Article
Gastroenterology & Hepatology
K. Ong, L. Bordeianou, M. Brunner, S. Buntzen, M. H. S. Collie, A. Hanly, C. W. Hunt, K. E. Matzel, P. R. O'Connell, M. Rydningen, L. Savitt, A. Totaro, C. J. Vaizey, Y. Maeda
Summary: This study aimed to determine whether the paradigm of surgical intervention for faecal incontinence has changed between 2000 and 2013. The results showed an increasing use of sacral neuromodulation over time, indicating a shift in the surgical intervention paradigm for faecal incontinence.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Anthony Y. Lin, Chris Varghese, Niranchan Paskaranandavadivel, Sean Seo, Peng Du, Phil Dinning, Ian P. Bissett, Greg O'Grady
Summary: The rectosigmoid brake was suppressed in patients with faecal incontinence, and sacral neuromodulation (SNM) may exert a therapeutic effect by modulating this rectosigmoid brake.
COLORECTAL DISEASE
(2022)
Article
Clinical Neurology
Luigi Valentino Berra, Daniele Armocida, Mauro Palmieri, Valerio Di Norcia, Luca D'Angelo, Massimo Mongardini, Massimo Vigliotta, Edoardo Maccari, Antonio Santoro
Summary: Reconstructing sacrificed nerves during sacral tumor removal has been proven effective in restoring sphincter and sexual function, offering promising potential to significantly enhance patients' quality of life.
Article
Gastroenterology & Hepatology
C. Seifarth, N. Slavova, C. Degro, K. S. Lehmann, M. E. Kreis, B. Weixler
Summary: This study evaluated the use of sacral nerve stimulation (SNS) in patients with high stool frequency or fecal incontinence after proctocolectomy with IPAA. The results showed that SNS improved symptoms in over two-thirds of patients, suggesting its feasibility as a therapeutic option in this patient population.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Charlotte Desprez, Audrey Grange, Guillaume Gourcerol, Alexis Deperrois, Oriane Garconnet, Clemence Leroux, Gregory Mosni, Laurence Poux, Justine Breemeersch, Cecile Goblot, Sebastien Kepka, Julie Ruillon, Margot Vannier, Valerie Bridoux, Anne-Marie Leroi
Summary: Regular follow-up and reprogramming of stimulation parameters in patients with implanted SNM devices can optimize the efficacy of treatment for fecal incontinence.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Guillaume Meurette, Laurent Siproudhis, Anne-Marie Leroi, Henri Damon, David Urs Josef Keller, Jean-Luc Faucheron
Summary: This study confirms the clinical effectiveness, safety, and positive effect of sacral neuromodulation with the InterStim(TM) system for the treatment of faecal incontinence, showing significant improvements in quality of life and symptoms with high patient satisfaction. Main device-related adverse events include the need for reprogramming, infection, and surgical revision.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Mario de Miguel J. Valencia, Juan Cabases M. Hita, Eduardo Sanchez Iriso, Fabiola Oteiza Martinez, Inaki Alberdi Ibanez, Alfonso Alvarez Lopez, Hector Ortiz Hurtado, Mario J. de Miguel J. Velasco
Summary: The aim of this study was to evaluate the long-term cost-effectiveness of sacral neuromodulation in the treatment of severe faecal incontinence as compared with symptomatic management. The results showed that sacral neuromodulation may be considered a cost-effective technique in the long-term treatment of severe faecal incontinence from the societal and health care sector perspectives, with incremental cost-effectiveness ratios of 14347euro/QALY and 28523euro/QALY, respectively.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
M. Bosch-Ramirez, L. Sanchez-Guillen, M. J. Alcaide-Quiros, M. M. Aguilar-Martinez, M. Bellon-Lopez, A. Lopez Delgado, F. Lopez-Rodriguez-Arias, A. Munoz-Duyos, X. Barber-Valles, A. Arroyo
Summary: This study evaluated the long-term efficacy of percutaneous tibial nerve stimulation (PTNS) for patients with refractory faecal incontinence (FI), and found that after 1 year of treatment, the majority of patients achieved optimal responses, and even those who initially had only partial responses maintained long-term continence after 3 years.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Gastroenterology & Hepatology
Assia Daikh, Fabienne Reymond, Dorothee Lombardo, Caroline Thuillier, Pierrick Bedouch, Jean-Luc Faucheron
Summary: Sacral nerve neuromodulation (SNM) is a safe and effective therapy for managing fecal and/or urinary incontinence. This study evaluated the lifespan of InterStim(TM) and InterStim(TM) II generators and the long-term hospital costs associated with SNM therapy. The results showed that the lifespan of InterStim(TM) II is shorter than the first-generation device, leading to increased hospital costs over time.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Neurosciences
Liyun Wang, Payam Gharibani, Yi Yang, Yu Guo, Jieyun Yin
Summary: This study investigated the effects of sacral nerve stimulation (SNS) on Loperamide-induced constipation in rats. The results showed that SNS with appropriate parameters improved whole colon transit time, resolved constipation, reversed the detrimental effects of Loperamide on enteric neurons, and increased the expressions of GDNF and p-AKT in colon tissue. The findings suggest that SNS may be a potential treatment for opioid-induced constipation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Gastroenterology & Hepatology
Marcus V. Ortega, Youngwu Kim, Caroline Mitchell, Kaitlyn James, Lieba Savitt, Emily Von Bargen, Liliana G. Bordeianou, Milena M. Weinstein
Summary: The study found that in women with pelvic floor disorders, the presence of FI is associated with a higher prevalence of urinary incontinence. Healthcare providers should assess the presence of FI along with urinary incontinence symptoms to guide appropriate therapy.
COLORECTAL DISEASE
(2021)
Review
Surgery
Alimohammad Bananzadeh, Maryam Sohooli, Tahereh Shamsi, Mohammadhassan Darabi, Reza Shahriarirad, Ramin Shekouhi
Summary: Neuromodulatory treatments, such as posterior tibial nerve stimulation (PTNS), show potential effectiveness in relieving pain and promoting healing in recurrent anal fissures, although they may not provide long-term improvement comparable to lateral internal sphincterotomy (LIS).
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Zakir Mridha, Jan Willem de Gee, Yanchen Shi, Rayan Alkashgari, Justin Williams, Aaron Suminski, Matthew P. Ward, Wenhao Zhang, Matthew James McGinley
Summary: The study demonstrates that pupil dilation is a reliable and noninvasive biosensor for titratable VNS-evoked cortical neuromodulation by acetylcholine in mice.
NATURE COMMUNICATIONS
(2021)
Article
Obstetrics & Gynecology
Margaret G. Mueller, Promi Das, Uduak Andy, Lisa Brennaman, Alexis A. Dieter, Denicia Dwarica, Anna C. Kirby, Jonathan P. Shepherd, W. Thomas Gregory, Cindy L. Amundsen
Summary: This study evaluated the stability of the urinary microbiome communities in women undergoing SNM for UUI. The results showed that the urinary microbiome remained relatively stable, despite variability amongst the cohort.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Review
Medicine, General & Internal
Ximeng Wang, Jiande D. Z. Chen
Summary: The systematic review aims to introduce the clinical applications and potential mechanisms of sacral nerve stimulation (SNS) for various gastrointestinal diseases. The results showed that SNS is highly effective in treating fecal incontinence, but it is ineffective for constipation. Further research is needed to explore the potential applications of SNS for irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2023)
