Article
Gastroenterology & Hepatology
Badr Al-Bawardy, Lisa Malter, Adam C. Ehrlich, Florian Rieder, Jill K. J. Gaidos, Deborah Proctor, Donna M. Windish
Summary: In this multicenter survey study, it was found that a significant number of gastroenterology fellows lacked confidence and desired more training in important inflammatory bowel disease management domains.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Nanne K. H. de Boer, Melek Simsek, Berrie Meijer, Markus F. Neurath, Ad van Bodegraven, Chris J. J. Mulder
Summary: Drug rediscovery refers to the principle of using 'old' drugs outside their original indications. This study focuses on the rediscovery of thioguanine (TG) in the treatment of inflammatory bowel disease in the Netherlands and highlights the global need for optimal use and development of potentially useful drugs. The paper also provides an overview of the registration process for TG, aiming to guide future drug rediscovery efforts.
Article
Nutrition & Dietetics
Sarah M. M. Ajabnoor, Atheer Attar, Noof BinJahlan, Nawal Almutairi, Shimaa Bashmail, Almoutaz Hashim, Alastair Forbes, Hani Jawa
Summary: This study investigated the practices and perceptions of gastroenterologists in Saudi Arabia regarding the use of enteral nutrition (EN) in patients with inflammatory bowel disease (IBD). The results showed that EN was mostly used for the prevention and correction of undernutrition, preoperative optimization, and induction of remission in patients with active and long-standing Crohn's disease (CD). The study also identified barriers to using EN, such as low patient acceptance and poor adherence.
Review
Gastroenterology & Hepatology
Alexander Booth, Wilson Ford, Emily Brennan, Gayenell Magwood, Erin Forster, Thomas Curran
Summary: Existing evidence suggests disparities in management of inflammatory bowel disease, but the research is fragmented and heterogeneous. Race and socioeconomic status have an impact on treatment outcomes, and there is a lack of understanding on how to address these disparities.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Johan Burisch, Mirabella Zhao, Selwyn Odes, Peter De Cruz, Severine Vermeire, Charles N. Bernstein, Gilaad G. Kaplan, Dana Duricova, Dan Greenberg, Hans O. Melberg, Mamoru Watanabe, Hyeong Sik Ahn, Laura Targownik, Valerie E. H. Pittet, Vito Annese, K. T. Park, Konstantinos H. Katsanos, Marte L. Hoivik, Zeljko Krznaric, Maria Chaparro, Edward V. Loftus, Peter L. Lakatos, Javier P. Gisbert, Willem Bemelman, Bjorn Moum, Richard B. Gearry, Michael D. Kappelman, Ailsa Hart, Marieke J. Pierik, Jane M. Andrews, Siew C. Ng, Renata D'Inca, Pia Munkholm
Summary: The cost of caring for patients with inflammatory bowel disease (IBD) continues to increase worldwide due to the steady increase in prevalence, the chronic nature of the diseases, expensive treatments, intensive monitoring, and their impact on productivity. This Commission urges evaluation of cost increases against improved disease management and the need for data interoperability and big data approaches to assess effectiveness and cost-effectiveness. International collaborations and novel care models should be sought to enhance education and training for clinicians, patients, and policy makers.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Livnat Blum, Carlotta Micaela Jarach, Moriah E. Ellen
Summary: This study aimed to identify barriers and facilitators to shared decision-making (SDM) in inflammatory bowel disease (IBD) clinics across Israel. The main barriers to SDM were limited or nonexistent training and a lack of awareness of SDM guidelines and techniques. The main facilitators of SDM were the social and professional role of clinicians and their beliefs about the impact of IBD and/or CD.
