Article
Radiology, Nuclear Medicine & Medical Imaging
Mirza S. Baig, Wais Habib, Veronica Attard, Ban Sharif, Daniel Lindsay, Bhavin Upadhyay, Asif Saifuddin
Summary: This study aimed to determine the prevalence of pulmonary metastases on re-staging chest CT at the time of first local recurrence of trunk or extremity soft tissue sarcoma. The results showed that pulmonary metastases were diagnosed in 23.9% of cases, most commonly associated with grade 3 STS and specific sub-types of tumors. This supports the recommendation for chest CT at the time of local recurrence in line with UK guidelines for sarcoma management.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Seijong Kim, Jung Wook Huh, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Yoon Ah Park, Jung Kyong Shin
Summary: This study compared the oncologic outcomes of radical operation and adjuvant CCRT/RT in high-risk early rectal cancer patients. The results showed that patients who underwent radical operations had better survival rates compared to those treated with adjuvant CCRT/RT. Treatment type and preoperative CEA were identified as important prognostic factors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Thomas W. A. Koedam, Boukje T. Bootsma, Charlotte L. Deijen, Tim van de Brug, Geert Kazemier, Miguel A. Cuesta, Alois Furst, Antonio M. Lacy, Eva Haglind, Jurriaan B. Tuynman, Freek Daams, Hendrik J. Bonjer
Summary: Anastomotic leakage after rectal cancer surgery negatively affects long-term oncological outcomes, leading to increased local recurrences and decreased disease-free survival. However, its impact on outcomes after colon cancer surgery remains inconclusive.
Article
Oncology
Sophia Waldenstedt, Eva Haglind, Eva Angenete
Summary: This study aimed to investigate the symptoms and diagnostic methods of local recurrence in patients after rectal cancer surgery, and found that pain was a common alarm symptom for local recurrence. The majority of patients with local recurrence were diagnosed outside of scheduled follow-ups.
Article
Oncology
I-Li Lai, Jeng-Fu You, Yih-Jong Chern, Wen-Sy Tsai, Jy-Ming Chiang, Pao-Shiu Hsieh, Hsin-Yuan Hung, Yu-Jen Hsu
Summary: Radical resection is associated with good prognosis for patients with cT1/T2Nx rectal cancer, but some still experience recurrence. In this study of 279 patients with pT1/pT2N0 mid-low rectal cancer, factors like insufficient distal resection margin and preoperative CEA levels were identified as risk factors for recurrence. Multidisciplinary treatment was found to provide acceptable survival outcomes.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Gowoon Yang, Jee Suk Chang, Jeong Eun Choi, Eun Sil Baek, Seung-Seob Kim, Hwa Kyung Byun, Yeona Cho, Woong Sub Koom, Seung Yoon Yang, Byung Soh Min, Sang Joon Shin
Summary: The study investigated the prognostic impact of neutrophil-to-lymphocyte ratio (NLR) in locally advanced rectal cancer (LARC) patients and whether modifiable factors in radiotherapy (RT) influenced the NLR. The results showed that increased NLR after neoadjuvant RT is associated with increased distant metastasis risk and poor survival outcome in patients with LARC. Moreover, high NLR following RT is directly related to RT fractionation, delivery modality, and tumor characteristics.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Ana Luzarraga Aznar, Vicente Bebia, Carlos Lopez-Gil, Alexandra Giraldo, M. P. Montoya, Ramona Verges, Alberto Jauregui, Josep Castellvi, Assumpcio Perez-Benavente, Eva Colas, Antonio Gil-Moreno, Silvia Cabrera
Summary: The objective of this study was to describe the characteristics of patients with endometrial cancer diagnosed with a first recurrence involving the lung, and to explore the prognostic role of the molecular profile. The study also aimed to describe the prognostic outcomes after local treatment of isolated lung recurrence.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Urology & Nephrology
Nicholas H. Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A. Ornellas, Mario Catanzaro, Oliver W. Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E. Spiess
Summary: This study found that 31.9% of pSCC patients experienced post-ILND recurrence, which was associated with high pN staging. Over 95% of distant, inguinal, and pelvic recurrences occurred within 48 months post-ILND. Local recurrences occurred over a longer timeline, highlighting the necessity of long-term surveillance of the primary site.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Sunmin Park, Won Park, Shin Hyung Park, Joo-Young Kim, Jin Hee Kim, Haeyoung Kim, Yeon-Sil Kim, Won Kyung Cho, Won Sup Yoon, Dae Sik Yang
Summary: This study aimed to evaluate the oncologic outcomes in uterine cervical cancer patients with metachronous distant metastases according to disease burden. The results showed that salvage treatments in selected patients with a long disease-free interval, low metastatic burden, and/or lymphatic-only metastasis can lead to favorable oncologic outcomes.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Tai Ma, Zhijun Wu, Xiaopeng Zhang, Hui Xu, Ying Feng, Cheng Zhang, Minmin Xie, Yahui Yang, Yi Zhang, Chong Feng, Guoping Sun
Summary: A prognostic scoring model for mortality risk stratification in patients with advanced gastric carcinoma was constructed and validated in two hospital cohorts. The model incorporated multiple survival risk factors and stratified patients based on different risk levels. Results showed the model had good predictive performance in both cohorts.
