Review
Medicine, General & Internal
Esmee J. Grobbee, Pieter Ha Wisse, Eline H. Schreuders, Aafke van Roon, Leonie van Dam, Ann G. Zauber, Iris Lansdorp-Vogelaar, Wichor Bramer, Sarah Berhane, Jonathan J. Deeks, Ewout W. Steyerberg, Monique E. van Leerdam, Manon Cw Spaander, Ernst J. Kuipers
Summary: FIT is superior to gFOBT in detecting advanced colorectal neoplasia and colorectal cancer in average-risk individuals. The specificity of both tests was similar, while the sensitivity of FIT was significantly higher than gFOBT at pre-specified specificities.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Multidisciplinary Sciences
Miriam P. van der Meulen, Esther Toes-Zoutendijk, Manon C. W. Spaander, Evelien Dekker, Johannes M. G. Bonfrer, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, M. F. van Velthuysen, Maarten G. J. Thomeer, Harriet van Veldhuizen, Harry J. de Koning, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The participation rate in FIT screening is lower for individuals with a lower socioeconomic status (SES), but they have a higher detection rate for advanced neoplasia. Screening has the potential to reduce health inequalities in CRC mortality.
Review
Gastroenterology & Hepatology
Noel Pin-Vieito, Manuel Puga, Daniel Fernandez-de-Castro, Joaquin Cubiella
Summary: FIT is widely used as a biomarker for colorectal cancer diagnosis and plays a crucial role in screening and surveillance. This review summarizes the diagnostic efficacy of FIT in symptomatic patients and post-adenoma resection, as well as discusses the potential impact of FIT strategies on healthcare resources and CRC prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Lasse Kaalby, Ulrik Deding, Issam Al-Najami, Gabriele Berg-Beckhoff, Thomas Bjorsum-Meyer, Tinne Laurberg, Aasma Shaukat, Robert J. C. Steele, Anastasios Koulaouzidis, Morten Rasmussen, Morten Kobaek-Larsen, Gunnar Baatrup
Summary: New research suggests that faecal haemoglobin concentration (f-Hb) can indicate the presence of serious diseases not related to colorectal cancer (CRC). This study found an association between increasing f-Hb and the risk of mortality, as well as an increased risk of dying from respiratory disease, cardiovascular disease, and other cancers. f-Hb may be a potential biomarker for non-CRC diseases.
Article
Public, Environmental & Occupational Health
Johanna Wangmar, Yvonne Wengstrom, Anna Jervaeus, Kaisa Fritzell
Summary: The acceptability of colorectal cancer screening procedures is crucial for the success of screening programs. This study explored how individuals experience CRC screening, finding that experiences vary from having no worries to experiencing bothersome emotions, logistical concerns, inconsistent information, and unmet expectations. Improving patient experiences may involve using one-sample FITs, optimizing bowel preparation for colonoscopies, and delivering clear information and emotional support at the right time.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Gemma Ibanez-Sanz, Nuria Mila, Carmen Vidal, Judith Rocamora, Victor Moreno, Rebeca Sanz-Pamplona, Montse Garcia
Summary: This study found a significant increase in mortality rate in patients with interval CRC compared to screen-detected CRC, with a 74% increase in mortality rate. These differences were still present even when restricting for advanced-cancers participants. Stratified analysis for type of faecal occult blood test showed a lower mortality rate only among FIT screen-detected CRCs.
Article
Oncology
Anton Gies, Tobias Niedermaier, Elizabeth Alwers, Thomas Hielscher, Korbinian Weigl, Thomas Heisser, Petra Schrotz-King, Michael Hoffmeister, Hermann Brenner
Summary: This study evaluated the performance of nine fecal immunochemical tests in screening colonoscopy participants, with differences in diagnostic performance observed by sex and age. Females consistently showed lower sensitivities and higher specificities than males, with higher negative predictive values. A negative FIT was found to be less reliable in ruling out AN among men and older participants than among women and younger participants.