PATIENT EDUCATION AND COUNSELING
(2023)
Review
Gastroenterology & Hepatology
Mirabella Zhao, Lorant Gonczi, Peter L. Lakatos, Johan Burisch
Summary: New data shows that the incidence and prevalence of inflammatory bowel diseases (IBD) are on the rise worldwide, with approximately 0.2% of the European population currently suffering from IBD. Medical therapy and disease management have significantly advanced, emphasizing close monitoring of disease progression and a treat-to-target approach to prevent early bowel damage and disability. The surgical rate in Europe has decreased over time, with high health economic burden associated with IBD in the region.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Medicine, General & Internal
Majid Moshirfar, David A. Fuhriman, Amir Ali, Varshini Odayar, Yasmyne C. Ronquillo, Phillip C. Hoopes
Summary: Inflammatory bowel disease may have negative effects on surgical outcomes for patients undergoing elective ophthalmic procedures. This case series demonstrates successful surgical outcomes in patients with ulcerative colitis or Crohn's disease, with postoperative symptoms improving over time and no flare-ups of their disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Sara Massironi, Chiara Vigano, Andrea Palermo, Lorena Pirola, Giacomo Mulinacci, Mariangela Allocca, Laurent Peyrin-Biroulet, Silvio Danese
Summary: Inflammatory bowel disease (IBD) has been on the rise worldwide, with impaired nutritional status in patients presenting in various forms such as malnutrition, sarcopenia, and micronutrient deficiency, as well as overweight, obesity, and sarcopenic obesity. Malnutrition can disrupt the gut microbiome, leading to an imbalanced state that triggers inflammation. Despite the clear link between IBD and malnutrition, little is known about the underlying mechanisms that promote inflammation and malnutrition. This Review explores the potential mechanisms behind the vicious cycle of malnutrition and inflammation, and their implications for clinical treatment.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Mohamed A. Abd-El-Aziz, Martin Hubner, Nicolas Demartines, David W. Larson, Fabian Grass
Summary: The present large scale study aimed to assess the prevalence and consequences of malnutrition in surgical IBD patients in the US. The study found that the true prevalence of malnutrition was greatly underestimated when only using clinical assessment based on BMI and weight loss. Patients with malnutrition had higher rates of complications, longer hospital stays, and higher mortality rates.
Article
Gastroenterology & Hepatology
Stephanie L. Stovall, Celine R. Soriano, Jennifer A. Kaplan, Danielle La Selva, James Lord, Ravi Moonka, Timothy L. Zisman, Vlad V. Simianu
Summary: Hospitalizations for inflammatory bowel disease (IBD) in Washington State were predominantly emergent and non-operative, while elective admissions were centralized and often involved surgery. Understanding the factors driving IBD hospitalizations can help optimize emergent medical and elective surgical care at the state level.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Chemistry, Medicinal
Dandan Liu, Varma Saikam, Katie A. Skrada, Didier Merlin, Suri S. Iyer
Summary: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, which can be diagnosed through endoscopy and biopsy. However, these methods are expensive and invasive, so alternative noninvasive biomarkers are being explored for disease management and prognosis.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Gastroenterology & Hepatology
Anna M. Buchner, Yecheskel Schneider, Gary R. Lichtenstein
Summary: Biological therapy targeting tumor necrosis factor-alpha has become crucial in treating patients with inflammatory bowel disease, but high costs limit accessibility. Biosimilars offer the potential to reduce expenditures and increase availability, providing more options for patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Pediatrics
Brad D. Constant, Edwin F. de Zoeten, Marisa G. Stahl, Ravy K. Vajravelu, James D. Lewis, Blair Fennimore, Mark E. Gerich, Frank Scott
Summary: Prior authorizations are associated with prolonged biologic initiation time and increased IBD-related healthcare utilization.
Review
Gastroenterology & Hepatology
Floris P. J. den Hartog, Sarah van Egmond, Marijn M. Poelman, Anand G. Menon, Gert-Jan Kleinrensink, Johan F. Lange, Pieter J. Tanis, Eva B. Deerenberg
Summary: The aim of this study was to determine the pooled incidence of incisional hernia (IH) for each type of extraction site and compare the rates of IH after midline, nonmidline, and Pfannenstiel extraction.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Andrea Balla, Federica Saraceno, Marika Rullo, Salvador Morales-Conde, Eduardo M. Targarona Soler, Salomone Di Saverio, Mario Guerrieri, Pasquale Lepiane, Nicola Di Lorenzo, Michel Adamina, Isaias Alarcon, Alberto Arezzo, Jesus Bollo Rodriguez, Luigi Boni, Sebastiano Biondo, Francesco Maria Carrano, Manish Chand, John T. Jenkins, Justin Davies, Salvadora Delgado Rivilla, Paolo Delrio, Ugo Elmore, Eloy Espin-Basany, Alessandro Fichera, Blas Flor Lorente, Nader Francis, Marcos Gomez Ruiz, Dieter Hahnloser, Eugenio Licardie, Carmen Martinez, Monica Ortenzi, Yves Panis, Carlos Pastor Idoate, Alessandro M. Paganini, Miguel Pera, Roberto Perinotti, Daniel A. Popowich, Timothy Rockall, Riccardo Rosati, Alberto Sartori, Daniele Scoglio, Mostafa Shalaby, Vicente Simo Fernandez, Neil J. Smart, Antonino Spinelli, Patricia Sylla, Pieter J. Tanis, Javier Valdes-Hernandez, Steven D. Wexner, Pierpaolo Sileri
Summary: This qualitative study investigated the decision-making process of surgeons regarding protective ileostomy creation after rectal cancer surgery. The results showed that 76% of surgeons supported the creation of ileostomy. When making the decision, 88% of surgeons considered risk factors. Emotions influenced the decision-making process in 22% of cases, and personal experiences influenced it in 49% of cases. The most frequently considered risk factors were the distance between the anus and the tumor (96%), neoadjuvant chemoradiotherapy (88%), positive intraoperative leak test (65%), blood loss (37%), and immunosuppression therapy (35%).
