Article
Neurosciences
Paloma Barjola, Irene Pelaez, David Ferrera, Jose Luis Gonzalez-Gutierrez, Lilian Velasco, Cecilia Penacoba-Puente, Almudena Lopez-Lopez, Roberto Fernandes-Magalhaes, Francisco Mercado
Summary: This study revealed the presence of dysfunction in pain expectation mechanisms in fibromyalgia patients, which may result in worsening symptoms and ineffective pain coping strategies. Understanding the neural correlates of pain processing is crucial for treating chronic pain syndromes.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Anesthesiology
Juan Antonio Valera-Calero, Edurne Ubeda-D'Ocasar, Jose Luis Arias-Buria, Cesar Fernandez-de-las-Penas, Gracia Maria Gallego-Sendarrubias, Margarita Cigaran-Mendez
Summary: This study found that age, pain intensity at rest and pain during daily living activities, anxiety levels and pressure pain sensitivity are associated with the central sensitization inventory (CSI) in women with fibromyalgia (FMS).
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Anesthesiology
Daniel Whibley, David A. Williams, Daniel J. Clauw, Martin J. Sliwinski, Anna L. Kratz
Summary: This study investigates the relationship between pain intensity and cognitive function, revealing that an increase in pain is associated with an increase in cognitive dysfunction, especially for individuals with fibromyalgia. This finding has significant implications for the treatment and prognosis of fibromyalgia.
Article
Multidisciplinary Sciences
Justyna Swidrak, Ana Arias, Edgar Rodriguez de la Calle, Antonio Collado Cruz, Maria V. Sanchez-Vives
Summary: Chronic pain alters bodily perception and affects the ownership of a body. The study examined whether women with fibromyalgia are receptive to virtual bodily illusions and what factors influence this experience. The findings showed that patients with FM can experience virtual embodiment and their reactions vary depending on affective responses, cognitive body distortions, and symptom intensity. It is important to consider individual differences among patients in future VR-based interventions.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Janell S. Payano Sosa, Joyce T. Da Silva, Shana A. B. Burrowes, Soo Y. Yoo, Michael L. Keaser, Timothy F. Meiller, David A. Seminowicz
Summary: Research showed that BMS type I patients exhibited higher pain sensitivity on the forearm to phasic heat stimuli, but no differences in pain thresholds regardless of time of day or body area tested. However, they had lower warmth and cold detection thresholds on the forearm and lower warmth detection threshold on the face. These differences were more pronounced in the morning.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Psychiatry
Lan Duo, Xintong Yu, Ruihan Hu, Xiping Duan, Jia Zhou, Ke Wang
Summary: Chronic pain and sleep disorders are common problems that seriously affect patients' quality of life, but there is still a lack of comprehensive understanding of this comorbidity. This review article summarizes the prevalence of comorbid sleep disorders in chronic pain patients, sleep detection methods, sleep characterization in chronic pain, the impact of sleep disorders on chronic pain, and current therapies. The neurochemical mechanisms underlying the comorbidity of chronic pain with sleep disorders are still limited.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Anesthesiology
Ericka N. Merriwether, Nilesh M. Agalave, Dana L. Dailey, Barbara A. Rakel, Sandra J. Kolker, Melissa E. Lenert, William H. Spagnola, Ying Lu, Katharine M. Geasland, Lee-Ann H. Allen, Michael D. Burton, Kathleen A. Sluka
Summary: This study found that IL-5 secretion from monocytes was higher in women with FM compared to those without pain, and its levels were significantly associated with pain and other relevant symptoms of FM. Furthermore, in FM patients, higher pain levels were linked to lower percentage of intermediate monocytes and higher percentage of nonclassical monocytes. Animal models also showed that IL-5 could induce analgesia and transform monocytes towards an anti-inflammatory phenotype, suggesting a potential role of IL-5 in managing pain in FM.
