kao, Stephen Clarke, Georges E. R. Grau, Elham Hosseini-Beheshti
Summary: This study reviewed protein data in relevant literature to investigate the role of specific proteins in lung cancer extracellular vesicles. The findings suggest that the importance of specific proteins may vary in different types of lung cancer, but there is currently limited research on extracellular vesicle proteins in some cancers.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Oncology
Malinda Itchins, Hannah Ainsworth, Marliese Alexander, Samantha Dean, Devi Dharmaraj, Nick Pavlakis, Stephen J. Clarke, Chris Brown, Javier Torres, Ayesha Saqib, Rahul Ladwa, Kenneth O'Byrne, Melissa Moore, Po Yee Yip, Ben Ben Solomon, Tom John, Steven Kao, Paul Mitchell, Sagun Parakh
Summary: Limited real world data exist on the IMpower150 regimen, and this study adds to the knowledge base by demonstrating its efficacy in EGFR mutant patients, including those with CNS metastases. The overall response rate for all patients was 51%, and for EGFR mutant patients it was 52%, highlighting the positive outcomes of this treatment approach.
CLINICAL LUNG CANCER
(2022)
Article
Oncology
Christopher B. Nahm, John Turchini, Sumit Sahni, Elizabeth Moon, Malinda Itchins, Jennifer Arena, Angela Chou, Emily K. Colvin, Viive M. Howell, Nick Pavlakis, Stephen Clarke, Jaswinder S. Samra, Anthony J. Gill, Anubhav Mittal
Summary: A triple biomarker panel can predict genetic subtypes, clinical phenotypes and optimal treatment strategies for resectable and borderline resectable pancreatic cancer.
Article
Medicine, General & Internal
Kathleen Batty, Amelia M. Taylor, Elizabeth J. Bernard, Connie Diakos, Stephen J. Clarke, Alexander Guminski, Sally Baron-Hay, Frances Boyle, Nick Pavlakis, David L. Chan
Summary: This study retrospectively analyzed a series of patients with metastatic neuroendocrine carcinoma of the breast to investigate their clinical characteristics, treatment modalities, and prognosis. The results showed that multiple treatment modalities were used with different sequencing in different patients, but the progression-free survival with first-line therapy was short.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Multidisciplinary Sciences
Stephen Clarke, Belinda E. Butcher, Andrew J. McLachlan, Jeremy D. Henson, David Rutolo, Sean Hall, Luis Vitetta
Summary: This pilot study assessed the safety, tolerability, pharmacokinetics, and exploratory analgesic effect of a novel water-soluble cannabis-based medicine in patients with advanced incurable malignancy. The results showed acceptable bioavailability and preliminary evidence of analgesic efficacy, but also reported mild to moderate adverse events.
Review
Public, Environmental & Occupational Health
N. Bhimani, G. Y. M. Wong, C. Molloy, N. Pavlakis, C. I. Diakos, S. J. Clarke, M. Dieng, T. J. Hugh
Summary: This systematic review examines the direct cost of treating metastatic colorectal cancer and highlights the significant economic burden it places on healthcare systems. The review emphasizes the need for future research to define cost components and examine the relationship between spending, overall survival, and quality of life.
