Article
Gastroenterology & Hepatology
Anthony Y. Lin, Chris Varghese, Niranchan Paskaranandavadivel, Sean Seo, Peng Du, Phil Dinning, Ian P. Bissett, Greg O'Grady
Summary: The rectosigmoid brake was suppressed in patients with faecal incontinence, and sacral neuromodulation (SNM) may exert a therapeutic effect by modulating this rectosigmoid brake.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
K. Ong, L. Bordeianou, M. Brunner, S. Buntzen, M. H. S. Collie, A. Hanly, C. W. Hunt, K. E. Matzel, P. R. O'Connell, M. Rydningen, L. Savitt, A. Totaro, C. J. Vaizey, Y. Maeda
Summary: This study aimed to determine whether the paradigm of surgical intervention for faecal incontinence has changed between 2000 and 2013. The results showed an increasing use of sacral neuromodulation over time, indicating a shift in the surgical intervention paradigm for faecal incontinence.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Charlotte Desprez, Audrey Grange, Guillaume Gourcerol, Alexis Deperrois, Oriane Garconnet, Clemence Leroux, Gregory Mosni, Laurence Poux, Justine Breemeersch, Cecile Goblot, Sebastien Kepka, Julie Ruillon, Margot Vannier, Valerie Bridoux, Anne-Marie Leroi
Summary: Regular follow-up and reprogramming of stimulation parameters in patients with implanted SNM devices can optimize the efficacy of treatment for fecal incontinence.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Guillaume Meurette, Laurent Siproudhis, Anne-Marie Leroi, Henri Damon, David Urs Josef Keller, Jean-Luc Faucheron
Summary: This study confirms the clinical effectiveness, safety, and positive effect of sacral neuromodulation with the InterStim(TM) system for the treatment of faecal incontinence, showing significant improvements in quality of life and symptoms with high patient satisfaction. Main device-related adverse events include the need for reprogramming, infection, and surgical revision.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Mario de Miguel J. Valencia, Juan Cabases M. Hita, Eduardo Sanchez Iriso, Fabiola Oteiza Martinez, Inaki Alberdi Ibanez, Alfonso Alvarez Lopez, Hector Ortiz Hurtado, Mario J. de Miguel J. Velasco
Summary: The aim of this study was to evaluate the long-term cost-effectiveness of sacral neuromodulation in the treatment of severe faecal incontinence as compared with symptomatic management. The results showed that sacral neuromodulation may be considered a cost-effective technique in the long-term treatment of severe faecal incontinence from the societal and health care sector perspectives, with incremental cost-effectiveness ratios of 14347euro/QALY and 28523euro/QALY, respectively.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
M. Bosch-Ramirez, L. Sanchez-Guillen, M. J. Alcaide-Quiros, M. M. Aguilar-Martinez, M. Bellon-Lopez, A. Lopez Delgado, F. Lopez-Rodriguez-Arias, A. Munoz-Duyos, X. Barber-Valles, A. Arroyo
Summary: This study evaluated the long-term efficacy of percutaneous tibial nerve stimulation (PTNS) for patients with refractory faecal incontinence (FI), and found that after 1 year of treatment, the majority of patients achieved optimal responses, and even those who initially had only partial responses maintained long-term continence after 3 years.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Gastroenterology & Hepatology
Assia Daikh, Fabienne Reymond, Dorothee Lombardo, Caroline Thuillier, Pierrick Bedouch, Jean-Luc Faucheron
Summary: Sacral nerve neuromodulation (SNM) is a safe and effective therapy for managing fecal and/or urinary incontinence. This study evaluated the lifespan of InterStim(TM) and InterStim(TM) II generators and the long-term hospital costs associated with SNM therapy. The results showed that the lifespan of InterStim(TM) II is shorter than the first-generation device, leading to increased hospital costs over time.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Neurosciences
Liyun Wang, Payam Gharibani, Yi Yang, Yu Guo, Jieyun Yin
Summary: This study investigated the effects of sacral nerve stimulation (SNS) on Loperamide-induced constipation in rats. The results showed that SNS with appropriate parameters improved whole colon transit time, resolved constipation, reversed the detrimental effects of Loperamide on enteric neurons, and increased the expressions of GDNF and p-AKT in colon tissue. The findings suggest that SNS may be a potential treatment for opioid-induced constipation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Zakir Mridha, Jan Willem de Gee, Yanchen Shi, Rayan Alkashgari, Justin Williams, Aaron Suminski, Matthew P. Ward, Wenhao Zhang, Matthew James McGinley
Summary: The study demonstrates that pupil dilation is a reliable and noninvasive biosensor for titratable VNS-evoked cortical neuromodulation by acetylcholine in mice.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
C. Seifarth, N. Slavova, C. Degro, K. S. Lehmann, M. E. Kreis, B. Weixler
Summary: This study evaluated the use of sacral nerve stimulation (SNS) in patients with high stool frequency or fecal incontinence after proctocolectomy with IPAA. The results showed that SNS improved symptoms in over two-thirds of patients, suggesting its feasibility as a therapeutic option in this patient population.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Review