Article
Neurosciences
L. R. Fischer-Jbali, C. Montoro, P. Montoya, W. Halder, S. Duschek
Summary: This study investigated the central nervous correlates of affective and attentional processing in fibromyalgia syndrome (FMS) through an implicit task. The results showed that FMS patients exhibited abnormal brain potentials and attention deficits, with task performance being more closely related to pain severity.
Review
Neurosciences
Kirsty Bannister, Rory V. Smith, Patrick Wilkins, Tatum M. Cummins
Summary: Patients with Parkinson's disease may live for many years after diagnosis, experiencing a range of symptoms including persistent pain. However, limited treatment options and incomplete understanding of the mechanisms underlying pain in PD pose challenges. The heterogeneity and methodological differences in research studies lead to inconclusive evidence and a lack of clear conclusions.
NPJ PARKINSONS DISEASE
(2021)
Article
Multidisciplinary Sciences
Carmen M. Galvez-Sanchez, Pablo de la Coba, Jose M. Colmenero, Gustavo A. Reyes del Paso, Stefan Duschek
Summary: The study compared attentional performance between patients with FMS and RA, finding that FMS patients exhibited longer reaction times and more errors in attention tests compared to RA patients and healthy individuals. The differences in performance did not vary by experimental conditions, suggesting a general attentional deficit in FMS rather than specific impairments in different attention domains.
Article
Clinical Neurology
Daniel Ta, Abdullah Ishaque, Ojas Srivastava, Chris Hanstock, Peter Seres, Dean T. Eurich, Collin Luk, Hannah Briemberg, Richard Frayne, Angela L. Genge, Simon J. Graham, Lawrence Korngut, Lorne Zinman, Sanjay Kalra
Summary: The study found that ALS patients have reduced NAA ratios in the motor cortex, which are associated with more rapid disease progression and greater UMN signs. Prefrontal cortex NAA ratios were only reduced in cognitively impaired patients. The use of standardized imaging protocols may play a role in clinical trials for patient selection or subgrouping.
Review
Pharmacology & Pharmacy
Stephanie L. Bourke, Anne Katrin Schlag, Saoirse Elizabeth O'Sullivan, David J. Nutt, David P. Finn
Summary: Fibromyalgia is a condition characterized by chronic widespread musculoskeletal pain, generalised hyperalgesia, and psychological distress. The endocannabinoid system has been found to play a significant role in pain modulation and the stress response. Inhibition of fatty acid amide hydrolase (FAAH) has shown promise in preclinical studies, but more research is needed to assess the therapeutic potential of cannabinoids in fibromyalgia.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Kuo-Tung Tang, Tsai-Ling Liao, Yi-Hsing Chen, Der-Yuan Chen, Kou-Lung Lai
Summary: In this study, FM patients were treated with subcutaneous tocilizumab and their symptoms were evaluated using various questionnaires. The results showed significant improvements in symptoms after treatment. However, a randomized controlled trial is needed to confirm the efficacy of tocilizumab for FM patients.
Article
Biochemistry & Molecular Biology
Edurne Ubeda-D'Ocasar, Juan Antonio Valera-Calero, Gracia Maria Gallego-Sendarrubias, Cesar Fernandez-de-Las-Penas, Jose Luis Arias-Buria, Matilde Morales-Cabezas, Lars Arendt-Nielsen, Margarita Cigaran-Mendez
Summary: This study found a good convergent association between S-LANSS and PainDETECT in women with FMS. Additionally, S-LANSS was associated with PPTs whereas PainDETECT was associated with pain intensity and CSI, suggesting that both questionnaires assess different spectrums of the neuropathic and pain sensitization components of the condition and hence provide synergistic information.
Review
Biochemistry & Molecular Biology
Martina Favretti, Cristina Iannuccelli, Manuela Di Franco
Summary: Fibromyalgia is a complex and heterogeneous clinical syndrome characterized by widespread pain and various other symptoms, negatively impacting the lives of patients. The diagnosis of fibromyalgia is still clinical, leading to diagnostic uncertainties and patient dissatisfaction. Research for a specific biomarker for fibromyalgia has been unsuccessful. The discovery of a reliable biomarker would aid in early identification and intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)