☆ 4.5 Article

Treatment of slow-transit constipation with sacral nerve modulation

COLORECTAL DISEASE (2010)

Journal

COLORECTAL DISEASE

Volume 12, Issue 11, Pages 1149-1152

Publisher

WILEY

DOI: 10.1111/j.1463-1318.2009.02067.x

Keywords

Slow transit constipation; sacral nerve modulation; constipation; neuromodulation; treatment

Categories

Gastroenterology & Hepatology Surgery

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

Aim Constipation is common and a selection of the best treatment is difficult, especially for slow-transit constipation (STC). The aim of the study was to assess the effect of sacral nerve modulation (SNM) on STC. Method A retrospective analysis of patients with STC, treated with SNM was undertaken. All were evaluated by cincdefecography, colon transit-time, Cleveland Clinic Constipation Score (CCS), SF-36 Quality of Life (QoL) and a bowel diary. Initially, all patients underwent a temporary implant for 4 weeks. The criteria of success were disappearance of necessity for laxatives or enema requirement, and improvement in QoL. Results Fifteen patients with STC were treated from March 2003 to May 2006. Nine (60%) underwent permanent implantation. After SNM, the mean improvement of Wexner Constipation Score (CCS) and QoL was 10 and 6.2 respectively. There were no complications. The mean follow-up period was 42 months. Conclusion Sacral nerve modulation seems to be a useful option for STC.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Gastroenterology & Hepatology

Effects of temporary sacral nerve stimulation on gastrointestinal motility and function in patients with chronic refractory slow-transit constipation

D. F. Altomare, A. Picciariello, A. Di Ciaula, M. Rinaldi, M. De Fazio, P. Portincasa

Summary: Temporary sacral nerve stimulation (SNS) did not have any effect on upper/lower gastrointestinal motility and transit in patients with severe constipation.

TECHNIQUES IN COLOPROCTOLOGY (2021)

Add to Collection

Article Neurosciences

Regulation of enteric nervous system via sacral nerve stimulation in opioid-induced constipated rats

Liyun Wang, Payam Gharibani, Yi Yang, Yu Guo, Jieyun Yin

Summary: This study investigated the effects of sacral nerve stimulation (SNS) on Loperamide-induced constipation in rats. The results showed that SNS with appropriate parameters improved whole colon transit time, resolved constipation, reversed the detrimental effects of Loperamide on enteric neurons, and increased the expressions of GDNF and p-AKT in colon tissue. The findings suggest that SNS may be a potential treatment for opioid-induced constipation.

FRONTIERS IN NEUROSCIENCE (2023)

Add to Collection

Article Plant Sciences

Research progress in the treatment of slow transit constipation by traditional Chinese medicine

LiangFeng Wang, Fei Wu, YanLong Hong, Lan Shen, LiJie Zhao, Xiao Lin

Summary: Traditional Chinese medicine (TCM) shows good clinical efficacy in treating slow transit constipation (STC) with multiple mechanisms, focusing on balancing yin and yang, qi and blood, and liver qi. Single Chinese herbs and active ingredients also exhibit promising efficacy in STC treatment.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Add to Collection

Article Medicine, General & Internal

Prevalence and Clinical Characteristics of Dyssynergic Defecation and Slow Transit Constipation in Patients with Chronic Constipation

Samuel Tanner, Ahson Chaudhry, Navneet Goraya, Rohan Badlani, Asad Jehangir, Dariush Shahsavari, Zubair Malik, Henry P. Parkman

Summary: In patients with chronic constipation, about 22% have dyssynergic defecation (DD), about 55% have slow transit constipation (STC), and 13% have both DD and STC. There were no specific symptoms differentiating STC from DD, but patients with STC and DD reported more severe constipation symptoms.

