Article
Chemistry, Physical
Nidhi N. Patel, Kiran Patel, Nandhibatla V. Sastry, Vaibhav K. Patel, Pradip M. Macwan, Deep S. Sharma, Sanjay. H. Panjabi
Summary: This study reports the synthesis of Halogen-free COOH-functionalized Imidazolium and Pyridinium-based SAILs and investigates their surface activity, aggregation behavior, thermodynamic parameters, and antimicrobial activity. The findings show that the micellization process of the synthesized SAILs is spontaneous and entropy-driven, and the introduction of an acid group significantly enhances the antimicrobial activity.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lukasz Palkowski, Maciej Karolak, Andrzej Skrzypczak, Marta Wojcieszak, Filip Walkiewicz, Jonasz Podemski, Karol Jaroch, Barbara Bojko, Katarzyna Materna, Jerzy Krysinski
Summary: This study synthesized a series of novel quaternary imidazolium derivatives with ionic liquid properties, and tested their antimicrobial activity, cytotoxicity, and surface properties. The results showed that all synthesized compounds exhibited antimicrobial and cytotoxic activity, making them potential candidates for new antimicrobial agents or surfactants.
Article
Pharmacology & Pharmacy
Maria Teresa Garcia, Elena Bautista, Ana de la Fuente, Lourdes Perez
Summary: This study investigated the antimicrobial activity of a series of surface-active cholinium-based ionic liquids (Chol-ILs). The results showed that Chol-ILs with alkyl chain lengths ≥12 C exhibited broad-spectrum antibacterial activity and were able to effectively eliminate biofilms. The biodegradation rate of the Chol-ILs decreased with alkyl chain elongation. These findings suggest that cholinium-based ILs have great potential as multifunctional compounds in pharmaceutical and biomedical formulations.
Article
Pharmacology & Pharmacy
Blanca de Juan Mora, Luis Filipe, Andreia Forte, Miguel M. Santos, Celso Alves, Fernando Teodoro, Rui Pedrosa, Manuela Ribeiro Carrott, Luis C. Branco, Sandra Gago
Summary: In this study, two nanomaterials based on mesoporous silica nanoparticles immobilized with ciprofloxacin were prepared and characterized for their structures and antimicrobial activities. The nanomaterials showed promising antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumoniae, with higher activity than the precursor and neutral ciprofloxacin.
Article
Chemistry, Physical
Qi Han, Stuart J. Brown, Calum J. Drummond, Tamar L. Greaves
Summary: Ionic liquids are widely used as solvents for proteins in various fields such as biotechnology, pharmaceutics, and medicine due to their tunable properties. Recent studies have identified key properties of ILs and IL-water mixtures related to protein performance, suggesting the potential for using ILs to inhibit protein aggregation and control protein behavior. This review aims to inspire further advances in understanding protein behavior and optimizing bioprocesses.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Marta Wojcieszak, Aneta Lewandowska, Agnieszka Marcinkowska, Lukasz Palkowski, Maciej Karolak, Andrzej Skrzypczak, Anna Syguda, Katarzyna Materna
Summary: A series of monocationic and dicationic surface-active ionic liquids (SAILs) were synthesized and characterized. The structures of SAILs were confirmed by spectral analyses of 1H NMR and 13C NMR. The relationship between the structure, surface activity, and biological action of newly SAILs on bacteria and fungi was investigated.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Fabio M. S. Costa, M. Lucia M. F. S. Saraiva, Marieta L. C. Passos
Summary: Antimicrobial resistance is a growing concern caused by the overuse and misuse of antimicrobial drugs, as well as the lack of development of new drugs. It leads to significant economic costs and challenges in the healthcare system. Inadequate conditions and poor sanitation further contribute to the spread of drug-resistant pathogens. Strategies to combat antimicrobial resistance include the synthesis and evaluation of new compounds, combination therapy, and nanotechnology.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Bingyan Han, Qin Yan, Ze Xin, Qifang Yan, Jingmei Jiang
Summary: A novel and facile approach was developed to synthesize highly luminescent CuNCs@MMI within 30 seconds with the assistance of ionic liquid [Bmim]BF4. The CuNCs@MMI showed potential for pH sensing applications based on its pH-responsion in photoluminescence intensity.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Review
Immunology
Xizi Song, Rujin Tian, Kai Liu
Summary: Airborne transmission is an unpredictable route of infection that has become more prevalent due to complex air environments. Traditional air purification methods are ineffective against active microorganisms like bacteria, viruses, and fungi. Effective filtration materials with antimicrobial activity, such as ionic liquids (ILs), are needed to solve this problem. ILs are stable salts that remain liquid at room temperature and have a wide range of potential applications. This study focuses on the antimicrobial activity and safety of new types of ILs for air purification and discusses their synthesis and potential applications in medical instruments and indoor environments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Chemistry, Physical
Shoaib Muhammad, Firdous Imran Ali, Muhammad Naveed Javed, Agha Arsalan Wasim, Ahmed Bari, Faisal Rafique, Muhammad Amjad Ilyas, Kashif Riaz, Syed Junaid Mahmood, Amir Ahmed, Imran Ali Hashmi
Summary: This study focuses on the influence of the aggregation behavior of RTILs on catalytic activity, with the synthesis of new RTILs and experimentation showing improved catalytic performance in one specific compound. Various experiments were conducted to explore the mechanism of aggregation in RTILs.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Thermodynamics
Yue Zhao, Chun Guo, Wenqing Wu, Jing Tong
Summary: Two hydroxyl functionalized ionic liquids were synthesized and characterized in this study. The influence of anionic structure on the physical properties and thermodynamic behavior of the ionic liquids was investigated.
