Article
Chemistry, Multidisciplinary
Kyung Ho Kim, Sung Eun Seo, Chul Soon Park, Soomin Kim, Soohyun Lee, Choong-Min Ryu, Dongeun Yong, Yoo Min Park, Oh Seok Kwon
Summary: This study demonstrated the fabrication of a highly stable and efficient nanobiosensor using OICs as linkers on graphene. OPE was shown to have higher binding energy and lower band gap compared to other OICs, and it improved the immobilization efficiency of bioprobes by forming a self-assembly monolayer. The MOGMFET constructed using this technology exhibited high sensitivity, high selectivity, and a low detection limit.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Yinqi Fan, Sylvain Pitie, Chenguang Liu, Cezhou Zhao, Chun Zhao, Mahamadou Seydou, Yannick J. Dappe, Richard J. Nichols, Li Yang
Summary: This study investigates the effect of introducing asymmetry into single-molecule junctions by using different electrodes materials. The results show that the introduction of a graphene electrode leads to lower conductance values, which can be attributed to shifts in electronic molecular levels driven by acetylene groups.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Physical
Xintai Wang, Ali Ismael, Shanglong Ning, Hanan Althobaiti, Alaa Al-Jobory, Jan Girovsky, Hippolyte P. A. G. Astier, Luke J. O'Driscoll, Martin R. Bryce, Colin J. Lambert, Christopher J. B. Ford
Summary: This study investigates the effect of the molecule-electrode interface in SAMs using a micro-pore device, overcoming challenges with the tetrapodal anchor and single layered graphene top electrode with an ionic liquid gate. Experimental results show that molecules with the same backbone but different molecule-electrode interfaces exhibit significantly different conductances near zero bias.
NANOSCALE HORIZONS
(2022)
Article
Oncology
Qian Yuan, Yu Wang, Pu Yao, Jun Lv, Qianmei Wang, Fengjun Sun, Wei Feng
Summary: The study synthesized a molecule named OPE3 with significant antibacterial activity against multidrug-resistant bacteria, especially gram-positive bacteria. In a mouse burn infection model, OPE3 treatment resulted in a significant reduction in bacterial load and skin lesions, as well as decreased levels of inflammatory cytokines TNF-alpha and IL-6 in the serum.
JOURNAL OF CHEMOTHERAPY
(2021)
Article
Chemistry, Physical
Yusuke Hattori, Wakana Matsuda, Shu Seki
Summary: In this study, the investigation of conjugated oligomers with distinct chain lengths revealed a unique solid-solid transition only in the pentamer, resulting in uniaxial expansion in the condensed phase. Time-resolved microwave conductivity measurements highlighted the interplay between thermal activation of charge carriers and uniaxial expansion reducing electronic coupling in pi-stacking of adjacent molecules.
CHEMICAL PHYSICS LETTERS
(2022)
Article
Polymer Science
Jiucheng Nie, Xiaoyu Huang, Guolin Lu, Mitchell A. Winnik, Chun Feng
Summary: The backbone symmetry of pi-conjugated blocks significantly affects both self-seeding and seeded growth behaviors of living CDSA. BCPs with a symmetric backbone exhibit a reverse trend of the dependence of L-n on the seed concentration compared to BCPs with an asymmetric backbone.
Article
Polymer Science
Jiucheng Nie, Xiaoyu Huang, Guolin Lu, Mitchell A. Winnik, Chun Feng
Summary: This study investigates the influence of different architectures of pi-conjugated blocks on the crystallization-driven self-assembly (CDSA) of BCPs. The results show that different block architectures can lead to different aggregate morphologies. Furthermore, experiments on heterogeneous seeded growth reveal differences in the behavior of BCPs with different architectures.
Article
Polymer Science
Jiucheng Nie, Longgang Xia, Xiaoyu Huang, Guolin Lu, Chun Feng
Summary: Living crystallization-driven self-assembly (CDSA) enables the formation of uniform fiber-like micelles with precise length/composition. The kinetic stability of formed micelles is crucial for realizing the living characteristic of CDSA. In this study, a series of block copolymers with different chain lengths were synthesized to investigate the influence of chain length and solvent on the kinetic stability and self-seeding behaviors of micelles. The results showed that the micelles could be kinetically frozen and the elongation mechanism varied depending on the chain length and solvent polarity.
Article
Chemistry, Physical
Zhiqiang Zhao, Zheng Bian, Yu Chen, Chuanqing Kang, Lianxun Gao, Guangshan Zhu
Summary: The study shows that chiral oligomers can self-assemble into vesicle-like particles in hydrophobic or hydrophilic solvent systems independently of molecular design and chemical environments. The vesicular membranes are likely stabilized by pi-pi stacking interactions between foldamer backbones and collective van der Waals interactions between side chains, as supported by TEM, UV, CD and PXRD data.