JOURNAL OF CLINICAL MEDICINE (2021)

Add to Collection

Article Pharmacology & Pharmacy

Astragaloside IV improves slow transit constipation by regulating gut microbiota and enterochromaffin cells

Xingyang Wan, Qian Zhou, Huaxian Chen, Zhen Li, Mianling Mo, Zhimin Liu, Heng Zhang, Zhuojie He, Guozhong Xiao, Yihui Zheng, Hongcheng Lin, Donglin Ren

Summary: This study found that treatment with AS-IV improved symptoms in STC mice and affected changes in gut microbiota and metabolites, with correlations found between specific gut microbes and fecal metabolites such as 3-BrY. It was suggested that 3-BrY may reduce caspase-dependent apoptosis of ECs and protect cell survival by inhibiting the activation of the p38 MAPK and ERK signaling pathways.

FRONTIERS IN PHARMACOLOGY (2023)

Add to Collection

Article Gastroenterology & Hepatology

METTL3 contributes to slow transit constipation by regulating miR-30b-5p/PIK3R2/Akt/mTOR signaling cascade through DGCR8

Wen-jing Gong, Rong Li, Qiao-qiong Dai, Peng Yu

Summary: The study found that METTL3, DGCR8, miR-30b-5p, and m6A methylation levels were significantly increased in tissues from patients with slow transit constipation (STC) and in glutamic acid-induced interstitial cells (ICCs). Inhibiting METTL3 and miR-30b-5p can reduce cell death in ICCs, while overexpression of miR-30b-5p can reverse the protective effect of METTL3 knockdown on cells.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022)

Add to Collection

Article Nutrition & Dietetics

Effects of Lactiplantibacillus plantarum GUANKE on Diphenoxylate-Induced Slow Transit Constipation and Gut Microbiota in Mice

Yuanming Huang, Yanan Guo, Xianping Li, Yuchun Xiao, Zhihuan Wang, Liqiong Song, Zhihong Ren

Summary: This study evaluated the impact of Lactiplantibacillus plantarum GUANKE (GUANKE) on diphenoxylate-induced slow transit constipation in a mouse model. GUANKE alleviated constipation symptoms by regulating intestinal factors, neurotransmitters, hormones, and specific bacterial taxa.

NUTRIENTS (2023)

Add to Collection

Article Medicine, General & Internal

Gut Metagenome as a Potential Diagnostic and Predictive Biomarker in Slow Transit Constipation

Hongliang Tian, Chen Ye, Bo Yang, Jiaqu Cui, Zhijun Zheng, Chunyan Wu, Shailan Zhou, Xiaoqiong Lv, Nan Qin, Huanlong Qin, Ning Li, Qiyi Chen

Summary: In this study, the researchers found significant differences in the intestinal microbiome of patients with slow transit constipation (STC) compared to healthy individuals. The differences were observed at the phylum, genus, and species level. The study also identified potential biomarkers and pathways associated with STC. These findings suggest that alterations in the microbiome and microbial-derived metabolites may contribute to the development of constipation, providing potential targets for the development of microbial drugs.

FRONTIERS IN MEDICINE (2022)

Add to Collection

Article Endocrinology & Metabolism

Intervention Effect of Benzoylmesaconine on Slow Transit Constipation in Rats

Yuanzhe Zhang, Shengnan Jian, Yuchuan Li

Summary: This study explored the role and mechanism of Benzoylmesaconine (BAC) in the treatment of slow transit constipation (STC). The results showed that BAC improved the symptoms of STC and improved the composition of intestinal microflora associated with STC.

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS (2023)

Add to Collection

Article Plant Sciences

Zhizhu decoction alleviates slow transit constipation by regulating aryl hydrocarbon receptor through gut microbiota

Yong Wen, Yu Zhan, Shiyu Tang, Fang Liu, Rong Wu, Pengfei Kong, Qian Li, Xuegui Tang

Summary: This study explores the analgesic effect and mechanism of a traditional Chinese medicine compound Zuotong Capsule on cancer pain. The results demonstrate that this compound can significantly alleviate the severity of cancer pain by inhibiting the release of inflammatory factors and regulating the levels of neurotransmitters. These findings provide a theoretical basis for further research and application of traditional Chinese medicine compounds.