Medicine, General & Internal
Ximeng Wang, Jiande D. Z. Chen
Summary: The systematic review aims to introduce the clinical applications and potential mechanisms of sacral nerve stimulation (SNS) for various gastrointestinal diseases. The results showed that SNS is highly effective in treating fecal incontinence, but it is ineffective for constipation. Further research is needed to explore the potential applications of SNS for irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2023)
Article
Pediatrics
Stephen Trinidad, Amanda Jensen, Monica Holder, Allison Elsner, Nelson Rosen, Aaron Garrison, Beth Rymeski, Jason S. Frischer
Summary: This study evaluated the outcomes of sacral nerve stimulation (SNS) in patients with medically refractory fecal incontinence or severe constipation. A retrospective cohort study was conducted on patients who underwent SNS placement after failed medical management at a single center. The rates of involuntary bowel movements were compared pre- and post-SNS using a bowel severity score questionnaire.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Neurosciences
Gerrit E. Gmel, Paul F. Vollebregt, Marjolein E. G. Thijssen, Rosana Santos Escapa, Eleanor McAlees, Dave Mugan, John L. Parker, Charles H. Knowles
Summary: This study aimed to determine if electrophysiological responses can be recorded directly from the S3 sacral nerve during therapeutic SNM in patients with fecal incontinence, and to characterize such responses in order to better understand the mechanism of action (MOA) and changes in stimulation with posture. The findings show both neural and myoelectric responses, highlighting the heterogeneity of these responses and confirming that electrode lead position can change with posture.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Health Care Sciences & Services
David G. Jayne, Annabelle E. Williams, Neil Corrigan, Julie Croft, Alison Pullan, Vicky Napp, Rachel Kelly, David Meads, Armando Vargas-Palacios, Adam Martin, Claire Hulme, Steven R. Brown, Karen Nugent, Jen Lodge, David Protheroe, Sushil Maslekar, Andrew Clarke, Pasha Nisar, Julia M. Brown
Summary: A study comparing FENIX and sacral nerve stimulation for treating adult faecal incontinence found no significant difference in success rates after 18 months, but a higher complication rate in the FENIX group. Sacral nerve stimulation was more cost-effective over the lifetime, indicating a need for further research in treatment pathways.
HEALTH TECHNOLOGY ASSESSMENT
(2021)
Review
Biochemistry & Molecular Biology
Beniamina Mercante, Paolo Enrico, Franca Deriu
Summary: In recent years, there has been a significant scientific effort to find effective and safe treatments for cognitive decline. Non-invasive neuromodulation, particularly trigeminal nerve stimulation (TNS), has gained attention for its potential cognitive effects. However, the use of TNS for cognitive enhancement and treatment of cognitive decline still faces challenges due to the lack of standardization in stimulation protocols.
Article
Obstetrics & Gynecology
Eva Martinez Franco, Jose Luis Lopez Negre, David Pares, Cristina Ros Cerro, Lluis Amat Tardiu, Daniel Cuadras, Montserrat Espuna Pons
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2019)
Article
Immunology
Boris Revollo, Sebastian Videla, Josep M. Llibre, Roger Paredes, Marta Pinol, Francesc Garcia-Cuyas, Arelly Ornelas, Jordi Puig, David Pares, Javier Corral, Bonaventura Clotet, Guillem Sirera
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Surgery
Manel Cremades, Georgina Ferret, David Pares, Jordi Navines, Franc Espin, Fernando Pardo, Albert Caballero, Marta Viciano, Joan Francesc Julian
AMERICAN JOURNAL OF SURGERY
(2020)
Article
Gastroenterology & Hepatology
Montserrat Guasch, Emili Vela, Miriam Manosa, Montserrat Cleries, Fiorella Canete, David Pares, Alex Guarga, Jose Troya, Margalida Calafat, Eugeni Domenech
Summary: In the era of biological agents, the postoperative mortality rate for IBD patients is mostly influenced by comorbidities and age.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Sara Senti, Clara Gene, Jose Troya, Cristina Pacho, Raquel Nunez, Mauricio Parrales, Irene Jimenez, Jaume Fernandez-Llamazares, Joan-Francesc Julian, David Pares
Summary: Comprehensive geriatric assessment using different scales is an effective tool to assess postoperative mortality in the mid-term postoperative period.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2021)
Editorial Material
Surgery
David Pares
Article
Obstetrics & Gynecology
Cristina Molinet Coll, Eva Martinez Franco, Laura Altimira Queral, Daniel Cuadras, Lluis Amat Tardiu, David Pares
Summary: Hormonal changes, particularly higher progesterone concentration, and weaker pelvic floor muscles are risk factors for stress urinary incontinence (SUI) during pregnancy. The presence and severity of SUI during pregnancy increase the risk of persistent symptoms 6 months postpartum.
