Article
Pharmacology & Pharmacy
Clea Chesneau, Alpha Oumar Sow, Fadila Hamachi, Laurent Michely, Sena Hamadi, Remy Pires, Andre Pawlak, Sabrina Belbekhouche
Summary: Tailor-made micro- and nanocarriers, combining cyclodextrin and calcium carbonate, were developed for loading hydrophobic drugs. The particle size of the resulting cyclodextrin-CaCO3 particles can be controlled by adjusting the concentration of PVSA or gly and the mixing time. These particles show high stability and biocompatibility, and exhibit selective release in acidic media.
Article
Materials Science, Biomaterials
Alexey M. Yashchenok, Olga Gusliakova, Elena Konovalova, Marina Novoselova, Victoria O. Shipunova, Tatiana O. Abakumova, Olga Efimova, Roman Kholodenko, Alexey A. Schulga, Timofei S. Zatsepin, Dmitry A. Gorin, Sergey M. Deyev
Summary: The study focuses on immobilizing bacterial ribonuclease barnase into submicron porous calcium carbonate particles, exploring different encapsulation methods and their effects. The use of negatively charged dextran sulfate and ribonucleic acid from yeast significantly increases the loading capacity of the enzyme. Enzyme activity in the particles is dependent on the loading capacity and the transformation of metastable vaterite to stable calcite.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Pharmacology & Pharmacy
Valeria Ambrogi
Summary: Calcium carbonate is a versatile excipient that can be used to improve the dissolution rate of poorly soluble drugs. Its many interesting characteristics, including quick dissolution in gastric fluid, low cost, and safety, make it an attractive option. This review provides an overview of the use of calcium carbonate as an excipient for enhancing drug dissolution rates, including the drug loading procedure, physical characterization of the drug/CaCO3 samples, and discussion of potential mechanisms for dissolution improvement.
Review
Pharmacology & Pharmacy
Maryam Farzan, Roger Roth, Joachim Schoelkopf, Jorg Huwyler, Maxim Puchkov
Summary: Porous materials have properties suitable for depositing therapeutic compounds, allowing for drug protection, controlled release rates, and improved solubility. However, effective incorporation of the drug in the internal porosity of the carrier is crucial for successful porous delivery systems. This review aims to provide a comprehensive overview of the loading processes, carrier characteristics, drug release kinetics, and mathematical modeling approaches for porous materials in drug delivery systems.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Alexander V. Mikheev, Tatiana N. Pallaeva, Ivan A. . Burmistrov, Vladimir V. Artemov, Dmitry N. Khmeleni, Fedor S. Fedorov, Albert G. Nasibulin, Daria B. Trushina
Summary: A hybrid core-shell system was fabricated using two technical approaches and freezing-induced loading was found to be more preferable compared to physical adsorption.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Physical
Fuwang Mo, Qiujuan Chen, Xiaohui Zhang
Summary: Hollow calcium carbonate microspheres were synthesized by a water hydrothermal method and loaded with doxorubicin hydrochloride (DOX). The sustained release of DOX was confirmed qualitatively by the luminescence of carbon quantum dots (CQDs) and quantitatively measured by UV absorption spectra in simulated solutions of cellular metabolism.
Article
Chemistry, Multidisciplinary
Yixin Jiao, Tongming Su, Yongmei Chen, Minggui Long, Xuan Luo, Xinling Xie, Zuzeng Qin
Summary: By preparing a porous calcium carbonate composite superabsorbent polymer, the water absorbency and water-retention rate of the superabsorbent material can be improved. The porous calcium carbonate forms multidirectional crosslinking points with the -COO- groups in acrylic acid, increasing the flexibility of the crosslinking network and promoting the formation of internal pores to enhance water storage space. Additionally, the double-crosslinking of the crosslinking agent and porous calcium carbonate enhances the stability of the crosslinking network.
