Article
Materials Science, Multidisciplinary
Chandrakantsing V. Pardeshi, Rahul N. Dhangar, Vilas R. Jagatap, Raju O. Sonawane
Summary: The study investigated the mucoadhesion and gelling behavior of mucilage from Eulophia herbacea tubers, as well as the possibility of enhanced brain targetability through cationic neuronanoemulsions (cNNEs) in a hydrogel formulation. The results showed that the hydrogel had high bioadhesion potential and promising drug delivery approach after extensive preclinical characterization.
MATERIALS TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Ilker S. Bayer
Summary: Mucoadhesion is an important field in adhesion science, and understanding and controlling mucoadhesion can lead to life-saving materials and technologies. Mucin plays a crucial role in mucoadhesion processes. This review discusses the role of mucin in wet adhesion under different physiological conditions and highlights advancements in mucoadhesion measurement techniques and new mucoadhesive systems. This knowledge expands our understanding of mucoadhesion in soft materials and contributes to the design and application of new membranes, drugs, pharmaceutical devices, and lubricated surfaces.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Gergely Stankovits, Agnes Abraham, Eva Kiss, Zoltan Varga, Anil Misra, Andras Szilagyi, Benjamin Gyarmati
Summary: The type and concentration of charged groups in polymers play a crucial role in mucoadhesive interactions. This study investigated the correlation between chemical structure and mucin-polymer interactions by designing cationic poly(amino acid)s with different charge densities. The results showed that the interactions between mucin and polyaspartamides with at least 50% cationic groups displayed a non-linear change, causing increased light scattering. The analysis further revealed that fully cationic polyaspartamide is not necessarily superior, and the maximum adsorbed mass of polymers on mucin occurred at medium cationic group contents. This highlights the importance of cationic polyaspartamides as mucoadhesive excipients due to their multiple functionalities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Deni Rahmat, Clairine Devina
Summary: This study focuses on the synthesis of ethyl cellulose (EC) nanoparticles with mucoadhesive and lipophilic properties through thiolation using cysteamine. The nanoparticles exhibited improved drug release, stability, and biocompatibility, while demonstrating low cytotoxicity.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Rabab Fatima, Parteek Prasher, Mousmee Sharma, Dinesh Kumar Chellappan, Gaurav Gupta, Sachin Kumar Singh, Vandana B. Patravale, Kamal Dua
Summary: The presence of diverse functional groups on polysaccharides allows for their modification and conjugation with bioactive molecules. The introduction of amine linkages on polysaccharide backbones generates reactive sites that facilitate further modification and attachment of drugs and other bioactive compounds. The modification of amine groups enables the tailoring of physicochemical properties to meet specific therapeutic needs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Ajay Kumar, Vibhu Kumar, Anas Ahmad, Rakesh Kumar Mishra, Ahmed Nadeem, Nahid Siddiqui, Md Meraj Ansari, Syed Shadab Raza, Kanthi Kiran Kondepudi, Rehan Khan
Summary: The enzyme-responsive injectable hydrogel shows potential for the treatment of ulcerative colitis due to its prolonged retention and enzyme responsiveness. By encapsulating budesonide in the hydrogel, it effectively alleviates symptoms of ulcerative colitis and restores damaged colonic tissue.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Mohamed Abdallah Ahmed, Wedian Younis Abdelgawad, Mary Kamal Gad, Magdy Ibrahim Mohamed
Summary: A mucoadhesive proniosome gel with a potent corticosteroid drug was formulated for the local treatment of oral ulcerative lesions. Full factorial design was used to study the effects of surfactant type and cholesterol concentration on entrapment efficiency and vesicle size. The optimal formula showed high mucoadhesion force and drug release following Higuchi diffusion model.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Biomedical
Hongbo Cheng, Zhixiang Cui, Shuang Guo, Xin Zhang, Yingnan Huo, Shirui Mao
Summary: Mucoadhesive and mucopenetrating nanoparticles have different absorption mechanisms in enhancing oral insulin absorption. Mucopenetrating nanoparticles have a faster onset of action, while mucoadhesive nanoparticles show a sustained hypoglycemic effect. Overall, there is no significant difference in pharmacological availability between the two types of nanoparticles.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Xinyu Li, Ping He, Ruoteng Ma, Cuihua Dong, Yong Lv, Lei Dai
Summary: This study systematically investigated the influence of four factors (carboxylate content and size of TOCN, freezing-thawing treatment, and solid content of hydrogel) on the structure and performance of TOCN/CGG hydrogel. The results showed that increasing carboxylate content, freezing-thawing cycles, and solid content all led to higher crosslinking density, compact structures, and improved rheological properties of the hydrogels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mariana Chelu, Jose Calderon Moreno, Irina Atkinson, Jeanina Pandele Cusu, Adriana Rusu, Veronica Bratan, Ludmila Aricov, Mihai Anastasescu, Ana-Maria Seciu-Grama, Adina Magdalena Musuc
Summary: A facile and green synthesis method was developed to obtain zinc oxide nanoparticles using three polysaccharide gums. The biosynthesized nanoparticles were then incorporated into a functionalized chitosan hydrogel matrix. The study showed that the use of polysaccharides as chelates allows for the synthesis of ZnO nanoparticles with controlled morphology. The hydrogels exhibited corrugated topographies and were cytocompatible in cell culture experiments. These novel green hydrogels show promising potential as delivery systems for biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Paula de Freitas Rosa Remiro, Mariana Harue Taniguchi Nagahara, Martina Ghezzi, Alessia Filippini, Anna Demurtas, Silvia Pescina, Patrizia Santi, Cristina Padula, Angela Maria Moraes, Sara Nicoli
Summary: This study developed buccal formulations for topical administration of imiquimod, aiming to improve mucosal retention and reduce trans-mucosal permeation compared to the reference formulation. The developed hydrogels and films showed comparable in vitro performance to the commercial formulation, with significantly reduced permeation in the case of the xanthan gum film.