PHARMACEUTICAL BIOLOGY (2023)

Add to Collection

Article Neurosciences

Frequency-Specific Modulation of Slow-Wave Neural Oscillations via Weak Exogeneous Extracellular Fields Reveals a Resonance Pattern

Boateng Asamoah, Ahmad Khatoun, Myles Mc Laughlin

Summary: Through applying exogenous extracellular fields to modulate slow-wave neural oscillations in anesthetized rats, it has been demonstrated that these fields can modulate the amplitude of endogenous neural oscillations in a frequency-specific resonance pattern without affecting spike rate.

JOURNAL OF NEUROSCIENCE (2022)

Add to Collection

Article Chemistry, Applied

Physicochemical properties, structure, and ameliorative effects of insoluble dietary fiber from tea on slow transit constipation

Xiaoli Bai, Yi He, Bingyan Quan, Ting Xia, Xianglong Zhang, Yongqi Wang, Yu Zheng, Min Wang

Summary: This study investigated the physicochemical properties and structure of tea insoluble dietary fiber (T-IDF), and found that T-IDF exhibits excellent physical and chemical properties. Consumption of T-IDF significantly promoted defecation and enhanced the production of short chain fatty acids.

FOOD CHEMISTRY-X (2022)

Add to Collection

Review Immunology

The Fecal Microbiota Transplantation: A Remarkable Clinical Therapy for Slow Transit Constipation in Future

Jiafei Liu, Liqiang Gu, Mingqing Zhang, Shiwu Zhang, Min Wang, Yu Long, Xipeng Zhang

Summary: Slow transit constipation is a common and challenging condition to treat, with fecal microbiota transplantation showing significant therapeutic effects and the ability to inhibit the engraftment of pathogens by maintaining intestinal homeostasis.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Add to Collection

Article Gastroenterology & Hepatology

Analysis of Gut Microbiome and Metabolite Characteristics in Patients with Slow Transit Constipation

Hongliang Tian, Qiyi Chen, Bo Yang, Huanlong Qin, Ning Li

Summary: The study found significant differences in gut microbiome diversity between the STC and control groups, with greater diversity in the STC group and differences in species composition at different classification levels. Acetate concentrations were significantly reduced in the STC group compared to the control group, while other SCFAs showed no significant difference. These differences may serve as valuable biomarkers for STC.

DIGESTIVE DISEASES AND SCIENCES (2021)

Add to Collection

Letter Gastroenterology & Hepatology

Preservation of the superior rectal artery in laparoscopic colectomy for slow transit constipation: Is it really associated with better outcomes?

Rogerio Serafim Parra, Omar Feres, Jose Joaquim Ribeiro Rocha

Summary: Subtotal colectomy with ileorectal anastomosis can benefit some patients with slow-transit constipation, but the study had limitations such as lack of a comparison group and not presenting the functional results of patients after surgery. Additionally, the authors found the surgical procedure to be safe with no cases of leakage.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Add to Collection

Article Oncology

Hepatocellular carcinoma on cirrhosis complicated with tumoral thrombi extended to the right atrium: results in three cases treated with major hepatectomy and thrombectomy under hypothermic cardiocirculatory arrest and literature review

Benedetta Pesi, Francesco Giudici, Luca Moraldi, Gianfranco Montesi, Stefano Romagnoli, Fulvio Pinelli, Pierluigi Stefano, Giacomo Batignani

WORLD JOURNAL OF SURGICAL ONCOLOGY (2016)

Add to Collection

Article Gastroenterology & Hepatology

New approach to large haemorrhoidal prolapse: double stapled haemorrhoidopexy

Gabriele Naldini, Jacopo Martellucci, Pasquale Talento, Angelo Caviglia, Luca Moraldi, Mauro Rossi

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2009)

