Article
Public, Environmental & Occupational Health
Cheng Peng, Ziyi Wang
Summary: Most clinical stroke patients face difficulties in movement, affecting their self-care ability and quality of life, as well as disrupting the lives and work of family members. The near-infrared spectroscopy imaging technology (fNIRS) combines sports injury diagnosis with brain function mechanisms, offering fast and non-invasive detection of brain activity. fNIRS technology has proven valuable in the biomedical field, particularly in brain science, and can be used to detect hemodynamic changes during training, providing a basis for clinical application.
PREVENTIVE MEDICINE
(2023)
Article
Neurosciences
Giles Blaney, Cristianne Fernandez, Angelo Sassaroli, Sergio Fantini
Summary: This study focuses on the contamination of optical signals in non-invasive optical measurements of the human brain caused by superficial hemodynamics. The authors identified optimal source-detector distances for dual-slope measurements in frequency-domain near-infrared spectroscopy (NIRS) and demonstrated the preferential sensitivity of dual-slope imaging to deeper tissue (brain) compared to superficial tissue (scalp). The results showed that the mean distance between the two source-detector distances is the key factor for depth sensitivity. Dual-slope imaging with frequency-domain NIRS may suppress confounding contributions from superficial hemodynamics and has significant implications for non-invasive optical measurements of the human brain.
Article
Multidisciplinary Sciences
Xiaoxue Fu, John E. Richards
Summary: The study utilized photon propagation simulation methods to investigate the sensitivity profiles of diffuse optical tomography in realistic head models across different age groups. It found that the sensitivity profiles varied with different source-detector separation distances.
Review
Pharmacology & Pharmacy
Li Zhang, Yue Liu, Haiyan Huang, Hui Xie, Baozhu Zhang, Wujiong Xia, Bing Guo
Summary: Malignant brain tumors are a group of tumors with high invasiveness and destructiveness, and near-infrared optical imaging techniques show potential in the diagnosis and treatment of brain tumors due to their noninvasiveness, high resolution, and large penetration depth.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Neurosciences
Morris Vanegas, Miguel Mireles, Qianqian Fang
Summary: This study aims to create a systematic software platform for the design, characterization, and comparison of modular fNIRS probes. It provides examples of how parameters such as module shape, orientation, and spatial layout can affect probe performance, offering a new approach for the fNIRS user community to address the challenging problem of module and probe parameter selection and fine-tuning.
Article
Engineering, Environmental
Feng Liu, Biao Huang, Tao Tang, Fanjie Wang, Ran Cui, Mingxi Zhang, Taolei Sun
Summary: Researchers developed a fluorescent nanozyme by doping Mn atoms into PbS/CdS quantum dots, which showed excellent antioxidant activity and could effectively scavenge ROS, thus providing neuroprotective effects for traumatic brain injury treatment. Additionally, the nanozyme exhibited exceptional NIR-IIb fluorescence performance, allowing for dynamic monitoring of the blood-brain barrier status to guide precise treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Multidisciplinary Sciences
Zhuoran Ma, Feifei Wang, Weizhi Wang, Yeteng Zhong, Hongjie Dai
Summary: This study utilized artificial neural networks to transform fluorescence images in the shorter-wavelength NIR window to images resembling NIR-IIb window, achieving high signal-to-background ratio in vivo lymph node imaging with human-approved molecular probes. Translation of PD-L1 or EGFR imaging greatly enhanced tumor-to-normal tissue ratio and improved tumor margin localization, showcasing the potential of deep learning in enhancing noninvasive NIR imaging and microscopy. Deep learning equipped NIR imaging could facilitate basic biomedical research and clinical diagnostics and imaging-guided surgery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Computer Science, Software Engineering
Weiwei Jiang, Difeng Yu, Chaofan Wang, Zhanna Sarsenbayeva, Niels van Berkel, Jorge Goncalves, Vassilis Kostakos
Summary: This article introduces a low-cost and practical method for non-invasive inspection using a miniaturized near-infrared spectroscopy scanner and a computer-controlled 2D plotter. The method can successfully extract occluded text through a paper stack of up to 16 pages and improve image quality and decompose overlapping content using a deep-learning-based image enhancement model. It can also be applied to different inks and other layered materials. The approach enables various content embedding applications, including chipless information embedding, physical secret sharing, 3D print evaluations, and steganography.
