Article
Pharmacology & Pharmacy
Tadej Ojstersek, Grega Hudovornik, Franc Vrecer
Summary: This study investigated the influence of selected excipients on the release performance of carvedilol from HPMC-based matrix tablets. Compression mixtures were directly compressed using different grades of excipients. LOESS modelling was used to compare the release profiles by estimating burst release, lag time, and times at which a certain % of carvedilol was released. The similarity between the release profiles was evaluated using the bootstrapped similarity factor (f(2)). The best control of carvedilol release was achieved with POLYOX® WSR N-80 and Polyglykol® 8000 P in water-soluble excipients, and AVICEL® PH-102 and AVICEL® PH-200 in water-insoluble excipients.
Article
Pharmacology & Pharmacy
Gustavo Vaiano Carapeto, Marcelo Dutra Duque, Michele Georges Issa, Humberto Gomes Ferraz
Summary: This study aimed to develop a biopredictive dissolution method for desvenlafaxine ER tablets using design of experiments (DoE) and physiologically based biopharmaceutics modeling (PBBM) to reduce the risk of product failure in bioequivalence studies. A PBBM was developed in GastroPlus(R) and combined with a Taguchi L9 design to evaluate different drug products and dissolution test conditions on desvenlafaxine release. The influence of tablet's superficial area/volume ratio (SA/V) was observed, mainly for Generic #1, which had higher SA/V and showed a higher amount of drug dissolved. The biopredictive dissolution method using 900 mL of 0.9% NaCl and paddle at 50 rpm with sinker demonstrated virtual bioequivalence for all tested products.
Article
Medicine, Research & Experimental
Yihong Qiu, Donghua Alan Zhu, Kathleen Apfelbaum, Hui Zu, Hao Xiong
Summary: This study developed an in vitro drug release test to establish an in vitro-in vivo correlation (IVIVC) model for potassium chloride extended-release (ER) matrix tablets. The effects of in vitro test conditions on drug release were investigated, and a discriminatory drug release method was successfully developed. This method enabled the establishment and validation of an IVIVC model for the potassium chloride ER tablet.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Katarina Rede, Tjasa Felicijan, Marija Bogataj
Summary: The study found that the concentration of SDS significantly affected the release of DF-Na in HPMC matrix tablets, while the concentration of HPMC affected the transmittance of SDS. SDS concentrations below the CMC (0.03-0.08%) led to a decrease in DF-Na release in HPMC matrix tablets.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Xavier Pepin, Mateo Goetschy, Susanna Abrahmsen-Alami
Summary: This study aims to improve the prediction of drug product dissolution by proposing new hydrodynamic models and estimating the impact of formulation and drug sedimentation or coning. The models were validated on 166 dissolution experiments and 18 different drugs, showing satisfactory predictive power with improved precision in experiments where coning was suspected.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Paczkowska-Walendowska, Andrzej Miklaszewski, Daria Szymanowska, Krystyna Skalicka-Wozniak, Judyta Cielecka-Piontek
Summary: Hot Melt Extrusion (HME) technology was developed to improve the rheological properties of blends containing lyophilized Scutellariae baicalensis root extract and chitosan through the use of different ratios of (Hydroxypropyl)methyl cellulose (HPMC) as amorphous matrix formers. The systems were characterized and tablets were prepared from the extrudates. HPMC-based systems showed delayed release of baicalin due to the swelling behavior of HPMC, and the best tabletability properties were observed in the formulation containing lyophilized extract HPMC 50:50 w/w, which maintained good mucoadhesive properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Helena Vrbanac, Jurij Trontelj, Ajda Osojnik, Katja Berginc, Biljana Jankovic
Summary: This study evaluated the effect of pH modifiers on the micro-environmental pH in HPMC matrix and prepared sustained-release matrix systems with improved drug dissolution by utilizing different dissolution methods. The research demonstrated significantly higher drug dissolution rates in bio-relevant dissolution models for mechanically sensitive HPMC tablets with weakly basic drugs containing pH modifiers.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Connor O'Farrell, Mark J. H. Simmons, Hannah K. Batchelor, Konstantinos Stamatopoulos
Summary: This study investigates the in vitro release of theophylline from an extended-release dosage form in different hydrodynamic conditions using a Dynamic Colon Model (DCM) and USP dissolution system II. The results demonstrate that hydrodynamic conditions and motility patterns affect the dissolution profiles and concentration distribution of theophylline. These findings are important for drug release research.