Article
Oncology
Johanna Bendell, Patricia LoRusso, Michael Overman, Anne M. Noonan, Dong-Wan Kim, John H. Strickler, Sang-We Kim, Stephen Clarke, Thomas J. George, Peter S. Grimison, Minal Barve, Manik Amin, Jayesh Desai, Trisha Wise-Draper, Steven Eck, Yu Jiang, Anis A. Khan, Yuling Wu, Philip Martin, Zachary A. Cooper, Nairouz Elgeioushi, Nancy Mueller, Rakesh Kumar, Sandip Pravin Patel
Summary: This study evaluated the use of oleclumab in patients with advanced colorectal cancer, pancreatic ductal adenocarcinoma, and epidermal growth factor receptor-mutant non-small-cell lung cancer. The results showed that oleclumab had a manageable safety profile and demonstrated antitumor activity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Tamkin Ahmadzada, Abhishek Vijayan, Fatemeh Vafaee, Ali Azimi, Glen Reid, Stephen Clarke, Steven Kao, Georges E. Grau, Elham Hosseini-Beheshti
Summary: In this study, we characterized different populations of extracellular vesicles (EVs) derived from pleural mesothelioma cell lines and identified unique cancer-specific proteomes and oncogenic cargo in each subtype. We also established a comprehensive proteomic database of cancer-associated proteins in EVs, which could serve as new targets for future biomarker studies in pleural mesothelioma.
Article
Biochemistry & Molecular Biology
Joe Q. Q. Wei, Alexander Yuile, Malinda Itchins, Benjamin Y. Y. Kong, Bob T. T. Li, Nick Pavlakis, David L. L. Chan, Stephen J. J. Clarke
Summary: Platinum-based chemotherapy combined with anti-PD-1 or PD-L1 monoclonal antibodies is the standard first-line therapy for mNSCLC patients without sensitizing driver mutations. Using network meta-analysis, we compared the efficacy of these two antibodies indirectly due to the absence of head-to-head randomized control trials. The results showed that anti-PD-1 mAb + chemotherapy had superior overall survival, progression-free survival, and objective response rate compared to anti-PD-L1 mAb + chemotherapy, with similar rates of grade 3 and higher toxicities. However, head-to-head RCTs are still needed in the future.
Meeting Abstract
Gastroenterology & Hepatology
Stuart Keith Roberts, Ashika Maharaj, John Lubel, Eileen Lam, Paul J. Clark, Oliver Duncan, Jacob George, Gary P. Jeffrey, Lara Lipton, Howard Liu, Geoffrey McCaughan, Eu-Ling Neo, Jenny Philip, Simone I. Strasser, Katherine Stuart, Alexander Thompson, Jonathan Tibbals, Thomas Tu, Michael C. Wallace, Alan Wigg, Marnie Wood, Amany Zekry, Elysia Greenhill, Liane J. Ioannou, Golo Ahlenstiel, Kaye Bowers, Stephen J. Clarke, Anouk Dev, Mark Goodwin, Christos Karapetis, Miriam T. Levy, Kate Muller, James Patrick O'Beirne, David Pryor, James Seow, Caroline J. Tallis, Nick Butler, John K. Olynyk, John Zalcberg
Article
Gastroenterology & Hepatology
Ashika D. Maharaj, John Lubel, Eileen Lam, Paul J. Clark, Oliver Duncan, Jacob George, Gary P. Jeffrey, Lara Lipton, Howard Liu, Geoffrey McCaughan, Eu-Ling Neo, Jennifer Philip, Simone Strasser, Katherine Stuart, Alexander Thompson, Jonathan Tibballs, Thomas Tu, Michael C. Wallace, Alan Wigg, Marnie Wood, Amany Zekry, Elysia Greenhill, Liane J. Ioannou, Golo Ahlenstiel, Kaye Bowers, Stephen J. Clarke, Anouk Dev, Michael Fink, Mark Goodwin, Christos S. Karapetis, Miriam T. Levy, Kate Muller, James O'Beirne, David Pryor, James Seow, Nicholas Shackel, Caroline Tallis, Nick Butler, John K. Olynyk, Kate Reed-Cox, John R. Zalcberg, Stuart K. Roberts
Summary: This study aimed to develop a core set of quality indicators for the management of hepatocellular carcinoma (HCC). Through a Delphi consensus study, 23 specific indicators were identified, covering aspects such as diagnosis, staging, and treatment of HCC. Adherence to these indicators can improve the quality of care and patient outcomes, including survival.
HEPATOLOGY COMMUNICATIONS
(2022)