Article
Biochemistry & Molecular Biology
Eltayeb E. M. Eid, Amer A. Almaiman, Salah Abdalrazak Alshehade, Wardah Alsalemi, Sareh Kamran, FakhrEldin O. Suliman, Mohammed Abdullah Alshawsh
Summary: This study aimed to improve the solubility of TQ by forming inclusion complexes with SBE-beta-CD and found that these complexes exhibited enhanced antiproliferative activity against various cancer cell lines. However, further research is needed to fully understand the mechanisms and potential side effects of using SBE-beta-CD as a drug delivery system for TQ.
Article
Chemistry, Physical
Nabab Khan, Garima Slathia, Ankit Saneja
Summary: This study investigated the complexation of phloretin with sulfobutyletherfl-cyclodextrin to enhance its solubility and examined the anticancer potential of the complex. The results showed that the complex had higher antiproliferative activity against lung carcinoma and pancreatic cancer cells compared to free phloretin.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Yu-Yang Hu, Xian-Yin Dai, Xiaoyun Dong, Man Huo, Yu Liu
Summary: In this study, solid supramolecular bromonaphthylpyridinium polymers (P-BrNp) with tunable phosphorescence emission were reported, enabled by sulfobutylether-beta-cyclodextrin (SBE-beta-CD) and diarylethene derivatives. The addition of SBE-beta-CD enhanced the phosphorescent quantum yield of P-BrNp and changed the photoluminescence emission color. Diarylethene monomers were used as photoswitches to achieve reversible RTP emission.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Amy Oo, Panupong Mahalapbutr, Kuakarun Krusong, Ponsiri Liangsakul, Sariyarach Thanasansurapong, Vichai Reutrakul, Chutima Kuhakarn, Phornphimon Maitarad, Atit Silsirivanit, Peter Wolschann, Siyaporn Putthisen, Khanittha Kerdpol, Thanyada Rungrotmongkol
Summary: Encapsulation with beta-cyclodextrin (β-CD) has been explored to enhance the solubility of emodin (ED) for pharmaceutical applications. In this study, inclusion complexation of ED with β-CD and its derivatives was performed to identify the most promising drug carrier. The ED/DM-β-CD complex showed the highest stability and water solubility, followed by ED/SBE7-β-CD and ED/HP-β-CD complexes. The SEM micrographs and DSC thermograms confirmed the inclusion complex formation, and molecular docking suggested C-form insertion as the preferred binding mode. Moreover, the inclusion complexes, especially ED/DM-β-CD, showed significantly higher anti-proliferative effects on cancer cell lines compared to ED alone.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Instruments & Instrumentation
Mona Ebrahim Elmoghayer, Noha Mohamed Saleh, Irhan Ibrahim Abu Hashim
Summary: The study aimed to prepare and evaluate Hsd-loaded sulfobutylether-beta-cyclodextrin/chitosan nanoparticles (Hsd/CD/CS NPs) for improving the oral delivery and hypoglycemic activity of Hsd. The results showed that Hsd/CD/CS NPs could enhance the oral delivery and antidiabetic activity of Hsd, with good stability and biocompatibility.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Physical
Farhad Bayat, Seyed Saied Homami, Amirhossein Monzavi, Mohamad Reza Talei Bavil Olyai
Summary: Inclusion complexes of Ataluren (ALN) with different cyclodextrins (CDs) were prepared to enhance solubility and bioavailability. Various characterization techniques were used, including phase solubility studies, Job's plot, 1H-NMR, DSC, XRD, and FTIR analysis. The stability constants of ALN with different CDs were determined, and all CDs improved the solubility of ALN in aqueous media, with RMBCD showing the highest increase.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biophysics
Huiyan Wang, Jie Li, Han Liang, Xinrong Huang, Na Meng, Ninglin Zhou
Summary: In this study, a method was explored to prepare an effective antibacterial nanocomposite of silver nanoparticles/graphene oxide-sulfobutylether-beta-cyclodextrin (AgNPs/GO-SBE-beta-CD). Dopamine was used as a green and mild reductant to directly reduce silver nitrate on SBE-beta-CD modified graphene oxide. The synthesized nanocomposite showed uniform distribution of silver nanoparticles and exhibited strong antibacterial properties against gram-negative and gram-positive bacteria. It also demonstrated good biocompatibility, making it a promising material for preventing bacterial infection and wound healing applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Physical
Ben Chen, Songlin Chen, Mengyi Wen, Junchao Zhu, Shengqiang Tong
Summary: The chiral recognition ability of five racemic drugs/intermediates in enantioselective liquid-liquid extraction using functionalized magnetic nanoparticles synthesized with SBE-beta-CD as the functional molecule was studied. Three types of functionalized magnetic nanoparticles were synthesized and characterized. The loading amount of SBE-beta-CD on the surface was determined, and the optimal chiral extractant for each enantiomer was found. Functionalized magnetic nanoparticles III showed the highest enantioseparation factors for trans-paroxol and N-methyl duloxetine, while functionalized magnetic nanoparticles I were ideal for fluoxetine, tropic acid, and acetyltropic acid.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Materials Science, Multidisciplinary
