Review
Pharmacology & Pharmacy
Jeongrae Kim, Yongwhan Choi, Dong-Hwee Kim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: This review summarizes recent advances in the use of injectable hydrogels for combination immunotherapy in treating tumors. Injectable hydrogels, with their biocompatibility, degradability, and controllable properties, can effectively encapsulate various immunotherapeutic agents and elicit antitumor immune responses. The review also discusses the application of injectable hydrogels in chemoimmunotherapy, photoimmunotherapy, and radioimmunotherapy.
Article
Biophysics
Yin Xiao, Yuhong Gu, Li Qin, Lin Chen, Xiaoliang Chen, Weiheng Cui, Fuling Li, Ni Xiang, Xiaoai He
Summary: Injectable thermosensitive hydrogel is an attractive drug delivery system that has become increasingly important in cancer therapy due to its ability to provide high local drug concentration, sustained release, minimal invasiveness, and low systemic toxicities. This review highlights its extensive application in local cancer therapy, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, chemo-photothermal combined therapy, and chemo-/immuno- combined therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Zhenyu Zhao, Zhen Wang, Gen Li, Zhengwei Cai, Jiezhou Wu, Lei Wang, Lianfu Deng, Ming Cai, Wenguo Cui
Summary: Microfluidic hydrogel microspheres have been widely studied and used in various industries, with a focus on their applications in the medical field for controlled delivery of cells and drugs. These materials enable efficient encapsulation and control of functionalities, promoting collaboration across disciplines and advancing precision medicine and applied materials.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Polymer Science
Qi Wang, Yanfei Qu, Ziyi Zhang, Hao Huang, Yufei Xu, Fengyun Shen, Lihua Wang, Lele Sun
Summary: Regulated drug delivery is an important area of research in medicine and healthcare. Injectable hydrogels, particularly DNA hydrogels, have gained significant attention for their biocompatibility and biodegradability in controlled drug release and immunotherapy. DNA hydrogel, a three-dimensional network formed by linking hydrophilic DNA strands, offers precise design of mechanical properties and functions through its editable sequence and hybridization reactions. Additionally, integration with other functional materials enriches the capabilities of DNA hydrogels. This review provides an overview of DNA hydrogel types, synthesis methods, and recent research progress in local drug delivery and immunotherapy, as well as discusses challenges and future directions.
Article
Engineering, Biomedical
Heng An, Yan Yang, Ziwei Zhou, Yunyi Bo, Yong Wang, Yingna He, Dong Wang, Jianglei Qin
Summary: The injectable and biodegradable self-healing hydrogel based on pectin shows enhanced anticancer drug release property. The mechanical properties of the hydrogel can be regulated by the weight ratio of P(NIPAM-stat-AH) to pectin-CHO. The hydrogel exhibits good biocompatibility, biodegradability, decreases drug toxicity to living body, and displays controlled drug release behavior as synergetic anti-tumor drug delivery carriers.
ACTA BIOMATERIALIA
(2021)
Article
Polymer Science
Sungjun Kim, Wonjeong Lee, Heewon Park, Kyobum Kim
Summary: In this study, a drug delivery system for colon cancer treatment was developed by embedding the anticancer drug 6-mercaptopurine (6-MP) in a thiolated gelatin/polyethylene glycol diacrylate hydrogel (6MP-GPGel). The 6MP-GPGel continuously released 6-MP, with an accelerated release rate in acidic or glutathione environments. The results demonstrated that the 6MP-GPGel formulation effectively suppressed the survival rate of cancer cells compared to treatment with pure 6-MP.
Review
Biotechnology & Applied Microbiology
Chutong Liu, Yingying Liao, Lei Liu, Luoyijun Xie, Junbo Liu, Yumao Zhang, Yuzhen Li
Summary: Immunotherapy is a revolutionary and promising approach to cancer treatment, and hydrogels as drug carriers have many advantages in achieving controlled release of drugs and triggering anti-tumor effects. This paper reviews recent advances in injectable hydrogel-based cancer immunotherapy, including immunotherapy alone, immunotherapy with combination chemotherapy, radiotherapy, phototherapy, and DNA hydrogel-based immunotherapy. The potential and limitations of injectable hydrogels in cancer immunotherapy are also discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sicheng Yang, Jiaoyu Ren, Hong Wang
Summary: An injectable micromotor@hydrogel drug delivery system is proposed to protect micromotors from the external environment, showing excellent antibacterial effect and enhanced diffusion in the surroundings of bacteria.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Sicheng Yang, Jiaoyu Ren, Hong Wang
Summary: The drug delivery system based on nano/micromotors has attracted significant research interest. In this study, an injectable micromotor@hydrogel drug delivery system was developed to protect micromotors from the external environment and enhance sustained drug release.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Chao Gao, Keman Cheng, Yao Li, Ruining Gong, Xiao Zhao, Guangjun Nie, He Ren
Summary: In this study, a novel hydrogel was developed for pancreatic cancer immunotherapy. The hydrogel can reshape the tumor microenvironment, increase the number of M1 phenotype macrophages, and control tumor growth.
Article
Chemistry, Multidisciplinary
Jiawei Lin, Liang Chen, Jielai Yang, Xingchen Li, Juan Wang, Yuan Zhu, Xiangyang Xu, Wenguo Cui
Summary: This study presents a functional hydrogel microsphere designed for efficient drug delivery to joints. The microspheres exhibit targeting properties, cartilage penetration, and cellular phagocytosis, addressing the challenges of drug delivery in damaged tissues. The microspheres can be adsorbed onto the cartilage surface and release drugs over an extended period of time, effectively improving drug delivery efficiency and delaying the development of osteoarthritis.