Article
Pharmacology & Pharmacy
Daniela Amaral Silva, Marcelo Gomes Davanco, Neal M. Davies, Johannes Kraemer, Patricia de Oliveira Carvalho, Raimar Lobenberg
Summary: The study found that using physiologically relevant bicarbonate buffer (BCB) was more discriminative and physiologically relevant compared to compendial phosphate buffer in evaluating the in vitro performance of test and reference formulations of EC pantoprazole tablets. Incorporating BCB as an additional test for assessing EC products in vitro may improve the comparison between formulations and mitigate the risks associated with the development of generic EC formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Seyedreza Goldoozian, Valentyn Mohylyuk, Andriy Dashevskiy, Roland Bodmeier
Summary: The study aimed to correlate the gel strength of swollen matrix tablets with their in vitro robustness against agitation intensity and applied mechanical forces. Tablets formulated with higher viscosity HPMC demonstrated gel strength in swollen state above 0.02 MPa, unaffected by stirring speed, while tablets with lower viscosity HPMC showed decreased gel strength and were affected by mechanical stress.
PHARMACEUTICAL RESEARCH
(2021)
Article
Environmental Sciences
Yu-Chen Chang, Ku-Fan Chen, Ting-Yu Chen, Hung-Hsiang Chen, Wei-Yu Chen, Ying-Chih Mao
Summary: In this study, a biodegradable binder, hydroxypropyl methyl cellulose (HPMC), was used for the first time to develop persulfate-releasing tablets for remediation of TCE-contaminated groundwater. The persulfate tablets showed controlled release of persulfate, which could effectively degrade highly concentrated TCE. The results also demonstrated the biodegradation efficiency of HPMC by microbes under different conditions.
Article
Pharmacology & Pharmacy
Ewelina Juszczyk, Kamil Kislo, Pawel Zero, Ewa Tratkiewicz, Maciej Wieczorek, Jadwiga Paszkowska, Grzegorz Banach, Marcela Wiater, Dagmara Hoc, Grzegorz Garbacz, Jaroslaw Sczodrok, Dorota Danielak
Summary: The study discusses the development of robust SR matrix tablets with a novel GPR40 agonist for first-in-human studies and introduces a general workflow for successful development of SR formulations. Evaluation of the tablets using various methods revealed their strong robustness towards mechanical and physicochemical conditions of bio-predictive tests, ensuring a comparable drug delivery rate despite varying conditions.
Article
Chemistry, Analytical
Ahmed S. Fayed, Nada S. Ayish, Badr A. El-Zeany, Hoda M. Marzouk
Summary: A novel sensor for monitoring drug dissolution patterns was developed, with high sensitivity and fast response time. The sensor was successfully applied for determining FAM in its pure form and Fampyra tablets without any sample pretreatments. Furthermore, real-time in-line monitoring of Fampyra tablets' dissolution profile using US FDA dissolution parameters was achieved.
MICROCHEMICAL JOURNAL
(2021)
Article
Environmental Sciences
Anni Tang, Jun Wang, Yisheng Zhang, Maoxin Hong, Yang Liu, Baojun Yang
Summary: This study investigated the effect mechanism of pyrite on arsenopyrite oxidation and arsenic release. It was found that the presence of pyrite significantly accelerated the dissolution of arsenopyrite and the oxidation of As (III) to As (V), due to the galvanic effect, an increase in the Fe3+/Fe2+ ratio and the oxidation-reduction potential (Eh) value, and a decrease in pH level. Sulphur was identified as the main obstructive factor during arsenopyrite oxidation, and the addition of pyrite accelerated its oxidation. The relationship between different mineral proportions and the galvanic effect was also discussed.