Kiruthiga Kaliyamoorthi, Archana Sumohan Pillai, Aleyamma Alexander, Sivaraj Ramasamy, Anitha Arivarasu, Israel V. M. V. Enoch
Summary: The study discusses the synthesis of a novel magnetic drug carrier and its application in enhancing anticancer activity. By synthesizing nanoparticles and coating drugs with polymers, the drug loading percentage can be improved and the anticancer activity enhanced.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sangita Bhattacharyya, Hindole Ghosh, Obdulia Covarrubias-Zambrano, Krishan Jain, K. Venkateswara Swamy, Anup Kasi, Ameer Hamza, Shrikant Anant, Michael VanSaun, Scott J. Weir, Stefan H. Bossmann, Subhash B. Padhye, Prasad Dandawate
Summary: Pancreatic ductal adenocarcinoma (PDAC) is the leading cause of cancer-related deaths in the US. The development of novel drugs with improved delivery is crucial due to factors such as genetic mutations, drug resistance, multiple signaling pathways, cancer stem cells (CSCs), and desmoplastic stroma. Curcumin shows promise in inhibiting PDAC, but its clinical applicability is limited by poor solubility and metabolic instability. A difluorinated curcumin analog (CDF) has been developed, which selectively accumulates in the pancreas and inhibits PDAC growth. Its inclusion complex with 2-hydroxy-propyl-beta-cyclodextrin (HCD) increases water solubility and hydrolytic stability, leading to improved therapeutic efficacy against PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Guido Angelini, Carla Gasbarri
Summary: In this study, spherical and monodisperse silver nanoparticles were successfully obtained in aqueous solution at neutral pH using an eco-friendly approach. The SBE-β CD molecules were found to act as stabilizers, preventing aggregation of the AgNPs in solution. Additionally, the dissolution of the nanoparticles was tested through oxidation in the Fenton-like reaction.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Multidisciplinary
Ashok Kumar Jangid, Raghu Solanki, Sunita Patel, Kanakaraju Medicherla, Deep Pooja, Hitesh Kulhari
Summary: In this study, poly(ethylene) glycol (PEG4000) conjugated chrysin nanoparticles were prepared to achieve tumor microenvironment-specific drug release. The conjugated nanoparticles showed better drug release profile and higher anticancer activity against human breast cancer cells.
Article
Chemistry, Multidisciplinary
Qiao Qin, Qing-Sheng Zhao, Hang Li, Yu-Heng Ren, Sheng-hua Zha, Rong-Rong Tian, Jing Li, Shou-bu Hou
Summary: In this study, a green and rapid method was used to prepare phillyrin with a purity greater than 93% from Forsythia suspensa leaves. The water solubility of phillyrin was improved by interacting with different cyclodextrins (CDs). The inclusion complexes significantly enhanced the water solubility and antioxidant capacity of phillyrin, making them suitable for use in the functional food industry.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Vineela Parvathaneni, Rasha S. Elbatanony, Mimansa Goyal, Tejashri Chavan, Nathan Vega, Srikanth Kolluru, Aaron Muth, Vivek Gupta, Nitesh K. Kunda
Summary: Repurposed drugs show promising efficacy against cancer, with bedaquiline being explored in an inhalable cyclodextrin complex formulation for treating non-small cell lung cancer. The complex demonstrates efficient lung deposition and cytotoxicity, indicating potential for NSCLC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Juliana Souza de Freitas Domingues, Silmara Martins Dias dos Santos, Julia das Neves Rodrigues Ferreira, Bianca Miguel Monti, Darciane Favero Baggio, Wagner Hummig, Erika Ivanna Araya, Eneida de Paula, Juliana Geremias Chichorro, Luiz Eduardo Nunes Ferreira
Summary: This study aimed to improve the biopharmaceutical properties of bupivacaine hydrochloride (BVC) by forming a complex in sulfobutylether-beta-cyclodextrin (SBE beta CD). The complex formation was confirmed through various characterization techniques, and it demonstrated long-lasting analgesic effects.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Antonia Mancuso, Eleonora Cianflone, Maria Chiara Cristiano, Nadia Salerno, Martine Tarsitano, Fabiola Marino, Claudia Molinaro, Massimo Fresta, Daniele Torella, Donatella Paolino
Summary: The regeneration of cardiac tissue is a crucial area of research for improving the health of patients after a heart attack. This study suggests a new application for glyceryl monooleate-based lyotropic liquid crystals (LLCs) as a biocompatible and inert material for myocardial treatment. In vivo studies demonstrated the biocompatibility and inertness of LLCs, showing their potential use for cardiac drug delivery.
