Article
Biochemistry & Molecular Biology
Hui Tian, Yanwen Jiao, Mingyue Guo, Yilin Wang, Ruiqi Wang, Cao Wang, Xiongbiao Chen, Weiming Tian
Summary: In this study, we discovered the involvement of klf7 in regulating circadian rhythm. Knocking down klf7 disrupted circadian rhythm and led to autism-like behavior. We also observed downregulation of the Clock gene and disturbance of its downstream rhythm genes in the brain of klf7 knockout mice. Melatonin, a circadian regulation drug, was able to regulate the expression of rhythm genes in klf7 knockout cells and rescue the autistic behavior of klf7 knockout mice.
CELL AND BIOSCIENCE
(2022)
Article
Multidisciplinary Sciences
Annika F. Barber, Shi Yi Fong, Anna Kolesnik, Michael Fetchko, Amita Sehgal
Summary: Regulation of circadian behavior and physiology by the Drosophila brain clock requires communication from central clock neurons to downstream output regions. Morning and evening clock neurons have time-of-day-dependent connectivity to the pars intercerebralis, which is regulated by specific peptides and fast neurotransmitters. This study provides insights into mechanisms by which clock neurons signal to nonclock cells to drive rhythms of behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Shaunak Deota, Satchidananda Panda
Summary: Metabolic homeostasis is regulated by endocrine factors, signaling cascades, and metabolic pathways, which are also modulated by circadian rhythm. Disruption of circadian rhythm can increase the risk for metabolic diseases. Understanding factors affecting circadian rhythm allows for implementing new interventions to prevent and manage metabolic disorders.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Si-Ke He, Jia-Hao Wang, Tao Li, Shan Yin, Jian-Wei Cui, Yun-Fei Xiao, Yin Tang, Jia Wang, Yun-Jin Bai
Summary: This article reviews the relationship between circadian rhythm disturbance and kidney stone disease (KSD), summarizing the risk factors and treatment methods. The results indicate that KSD is associated with systemic disorders such as metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis, and some chronotherapies have been proven effective.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Yujie Hu, Yefan Lv, Xiaoyan Long, Guoshuai Yang, Jinxia Zhou
Summary: This study investigated the effects of melatonin on chronic rapid eye movement sleep deprivation-induced cognitive impairment and circadian dysfunction. The findings suggest that melatonin treatment attenuates cognitive deficits caused by sleep deprivation by regulating the interaction between HDAC3, Bmal1, and Clock.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Nutrition & Dietetics
An-Yu Xia, Hui Zhu, Zhi-Jia Zhao, Hong-Yi Liu, Peng-Hao Wang, Lin-Dan Ji, Jin Xu
Summary: This article focuses on the association between night-shift work, sleep disorders, and type 2 diabetes (T2DM), and highlights the involvement of circadian rhythm disruption. Several signaling pathways linking melatonin receptors MT1 and MT2 to insulin secretion and T2DM occurrence have been identified. This review provides a comprehensive explanation of these pathways and establishes a concrete molecular and evolutionary mechanism underlying the macroscopic association between circadian rhythm and T2DM. It offers new insights into the pathology, treatment, and prevention of T2DM.
Article
Endocrinology & Metabolism
Jeanne F. Duffy, Wei Wang, Joseph M. Ronda, Charles A. Czeisler
Summary: Aging is associated with changes in sleep, and improving sleep can have important consequences for the health and quality of life of older adults. Melatonin, especially at higher doses, may be a viable option for sleep aid in older adults, as it can increase sleep efficiency during both the day and night.
JOURNAL OF PINEAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Linh Pham, Leonardo Baiocchi, Lindsey Kennedy, Keisaku Sato, Vik Meadows, Fanyin Meng, Chiung-Kuei Huang, Debjyoti Kundu, Tianhao Zhou, Lixian Chen, Gianfranco Alpini, Heather Francis
Summary: The daily rhythmicity in our body is controlled by a circadian clock in the suprachiasmatic nucleus in the hypothalamus. Mast cells play a protective role against pathogens and inflammation and are associated with the circadian rhythm. Melatonin and histamine modulate circadian rhythms by regulating NF-kappa B, offering a promising therapeutic strategy for MC-mediated inflammatory diseases.
JOURNAL OF PINEAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Dmytro Boiko, Anastasiia D. Shkodina, Mohammad Mehedi Hasan, Mainak Bardhan, Syeda Kanza Kazmi, Hitesh Chopra, Prerna Bhutra, Atif Amin Baig, Andrii M. Skrypnikov
Summary: Depressive disorders involve multiple physiological systems and disruption of circadian rhythms. Melatonin, through its action on MT1 and MT2 receptors, may serve as a potential target for novel antidepressants by regulating neurotrophins, neurotransmitters, and reducing inflammation. Targeting melatonergic receptors could improve the quality of therapeutic interventions in treating depression.
NEUROCHEMICAL RESEARCH
(2022)
Review
Cell Biology
Yihao Tian, Jian Ming
Summary: Osteoporosis is a common and impactful disease with no known treatments. Recent studies have shown that melatonin can be used to treat osteoporosis by regulating biological rhythms in bone tissue, promoting bone formation and inhibiting bone resorption. This review provides an overview of these processes and offers treatment and management strategies for individuals with osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Analytical
Meenakshi Pundir, Liubov Lobanova, Silvana Papagerakis, Xiongbiao Chen, Petros Papagerakis
Summary: This study presents the development of a novel colorimetric assay for the rapid and sensitive detection of salivary melatonin. The assay showed high sensitivity and selectivity, and could be used in a point-of-care system to accurately diagnose and monitor circadian rhythm sleep disorders.
ANALYTICA CHIMICA ACTA
(2023)
Review
Medicine, Research & Experimental
Eleni Pitsillou, Julia Liang, Andrew Hung, Tom C. Karagiannis
Summary: Circadian rhythms are regulated by a central oscillator in the brain's suprachiasmatic nucleus, which synchronises internal clocks in peripheral organs. Disruptions in the circadian machinery can lead to changes in protein activity and gene expression, contributing to various diseases. Misalignment between internal clocks and external stimuli can result in circadian misalignment, and as research progresses, small molecules may be used to modulate proteins involved in circadian cycles.
Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xiaomeng Liu, Niuben Cao, Xinchan Liu, Yu Deng, Yu Xin, Ruobing Fu, Xirui Xin, Yubo Hou, Weixian Yu
Summary: Circadian rhythms play a crucial role in regulating the body's homeostasis, and circadian rhythm disorders can have detrimental effects on metabolic and immune functions. However, the relationship between circadian rhythm disorders and periodontitis has not been well studied. This research aimed to investigate the role of the circadian rhythm control gene BMAL1 in periodontitis. The results showed that downregulation of BMAL1 in circadian rhythm disorder-induced periodontitis led to significant alveolar bone resorption, increased osteoclast differentiation, upregulation of the inflammatory signaling molecule NF-kappa B, elevated apoptosis and oxidative stress levels in periodontal tissues. This study suggests that BMAL1 is a key regulator in periodontitis exacerbated by circadian rhythm disorders, highlighting a potential avenue for periodontitis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Zhihao Xiao, Cheng Xu, Qian Liu, Qing Yan, Jingjia Liang, Zhenkun Weng, Xin Zhang, Jin Xu, Dong Hang, Aihua Gu
Summary: This prospective cohort study suggests that night shift work is associated with incident hypertension, and this association is modified by genetic susceptibility to hypertension. The findings of this study indicate a joint effect of night shift work and genetic risk on hypertension.
MAYO CLINIC PROCEEDINGS
(2022)