Article
Oncology
Obada Hasan, Momin Nasir, Muneeba Jessar, Mustafa Hashimi, Qiang An, Benjamin J. Miller
Summary: In general, LR with subsequent metastasis is a rare event. LR is best viewed as a marker of tumor aggressiveness rather than the cause of metastasis and poor survival. LR in bone sarcoma patients should warn providers of a high risk of imminent metastasis.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Urology & Nephrology
Esther W. C. Lee, Luca Antonelli, Allaudin Issa, James Churchill, Ashwin Sachdeva, Pedro Oliveira, Maurice Lau, Vijay Sangar, Arie Parnham, Christian D. Fankhauser
Summary: This study aimed to investigate the risk of local recurrence in men with no penile cancer but the precancerous lesion penile intraepithelial neoplasia at the surgical margin. The results showed that men with penile intraepithelial neoplasia-positive surgical margins had a higher risk of local recurrence compared to those with completely negative surgical margins.
JOURNAL OF UROLOGY
(2023)
Article
Gastroenterology & Hepatology
Woo Hyun Paik, Hee Seung Lee, Kyong Joo Lee, Sung Ill Jang, Woo Jin Lee, Jin-Hyeok Hwang, Chang Min Cho, Chang-Hwan Park, Jimin Han, Sang Myung Woo, Seok Jeong, Hyung Ku Chon, Tae Nyeun Kim, Jun Kyu Lee, Joung-Ho Han, Jai Hoon Yoon, Yong-Tae Kim, Jae Hee Cho
Summary: This study investigated the clinical course and risk factors for malignant potential of small PNENs, finding that WHO grade is responsible for the malignant potential of small PNENs <= 2 cm. Therefore, EUS-FNAB could be recommended for early treatment strategies.
Article
Oncology
Tadahiko Masaki, Hiroyoshi Matsuoka, Tomokazu Kishiki, Koichiro Kojima, Ayako Tonari, Nobuyoshi Aso, Ayumi Beniya, Aiko Iioka, Takashi Wakamatsu, Eiji Sunami
Summary: This study found that risk factors for local recurrence after rectal cancer surgery varied depending on the site of recurrence within the pelvis. Tumor distance from the anal verge was significantly associated with pelvic sidewall recurrence, while depth of tumor invasion and radial margin status were significantly correlated with the other type of local recurrence.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Surgery
Hyeong Seok Kim, Youngmin Han, Jae Seung Kang, Yoo Jin Choi, Yoonhyeong Byun, Haeryoung Kim, Kyung Bun Lee, Hongbeom Kim, Wooil Kwon, Jin-Young Jang
Summary: This study evaluated the factors and prognosis of patients with intraductal papillary mucinous neoplasms (IPMN) after surgical resection. It found that invasive IPMN had a higher risk of recurrence and worse survival compared to low-grade dysplasia (LGD) and high-grade dysplasia (HGD). This suggests the need for more effective postoperative treatment strategies for invasive IPMN, and regular follow-up for recurrence in LGD and HGD patients after 5 years. Additionally, achieving negative or LGD margins is important to improve outcomes.