Article
Environmental Sciences
Francesco Caridi, Sebastiano Ettore Spoto, Antonio Francesco Mottese, Giuseppe Paladini, Vincenza Crupi, Alberto Belvedere, Santina Marguccio, Maurizio D'Agostino, Giuliana Faggio, Rossella Grillo, Giacomo Messina, Francesco Barreca, Valentina Venuti, Domenico Majolino
Summary: An investigation was carried out on the natural radioactivity content of pyroclastic products from Mt. Etna, eastern Sicily, Southern Italy. The study assessed the average activity concentration of radionuclides, the radiological health risk for the population, and attempted to identify the source of naturally occurring radionuclides. The results indicated that the radiological hazards were reasonably excluded and the main radioisotope-bearing minerals in the pyroclastic products were identified. Correlation analysis was performed to determine the relationship between radioactivity parameters and sampling locations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Analytical
Marilena Celano, Agnese Gagliardi, Valentina Maggisano, Nicola Ambrosio, Stefania Bulotta, Massimo Fresta, Diego Russo, Donato Cosco
Summary: The manuscript describes the development of zein nanoparticles containing paclitaxel and JQ1, as well as their cytotoxicity on breast cancer cells. The nanoparticles showed good size and surface properties, and exhibited significant in vitro cytotoxic activity against breast cancer cells.
Article
Chemistry, Multidisciplinary
Francesco Caridi, Giuseppe Paladini, Antonio Francesco Mottese, Maurizio Messina, Valentina Venuti, Domenico Majolino
Summary: Potentially toxic elements contamination is a universal problem with adverse health effects. This study measured the concentrations of potentially toxic elements in pyroclastic products from Mount Etna and compared them with Italian legislation levels to evaluate the level of toxicity to the ecosystem. ICP-MS measurements and various indices were used to assess chemical pollution, and multivariate statistical analysis was performed. The approach used in this study can be applied to evaluate chemical risks in various environmental samples.
APPLIED SCIENCES-BASEL
(2022)
Review
Chemistry, Multidisciplinary
Maria Chiara Bruno, Maria Chiara Cristiano, Christian Celia, Nicola D'Avanzo, Antonia Mancuso, Donatella Paolino, Joy Wolfram, Massimo Fresta
Summary: Joint diseases are a major cause of global morbidity and disability. Osteoarthritis and rheumatoid arthritis are the main diseases affecting joint cartilage, requiring long-term treatment for symptom relief. There is an urgent need for improved drug delivery strategies, particularly those based on micro- and nanotechnology. Encapsulation of therapeutic agents in delivery systems reduces drug efflux and protects against rapid clearance in the joint. The use of drug delivery systems can decrease side effects, increase therapeutic efficacy, and reduce the frequency of intra-articular administration.
Article
Pharmacology & Pharmacy
Silvia Voci, Agnese Gagliardi, Nicola Ambrosio, Maria Cristina Salvatici, Massimo Fresta, Donato Cosco
Summary: Doxorubicin hydrochloride (DOX) is a widely used antitumor drug, but its off-target toxicity limits its administration. Nanoparticles made of wheat gliadin and polyoxyethylene (2) oleyl ether were investigated as carriers for DOX. These nanoparticles showed great stability, retained high amounts of drug, and exhibited prolonged and sustained release. The encapsulation of DOX modulated its cytotoxicity against breast cancer cells compared to the free form of the drug, demonstrating the potential use of these nanoparticles as carriers for hydrophilic antitumor compounds.
