Article
Biochemistry & Molecular Biology
Joanna Potas, Agnieszka Zofia Wilczewska, Pawel Misiak, Anna Basa, Katarzyna Winnicka
Summary: Polyelectrolyte multilayers (PEMs) based on polyelectrolyte complex (PEC) structures are interesting materials for functionalized coatings and drug delivery platforms. This study optimized the formulation of chitosan/low-methoxy amidated pectin multilayer films and investigated their thermal properties, chemical structure, mechanical properties, and internal structure. The results showed that films with confirmed multilayer architecture are promising for buccal drug delivery and have improved thermal stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Monika Bak, Judith Mihaly, Gergo Gyulai, Istvan Szalai, Imre Varga, Robert Meszaros
Summary: Experiments revealed the formation of solid films at liquid interfaces through the interfacial association of anionic polyelectrolytes and surfactants. These films possess temperature sensitivity and offer an alternative to previously synthesized solid polyion/surfactant assemblies.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Polymer Science
Giuseppe Rosario Del Sorbo, Viviana Cristiglio, Daniel Clemens, Ingo Hoffmann, Emanuel Schneck
Summary: Aqueous mixtures of polyelectrolytes and oppositely charged surfactants can form clear and homogeneous solutions when one component is in excess, but macroscopic precipitates are formed around charge equilibrium. Near the phase boundary, nanometric polyelectrolyte/surfactant complexes can greatly increase the viscosity of aqueous solutions, governed by the composition and chemical nature of the polyelectrolyte and surfactant. The interaction between polycation JR 400 and sodium tetradecyl sulfate (STS) leads to a significant increase in viscosity, while no such increase is observed with sodium octyl sulfate (SOS) due to the absence of mixed aggregates.
Article
Chemistry, Applied
T. N. Lugovitskaya, A. B. Shipovskaya, S. L. Shmakov, X. M. Shipenok
Summary: The dissolution of chitosan and L-aspartic acid in an aqueous solution was studied, along with the resulting chitosan salt properties over time. Changes in conductivity, viscosity, pH, and the formation of nanoparticles and microparticles were observed as ion pairs and multiplets formed in the system.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Geeta Kumari Wasupalli, Devendra Verma
Summary: This study developed a thermosensitive injectable hydrogel based on chitosan and polygalacturonic acid. By optimizing biocompatibility and gelation time, the researchers improved the cellular activity and mechanical properties of the hydrogel. The addition of gelatin and hydrothermally treated PEC fibers showed superior results.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Anna Khramenkova, Daria N. Izvarina, Konstantin M. Popov, Margarita A. Khimich, Igor Yu. Litovchenko
Summary: Hybrid materials based on chitosan and cobalt-nickel oxy-compounds were successfully synthesized using non-stationary electrolysis. The morphology, structure, and elemental composition of the materials were investigated. The hybrid materials exhibited excellent electrochemical properties with high specific capacitance, energy density, power density, and good cycling stability.
SOLID STATE IONICS
(2023)
Article
Biochemistry & Molecular Biology
Galina N. Gubanova, Valentina A. Petrova, Svetlana V. Kononova, Elena N. Popova, Valentina E. Smirnova, Alexander N. Bugrov, Vera V. Klechkovskaya, Yury A. Skorik
Summary: This study investigated the thermal and structural properties of multilayer composites based on chitosan and different polyanions. The results showed that the type of polyanion used influenced the thermal degradation and crystallization behavior of the composite materials. Strong acid salts as counterions to chitosan led to strong interactions between layers, while weak polyacid salts resulted in weaker PEC formation.
Article
Agricultural Engineering
Wenkai Nie, Yan Lin, Xin Wu, Shaohua Wu, Xiang Li, Jay J. Cheng, Chunping Yang
Summary: In this study, chitosan-Fe3O4 was prepared and its effects on anaerobic digestion processes under acid stress were investigated. The results revealed that chitosan-Fe3O4 significantly increased the methanogenesis rate and accelerated the restoration of acidified anaerobic systems. The analysis of sludge characteristics indicated that chitosan-Fe3O4 promoted the secretion of proteins and humic substances, and enhanced the electron transfer activity of the system. Microbial community analysis showed that chitosan-Fe3O4 enriched the abundance of Peptoclostridium and facilitated direct interspecies electron transfer. These findings suggest that chitosan-Fe3O4 can be used to improve the efficiency of anaerobic digestion of high concentration organic wastewater under acid inhibition conditions.
BIORESOURCE TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Bruna Ortolani Turco, Fernanda Isadora Boni, Maria Palmira Daflon Gremiao, Marlus Chorilli
Summary: The study demonstrated the potential of nanostructured polyelectrolyte complexes (nano PECs) based on chitosan (CS) and sodium alginate (SA) for drug delivery in treating tuberculosis. By adjusting polymer proportions and homogenization methods, the characteristics of nano PECs can be modified to influence drug release and stability. Incorporation of rifampicin (RIF) in nano PECs showed sustained drug release with different mechanisms depending on particle composition, making it a promising system for tuberculosis treatment.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Polymer Science
Tea Kaurin, Tanja Pusic, Mirjana Curlin
Summary: This research focuses on functionalizing a standard polyester fabric with biopolymer chitosan, using alkaline hydrolysis with the addition of cationic and anionic surfactants as promoters. The study compares the compatibility of chitosan with untreated and alkali-hydrolyzed fabrics through the analysis of mechanical and physico-chemical properties. The results show that alkaline hydrolysis of polyester fabric has the best potential for functionalization with chitosan, and the addition of surfactants as promoters is not necessary in the pretreatment process phase.