Article
Multidisciplinary Sciences
Tilman A. Grunewald, Stefano Checchia, Hamadou Dicko, Gilles Le Moullac, Manaarii Sham Koua, Jeremie Vidal-Dupiol, Julien Duboisset, Julius Nouet, Olivier Grauby, Marco Di Michiel, Virginie Chamard
Summary: This study utilizes nanobeam X-ray total scattering and reverse Monte Carlo modeling to spatially resolve the amorphous calcium carbonate compounds in mollusc shells. Three distinct amorphous compounds were discovered, and the presence of magnesium in the shell and its role in the amorphous-to-crystal transition were demonstrated. The findings contribute to the understanding of biomineralization and provide insights for bioinspired synthetic strategies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biotechnology & Applied Microbiology
Yang Li, Chunyu Huang, Youhua Xu
Summary: Sonodynamic therapy (SDT) has unique advantages but also faces challenges such as low water solubility of sonosensitizers and the influence of tumor microenvironment (TME). In this study, a bionic nano-system (ECaC) was designed by coating mesoporous calcium carbonate nanoparticles (CaCO3 NPs) and sonosensitizer curcumin (Cur) into tumor-derived exosomes, aiming to enhance SDT. The biomimetic nano-system effectively targeted tumor cells and released the drug in response to the acidic microenvironment, resulting in significant anti-tumor effects without toxic side effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yanqi Huang, Lin Cao, Bogdan V. Parakhonskiy, Andre G. Skirtach
Summary: This article introduces the characteristics and applications of inorganic calcium carbonate particles and organic alginate hydrogels as drug delivery carriers, as well as hybrid structures containing both types of carriers. It proposes the rational combination of these two carrier types to enhance their performance, and discusses their similarities and differences.
Article
Materials Science, Multidisciplinary
Bojan Jankovic, Snezana Papovic, Milan Vranes, Teodora Knezevic, Sanja Przulj, Sasa Zeljkovic, Suzana Velickovic, Filip Veljkovic, Dijana Jelic
Summary: A powdered PVA/CaCO3 nanocomposite carrier was successfully fabricated for loading vitamin D-3 (VD3). The VD3/PVA/CaCO3 nanocomposite scaffold showed the existence of calcite staircase dendrites and enhanced thermal stability of VD3. The characterization techniques included XRD, FTIR, MALDI-MS, BET-NLDFT, SEM, TG-DTG, and coupled TG-MS.
JOURNAL OF MATERIALS SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Anna S. Vikulina, Jack Campbell
Summary: An undeniable trend in modern bioengineering and nanotechnology is the use of various biomolecules, primarily polymeric, for designing novel functional materials in controlled drug delivery, bioimaging, tissue engineering, and other bioapplications. Biogenic polymers with features like biocompatibility, biodegradability, replicating natural cellular microenvironments, and minimal toxicity, have gained growing interest as building blocks for fourth-generation biomaterials. Recent studies highlight the promise of hard-templating approach in fabricating nano- and microparticles using biopolymers, covering up-to-date knowledge on this topic and assessing the progress and challenges in the field.
Article
Chemistry, Multidisciplinary
Francesca Persano, Concetta Nobile, Clara Piccirillo, Giuseppe Gigli, Stefano Leporatti
Summary: Calcium carbonate (CaCO3) particles are a promising choice for drug delivery systems due to their biocompatibility, biodegradability, simplicity, cost-effectiveness, and stimulus-responsiveness. This study investigated the synthesis parameters that affect the particle size, and found that salt concentration and temperature had a significant impact, allowing the preparation of well-dispersed spherical nanoparticles below 200 nm. The successful encapsulation of the anti-tumor agent resveratrol into CaCO3 nanoparticles, without affecting their overall size and morphology, was achieved under optimized synthesis conditions.
Article
Chemistry, Multidisciplinary
Francesca Scalera, Alessandra Quarta, David M. Tobaldi, Robert C. Pullar, Clara Piccirillo
Summary: Research has shown that HA-based materials can be tailored for various applications by using a naturally templated precursor. These materials have shown promising results in environmental remediation and biocompatibility for biomedical applications. Cork has been identified as an excellent template agent for designing HA materials with diverse properties.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Materials Science, Ceramics
Masaya Shimabukuro, Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
Summary: Increasing CO32- concentration in Na2HPO4 solution accelerates the fabrication rate of CO3Ap and results in changes in crystal shape and crystallite size. Higher CO32- concentration leads to more CO3 content in CO3Ap, larger pores, and altered pore distribution.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Pritam Singh, Zarina Ansari, Santanu Ray, Bilwadal Bandyopadhyay, Kamalika Sen
MATERIALS CHEMISTRY AND PHYSICS
(2020)
Review
Environmental Sciences
S. Ghosh, R. Patra, D. Majumdar, K. Sen
Summary: This review article analyses various aspects of titania-modified building materials for environmental remediation, focusing on their photocatalytic activity in degrading toxic pollutants. It discusses the relationship between TiO(2) amount and main building block constituents, as well as the application details. Environmental and product-related parameters affecting the efficacy of these modified matrices are highlighted, along with areas for further research and development.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Debashree Das, Souvik Sen, Kamalika Sen
Summary: Organoselenium drugs like SeU and SeC interact with the major erythroid protein Hb, with SeU rapidly converting to nanoselenium in the presence of nitrite, and SeC showing a dose-dependent reduction in nitrite-induced metHb formation. However, SeC was less effective in diabetic samples compared to non-diabetic ones.
