Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 88, Issue 1, Pages 534-538Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2011.07.031
Keywords
Thin film; Polysaccharide; Polyion complex; Hot press technique; Hydroxyapatite (HAp); Simulated body fluid (SBF)
Funding
- Japan Society for the Promotion of Science (JSPS), japan [22550155]
- Association for the Progress of New Chemistry (ASPRONC), Japan
- Grants-in-Aid for Scientific Research [22550155] Funding Source: KAKEN
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This study demonstrated that gel-like polyion complexes obtained by mixing of aqueous solution of chondroitin sulfate, heparin, and hyaluronic acid with that of chitosan were able to form their freestanding films using hot press treatments. These films, having thicknesses ca. 50 and 100 mu m, depending on the spacer thickness, were homogeneous and non-porous at the microscopic level, and were not water-soluble. The present fabrication process required neither cross-coupling agents nor introduction of other functional groups to the polysaccharides. Hydroxyapatite deposition on the film surfaces under body fluid conditions was also achieved. (C) 2011 Elsevier B.V. All rights reserved.
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