Review
Public, Environmental & Occupational Health
B. R. Chand, L. Phillipson, T. Ha
Summary: This comprehensive review examines the factors influencing participation in organised faecal occult blood test (FOBT) screening programmes among culturally and linguistically diverse populations. The review identifies barriers such as faecal aversion, fear of cancer, language barriers, and low knowledge and awareness of colorectal screening. Facilitators include positive attitudes towards screening, general practitioner recommendations, and social support. The review suggests multicomponent interventions to address low screening uptake and highlights the importance of successful community-level interventions and leveraging the general practitioner relationship.
Article
Oncology
Sara G. Ribe, Edoardo Botteri, Magnus Loberg, Kristin R. Randel, Mette Kalager, Jens Aksel Nilsen, Elisabeth H. Gulichsen, Oyvind Holme
Summary: This study investigated the impact of time interval between faecal immunochemical testing (FIT) cycles on the detection rate of colorectal cancer (CRC) and advanced neoplasia (AN). The results showed that although the detection rates of CRC and AN increased with increasing time interval between FITs, individuals who had undetectable faecal haemoglobin (f-Hb) at the first screening round had a substantially lower risk of CRC at the next screening round compared to individuals with detectable f-Hb.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Manuel Zorzi, Jessica Battagello, Kevin Selby, Giulia Capodaglio, Susanna Baracco, Silvia Rizzato, Enrico Chinellato, Stefano Guzzinati, Massimo Rugge
Summary: A study conducted in the Veneto region of Italy found that the risk of colorectal cancer mortality is significantly higher among individuals who do not undergo colonoscopy after a positive FIT result, highlighting the importance of increasing compliance in this high-risk population.
Article
Oncology
Rafael Cardoso, Feng Guo, Thomas Heisser, Monika Hackl, Petra Ihle, Harlinde De Schutter, Nancy Van Damme, Zdravka Valerianova, Trajan Atanasov, Ondrej Majek, Jan Muzik, Mef Christina Nilbert, Anne Julie Tybjerg, Kaire Innos, Margit Magi, Nea Malila, Anne-Marie Bouvier, Veronique Bouvier, Guy Launoy, Anne-Sophie Woronoff, Melanie Cariou, Michel Robaszkiewicz, Patricia Delafosse, Florence Poncet, Alexander Katalinic, Paul M. Walsh, Carlo Senore, Stefano Rosso, Ieva Vincerzevskiene, Valery E. P. P. Lemmens, Marloes A. G. Elferink, Tom Borge Johannesen, Hartwig Korner, Frank Pfeffer, Maria Jose Bento, Jessica Rodrigues, Filipa Alves da Costa, Ana Miranda, Vesna Zadnik, Tina Zagar, Arantza Lopez de Munain Marques, Rafael Marcos-Gragera, Montse Puigdemont, Jaume Galceran, Maria Carulla, Maria-Dolores Chirlaque, Monica Ballesta, Kristina Sundquist, Jan Sundquist, Marco Weber, Andrea Jordan, Christian Herrmann, Mohsen Mousavi, Anton Ryzhov, Michael Hoffmeister, Hermann Brenner
Summary: There are diverse trends in colorectal cancer incidence, mortality, and stage distribution across European countries, mainly due to variations in the implementation of colorectal cancer screening programs.
Article
Gastroenterology & Hepatology
Reinier G. S. Meester, Hilliene J. van de Schootbrugge-vandermeer, Emilie C. H. Breekveldt, Lucie de Jonge, Esther Toes-Zoutendijk, Arthur Kooyker, Daan Nieboer, Christian R. Ramakers, Manon C. W. Spaander, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, Iris D. Nagtegaal, Evelien Dekker, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The prognostic potential of repeated faecal haemoglobin (F-Hb) concentration measurements in faecal immunochemical test (FIT)-based screening for colorectal cancer (CRC) was examined. The study found that F-Hb concentrations in rounds 1 and 2 were the strongest predictors. In external validation, the model retained similar discrimination accuracy. This suggests that individuals can be accurately identified as low or high risk based on age, sex, and prior F-Hb concentrations, and risk stratification should be considered based on this information.
