Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 441, Issue -, Pages 34-42Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfa.2013.08.070
Keywords
Polyurethane; Poly(ethylene oxide); Hemocompatibility; Surface modification
Categories
Funding
- National Important Science Research Program of China [2011CB933500, 2011CB933503]
- National Natural Science Foundation of China [31200757]
- Basic Research Program of Jiangsu Province (Natural Science Foundation) [BK2011036]
- Special Funds of the National Natural Science Foundation of China [61127002]
- Special Project on Development of National Key Scientific Instruments and Equipment of China [2011YQ03013403]
- program for New Century Excellent Talents in University [NCET-09-0298]
- Science and Technology Project in Suzhou [SYG201210]
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Poly(ethylene oxide) (PEO) has been widely applied in the modification of biomaterials because it shows high hydrophilicity and excellent biocompatibility. In the current study, the surface of medical polyurethahe (PU) films was modified to improve hydrophilicity and hemo compatibility by a facile method without catalyst. PU films were modified directly using poly(ethylene oxide) (PEO) with various molecular weights. The existence, morphology, hydrophilicity and hemocompatibility were approved and studied respectively by attenuated total reflectance infrared spectroscopy (ATR-IR), atomic force microscopy (AFM), scanning electron microscopy (SEM), contact angel measurement and platelet-rich plasma adhesion study. Compared with the raw counterpart, the PEO-modified PU films have significant improved hydrophilicity and reduced platelet adhesion, as well as less shape deformation, especially for the one modified by the PEO (M-n = 300,000). These substantial improvements indicate potential application as blood-contacting coating in medical device. (C) 2013 Elsevier B.V. All rights reserved.
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