JOURNAL OF CHEMICAL THERMODYNAMICS
(2023)
Article
Engineering, Mechanical
Yurong Wang, Ping Yang, Bin Guo, Nan Jiang, Jingyin Chi, Jinjie Liu, Yijing Liang, Qiangliang Yu, Shuyan Yang, Feng Guo, Meirong Cai, Feng Zhou
Summary: Experimental results show that NP44 and NP88, as additives of PEG, can significantly improve tribological performance by forming stable protective films and enhancing lubrication properties. Additionally, they can increase film thickness in elastohydrodynamic lubrication to delay oil depletion on the lubrication track.
TRIBOLOGY INTERNATIONAL
(2021)
Review
Chemistry, Physical
Zari Fallah, Ehsan Nazarzadeh Zare, Moonis Ali Khan, Sidra Iftekhar, Matineh Ghomi, Esmaeel Sharifi, Mahmood Tajbakhsh, Nasser Nikfarjam, Pooyan Makvandi, Eric Lichtfouse, Mika Sillanpaa, Rajender S. Varma
Summary: Efforts to broaden the applications of ionic liquids have advanced in the past two decades. Ionic liquids show promise as antimicrobial systems, as they can be tailored in various sizes, morphologies, and surface charges. Common methods for preparing ionic liquid-based materials include crosslinking, loading, grafting, and combining with other polymeric materials. Recent research focuses on tuning the biological properties of these materials for antimicrobial applications in water treatment, air filtration, food packaging, and anticorrosion.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Physical
Nabeel Mujtaba Abbasi, Victoria R. Zeger, Anis Biswas, Jared L. Anderson
Summary: This study focuses on magnetic ionic liquids (MILs) containing paramagnetic centers. It shows that modifications in the chemical structure of diglycolamides can influence the physico-chemical properties of MILs. Transition metals can improve thermal stability and reduce viscosity, leading to higher effective magnetic moments. The results highlight the importance of structural tunability in MILs for various applications such as organic synthesis and chemical separations.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Vijay Padwal, Aditya Narvekar, Shailesh Dugam, Radhika Pachpore, Prajakta Dandekar, Ratnesh Jain
Summary: Evaluating the stability and biological activity of monoclonal antibodies is crucial for their optimal performance. pH buffers, surfactants, salts, and sugars are commonly used to control aggregation of antibodies. In this study, 2-MIDHP was found to be a potent acid-resistant agent that effectively prevented aggregation of Bevacizumab.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Zakaria Hafidi, Mohammed El Achouri, Francisco F. O. Sousa, Lourdes Perez
Summary: The study demonstrates that amino-alcohols based cationic surfactants exhibit good antifungal activity against different Candida strains, with minimum inhibitory concentrations ranging from 0.002 to 0.30 mM. The antifungal activity increased with the hydrophobicity of the inhibitors in the majority of Candida strains tested during the evaluation process.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Microbiology
Leticia S. S. Moreno, Francisca B. S. A. Nascimento, Cecilia R. da Silva, Livia G. A. Sa, Joao B. A. Neto, Jacilene Silva, Emmanuel M. Silva, Helcio S. dos Santos, Lourdes Perez, Anderson R. da Silva, Daniel S. Rodrigues, Amanda D. Barbosa, Lara Ea Moreira, Bruno C. Cavalcanti, Manoel O. de Morais, Helio V. N. Junior
Summary: The study evaluated the antibacterial effect of two new cationic surfactants against Staphylococcus aureus, showing promising pharmacological activity against MRSA strains but no effect on mature biofilms.