Article
Biochemistry & Molecular Biology
Jacopo Troisi, Maria Tafuro, Martina Lombardi, Giovanni Scala, Sean M. Richards, Steven J. K. Symes, Paolo Antonio Ascierto, Paolo Delrio, Fabiana Tatangelo, Carlo Buonerba, Biancamaria Pierri, Pellegrino Cerino
Summary: The objective of this study was to develop a novel screening approach for colorectal cancer using serum metabolomic profiles, and to evaluate the metabolic alterations associated with the disease. The results showed that the metabolomic signature can be used as a non-invasive screening tool for colorectal cancer, and identified differences primarily associated with cell glucose metabolism.
Review
Public, Environmental & Occupational Health
Zilin Luo, Xuesi Dong, Chenran Wang, Wei Cao, Yadi Zheng, Zheng Wu, Yongjie Xu, Liang Zhao, Fei Wang, Jibin Li, Jiansong Ren, Jufang Shi, Wanqing Chen, Ni Li
Summary: This study systematically reviewed observational studies on the association between socioeconomic status (SES) and adherence to colorectal cancer (CRC) screening. The findings showed that individuals with high SES had higher adherence to screening compared to those with low SES. Neighborhood SES or small-area SES was more effective in assessing the association between SES and adherence than individual SES.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Medicine, General & Internal
Paulina Wieszczy, Michal F. Kaminski, Magnus Loberg, Marek Bugajski, Michael Bretthauer, Mette Kalager
Summary: Estimates of overdiagnosis of colorectal cancer through screening methods such as sigmoidoscopy and FOBT varied significantly depending on model assumptions. Microsimulation models showed a wide range of overdiagnosis percentages for both screening methods, indicating caution should be exercised when using these models to inform guidelines.
Article
Surgery
Nicola Troisi, Athanasios Saratzis, Emmanuel Katsogridakis, Konstantinos Stavroulakis, Raffaella Berchiolli, Hany Zayed, Giovanni Torsello
Summary: This study aimed to report the mid-term outcomes of endovascular treatment for isolated atherosclerotic popliteal artery lesions. The study found that endovascular treatment was safe and associated with acceptable patency and freedom from clinically driven target lesion revascularization (F-CDTLR) in the mid-term. The most commonly used treatments included plain balloon angioplasty and drug-coated balloon angioplasty.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Orthopedics
Manolis Abatzis-Papadopoulos, Konstantinos Tigkiropoulos, Spyridon Nikas, Ioakeim Papoutsis, Olympia Kostopoulou, Kyriakos Stavridis, Dimitrios Karamanos, Ioannis Lazaridis, Nikolaos Saratzis
Summary: This study compared the effectiveness, safety, and mortality between direct oral anticoagulants (DOACs) and conventional pharmacologic venous thromboembolism (VTE) prophylaxis in patients undergoing hip fracture surgery (HFS). The meta-analysis found no significant difference in VTE, deep vein thrombosis, pulmonary embolism, major bleeding, minor bleeding, all bleeding events, and mortality between patients prescribed DOACs and patients prescribed low molecular weight heparin (LMWH). Further studies with larger sample sizes are needed to obtain safer conclusions.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2023)
Article
Surgery
Mustafa Musajee, Emmanuel Katsogridakis, Yusuf Kiberu, Christopher Banerjee, Rhys George, Bijan Modarai, Athanasios Saratzis, Becky Sandford
Summary: Acute kidney injury (AKI) is common in patients with acute type B aortic dissection (TBAD) and is associated with increased mortality and adverse kidney outcomes. This study investigated the incidence and impact of AKI in patients with acute TBAD and found that AKI was significantly associated with worse outcomes.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Editorial Material
Surgery
Athanasios Saratzis
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Gastroenterology & Hepatology
William Xu, Cameron I. Wells, Matthew McGuinness, Chris Varghese, Celia Keane, Chen Liu, Gregory O'Grady, Ian P. Bissett, Christopher Harmston
Summary: This study examined the readmission rates after colorectal cancer surgery in New Zealand and identified the risk factors and clinical reasons for unplanned readmissions. The rates of readmission were high and did not significantly improve over time, mainly due to comorbidities, advanced disease, and postoperative complications.