Article
Chemistry, Physical
Dominik Maskowicz, Rafal Jendrzejewski, Wioletta Kopec, Maria Gazda, Jakub Karczewski, Pawel Niedzialkowski, Armin Kleibert, Carlos A. F. Vaz, Yann Garcia, Miroslaw Sawczak
Summary: This study successfully prepared uniform and functional thin films of Fe(pz)Pt[CN](4) nanoparticles on Si and/or glass substrates using a tunable pulsed laser. Temperature-dependent Raman and UV-Vis spectroscopy confirmed the spin transition in the temperature range of 275 to 290 K.
Article
Chemistry, Physical
Takafumi Shimoaka, Yuta Yamaguchi, Nobutaka Shioya, Ayyappanpillai Ajayaghosh, Taizo Mori, Katsuhiko Ariga, Takeshi Hasegawa
Summary: One of the oligo(p-phenylene vinylene) derivatives, OPV-1, forms rod-shaped nanoaggregates on water surfaces, which can be transferred to thin films using the Langmuir-Blodgett technique. This study focuses on investigating the molecular structure of the alkyl chains in the Langmuir films. Using IR external reflection spectroscopy and p-polarized multiple-angle incidence resolution spectrometry, it is found that the alkyl chains in OPV-1 exhibit an ordered conformation and maintain their orientation even after the LB transfer.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Shaojun Qi, Ioannis Kiratzis, Pavan Adoni, Aekkachai Tuekprakhon, Harriet James Hill, Zania Stamataki, Aneesa Nabi, David Waugh, Javier Rodriguez Rodriguez, Stuart Matthew Clarke, Peter J. Fryer, Zhenyu J. Zhang
Summary: An effective antimicrobial surface film based on sustainable microfibrillated cellulose was developed in this study. The porous cellulose thin film showed excellent antimicrobial performance against both Gram-negative and Gram-positive bacteria, and rapid inactivation effect against SARS-CoV-2. It also exhibited nearly 100% resistance to scraping in dry conditions and good removability when wetted with water, making it suitable for daily use.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Sergiy Kyrylenko, Oleksiy Gogotsi, Ivan Baginskiy, Vitalii Balitskyi, Veronika Zahorodna, Yevheniia Husak, Ilya Yanko, Mykolay Pernakov, Anton Roshchupkin, Mykola Lyndin, Bernhard B. Singer, Volodymyr Buranych, Alexander Pogrebnjak, Oksana Sulaieva, Oleksandr Solodovnyk, Yury Gogotsi, Maksym Pogorielov
Summary: Innovative therapies, such as thermal ablation using MXenes for photothermal therapy, show potential for selectively targeting tumor cells. Pulsed 1064 nm lasers can effectively ablate tumor cells loaded with Ti3C2Tx MXene, demonstrating low toxicity and good biocompatibility. These studies lay the foundation for developing efficient and safe protocols for minimally invasive cancer therapies.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Tao Zhang, Qian Cheng, Yifan Li, Zhiguo Hu, Jinbang Ma, Yixin Yao, Yuxuan Zhang, Yan Zuo, Qian Feng, Yachao Zhang, Hong Zhou, Jing Ning, Chunfu Zhang, Jincheng Zhang, Yue Hao
Summary: In this study, beta-Ga2O3 films were deposited on (-201) homo-substrates using MOCVD method. It was found that the Ga source flow rate significantly influenced the surface morphology, and a relatively flat surface was obtained with appropriate TEGa and O-2 flow rates. The substrate morphology can be greatly improved by cleaning and thermal annealing, which promotes the surface flatness of the epilayer. Insertion of a buffer layer and optimization of growth conditions also contribute to achieving a higher surface flatness.
SCRIPTA MATERIALIA
(2022)
Article
Polymer Science
Valentina Grumezescu, Alexandru Mihai Grumezescu, Anton Ficai, Irina Negut, Bogdan Stefan Vasile, Bianca Galateanu, Ariana Hudita
Summary: This article presents the preparation and characterization of composite coatings based on hydroxyapatite (HAp), chitosan (CS), and FGF2, and investigates their effects on attachment, growth, and differentiation of cells through in vitro experiments. The results suggest that these coatings are suitable for bone tissue engineering applications.