COLORECTAL DISEASE
(2023)
Article
Oncology
Bobby Zamaray, J. V. Veld, T. A. Burghgraef, R. Brohet, H. L. van Westreenen, J. E. van Hooft, P. D. Siersema, P. J. Tanis, E. C. J. Consten
Summary: This retrospective multicentre cohort study aimed to identify risk factors for a permanent stoma (PS) in patients with left-sided obstructive colon cancer (LSOCC) and develop pre- and postoperative prediction models. The results showed that 37% of LSOCC patients had a PS, and 53% of those with a stoma directly after resection had a PS due to non-reversal. Both baseline characteristics and treatment strategies determine the risk of a PS in LSOCC patients. The developed predictive models will help physicians understand the role of individual variables in the risk of a PS and inform patients about the probability of a PS.
Article
Medicine, General & Internal
Daan F. L. Filippini, Laura A. Hagens, Nanon F. L. Heijnen, Claudio Zimatore, Leila N. Atmowihardjo, Ronny M. Schnabel, Marcus J. Schultz, Dennis C. J. J. Bergmans, Lieuwe D. J. Bos, Marry R. Smit
Summary: The RALE score is not universally prognostic in mechanically ventilated ICU patients, but early changes in RALE score are associated with mortality in ARDS patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Jasper Paul Sijberden, Antonino Spinelli, Alessandro Ferrero, Manish Chand, Steven Wexner, Marc G. Besselink, Ibrahim Dagher, Giuseppe Zimmitti, Burak Gorgec, Antonio de Lacy, Mayank Roy, Pieter Tanis, Carlo Tonti, Mohammed Abu Hilal
Summary: This study aimed to assess the attitudes of surgeons involved in the treatment of synchronous colorectal liver metastases (sCRLM). The study found that there were differences in clinical practices and viewpoints on the management of sCRLM among surgeons from different specialties and continents. However, there was consensus on a growing role for minimally invasive surgery (MIS) and a need for evidence-based input.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Alexander A. J. Grueter, Annabel S. S. Van Lieshout, Stefan E. E. van Oostendorp, Sofie P. G. Henckens, Johannes C. F. Ket, Suzanne S. S. Gisbertz, Boudewijn R. R. Toorenvliet, Pieter J. J. Tanis, Hendrik J. J. Bonjer, Jurriaan B. B. Tuynman
Summary: This systematic review provides a comprehensive overview of video-based objective surgical quality assessment (SQA) tools in laparoscopic procedures. The findings suggest that validated SQA tools enable objective assessment of surgical performance and are associated with clinical outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
K. Talboom, N. G. Greijdanus, N. Brinkman, R. D. Blok, S. X. Roodbeen, C. Y. Ponsioen, P. J. Tanis, W. A. Bemelman, C. Cunningham, F. B. de Lacy, Roel Hompes
Summary: This study aimed to compare different treatment strategies for anastomotic leakage (AL) after low anterior resection (LAR) and found that endoscopic vacuum-assisted surgical closure (EVASC) resulted in improved rates of healed and functional anastomosis compared to conventional treatment. Early initiation of EVASC within the first week after surgery achieved a 100% functional anastomosis rate.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Gastroenterology & Hepatology
Alexander A. J. T. Grueter, Usha E. Coblijn, Boudewijn Toorenvliet, Pieter L. Tanis, Jurriaan Tuynman
Summary: The purpose of this study is to identify surgical variations, determine the optimal and standardized minimally invasive right hemicolectomy, and train and implement this technique nationally to improve patient outcomes. The study aims to standardize and improve the surgical quality of MIRH for patients with right-sided colon cancer at a national level.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Surgery
Pepijn Krielen, Lisa P. A. Kranenburg, Martijn W. J. D. Stommel, Nicole J. Bouvy, Pieter J. Tanis, Jorn Willemsen, Jorne Migchelbrink, Rick de Ree, Esther M. G. Bormans, Harry van Goor, Richard P. G. ten Broek, ASBO Snapshot Study Grp Background