Article
Chemistry, Physical
Yao Luo, Guoyi Yu, Xiaobo Liu, Yanwen Feng, Pei Zhao, Jun Yue
Summary: Cationic hyperbranched polyureas are effective in killing bacteria and inhibiting biofilm formation. They can penetrate biofilms and eradicate them, making them promising in treating chronic wounds infected with bacteria.
CHEMISTRY OF MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jingfeng Yuan, Dong Zhang, Xiaomin He, Yifeng Ni, Lingbin Che, Jiang Wu, Baoyi Wu, Yang Wang, Shuguang Wang, Dongyong Sha, Si Yu Zheng, Jintao Yang
Summary: A cationic peptide-based, salt-responsive hydrogel dressing with triple functions of antifouling, bactericidal, and bacterial release was developed, demonstrating high antibacterial activity, biocompatibility, and cell proliferation efficacy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Peter J. Haddow, Marcelo A. da Silva, Daulet B. Kaldybekov, Cecile A. Dreiss, Ewelina Hoffman, Victoria Hutter, Vitaliy V. Khutoryanskiy, Stewart B. Kirton, Najet Mahmoudi, William J. McAuley, Michael T. Cook
Summary: Thermoreversible gels transitioning between liquid-like and solid-like states have enabled breakthroughs in novel healthcare technologies. This study synthesized ABA copolymers with varying molecular weights of PDEA and PEG blocks, revealing the necessity of high molecular weight PEG blocks for forming solid-like thermoreversible gels. Optimization led to a mucoadhesive, stable, and non-toxic thermoreversible gel with controlled release of hydrophobic drugs, showcasing high promise for healthcare applications.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mehboob Ur Rehman Kashif, Muhammad Sohail, Shujaat Ali Khan, Muhammad Usman Minhas, Arshad Mahmood, Syed Ahmed Shah, Sabeeh Mohsin
Summary: The study demonstrates that CSG-EH-NPs T-Hgel has an enhanced sustained release drug profile, with approximately 86% and 84% drug released in phosphate buffer saline and simulated nasal fluid respectively throughout 48 hours compared to EH-NPs. In-vivo pharmacokinetic parameters, such as mean residence time (MRT) and area under the curve (AUC(tot)), further establish the superiority of CSG-EH-NPs T-Hgel over EH-NPs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biophysics
K. Kaladhar, H. Renz, C. P. Sharma
COLLOIDS AND SURFACES B-BIOINTERFACES
(2015)
Article
Engineering, Biomedical
Maria J. Pina, Susan M. Alex, Francisco J. Arias, Mercedes Santos, Jose C. Rodriguez-Cabello, Rekha M. Ramesan, Chandra P. Sharma
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2015)
Article
Nanoscience & Nanotechnology
M. R. Rekha, Chandra P. Sharma
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2015)
Article
Chemistry, Applied
Radhika Raveendran, G. S. Bhuvaneshwar, Chandra P. Sharma
CARBOHYDRATE POLYMERS
(2016)
Article
Biophysics
Sunita Prem Victor, Willi Paul, V. M. Vineeth, Remya Komeri, Muthu Jayabalan, Chandra P. Sharma
COLLOIDS AND SURFACES B-BIOINTERFACES
(2016)
Article
Materials Science, Biomaterials
K. S. Joshy, Chandra P. Sharma, Nandakumar Kalarikkal, K. Sandeep, Sabu Thomas, Laly A. Pothen
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2016)
Article
Polymer Science
Radhika Raveendran, Kathleen M. Mullen, R. Mark Wellard, Chandra P. Sharma, Richard Hoogenboom, Tim R. Dargaville
EUROPEAN POLYMER JOURNAL
(2017)
Article
Metallurgy & Metallurgical Engineering
Hindumathi Ramaraj, Jagannatham Madiga, Hemaprabha Elangovan, Prathap Haridoss, Chandra P. Sharma
TRANSACTIONS OF THE INDIAN INSTITUTE OF METALS
(2017)
Article
Materials Science, Biomaterials
Sunita Prem Victor, M. G. Gayathri Devi, Willi Paul, Vineeth M. Vijayan, Jayabalan Muthu, Chandra P. Sharma
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2017)
Article
Materials Science, Biomaterials
Sunita Prem Victor, M. G. Gayathri Devi, Willi Paul, Vineeth M. Vijayan, Jayabalan Muthu, Chandra P. Sharma
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2017)
Article
Pharmacology & Pharmacy
P. H. Rajasree, Willi Paul, Chandra P. Sharma, Riyaz Ali M. Osmani, Umme Hani, Atul Srivastava
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2018)
Review
Materials Science, Biomaterials
Sunita P. Victor, Shivaram Selvam, Chandra P. Sharma
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Review
Materials Science, Biomaterials
Sunita P. Victor, Shivaram Selvam, Chandra P. Sharma
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Editorial Material
Engineering, Biomedical
Sunita P. Victor, Chandra P. Sharma
Meeting Abstract
Oncology
M. R. Rekha, K. Pal, P. Bala, M. Shetty, I. Mittra, G. S. Bhuvaneshwar, C. P. Sharma
EUROPEAN JOURNAL OF CANCER
(2016)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