ACM TRANSACTIONS ON GRAPHICS
(2023)
Article
Optics
Yanyan Li, Haijun Luo, Xinyan Fan, Yi Lv, Xiru Xie, Xia Luo, Pan Guo
Summary: Near-infrared spectroscopy (NIRS) is a noninvasive and portable technique that shows great advantages in early diagnosis of craniocerebral hematoma. In this study, brain tissue models of different types and depths of hematoma were simulated using COMSOL finite element simulation software, and the imaging results were optimized using an imaging algorithm and the derivative peak sharpening method. The results demonstrate that NIRS can accurately image single-target hematoma, with a coordinate offset within 1.4 mm. The accuracy of dual-target hematoma imaging is limited, but can be improved by optimizing the imaging effect through derivative peak sharpening and multidirectional measurement. The array scanning detector can detect information about hematomas located up to a depth of about 14 mm in the subcutaneous tissue.
LASER PHYSICS LETTERS
(2022)
Article
Engineering, Environmental
Takato Uema, Toshiya Ohata, Yutaka Washizuka, Ryo Nakanishi, Daisuke Kawashima, Naoto Kakuta
Summary: This paper presents a near-infrared imaging method for measuring concentrations of acid, base, and produced salt simultaneously in a microfluidic channel. Linear correlation models are used to convert absorbance to concentrations, and the images show clear concentration changes and salt production at the interface between acid and base solutions. This method has potential for analyzing reactions, mixing, and separation between aqueous components.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Ke Zhang, Fu-Rong Chen, Lidai Wang, Jinlian Hu
Summary: In this review, the advantages and various imaging technologies of near-infrared-II (NIR-II) bioimaging for deep brain imaging are discussed, along with the corresponding contrast agents. The applications of NIR-II bioimaging in visualizing cerebrovascular characteristics and monitoring pathology signals, as well as its potential for modulating brain structure and function, are outlined. Future perspectives for improving the clinical translation of NIR-II light are also proposed.
Article
Chemistry, Multidisciplinary
Samir Rosas, Keegan A. Schoeller, Edward Chang, Hongyan Mei, Mikhail A. Kats, Kevin W. Eliceiri, Xinyu Zhao, Filiz Yesilkoy
Summary: Label-free and nondestructive mid-infrared vibrational hyperspectral imaging is an important tissue analysis tool that provides spatially resolved biochemical information. This study introduces an advanced mid-infrared spectrochemical tissue imaging modality using metasurfaces to capture quantitative molecular maps of large-area murine brain tissue sections. The results demonstrate that plasmonic metasurfaces enhance chemical contrast in infrared images and enable the detection of ultrathin tissue regions. This imaging method has the potential to have a broad impact on translational research and clinical histopathology.
ADVANCED MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Sander De Bruyne, Marijn M. Speeckaert
Summary: Traditional renal biomarkers are insensitive for early detection of kidney disease. Infrared spectroscopy offers a label-free and non-destructive method for quick and inexpensive diagnosis of kidney disorders. This review provides an overview of the applications of near- and mid-infrared spectroscopy in patients with acute kidney injury and chronic kidney disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Analytical
Maria Roldan, Panayiotis A. Kyriacou
Summary: Traumatic brain injury (TBI) occurs when sudden trauma causes damage to the brain, with secondary injuries potentially affecting cerebral oxygenation and autoregulation. Near-infrared spectroscopy (NIRS) is a potential noninvasive monitoring technique for assessing TBI early, based on chromophore absorption of infrared light.
Article
Neurosciences
Rihui Li, Hadi Hosseini, Manish Saggar, Stephanie Christina Balters, Allan L. Reiss
Summary: Functional near-infrared spectroscopy (fNIRS) is a noninvasive optical imaging technique used to assess human brain activity. It has been widely used in psychiatric research and clinical practice due to its mobility, low cost, and tolerance for motion. This article summarizes the applications of fNIRS in psychiatry, the development of fNIRS instruments, and new study designs to explore brain activity associated with psychiatric disorders. The challenges and future perspectives of fNIRS in psychiatric research and clinical practice are also discussed.