Journal
COLLOID AND POLYMER SCIENCE
Volume 292, Issue 9, Pages 2111-2122Publisher
SPRINGER
DOI: 10.1007/s00396-014-3244-6
Keywords
Glycopolymer; RAFT; Self-assembly; Targeted; Biomolecule recognition
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Funding
- National Natural Science Foundation of China [21004031]
- Natural Science Foundation of Jiangsu Province [BK2011459]
- National Postdoctoral Foundation of China [20090461065]
- National Postdoctoral Foundation of Jiangsu Province [1001034B]
- Open Foundation of Stake Key Laboratory of Natural and Biomimetic Drugs, Peking University [K20110105]
- social development Foundation of Zhen jiang [SH2012024]
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Porphyrin-cored poly(l-lactide) (SPPLA) was successfully synthesized from ring-opening polymerization (ROP) of l-lactide initiated with porphyrin core. Then, SPPLA was coupled with benzylsulfanylthiocarbonylsufanylpropionic acid (BSPA), and a macro-reversible addition-fragmentation chain transfer (macroRAFT) polymerization agent SPPLA-BSPA was obtained. Finally, star-shaped porphyrin-cored poly(l-lactide)-b-poly(gluconamidoethyl methacrylate) (SPPLA-b-PGAMA) block copolymers were synthesized via RAFT of unprotected gluconamidoethyl methacrylate (GAMA) in 1-methyl-2-pyrrolidinone (NMP) solution at 70 A degrees C. The structure of this block copolymer was thoroughly studied by nuclear magnetic resonance spectroscopy (NMR), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC). Under the irradiation, such SPPLA-b-PGAMA copolymer exhibits efficient singlet oxygen generation and indicates high fluorescence quantum yields. Notably, with UV-vis and dynamic light scattering (DLS) analysis, SPPLA-b-PGAMA showed a very specific recognition with concanavalin A (ConA). Particularly, MTT shows that the cytotoxicity of SPPLA-b-PGAMA against COS-7 cells was very low and, when given a longer irradiation time, more BEL-7402 cancer cells died, which will be investigated in this study.
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