Journal
COLLOID AND POLYMER SCIENCE
Volume 287, Issue 10, Pages 1207-1214Publisher
SPRINGER
DOI: 10.1007/s00396-009-2084-2
Keywords
Alginate bead; Glucose oxidase; Liposomes; Glucose-sensitive release
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Funding
- Special Forest Research Program [S120708L1701104]
- Korea Forestry Research Program, Korea Forest Service, Republic of Korea
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Egg PC (EPC) liposomes bearing a copolymer of N-isopropylacrylamide, methacrylic acid, and octadecylacrylate (P(NIPAM-co-MAA-co-ODA)) were prepared as pH-sensitive liposomes. They were embedded in glucose oxidase (GOD)-immobilized alginate beads. The ratio of EPC/GOD/alginate in the beads was 7.8:1.0:140.4, and the beads were added to glucose solutions so that the concentration of GOD was 0.0068 mg/ml. The enzymatic activity of the immobilized GOD was one fifth to half of that of native enzyme. As the glucose concentration increased from 0 to 400 mg/dl, the degree of calcein release increased from 17% to 75%. The acidification induced by the enzymatic reaction would be responsible for the glucose-triggered release.
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