Article
Chemistry, Multidisciplinary
Xiaoping Zhang, Yage Sun, Tengling Wu, Xinrui Zhao, Rong Yang, Hongying Wang, Wenguang Liu
Summary: This study proposes a new strategy for treating myocardial infarction by combining liposome/pcircRNA and strontium ions-containing nanoparticles-encapsulated injectable hydrogel and NO-bearing liposome-loaded pericardial adhesive hydrogel patch. This strategy enables intramyocardial gene/ion delivery and epicardial NO delivery to inhibit cardiomyocyte apoptosis, inflammatory response, and promote angiogenesis.
Article
Engineering, Biomedical
Tianxu Fang, Xiaona Cao, Bingzheng Shen, Zhitong Chen, Guojun Chen
Summary: In this study, a hydrogel-mediated combination therapy was proposed to enhance the efficacy of immune checkpoint blockade (ICB) for cancer treatment. Cold atmospheric plasma (CAP) was used to induce cancer immunogenic cell death and release tumor-associated antigens, synergistically augmenting the effectiveness of ICB. Injecting CAP into tumor tissues with the Pluronic hydrogel delivery method effectively preserved the reactive oxygen species (ROS) and reactive nitrogen species (RNS) in CAP, which induced immunogenic cell death. This localized combination therapy evoked strong anti-tumor immune responses and inhibited tumor growth and potential metastatic spread.
Article
Biotechnology & Applied Microbiology
Farnaz Ghorbani, Behafarid Ghalandari, Zichen Liu, Dejian Li, Baoqing Yu
Summary: This study developed injectable light-assisted thermo-responsive methylcellulose hydrogels filled with sodium humate for photothermal ablation and localized cisplatin delivery. The results showed that an increase in sodium humate concentration and emission time improved hydrogel uniformity, reduced swelling ratio, and increased durability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Xianyan Qin, Liming He, Chenglan Feng, Donghao Fan, Wenlang Liang, Qin Wang, Jiyu Fang
Summary: The study synthesized an injectable micelle-incorporated hydrogel that sequentially releases chemotherapy drugs and immune checkpoint inhibitors at tumor sites, promoting cytotoxic T lymphocytes infiltration and inducing a robust antitumor immune response, ultimately showing synergetic therapeutic efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Wei Feng, Dongsong Li, Junting Zang, Li Fu
XENOTRANSPLANTATION
(2017)
Article
Medicine, Research & Experimental
Na Wei, Wei-Jie Xu, Dong Dong, Yu-Bao Gong
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2017)
Article
Orthopedics
Junting Zang, Katsufumi Uchiyama, Mitsutoshi Moriya, Zhengwei Li, Kensuke Fukushima, Takeaki Yamamoto, Jianguo Liu, Wei Feng, Naonobu Takahira, Masashi Takaso
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2018)
Article
Orthopedics
Junting Zang, Katsufumi Uchiyama, Mitsutoshi Moriya, Zhengwei Li, Kensuke Fukushima, Takeaki Yamamoto, Naonobu Takahira, Masashi Takaso, Jianguo Liu, Wei Feng
JOURNAL OF ORTHOPAEDIC SURGERY
(2018)
Article
Medicine, Research & Experimental
Siqiao Sun, Qi Wang, Yubao Gong, Xin Qi, Jianguo Liu
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Article
Orthopedics
Junting Zang, Katsufumi Uchiyama, Mitsutoshi Moriya, Kensuke Fukushima, Naonobu Takahira, Masashi Takaso
JOURNAL OF ORTHOPAEDIC SURGERY
(2019)
Article
Neurosciences
Zhennan Yun, Yuhang Wang, Wei Feng, Junting Zang, Daguang Zhang, Yuhang Gao
Article
Endocrinology & Metabolism
Yanyan Song, Wei Liu, Ke Tang, Junting Zang, Dong Li, Hang Gao
JOURNAL OF DIABETES RESEARCH
(2020)
Article
Biotechnology & Applied Microbiology
Yubao Gong, Zhengren Wei, Jianguo Liu
Summary: The study showed that miR-1225-5P inhibits osteosarcoma cell growth in vitro and tumor growth in vivo by targeting YWHAZ. This suggests that miR-1225-5P could be a potential therapeutic approach for treating osteosarcoma.
ONCOTARGETS AND THERAPY
(2021)
Article
Environmental Sciences
Yanyan Song, Wei Liu, Yao Zhao, Junting Zang, Hang Gao
Summary: OTA induces apoptosis in HK-2 through regulating PTEN/AKT signaling pathway via disrupting lipid raft formation.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yu-Bao Gong, Shao-Jie Fu, Zheng-Ren Wei, Jian-Guo Liu
Summary: This study used a network pharmacology approach to explore the molecular mechanisms of Dangshen in the treatment of osteosarcoma, identifying 15 active compounds linked to 48 therapeutic targets. The gene enrichment analysis showed that Dangshen may produce a therapeutic effect in osteosarcoma by regulating pathways associated with DNA damage, cell proliferation, apoptosis, invasion, and migration.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yanyan Song, Wei Liu, Yao Zhao, Junting Zang, Hang Gao
Summary: FB1 exposure induces apoptosis of HK-2 cells by regulating the PTEN/PI3K/AKT signaling pathway and disrupting lipid raft formation.
Article
Orthopedics
Yuhang Wang, Wei Feng, Junting Zang, Hang Gao
ORTHOPAEDIC SURGERY
(2020)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)