Summary: This study aimed to provide insight into the current management of adhesive small bowel obstruction (ASBO) and its associated outcomes. The findings suggest that oral water-soluble contrast and early surgical intervention can lead to shorter hospital stays and reduced complications. These results may support the standardization of ASBO treatment.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Daan R. Loke, H. Petra Kok, Roxan F. C. P. A. Helderman, Nicolaas A. P. Franken, Arlene L. Oei, Jurriaan B. Tuynman, Remko Zweije, Jan Sijbrands, Pieter J. Tanis, Johannes Crezee
Summary: In this study, a 3D-printed anatomically correct phantom of a female peritoneum was used to validate the thermal module of a treatment planning software. The software, based on OpenFoam, helps understand and map thermal heterogeneities during Hyperthermic IntraPeritoneal Chemotherapy (HIPEC) treatments. The experimental data compared well with simulated temperature distributions, indicating the accuracy of the software.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Roxan F. C. P. A. Helderman, Bella Bokan, Gregor G. W. van Bochove, Hans M. Rodermond, Elsy Thijssen, Wouter Marchal, Arezo Torang, Daan R. Loke, Nicolaas A. P. Franken, H. Petra Kok, Pieter J. Tanis, Johannes Crezee, Arlene L. Oei
Summary: In patients with limited peritoneal metastasis from colorectal cancer, cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy is a potentially curative treatment option. This study investigated the impact of treatment temperature and duration on the effectiveness of oxaliplatin and mitomycin C in preclinical models, and found that higher temperatures and longer treatment durations resulted in improved efficacy and reduced toxicity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Katrijn Daenen, Jilske A. Huijben, Anders Boyd, Lieuwe D. J. Bos, Sara C. M. Stoof, Hugo van Willigen, Diederik A. M. P. J. Gommers, Hazra S. Moeniralam, Corstiaan A. den Uil, Nicole P. Juffermans, Merijn Kant, Abraham J. Valkenburg, Janesh Pillay, David M. P. van Meenen, Frederique Paulus, Marcus J. Schultz, Virgil A. S. H. Dalm, Eric C. M. van Gorp, Janke Schinkel, Henrik Endeman
Summary: This study aims to determine the optimal dosing and timing of corticosteroid therapy for hospitalized patients with COVID-19 and provide a personalized treatment approach to reduce morbidity and mortality. It will investigate the effect of high-dose corticosteroids throughout the entire clinical course and explore biomarker profiles for targeted therapy.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Surgery
Jan M. van Rees, Myrtle F. Krul, Niels F. M. Kok, Dirk J. Grunhagen, E. N. D. Kok, Pieter M. H. Nierop, Klaas Havenga, Harm Rutten, Jacobus W. A. Burger, Johannes H. W. de Wilt, Jeroen Hagendoorn, Femke P. Peters, Johannes Buijsen, Pieter J. Tanis, Cornelis Verhoef, Koert F. D. Kuhlmann
BRITISH JOURNAL OF SURGERY
(2023)
Article
Oncology
Saskia I. Kreisel, Sarah Sharabiany, Joost Rothbarth, Roel Hompes, Gijsbert D. Musters, Pieter J. Tanis
Summary: This study found that the development of perineal hernia after abdominoperineal resection significantly worsens the quality of life in various domains.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tania C. Sluckin, Sanne-Marije J. A. Hazen, Karin Horsthuis, Doenja M. J. Lambregts, Regina G. H. Beets-Tan, Pieter J. Tanis, Miranda Kusters
Summary: This study aimed to evaluate the variation in measurements and anatomical classifications of lateral lymph nodes (LLNs) before and after training. The results showed that after training, there was an improvement in the correct identification of anatomical location and a reduction in the deviation of short-axis measurements. The conclusion of this study is that adequate training is crucial for the accurate evaluation of LLNs.
EUROPEAN RADIOLOGY
(2023)