Article
Biochemistry & Molecular Biology
Agnese Gagliardi, Silvia Voci, Nicola Ambrosio, Massimo Fresta, Andrea Duranti, Donato Cosco
Summary: A polymeric matrix made of PLGA was used to deliver rutin and URB894 simultaneously. The compounds were encapsulated in negatively-charged nanosystems with an average diameter of around 200 nm. The multidrug carriers exhibited an entrapment efficiency of approximately 50% for rutin and 40% for URB894. The co-encapsulation approach showed improved protective effects against oxidative stress compared to single-agent nanosystems.
Article
Chemistry, Multidisciplinary
Francesco Caridi, Giuseppe Paladini, Santina Marguccio, Alberto Belvedere, Maurizio D'Agostino, Maurizio Messina, Vincenza Crupi, Valentina Venuti, Domenico Majolino
Summary: In this study, the natural and anthropic radioactivity and heavy metals content in a basalt aggregate for concrete from Sicily were investigated. Various methods such as High-Purity Germanium (HPGe) γ-ray spectrometry and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) were used to evaluate the specific activity of radionuclides and measure heavy metal concentrations. Additionally, indexes such as alpha index, radium equivalent activity, absorbed γ-dose rate, and annual effective dose equivalent were assessed to evaluate the radiological risk. X-ray diffraction (XRD) was employed to identify the mineralogical phases present in the basalt aggregate.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Francesca Briani, Francesco Caridi, Francesco Ferella, Anna Maria Gueli, Francesca Marchegiani, Stefano Nisi, Giuseppe Paladini, Elena Pecchioni, Giuseppe Politi, Alba Patrizia Santo, Giuseppe Stella, Valentina Venuti
Summary: We carried out a comprehensive study on micro-fragments of original and previously restored paintings of the San Panfilo Church in Tornimparte, using a multi-scale approach and various techniques. The study aimed to identify the restoration materials used in previous conservation interventions and understand the degradation phenomena of the painted surfaces and architectural structures. Stratigraphic analysis helped evaluate the layers and materials present, and the main result was the identification of various pigments. These findings are crucial for guiding the restoration intervention and ensuring the compatibility of materials.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Federica De Gaetano, Consuelo Celesti, Giuseppe Paladini, Valentina Venuti, Maria Chiara Cristiano, Donatella Paolino, Daniela Iannazzo, Vincenza Strano, Anna M. Gueli, Silvana Tommasini, Cinzia Anna Ventura, Rosanna Stancanelli
Summary: In recent years, the focus of scientific research has been on bioactive compounds due to their unique properties and low toxicity. However, these compounds have low solubility, chemical stability, and bioavailability. Solid lipid nanoparticles (SLNs) have emerged as potential drug delivery systems to overcome these limitations. This study successfully prepared MRN-loaded SLNs using different lipids and investigated their properties. The MRN-SLNs showed spherical and non-aggregated morphology with high encapsulation efficiency. The release studies demonstrated sustained release of MRN over 10 days. Furthermore, ex vivo permeation studies confirmed the ability of SLNs to enhance the penetration of MRN.
Article
Polymer Science
Antonia Mancuso, Martine Tarsitano, Rosy Cavaliere, Massimo Fresta, Maria Chiara Cristiano, Donatella Paolino
Summary: This study improved the antioxidant activity of resveratrol by encapsulating it in nanocarriers and gelling the systems to improve contact time with the skin. Results showed that the resveratrol-loaded nanosystems had good antioxidant effects and potential for treating skin diseases.
Review
Polymer Science
Martine Tarsitano, Maria Chiara Cristiano, Massimo Fresta, Donatella Paolino, Concetta Rafaniello
Summary: Corneal transplantation has been the preferred treatment for irreversible damage to the anterior part of the eye. However, limited cornea donors and cases of graft rejection have led to the exploration of new biomaterials. Tissue engineering is crucial in developing a construct that mimics all the necessary properties of the cornea for proper vision. This review discusses the anatomy and physiology of the cornea, the roles of different corneal layers, and the requirements for manufacturing materials. Alginate has emerged as a promising candidate for corneal regeneration due to its adaptability, transparency, and low immunogenicity. Chemical modifications and blending with other compounds can further enhance its mechanical properties and cell-proliferation features.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