JOURNAL OF BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Rajib Karmakar, Pritam Singh, Kamalika Sen
Summary: In this study, mesoporous alumina was utilized as an adsorbent for the selective adsorption and separation of Th(IV), showing high adsorption capacities at different temperatures. Desorption of the adsorbed thorium was achieved by treatment with trisodium citrate.
SEPARATION SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bhavya Srivastava, Souvik Sen, Kamalika Sen
Summary: The measurement of sorbitol in serum can be used as an indicator for monitoring diabetic complications. Researchers have investigated the binding of sorbitol with caffeine to remove excess sorbitol from the body. The study used various techniques to establish the interaction between sorbitol and caffeine in serum medium, as well as the binding sites between them.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mita Halder, Anupam Singha Roy, Kamalika Sen
Summary: A green and efficient method using peanut skin to synthesize polyphenol capped iron oxide nanoparticles (ION) was characterized by FTIR, Powder XRD, and XPS analysis. The ION showed good catalytic activity in ring opening of epoxides by aromatic amines, with yields up to 90% and could be reused three times without significant loss in activity.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2021)
Article
Thermodynamics
Laboni Das, Sankar Prasad Paik, Kamalika Sen
Summary: A carbohydrate-based aqueous biphasic system was designed by adding an aqueous solution of sugar alcohols to poly(propylene glycol). The system is suitable for extracting different molecules of biological relevance by replacing the salt-rich phase for phase separation.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2021)
Review
Chemistry, Multidisciplinary
Priti Sengupta, Adity Bose, Kamalika Sen
Summary: This article discusses the potential applications of phenolic compounds in the food and pharmaceutical industries, as well as the limitations they face due to poor water solubility. The focus is on analyzing the effect of liposomal encapsulation on improving the water solubility and bioefficacy of phenolic compounds.
Article
Chemistry, Multidisciplinary
Pritam Singh, Kamalika Sen
Summary: This study reveals the potential selective adsorption of epigallocatechin gallate by Ga-doped TiO2 nanoparticles and demonstrates excellent adsorption and desorption performance. Different nanoparticle materials with varying pore diameter and specific surface area were synthesized, and the properties of the materials were controlled by adjusting the Ga content. The experimental results show that Ga-doped TiO2 nanoparticles exhibit the highest adsorption percentage in acidic conditions, and the adsorption process follows the Langmuir model and pseudo-second order kinetics.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Multidisciplinary
Arpita Manna, Nabanita Naskar, Kamalika Sen, Kakoli Banerjee
Summary: Phosphate ion biosorption is important in wastewater treatment, with key factors including pH, adsorbent: adsorbate ratio, etc. The physico-chemical properties of biosorbents directly affect adsorption efficiency, and the adsorption capacity of phosphate ions can be improved by modifying the adsorbents.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2022)
Article
Thermodynamics
Laboni Das, Kamalika Sen
Summary: This study aims to construct a biocompatible aqueous biphasic system (ABS) using amino acids and a block copolymer. The phase behavior of the systems was determined, and the newly designed ABSs were successfully used to extract medically relevant molecules from proton pump inhibitors. The block copolymer-rich phase was regenerated using thermoseparation and adsorption techniques, making this ABS method more environmentally friendly and cost-effective.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2022)
Article
Thermodynamics
Laboni Das, Kamalika Sen
Summary: By introducing carbohydrates as adjuvants, the concentration of the ionic liquid (IL) as a phase-forming component was significantly reduced in a polypropylene glycol (PPG#400)-based aqueous biphasic system (ABS). The ABS tailored with D-mannitol as an adjuvant was chosen for further extraction of polyphenols (rutin and morin), where approximately 75% of rutin and 91% of morin were extracted in the PPG#400-rich phase of the ABS.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2023)
Article
Chemistry, Analytical
Shalmali Basu, Debashree Das, David Morgan, Bibhas Hazra, Abhijit Saha, Kamalika Sen
Summary: We designed a simple, fast, green, and cost-effective method to synthesize copper iodide nanoparticles (CuI-NP) for spectroscopic detection of the cancer biomarker, carbohydrate antigen 19-9 (CA 19-9). The gamma-irradiated (24 h) CuI-NP (CuI-NP-gamma) showed higher sensitivity towards CA 19-9 sensing due to their surface activity and charged nature. CuI-NP-gamma delivered higher signal enhancement and lowered the limit of detection (LOD) of CA 19-9, even in the presence of high concentrations of glucose, cholesterol, bilirubin, and insulin.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Pritam Singh, Mita Halder, Santanu Ray, Adity Bose, Kamalika Sen
MATERIALS ADVANCES
(2020)
Article
Engineering, Environmental
Zarina Ansari, Pritam Singh, Kamalika Sen
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2020)
