Article
Multidisciplinary Sciences
Shixie Jiang, Jingyu Huang, Hao Yang, Ryan Wagoner, F. Andrew Kozel, Glenn Currier, Huabei Jiang
Summary: This study utilized a novel diffuse optical tomography (DOT) device to investigate the neurophysiological effects of rTMS in depressed and healthy subjects. The results demonstrated that depressed subjects had a delayed and less robust response to rTMS with decreased volume of activation compared to healthy subjects.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Ronald E. See, Branon Eusebio, David Agnew, Mark Heatwole
Summary: The study found that steroid hormones may not be reliable biomarkers of treatment response in patients with major depressive disorder undergoing repetitive transcranial magnetic stimulation (rTMS). While rTMS significantly improved symptoms, salivary biomarker levels did not show significant changes during the treatment sessions.
PSYCHIATRY RESEARCH
(2021)
Review
Clinical Neurology
Danielle Hett, Jack Rogers, Clara Humpston, Steven Marwaha
Summary: The existing literature suggests that rTMS could be effective in reducing depressive symptoms in adolescents, yet caution is needed due to the lack of sham controlled randomized trials. The studies suffered from multiple biases, limiting the interpretation and generalization of the results.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Brenton Hordacre, Kristina Comacchio, Lindy Williams, Susan Hillier
Summary: The study demonstrated that active rTMS significantly improved depression in stroke survivors and was well tolerated. The mechanistic role of theta frequency functional connectivity may warrant further investigation.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Hannah Ford, Lisa Hahn, Patrick Clarke, Shane Gill, Ben Carnell, Cherrie Galletly
Summary: In this study, it was found that 15-minute and 30-minute rTMS treatments showed no significant difference in partial response, response, and remission rates for treatment resistant depression, indicating that shorter treatment sessions were just as effective as longer sessions.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Computer Science, Interdisciplinary Applications
Matthew Squires, Xiaohui Tao, Soman Elangovan, Raj Gururajan, Xujuan Zhou, Yuefeng Li, U. Rajendra Acharya
Summary: Repetitive Transcranial Magnetic Stimulation (rTMS) is an evidence-based treatment for depression. Machine learning techniques combined with functional magnetic resonance imaging (fMRI) connectivity can predict treatment outcomes before the start of rTMS treatment. This study demonstrates that the proposed model outperforms existing methods and identifies key biomarkers for predicting rTMS treatment response.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Neurosciences
Shinya Nakamura, Yodai Kishimoto, Masaki Sekino, Motoaki Nakamura, Ken-Ichiro Tsutsui
Summary: Using low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) to inhibit neural activity in the ventral region of the medial frontal cortex (vMFC), this study found that the vMFC plays a causal role in regulating mood and the LF-rTMS-induced dysfunction of the vMFC serves as a valid nonhuman primate model of depression. The study also demonstrated that LF-rTMS targeting the vMFC induced depression-like symptoms in monkeys, including reduced movement activity, impaired sociability, decreased motivation, and increased plasma cortisol level.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Roger S. McIntyre, Yena Lee, Nelson B. Rodrigues, Flora Nasri, Guohui Lao, Wan Zeng, Biru Ye, Ripeng Li, Joshua D. Rosenblat, Rodrigo B. Mansur, Mehala Subramaniapillai, Leanna M. W. Lui, Kayla M. Teopiz, Tao Liu, Jiaqi Xiong, Ruoxi Zhang, Weicong Lu, Guiyun Xu, Xiong Huang, Kangguang Lin
Summary: This pilot study investigated the effects of rTMS on cognitive function in patients with bipolar disorder, demonstrating significant improvements in select cognitive domains for the active rTMS group compared to the sham group. No dyscognitive effects were observed across subdomains.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
A. M. Heath, M. Brewer, J. Yesavage, M. W. McNerney
Summary: This study demonstrates that repetitive transcranial magnetic stimulation (rTMS) applied between learning and retrieval phases can effectively improve memory in mice by promoting synaptic connections and maintaining key pathways in neurons.
Article
Multidisciplinary Sciences
Chloe Stengel, Marine Vernet, Julia L. Amengual, Antoni Valero-Cabre
Summary: Correlational evidence suggests that increases in inter-regional synchrony in the high-beta frequency band can be modulated by rhythmic transcranial magnetic stimulation, leading to improvements in conscious visual perception sensitivity.
SCIENTIFIC REPORTS
(2021)
Review
Psychiatry
Victor M. Tang, Rachel Goud, Laurie Zawertailo, Peter Selby, Adina Coroiu, Matthew E. Sloan, Meghan Jo-Ann Chenoweth, Daniel Buchman, Christine Ibrahim, Daniel M. Blumberger, Bernard Le Foll
Summary: Tobacco smoking is a major contributor to preventable diseases and deaths globally. Repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive neurostimulation approach, is able to modulate the neurocircuitry associated with nicotine dependence and has shown efficacy in clinical trials, receiving regulatory approval in the US and Canada. However, there is limited access to this intervention, resulting in a lack of replication studies and real-world patient effectiveness data.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Eisa Almheiri, Abdullah Alhelali, Mohamed A. Abdelnaim, Franziska C. Weber, Berthold Langguth, Martin Schecklmann, Tobias Hebel
Summary: A study analyzed the response to repetitive transcranial magnetic stimulation (rTMS) treatment in 505 depressed patients, of which 15.5% were elderly. The results showed comparable efficacy of rTMS treatment in elderly patients as in younger patients, but differences were observed in some HDRS single items, which require further investigation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Yi-Wen Bai, Qi-Hao Yang, Pei-Jie Chen, Xue-Qiang Wang
Summary: Neuropathic pain is a common condition caused by damage or disease to the nervous system, and is associated with excessive inflammation. Repetitive transcranial magnetic stimulation (rTMS) is an adjunctive treatment for neuropathic pain, which can regulate the neuroinflammation system to produce analgesic effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Psychiatry
Enoch Ng, Sean M. Nestor, Jennifer S. Rabin, Clement Hamani, Nir Lipsman, Peter Giacobbe
Summary: This study found that individuals with major depressive disorder (MDD) and a seasonal pattern of symptoms responded similarly to repetitive transcranial magnetic stimulation (rTMS) treatment compared to those without a seasonal pattern.
PSYCHIATRY RESEARCH
(2023)
Review
Clinical Neurology
Min Zhang, Junjian Mo, Huiying Zhang, Yaoyin Tang, Kaiheng Guo, Xinyue OuYang, Linghua Huang, Xiaomei Zhong, Yuping Ning
Summary: The meta-analysis suggests that rTMS is an effective and well-tolerated treatment for patients with late-life depression (LLD). Further efforts are needed to improve study methodologies and increase the homogeneity of rTMS parameters to ensure comparability between studies.
JOURNAL OF AFFECTIVE DISORDERS
(2023)