Add to Collection

Article Gastroenterology & Hepatology

Is simple mucosal resection really possible? Considerations about histological findings after stapled hemorrhoidopexy

Gabriele Naldini, Jacopo Martellucci, Luca Moraldi, Nicola Romano, Mauro Rossi

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2009)

Add to Collection

Editorial Material Obstetrics & Gynecology

Single-stage operation using hypothermic circulatory arrest to remove uterine intravenous leiomyomatosis extended to the vena cava and right atrium

Benedetta Pesi, Luca Moraldi, Lorenzo Antonuzzo, Giulia Meoni, Rami Addasi, Gianfranco Montesi, Pierluigi Stefano, Giacomo Batignani

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2015)

Add to Collection

Article Surgery

Pringle maneuver in robotic liver surgery: preliminary study

Benedetta Pesi, Luca Moraldi, Ilenia Bartolini, Federica Tofani, Francesco Guerra, Mario Annecchiarico, Andrea Coratti

MINERVA CHIRURGICA (2018)

Add to Collection

Article Surgery

Laparoscopy within a fast-track program enhances the short-term results after elective surgery for resectable colorectal cancer

Francesco Feroci, Katrin C. Kroening, Elisa Lenzi, Luca Moraldi, Stefano Cantafio, Marco Scatizzi

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2011)

Add to Collection

Letter Surgery

Early Versus Delayed Cholecystectomy for Acute Cholecystitis: Comments on the ACDC Study

Francesco Guerra, Luca Moraldi, Lucia Barni, Stefano Amore Bonapasta

ANNALS OF SURGERY (2017)

Add to Collection

Review Surgery

Time-to-administration in postoperative chemotherapy for colorectal cancer: does minimally-invasive surgery help?

Stefano Amore Bonapasta, Paolo Checcacci, Francesco Guerra, Vita Maria Mirasolo, Luca Moraldi, Angelo Ferrara, Mario Annecchiarico, Andrea Coratti

MINERVA CHIRURGICA (2016)

Add to Collection

Review Gastroenterology & Hepatology

Esophageal surgery in minimally invasive era

Lapo Bencini, Luca Moraldi, Ilenia Bartolini, Andrea Coratti

WORLD JOURNAL OF GASTROINTESTINAL SURGERY (2016)

Add to Collection

Article Surgery

FEASIBILITY AND EFFECTIVENESS OF LAPAROSCOPIC RIGHT COLECTOMY WITH EXTRACORPOREAL ANASTOMOSIS

F. Feroci, E. Lenzi, K. C. Kroening, L. Moraldi, S. Cantafio, A. Borrelli, G. Giaconi, M. Scatizzi

MINERVA CHIRURGICA (2011)

Add to Collection

Article Surgery

Laparoscopic versus open distal gastrectomy for locally advanced gastric cancer: a case-control study

Marco Scatizzi, Katrin C. Kro Ning, Elisa Lenzi, Luca Moraldi, Stefano Cantafio, Francesco Feroci

UPDATES IN SURGERY-ITALY (2011)

Add to Collection

Article Surgery

A new effective method to reduce pain after laparoscopic cholecystectomy

F. Feroci, K. C. Kroening, L. Moraldi, A. Borrelli, A. Ottaviano, M. De Prizio, M. Scatizzi

GIORNALE DI CHIRURGIA (2010)

Add to Collection

Article Surgery

THE DEVELOPMENT OF A FAST TRACK SURGERY PROGRAM AFTER LAPAROSCOPIC COLONIC SURGERY IN A GENERAL SURGERY UNIT

F. Feroci, K. C. Kroning, E. Lenzi, L. Moraldi, A. Borrelli, M. Scatizzi

MINERVA CHIRURGICA (2010)

Add to Collection

Article Surgery

Laparoscopic approach in acute bowel obstruction due to ileal endometriosis: case report

F. Feroci, M. De Prizio, K. C. Kroening, L. Moraldi, M. Scatizzi

GIORNALE DI CHIRURGIA (2010)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.