Article
Engineering, Biomedical
Yong Wu, Tianqi Chang, Weiqian Chen, Xiaoyu Wang, Jingjing Li, Yueqiu Chen, You Yu, Zhenya Shen, Qian Yu, Yanxia Zhang
Summary: Myocardial infarction is a serious cardiovascular disease with complex pathophysiology. Treatment with injectable composite hydrogel for dual-release of VEGF and BMP9 shows a collaborative effect in promoting angiogenesis and inhibiting myocardial fibrosis, demonstrating significant potential for cardiac clinical application.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Kunyan Lu, Yangcui Qu, Yuancheng Lin, Luohuizi Li, Yan Wu, Yi Zou, Tianqi Chang, Yanxia Zhang, Qian Yu, Hong Chen
Summary: Intracellular delivery of functional molecules is crucial in biomedical and biotechnology applications. Photothermal poration using nanoparticle-based systems has gained attention for its efficient and transient permeabilization of cells. However, safety concerns remain regarding the nanoparticles. This study developed a nanoplatform called M-PBA, which combines photothermal property and sugar-triggered cleaning ability for intracellular delivery. The M-PBA particles effectively bound to target cells through specific interactions and delivered exogenous molecules into cells efficiently using a photothermal poration mechanism. After delivery, the particles could be easily cleaned from the cell surface using sugar treatment, preventing potential side effects. This method is short, effective, and does not compromise cell viability and proliferation, making M-PBA particles promising intracellular delivery agents with efficiency, safety, and flexibility.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Yangcui Qu, Kunyan Lu, Yanjun Zheng, Chaobo Huang, Guannan Wang, Yanxia Zhang, Qian Yu
Summary: Regulation of cell behaviors is crucial for various biomedical applications. Photothermal scaffolds/surfaces, which contain photothermal agents, have shown great potential in regulating cell behaviors through methods such as hyperthermia, intracellular delivery of exogenous molecules, and modulation of surface properties.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Yangcui Qu, Xiaolong Zhu, Ran Kong, Kunyan Lu, Tiantang Fan, Qian Yu, Guannan Wang
Summary: This study successfully develops a dual-functional antibacterial film with antifouling and photothermal bactericidal activity, which effectively limits bacterial adhesion and biofilm formation. Compared to single-functional antibacterial surfaces, this dual-functional surface demonstrates superior antibacterial performance and antibiofilm ability, and has wide applicability in various healthcare applications.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Kui Wu, Yuanyuan Wang, Hong Yang, Yihuan Chen, Kunyan Lu, Yong Wu, Chunxia Liu, Haixin Zhang, Hanyu Meng, Qian Yu, Yanxia Zhang, Zhenya Shen
Summary: An injectable hydrogel based on a decellularized porcine extracellular matrix (dECM) is developed to encapsulate and deliver cardiomyocytes locally to the infarct area of the heart. This hydrogel exhibits good biocompatibility and chemotactic effects for endogenous cells and endothelial cells, improving cardiac function through promoting angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biophysics
Tianqi Chang, Chunxia Liu, Hong Yang, Kunyan Lu, Yanchao Han, Yu Zheng, Haoyue Huang, Yong Wu, Yumeng Song, Qian Yu, Zhenya Shen, Tingbo Jiang, Yanxia Zhang
Summary: Cardiac patch loaded with neuregulin-1 (NRG-1) promoted cardiomyocyte proliferation, reduced cell apoptosis, promoted angiogenesis, and inhibited fibrosis, leading to improved cardiac function.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Yuancheng Lin, Haixin Zhang, Yi Zou, Kunyan Lu, Luohuizi Li, Yan Wu, Jingjing Cheng, Yanxia Zhang, Hong Chen, Qian Yu
Summary: In this study, a superhydrophobic photothermal coating was developed to prevent biofilm formation. The coating demonstrated both anti-adhesive and photothermal bactericidal properties, and could be deposited on various substrates, showing great potential for diverse practical applications.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Physical
Sabila K. Pinky, Albert L. Kwansa, Buang Zhang, Adrienne D. Stiff-Roberts, Yaroslava G. Yingling
Summary: The morphology of conjugated polymer thin films is influenced by the emulsion characteristics, but the understanding of how these characteristics control the film properties and device performance is still unclear. In this study, molecular dynamics simulations were conducted on emulsions containing polyfluorene (PFO) polymer and various solvents to investigate the relationship between emulsion properties and the morphology of deposited PFO thin films. The results showed that a primary solvent with low solubility-in-water and high non-bonded interaction energy ratio among the solvent, polymer, and water produced smoother and denser films.
