Journal
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
Volume 12, Issue 8, Pages 741-751Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138620709789104933
Keywords
SPR; surface plasmon resonance imaging; surface plasmon resonance microscopy; microarrays; bioaffinity; antibody screening; kinetics; binding constants; protein arrays; DNA arrays
Funding
- National Institutes of Health
- National Science Foundation
- Plexera Bioscience LLC
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Surface plasmon resonance (SPR) sensors have proven themselves over the last 20 years to be an effective method to study biomolecular binding and kinetics without the use of labeling. More recently, the approach has been adapted to high throughput use with the imaging of SPR-active microarrays. This is an excellent tool for monitoring microarray binding in real-time where the microarray probes and targets can include a wide range of molecules. DNA, RNA, antibodies, enzymes, and a range of other proteins have been arrayed and quantitatively analyzed.
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