COLORECTAL DISEASE
(2023)
Article
Multidisciplinary Sciences
Stephanie Bienek, Maciej Kusmierczuk, Beatrix Schnorr, Ole Gemeinhardt, Stephanie Bettink, Bruno Scheller
Summary: The aim of this study was to investigate inhibition of neointimal proliferation in porcine peripheral vessels with different diameters covered by one single hyper-compliant drug-coated balloon (HCDCB), compared to conventional drug-coated balloons (DCB), each selected according to the respective vessel diameter. The results showed that one HCDCB had a similar anti-restenotic effect as two vessel diameter-adjusted DCB in narrow distal and wider proximal segments.
Correction
Surgery
Stavros A. Antoniou, Ivan D. Florez, Sheraz Markar, Patricia Logullo, Manuel Lopez-Cano, Gianfranco Silecchia, George A. Antoniou, Sofia Tsokani, Dimitrios Mavridis, Melissa Brouwers
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Rachael O. Forsythe, Isabelle Van Herzeele, Hany Zayed, Angeliki Argyriou, Konstantinos Stavroulakis, Athanasios Saratzis
Summary: This international study aimed to evaluate the characteristics of bullying, undermining behaviour, and harassment experienced by physicians treating vascular diseases at different career stages. The results showed that 43% of respondents personally experienced BUH, 75% witnessed BUH towards colleagues, and female sex and non-white ethnicity were associated with BUH.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Surgery
Christopher P. Twine, Stavros K. Kakkos, Victor Aboyans, Iris Baumgartner, Christian-Alexander Behrendt, Sergi Bellmunt-Montoya, Bernd Jilma, Joakim Nordanstig, Athanasios Saratzis, Jim A. Reekers, Petar Zlatanovic
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Medicine, General & Internal
Andrew W. Bradbury, Catherine A. Moakes, Matthew Popplewell, Lewis Meecham, Gareth R. Bate, Lisa Kelly, Ian Chetter, Athanasios Diamantopoulos, Arul Ganeshan, Jack Hall, Simon Hobbs, Kim Houlind, Hugh Jarrett, Suzanne Lockyer, Jonas Malmstedt, Jai Patel, Smitaa Patel, S. Tawqeer Rashid, Athanasios Saratzis, Gemma Slinn, Julian A. Scott, Hany Zayed
Summary: This study compared the effectiveness of vein bypass first and best endovascular treatment first revascularization strategies in patients with chronic limb-threatening ischemia. The results showed that the best endovascular treatment group had a lower rate of amputation and death, suggesting that more patients with chronic limb-threatening ischemia should be considered for a best endovascular treatment first revascularization strategy.