Review
Pharmacology & Pharmacy
Maria Karayianni, Theodore Sentoukas, Athanasios Skandalis, Natassa Pippa, Stergios Pispas
Summary: This review summarizes the recent developments in chitosan-based nanoparticles as nucleic acid delivery vehicles and gene therapy vectors, with special attention given to the technological aspects of chitosan complexes for nucleic acid delivery.
Article
Biochemistry & Molecular Biology
J. Andres Ortiz, Francesca Antonella Sepulveda, Concepcion Panadero-Medianero, Paola Murgas, Manuel Ahumada, Humberto Palza, Betty Matsuhiro, Paula A. Zapata
Summary: In this study, pH-responsive CMA/CS hydrogels were prepared and the model drug DS was successfully loaded into the PCE. The results showed that the hydrogels had high loading capacity and release efficiency. Cell viability assay demonstrated the non-toxic nature of the hydrogels. Therefore, CMA/CS PECs can be applied for dermal drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Abraham Garcia-Jimenez, Angelica Roman-Guerrero, Cesar Perez-Alonso, Benoit Fouconnier
Summary: This study investigates the effect of pH and ionic strength on the association interactions and phase separations in polyelectrolyte systems. The results show that the structure and phase transitions can be controlled by modifying the ionization degree, pKa, and charge screening. The findings provide insights into the functional properties of complexed polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Geeta Kumari Wasupali, Devendra Verma
Summary: This study investigated the effect of hydrothermal treatment on polyelectrolyte complex (PEC) fibrous biomaterials and its impact on scaffold morphology, cell viability, and function. The results showed that hydrothermal treatment increased the interconnectivity and pore size of the fibers, and improved the stiffness and aqueous stability of the scaffold. Additionally, scaffolds fabricated at 90 degrees C promoted better cell attachment, proliferation, and osteogenic differentiation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Chemistry, Applied
Michal Dziadek, Kinga Dziadek, Szymon Salagierski, Mariola Drozdowska, Andrada Serafim, Izabela-Cristina Stancu, Piotr Szatkowski, Aneta Kopec, Izabella Rajzer, Timothy E. L. Douglas, Katarzyna Cholewa-Kowalska
Summary: This study modified chitosan-based hydrogels with 2,3,4-trihydroxybenzaldehyde (THBA) for the first time and crosslinked them with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA). THBA served as a crosslinker, improving the mechanical properties, swelling capacity, and degradation rate of the hydrogels. It also exhibited high antioxidant activity and antiproliferative effect on cancer cells without harming normal cells. The addition of PC enhanced the mechanical strength of the hydrogels, while the combination with BG improved their stability in PBS. All hydrogels modified with BG showed the ability to mineralize in simulated body fluid (SBF). RA not only enhanced antioxidant and anticancer activities but also promoted the mineralization process.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Yan Huang, Yakov Lapitsky
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2017)
Article
Chemistry, Physical
Yuhang Cai, Yakov Lapitsky
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2017)
Article
Chemistry, Physical
Shuyue Huang, Mengmeng Zhao, Mahesh B. Dawadi, Yuhang Cai, Yakov Lapitsky, David A. Modarelli, Nicole S. Zacharia
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2018)
Article
Chemistry, Physical
Udaka K. de Silva, Kunal Choudhuri, Amanda C. Bryant- Friedrich, Yakov Lapitsky
Article
Chemistry, Multidisciplinary
Udaka K. de Silva, Jennifer L. Brown, Yakov Lapitsky
Article
Pharmacology & Pharmacy
Yuhang Cai, Yakov Lapitsky
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2019)
Article
Biophysics
Yuhang Cai, Yakov Lapitsky
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Biochemistry & Molecular Biology
Claudia E. Echeverri-Cuartas, Carmina Gartner, Yakov Lapitsky
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Physical
Sabrina S. Alam, Carolina B. Mather, Youngwoo Seo, Yakov Lapitsky
Summary: PAH/TPP coacervates allow for multi-month release of small, water-soluble molecules, such as anionic and cationic surfactants. The properties and performance of the coacervates in encapsulating and releasing cationic surfactants depend on the mixing order, concentration, and binding strength.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Kunal Choudhuri, Joshua D. Bastian, Jeremiah T. Berger, Udaka K. de Silva, Yakov Lapitsky
Summary: Template polymerization is an effective technique for generating nanoparticles with tunable, narrowly dispersed sizes and high yields. In this study, sub-50-nm PEC nanoparticles were synthesized through one-step free-radical polymerization on a polycationic template. The resulting particles showed narrow size distributions and could be readily tuned by adjusting the parent solution concentration.
COLLOID AND POLYMER SCIENCE
(2022)
Article
Polymer Science
Wesam A. A. Hatem, Yakov Lapitsky
Summary: Mechanical stimulation can accelerate the release of small molecules from complex coacervates and result in a deswelling effect. The mechanical activation effect is most pronounced in water and only subtle and short-lived in phosphate buffered saline.
Article
Nanoscience & Nanotechnology
Sabrina S. Alam, Youngwoo Seo, Yakov Lapitsky
ACS APPLIED BIO MATERIALS
(2020)
Article
Polymer Science
Andrew J. Worthen, Kelly S. Irving, Yakov Lapitsky
Article
Biophysics
Nader Sawtarie, Yuhang Cai, Yakov Lapitsky
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)
Article
Materials Science, Biomaterials
Kunal Choudhuri, Udaka K. de Silva, Vincent Huynh, Ryan G. Wylie, Yakov Lapitsky
JOURNAL OF MATERIALS CHEMISTRY B
(2018)