Article
Pharmacology & Pharmacy
A. S. Sousa, J. Serra, C. Estevens, R. Costa, A. J. Ribeiro
Summary: This study aims to evaluate the application of commonly used excipients in extended release formulations by analyzing their physical, compaction, and tablet properties, and their correlations with powder properties and mechanical properties, providing effective tools and methods for the development and manufacturing of direct compression-based extended release formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Vahid Safavizadeh, Mohammad Reza Afshar Mogaddam, Mir Ali Farajzadeh, Mozhgan Mojkar, Matthew D. Moore, Ali Nokhodchi, Maryann Naebi, Mahboob Nemati
Summary: This review discusses the harmful effects of aflatoxins on public health and the methods to reduce their levels. The study highlights the high levels of aflatoxins in Iranian foodstuffs, emphasizing the need for more public health intervention to decrease their presence.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Zaynab Sadeghi-Ghadi, Nicki Behjou, Pedram Ebrahimnejad, Mehrdad Mahkam, Hamid Reza Goli, Matthew Lam, Ali Nokhodchi
Summary: In recent years, the resistance and side effects of chemical antibiotics have led to a demand for natural substances and herbal components with antibacterial effects. This study developed a novel nanocomposite for delivering curcumin to enhance its antibacterial efficacy. The optimized formulation demonstrated good particle size distribution and stability, and showed lower minimum inhibitory concentration against common bacteria.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Pharmacology & Pharmacy
Nafiseh Mollazadeh Nazem, Javad Shokri, Nasim Nourani, Ali Rajabi Zangi, Matthew Lam, Ali Nokhodchi, Yousef Javadzadeh
Summary: This study investigated the combination of ball milling and liquisolid technology to improve the dissolution rate of celecoxib. The results showed that this novel approach can enhance the dissolution rate and is an efficient method for poorly water-soluble drugs.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Pharmacology & Pharmacy
Yaser Nasirzadeh Fard, Hamidreza Kelidari, Armaghan Kazeminejad, Seyed Jaber Mousavi, Mohammad Taghi Hedayati, Elham Mosayebi, Mojtaba Nabili, Leila Faeli, Kofi Asare-Addo, Ali Nokhodchi, Maryam Moazeni
Summary: The rising global incidence of skin mycosis, particularly dermatophytes, affects more than 20-25% of the world population. Nanotechnology is believed to be able to effectively treat this skin disease. This study aimed to use nanostructured lipid carriers (NLCs) in a gel formulation to deliver Zataria multiflora (ZM) essential oils more effectively through the skin for the management of mild to moderate cutaneous dermatophytosis. The ZM-NLCs gel showed significant reduction in inflammation, itching, scaling, and lesion size compared to the placebo group.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Soltani, Hossein Kamali, Abbas Akhgari, Mahboobeh Ghasemzadeh Rahbardar, Hadi Afrasiabi Garekani, Ali Nokhodchi, Fatemeh Sadeghi
Summary: In this study, chitosan nanoparticles loaded with budesonide were prepared using the ionic gelation technique to improve the delivery of orally administered nanoparticles to the colon. The size, zeta potential, encapsulation efficiency, shape, and drug release of the nanoparticles were investigated. The nanoparticles were then pelletized using the extrusion-spheronization method and coated with enteric and time-dependent polymers for colon-specific delivery. The formulations were tested for their anti-inflammatory effect in rats with induced colitis, and the relapse of colitis after treatment discontinuation was also monitored. The results showed that the pelletized budesonide nanoparticles released the drug steadily throughout the gastrointestinal tract, leading to long-lasting anti-inflammatory effects.
Article
Pharmacology & Pharmacy
Hossein Shahdadi Sardou, Fatemeh Sadeghi, Hadi Afrasiabi Garekani, Abbas Akhgari, Amir Hossein Jafarian, Mohammadreza Abbaspour, Ali Nokhodchi
Summary: The aim of this study was to evaluate and optimize the combination of time and pH-dependent polymers as a single coating for the design of the colon-specific drug delivery system of 5-aminosalicylic acid (5-ASA) pellets. The ratio of ES:EL:EC of 33:52:15 w/w at a coating level of 7% was discovered as the optimum coating for the delivery of 5-ASA matrix pellets to the colon.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Hamid Reza Samaeea, Gohar Eslami, Golnar Rahimzadeh, Majid Saeedi, Alireza Davoudi Badabi, Kofi Asare-Addo, Ali Nokhodchi, Fatemeh Roozbeh, Mahmood Moosazadeh, Roya Ghasemian, Ahmad Alikhani, Mohammad Sadegh Rezai
Summary: This study investigates the efficacy of inhalation phage therapy on bacterial pneumonia in patients with moderate to severe COVID-19. The results showed significant differences between the intervention and control group in terms of O2Sat change, negative sputum culture, absence of fever and dyspnea, duration of hospitalization, intubation, and ventilation. In conclusion, inhalation phage therapy may have a potential impact on secondary infection and outcomes in COVID-19 patients.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ali Nokhodchi, Salonee Chavan, Taravat Ghafourian
Summary: In vitro dissolution and permeability testing play a crucial role in simulating the behavior of inhaled drug products in the body. However, there is no commonly accepted test for assessing the dissolution pattern of orally inhaled formulations, unlike oral dosage forms such as tablets and capsules. Recent advances in dissolution methods for orally inhaled products have highlighted the importance of evaluating dissolution kinetics, especially for poorly water-soluble drugs. Dissolution and permeability testing can help identify differences between formulations and serve as a useful tool in correlating in vitro and in vivo studies, but a standard method of choice has not yet emerged.