Article
Gastroenterology & Hepatology
Chris Varghese, Matthew McGuinness, Cameron I. Wells, Brodie M. Elliott, Ashok Gunawardene, Melissa Edwards, Ravinder Vohra, Ewen A. Griffiths, Saxon Connor, Garth H. Poole, John A. Windsor, Deborah Wright, Christopher Harmston, Jim Hsu-Shun Wang, John Windsor, Elizabeth Chen, Kaustubha Ghate, Shayal Lal, Binura Lekamalage, Milidu Ratnayake, Arpita Bansal, John Windsor, Seagh von Keisenberg, Arthana Hemachandran, Megan Singhal, Nejo Joseph, Sameer Bhat, Jeremy Rossaak, Daniel Carson, Nandini Dubey, Marcus Pan, Liam Ferguson, Imogen Watt, Jenny Choi, Jared Mclauchlan, Saxon Connor, Ella Nicholas, Ibrahim Al-Busaidi, Douglas Wood, Cheyaanthan Haran, Anthony Lin, Paul Fagan, Andrea Bathgate, Saloni Patel, Josephine Mak, Emma Espiner, Garth Poole, Summer Hassan, Zunaira Javed, Madi Randall, Sydney Clough, William Cook, Sita Clark, Carys Finlayson, Garth Poole, Praharsh Bahl, Surya Singh, Cindy Lin, Clair Wang, Reina Kittaka, Mathew Morreau, Andrew Ing, Sarah Logan, Sam Guest, Kirsty Sutherland, Alex Lewis, Jessica Roberts, Bridget Watson, James Tietjens, Rebecca Teague, Bruce Su'a, Anupam Modi, Varun Modi, Yahaira Williams, Jonty Morreau, Choo Khoo, Brendan Desmond, Michael Young, Renee Christmas, Teresa Holm, Christopher Harmston, Kieran Long, Briar Garton, Niki Kau, Lucy Barber, Mostafa Amer, James Haddow, Mostafa Amer, Chekodi Fearnley-Fitzgerald, Karen Suresh, Edwin Zeng, Anastasia Young-Gough, Jordan Skeet, Falah El-Haddawi, Matias Alvarez, Son Nguyen, Jasmin King, James Crichton, Fraser Welsh, Melissa Edwards, Jeffrey Tan, Jonathon Luo, Karankumar Banker, Xavier Field, Philip Allan, Sarah Rennie, Chathura Bathiya Ratnayake, Sanket Srinivasa, Jee Hyun Gloria Kim, Sarah Bradley, Nivedita Singh, Grace Kang, William Xu, Sanket Srinivasa, Holly Cook, Vyoma Mistry, Kaavya Dabla, Abraham Montes de Oca, Vithushiya Yoganandarajah, Marianne Lill, Jacky Lu, Louis Antoine Bonnet, Thitapon Uiyapat
Summary: This study investigated the practice of cholecystectomy in New Zealand and found significant variations in the rates of index and elective cholecystectomy. These variations were not adequately explained by patient, operative, or hospital factors alone. Therefore, national quality improvement efforts are needed to standardise the availability of cholecystectomy.
Review
Surgery
Abdul -Rahman Gomaa, Ciaran Grafton-Clarke, Athanasios Saratzis, Robert S. M. Davies
Summary: This systematic review evaluates the evidence of using high-fidelity simulation in endovascular training and summarizes the current research findings. The results suggest that simulation training can significantly improve procedure and fluoroscopy time. However, high-quality randomized controlled trials are still needed to establish the clinical and economic benefits of simulation training.
ANNALS OF VASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Arsalan Wafi, Mohamed S. Hosny, Sanjay Patel, Lukla Biasi, Athanasios Saratzis, Hany Zayed
Summary: Aortoiliac occlusive disease (AIOD) is a complex condition to manage due to anatomical complexities and comorbidities. Traditional guidelines have been limited by a lack of quality evidence, but emerging data is showing comparable success rates between open and endovascular surgery. This review provides an overview of the evolution of techniques, contemporary management, limitations in evidence, and future treatment adjuncts for AIOD.
JOURNAL OF CARDIOVASCULAR SURGERY
(2023)
Meeting Abstract
Surgery
M. Musajee, E. Katsogridakis, Y. Kiberu, C. Banerjee, R. George, B. Modarai, A. Saratzis, B. Sandford
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Medicine, General & Internal
Josh Tiro, Olivia Lengyel, Matthew James McGuinness, Christopher Harmston
Summary: Most patients in Northland with acute diverticulitis are not undergoing colonic investigation according to recent guidelines, despite a low rate of colonic malignancy found in the study. Further research is needed to guide clinicians and improve resource utilization efficiency.
NEW ZEALAND MEDICAL JOURNAL
(2023)