Article
Engineering, Biomedical
Jianping Yuan, Hong Yang, Chunxia Liu, Lianbo Shao, Haixin Zhang, Kunyan Lu, Jingjing Wang, Yuanyuan Wang, Qian Yu, Yanxia Zhang, Yunsheng Yu, Zhenya Shen
Summary: Myocardial infarction (MI) is a severe cardiovascular disease that leads to uncontrolled and excessive cardiac fibrosis. A biocompatible microneedle patch loaded with exosomes containing miR-29b mimics is developed to prevent fibrosis after MI. The patch effectively delivers the exosomes to cardiac fibroblasts, upregulating miR-29b expression and downregulating fibrosis-related proteins, resulting in reduced inflammation, infarct size, fibrosis, and improved cardiac function in a mouse MI model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Buang Zhang, Sabila K. Pinky, Albert L. Kwansa, Spencer Ferguson, Yaroslava G. Yingling, Adrienne D. Stiff-Roberts
Summary: Thin films of polyfluorene (PFO) were successfully deposited using the emulsion based resonant infrared, matrix-assisted pulsed laser evaporation (RIR-MAPLE) method. It was found that the selection of surfactant can increase the crystalline-fi phase content and improve the color purity of light emission. Comparison of blue light-emitting diodes (LEDs) with different surfactants showed the significant impact of surfactant on device performance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Chunxia Liu, Yong Wu, Hong Yang, Kunyan Lu, Haixin Zhang, Yuanyuan Wang, Jingjing Wang, Linan Ruan, Zhenya Shen, Qian Yu, Yanxia Zhang
Summary: Myocardial infarction (MI) is a common cardiovascular disease and a major cause of global mortality. Transplantation of exogenous cardiomyocytes (CMs) has emerged as a promising treatment option due to the limited regenerative capacity of endogenous CMs. In this study, an injectable hydrogel composed of alginate and fibrin was developed for localized delivery of neonatal CMs and the angiogenesis agent vascular endothelial growth factor (VEGF) to the infarcted area of the heart. The hydrogel exhibited good biocompatibility, enabling the retention and integration of transplanted CMs in the host myocardium. Additionally, the delivered VEGF promoted blood recovery, mitigating the ischemic microenvironment and improving the survival of transplanted CMs. Intramyocardial injection of this hydrogel resulted in angiogenesis, inhibition of fibrosis, and improved cardiac function, highlighting its potential for MI treatment.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dongxu Jia, Yuancheng Lin, Yi Zou, Yanxia Zhang, Qian Yu
Summary: Bioinspired superhydrophobic antibacterial surfaces with both bacteria-repelling and bacteria-killing properties have been developed to overcome the limitations of conventional superhydrophobic surfaces. This review summarizes the recent advancements, including fabrication strategies, bacteria-repelling mechanism, and classification of these dual-function surfaces based on the bacteria-killing mechanism. The limitations, challenges, and future perspectives in this promising area are also discussed.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Kunyan Lu, Yuancheng Lin, Haixin Zhang, Jingjing Cheng, Yangcui Qu, Yan Wu, Yuheng Zhang, Yi Zou, Yanxia Zhang, Qian Yu, Hong Chen
Summary: This research develops a multifunctional platform based on candle soot modification, which can efficiently deliver bioactive macromolecules into cells and nondestructively harvest engineered cells through temperature and sugar-responsive components.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Yi Zou, Haixin Zhang, Yuheng Zhang, Yan Wu, Jingjing Cheng, Dongxu Jia, Chunxia Liu, Hong Chen, Yanxia Zhang, Qian Yu
Summary: A near-infrared light-triggered nano-domino system has been proposed for efficient eradication of bacterial biofilms and promoting the healing of MRSA biofilm-infected wounds.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Yuanyuan Wang, Jingjing Wang, Chunxia Liu, Jingjing Li, Kunyan Lu, Qian Yu, Yanxia Zhang, Zhenya Shen
Summary: An injectable composite hydrogel, composed of natural biomaterials, exosomes, and bioactive molecules, was developed to prevent or alleviate cardiac fibrosis after myocardial infarction. The encapsulation of curcumin, a natural molecule with antifibrotic activity, in exosomes derived from bone marrow-derived mesenchymal stem cells was shown to enhance its solubility and bioavailability. The composite exosomes effectively inhibited the transition of fibroblasts to myofibroblasts in vitro. The delivery of these composite exosomes using decellularized porcine cardiac extracellular matrix (dECM) hydrogel not only improved exosome retention but also provided mechanical support and structural protection. Injection of this hydrogel into a mouse myocardial infarction model resulted in decreased collagen deposition, alleviation of fibrosis, reduction of infarct size, and improvement in cardiac function. This study demonstrates the potential of the dECM hydrogel as a suitable platform for local delivery of antifibrotic biomolecule-encapsulating exosomes to prevent myocardial fibrosis and for the treatment of myocardial infarction in clinical settings.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