Article
Pharmacology & Pharmacy
Seyedeh Nesa Rezaeian Shiadeh, Farzin Hadizadeh, Elham Khodaverdi, Mahmoud Gorji Valokola, Saleh Rakhshani, Hossein Kamali, Ali Nokhodchi
Summary: Novel drug delivery systems based on in situ forming gel (ISFG) (PLGA-PEG-PLGA) and in situ forming implant (ISFI) (PLGA) were developed for one-month risperidone delivery in this study. Results indicated sustained release for about one month with the formulation containing 50% PLGA-PEG-PLGA triblock. ISFG showed higher cell viability than ISFI due to the gradual release of NMP. The optimized PLGA-PEG-PLGA exhibited consistent serum levels in vitro and in vivo through 30 days.
Article
Biochemistry & Molecular Biology
Azin Jahangiri, Ali Nokhodchi, Kofi Asare-Addo, Erfan Salehzadeh, Shahram Emami, Shadi Yaqoubi, Hamed Hamishehkar
Summary: The study aimed to develop carrier-free inhalable CLX microparticles for dry powder inhalation (DPI) using electrospraying. The results showed that electrosprayed particles prepared from the ethanol-acetone solvent mixture at a drug concentration of 3% exhibited the best in vitro aerosolization properties.
Review
Pharmacology & Pharmacy
Mehran Alavi, Ali Nokhodchi
Summary: Brucellosis, a challenging intracellular bacterial infection, can be transmitted through unpasteurized milk. Conventional antibiotics have limited effectiveness, but micro-and nanoformulations show promising potential. Different morphologies of nanomaterials have been extensively studied in order to overcome the limitations of traditional formulations.
DRUG DISCOVERY TODAY
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Soltani, Hossein Kamali, Abbas Akhgari, Mahboobeh Ghasemzadeh Rahbardar, Hadi Afrasiabi Garekani, Ali Nokhodchi, Fatemeh Sadeghi
Summary: Researchers developed a single-layer coating combining inulin and eudragit RS to sustain the release of budesonide pellets for targeted therapy in Crohn's disease. The optimized coating formulation showed a complete release profile and effectively reduced inflammation in rats.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Chemical
Shadi Yaqoubi, Mohaddese Sokuti, Sahand Mazloum-Ravasan, Kofi Asare-Addo, Hamed Hamishehkar, Ali Nokhodchi
Summary: In this study, a modified version of ultrasonic spray pyrolysis was used to prepare salbutamol sulfate dry powder. The engineered particles showed suitable characteristics for effective drug delivery to the lungs and demonstrated acceptable aerosolization performance. This newly introduced method appears to be capable of producing dry powder formulations of different drugs without the need for surfactants or stabilizers.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Pharmacology & Pharmacy
Maryam Kouhjani, Arezoo Saberi, Farzin Hadizadeh, Elham Khodaverdi, Malihe Karimi, Elaheh Gholizadeh, Hossein Kamali, Ali Nokhodchi
Summary: Subcutaneous injections of phosphatidylcholine (PC), sodium deoxycholate (NADC), and a mixture of them were found to be an effective option for treating cellulite. However, injection of NADC may lead to inflammation and necrosis. A sustained release formulation based on lipid-liquid crystal (LLC) could control NADC release and solve this problem. Spectrofluorimetry was used as a reliable, efficient, and economical method for accurately determining NADC concentration. Subcutaneous injection of LLC-NADC reduced inflammation and tissue necrosis, increased fat lysis, and showed no detrimental effects on kidney or heart tissue.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