FUTURE MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lourdes Perez, Adria Sentis, Zakaria Hafidi, Aurora Pinazo, Maria Teresa Garcia, Manuel Martin-Pastor, Francisco Fabio Oliveira de Sousa
Summary: Cationic surfactants carry antimicrobial activity through interaction and disruption of cell membranes, but their intrinsic toxicity limits their applicability. Using solid nanoparticles to improve their delivery is a feasible strategy. In this study, zein nanoparticles were loaded with cationic arginine-based surfactants and characterized in terms of size, polydispersity, and zeta potential. The nanocapsules effectively maintained the antimicrobial activity and reduced the hemolytic activity, indicating improved selectivity. This was attributed to the zein encapsulation interfering with the surfactant-membrane interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Lourdes Perez, Zakaria Hafidi, Aurora Pinazo, Maria Teresa Garcia, Manuel Martin-Pastor, Francisco Fabio Oliveira de Sousa
Summary: In this study, zein nanoparticles loaded with arginine-phenylalanine-based surfactants were developed. The stability, antimicrobial activity, and hemolytic activity were investigated for four different types of surfactants. NMR and molecular docking studies were conducted to examine the interaction mechanisms between the surfactants and zein. The results showed that the nanoparticles had satisfactory size, zeta potential, and dispersibility. The surfactants with arginine-phenylalanine residues exhibited higher stability, and the nanoencapsulation maintained their antimicrobial activity. This approach provides new possibilities for using cationic surfactants and harnessing their antimicrobial effects for various applications.
Article
Pharmacology & Pharmacy
Maria De Luca, Carlo Ignazio Giovanni Tuberoso, Ramon Pons, Maria Teresa Garcia, Maria del Carmen Moran, Giulio Ferino, Antonio Vassallo, Giuseppe Martelli, Carla Caddeo
Summary: The study focuses on the use of phospholipid vesicles for the nanoformulation of plant extracts, aiming to overcome limitations in their topical application. The Prunus spinosa berries were used as a source of bioactive compounds, and two types of phospholipid vesicles were developed for improved applicability as topical formulations. Various characterization and safety tests were conducted to assess their properties and potential.
Article
Biochemistry & Molecular Biology
Maria De Luca, Carlo Ignazio Giovanni Tuberoso, Ramon Pons, Maria Teresa Garcia, Maria del Carmen Moran, Giuseppe Martelli, Antonio Vassallo, Carla Caddeo
Summary: Formulating plant extracts in phospholipid vesicles is a promising strategy to overcome challenges like poor solubility, instability, low skin permeation, and short retention time. In this study, a hydro-ethanolic extract was prepared from Ceratonia siliqua ripe pods, showing antioxidant properties due to the presence of active compounds. Liposomes were used to improve the extract's applicability, characterized by small size, negative charge, high entrapment efficiency, and biocompatibility. The extract demonstrated antioxidant activity by scavenging free radicals, reducing ferric ions, and protecting skin cells from oxidative damage.
Article
Biochemistry & Molecular Biology
Francisco Fabio Oliveira de Sousa, Aurora Pinazo, Zakaria Hafidi, Maria Teresa Garcia, Elena Bautista, Maria del Carmen Moran, Lourdes Perez
Summary: The antimicrobial and antibiofilm properties of arginine-based surfactants were evaluated in this study. The surfactants demonstrated good activity against a wide range of bacteria, including MRSA and Pseudomonas aeruginosa. They also exhibited inhibitory effects on key enzymes involved in skin repairing processes. These arginine-based surfactants show promise as potential candidates for pharmaceutical and biological applications.
Article
Pharmacology & Pharmacy
Zakaria Hafidi, Lourdes Perez, Mohammed El Achouri, Ramon Pons
Summary: Cationic surfactants based on phenylalanine and tryptophan were synthesized using renewable raw materials and a green synthetic procedure. The synthesis, acid-base equilibrium, aggregation properties, and antibacterial activity of these surfactants were investigated. The surfactants showed promising antibacterial efficacy and had a high affinity for DPPC bilayers, although their antibacterial activity was reduced when incorporated in vesicles.
Article
Pharmacology & Pharmacy
Maria Teresa Garcia, Elena Bautista, Ana de la Fuente, Lourdes Perez
Summary: This study investigated the antimicrobial activity of a series of surface-active cholinium-based ionic liquids (Chol-ILs). The results showed that Chol-ILs with alkyl chain lengths ≥12 C exhibited broad-spectrum antibacterial activity and were able to effectively eliminate biofilms. The biodegradation rate of the Chol-ILs decreased with alkyl chain elongation. These findings suggest that cholinium-based ILs have great potential as multifunctional compounds in pharmaceutical and biomedical formulations.
Review
Biochemistry & Molecular Biology
Luisa Coderch, Cristina Alonso, M. Teresa Garcia, Lourdes Perez, Meritxell Marti
Summary: Human hair fibres are composed mainly of proteins and lipids. Lipids can be exogenous or endogenous, depending on their origin. Lipids play a crucial role in protecting hair from damage and maintaining its health.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