REPRODUCTIVE SCIENCES
(2022)
Article
Surgery
Nares Arroyo-Garcia, Josep M. Badia, Ana Vazquez, Miguel Pera, David Pares, Enric Limon, Alexander Almendral, Marta Piriz, Cecilia Diez, Domenico Fraccalvieri, Joaquin Lopez- Contreras, Miquel Pujol
Summary: This study investigated the effectiveness of an interventional surveillance program on surgical site infection (SSI) rates after elective colorectal surgery. The analysis of risk factors and postoperative infection in colorectal surgery allowed strategies for reducing SSI incidence to be designed, and the interventional surveillance program was proven effective in decreasing SIR and SSI rates.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Review
Surgery
Clara Gene Skrabec, Anna Vidal Carne, Manel Cremades Perez, Javier Corral, Andrea Fernandez Pujol, Marta Cuadrado, Jose Troya, Joan-Francesc Julian Ibanez, David Pares
Summary: The aim of this study was to review and assess the quality of scientific articles on early and late anastomotic leak (AL) after colorectal surgery and their risk factors. A systematic search was conducted using the MEDLINE database via PubMed, Cochrane, and Embase. The selected articles were reviewed and assessed for methodological quality using a validated methodology quality score (MINCIR score). The review was registered in the PROSPERO registry. Nine articles were finally reviewed, indicating the differentiation between early and late anastomotic leak based on technical factors and impaired healing.
Article
Obstetrics & Gynecology
Eva Martinez Franco, Cristina Molinet Coll, Laura Altimira Queral, Sol Balsells, Manel Carreras, David Pares
Summary: This study aimed to investigate the factors involved in LAM modifications during pregnancy. Data on physical examination, 4D transperineal ultrasound, and hormone concentrations were collected from 99 nulliparous pregnant women. The findings showed that LH dimensions increased during pregnancy, but no conclusive factors were found to predict LAM modifications.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Medicine, General & Internal
A. Morillo-Rodriguez, S. Alonso-Fernandeza, J. M. Modol Deltella, B. Soldevila Madorell, Ll. Benito-Aracil, D. Pares
Summary: This study aimed to adapt the AEP questionnaire to analyze the appropriateness of hospital admissions and stays in our healthcare reality. Through the Delphi method, experts in clinical management and hospital care contributed to the modification of the questionnaire. The resulting modified questionnaire includes 47 items in total, focused on assessing the appropriateness of admissions and extended stays.
REVISTA CLINICA ESPANOLA
(2023)
Article
Surgery
Josep Badia, Nares Arroyo-Garcia, Ana Vazquez, Alexander Almendral, Aina Gomila-Grange, Domenico Fraccalvieri, David Pares, Ana Abad-Torrent, Marta Pascual, Alejandro Solis-Pena, Mireia Puig-Asensio, Miguel Pera, Francesc Gudiol, Enric Limon, Miquel Pujol
Summary: This study investigated the implementation and outcomes of a nationwide care bundle for colorectal surgery. The results showed that the implementation of the care bundle significantly reduced the rate of surgical site infection.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
E. Sanchez-Haro, E. Vela, M. Cleries, S. Vela, I. Tapiolas, J. Troya, J. -F. Julian, D. Pares
Summary: The study aimed to determine the incidence of anorectal abscess and the development of a fistula in a specific population area, as well as identify potential risk factors associated with demographic, socioeconomic, and pre-existing diseases. The study found that approximately 20% of patients with anorectal abscess developed a fistula, with a higher likelihood in men and those with inflammatory bowel disease.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Letter
Surgery
David Pares, Jose Troya, Joan-Francesc Julian
Article
Health Care Sciences & Services
I. H. Rodriguez-Alvarez, D. Pares, J. F. Julian, M. Ballester
JOURNAL OF HEALTHCARE QUALITY RESEARCH
(2019)