Article
Clinical Neurology
Isabel C. Hostettler, Ghil Schwarz, Gareth Ambler, Duncan Wilson, Gargi Banerjee, David J. Seiffge, Clare Shakeshaft, Surabhika Lunawat, Hannah Cohen, Tarek A. Yousry, Rustam Al-Shahi Salman, Gregory Y. H. Lip, Martin M. Brown, Keith W. Muir, Henry Houlden, Hans Rolf Jager, David J. Werring
Summary: CT-based cerebral small vessel disease biomarkers are associated with 6-month functional outcome after intracerebral hemorrhage, but adding them does not significantly improve the performance of the existing ICH prediction score.
Article
Multidisciplinary Sciences
Diego Velasco-Rodriguez, Juan-Manuel Alonso-Dominguez, Rosa Vidal Laso, Daniel Lainez-Gonzalez, Aranzazu Garcia-Raso, Sara Martin-Herrero, Antonio Herrero, Ines Martinez Alfonzo, Juana Serrano-Lopez, Elena Jimenez-Barral, Sara Nistal, Manuel Perez Marquez, Elham Askari, Jorge Castillo Alvarez, Antonio Nunez, Angel Jimenez Rodriguez, Sarah Heili-Frades, Cesar Perez-Calvo, Miguel Gorgolas, Raquel Barba, Pilar Llamas-Sillero
Summary: A predictive model for in-hospital mortality of COVID-19 patients was developed, calibrated and validated, showing age, male gender, D-dimer levels, and prolonged PT as independently associated with increased mortality.
Article
Medicine, General & Internal
Kemal Goekcek, Aysel Goekcek, Ahmet Demir, Birdal Yildirim, Ethem Acar, Oemer Dogan Alatas
Summary: This study found that the shock index (SI), modified shock index (MSI), age shock index (ASI), and pulmonary embolism severity index (PESI) were significantly associated with in-hospital mortality in patients with acute pulmonary embolism. Among these indexes, ASI had the best predictive performance in identifying patients at risk for in-hospital mortality.
Article
Acoustics
J. E. Powel, E. W. Zantow, M. F. Bialko, L. G. Farley, M. L. Lawlor, S. J. Mullan, L. K. Vricella, T. M. Tomlinson
Summary: An index predictive of adverse perinatal outcome (APO) in pregnancies with fetal growth restriction (FGR) has been developed and validated. This index incorporates seven clinical factors that are readily available at the time of FGR diagnosis, providing useful information for counseling and management of FGR pregnancies.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Multidisciplinary Sciences
Henos Kiflom Zewde
Summary: This study evaluates the association between various process and timeliness indicators of comprehensive emergency obstetric care (CEmOC) and adverse maternal outcome in Keren Hospital. The study found that failure to provide necessary medication for postpartum hemorrhage, failure to administer prophylactic antibiotics, and delayed treatment for uterine rupture were significantly associated with adverse maternal outcomes. Delays in referral, triaging, seeing an obstetrician, and receiving definitive treatment were also strongly associated with adverse outcomes. Factors contributing to delay included erroneous diagnosis, inappropriate management, multiple referrals, unavailability of a senior obstetrician, and poor communication during referral. The study concludes that improving the referral system, upgrading the skills of health professionals, ensuring availability of life-saving drugs and equipment, and implementing standard management protocols are vital in reducing adverse maternal outcomes in Keren Hospital.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Adrian Diaz, Joal D. Beane, J. Madison Hyer, Diamantis Tsilimigras, Timothy M. Pawlik
Summary: This study aimed to investigate the impact of high-versus low-quality hospitals on the risk of adverse outcomes among patients undergoing hepatopancreatic surgery relative to social vulnerability. The results showed that socially vulnerable patients had considerably better outcomes at high-quality hospitals.
Article
Cardiac & Cardiovascular Systems
Mengyuan Miao, Yucong Bi, Lijun Hao, Anran Bao, Yaming Sun, Huaping Du, Liyan Song, Shoujiang You, Chongke Zhong
Summary: The study aimed to investigate the early prognostic value of the TyG index in patients with ischemic stroke. The results demonstrated that a higher TyG index was associated with an increased risk of unfavorable functional outcome at discharge and in-hospital mortality in patients with ischemic stroke.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Medicine, General & Internal
Maria Giulia Mosconi, Maurizio Paciaroni, Giancarlo Agnelli, Martino Marzano, Andrea Alberti, Michele Venti, Monica Acciarresi, Fabrizio Ruffini, Valeria Caso
Summary: In this study, the use of SMASH-U classification system for ICH patients revealed that systemic disease and medication groups were associated with intra-hospital mortality rates, while age and high NIHSS at admission were also significantly associated with mortality. The study suggests that the aetiology-oriented classification system may help predict intra-hospital mortality in acute haemorrhagic stroke patients and support clinicians in management.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Clinical Neurology
I. Putu Eka Widyadharma, Angga Krishna, Andreas Soejitno, A. A. A. Putri Laksmidewi, Kumara Tini, I. B. Kusuma Putra, I. G. N. Budiarsa, I. A. Sri Indrayani
Summary: The modified ICH (mICH) score was found to be more accurate and effective in predicting 30-day mortality and good outcome for non-traumatic ICH patients compared to the original ICH score (oICH).
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Tufan Cinar, Mert Ilker Hayiroglu, Vedat Cicek, Sahhan Kilic, Suha Asal, Samet Yavuz, Murat Selcuk, Emre Yalcinkaya, Nurgul Keser, Ahmet Lutfullah Orhan
Summary: This study revealed that the prognostic nutritional index (PNI) is closely associated with in-hospital mortality in patients with COVID-19 and cardiovascular risk factors. The predictive value of PNI was shown to be higher than other indicators such as CURB-65 and 4C mortality risk scores.
Article
Medicine, General & Internal
Jonas Rusnak, Tobias Schupp, Kathrin Weidner, Marinela Ruka, Sascha Egner-Walter, Jan Forner, Thomas Bertsch, Maximilian Kittel, Kambis Mashayekhi, Peter Tajti, Mohamed Ayoub, Michael Behnes, Ibrahim Akin
Summary: Cardiogenic shock (CS) patients with in-hospital cardiac arrest (IHCA) have higher 30-day all-cause mortality compared to those with out-of-hospital cardiac arrest (OHCA). This association is primarily driven by patients with acute myocardial infarction (AMI), while IHCA is not associated with mortality in non-AMI patients. Multivariable analysis confirms that IHCA is solely associated with higher 30-day all-cause mortality in AMI patients, but not in the non-AMI group and CAD subgroups. CS patients with IHCA and AMI have significantly increased all-cause mortality at 30 days, while there is no difference when differentiated by CAD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
F. Stellingwerf, L. F. E. Beumeler, H. Rijnhart-de Jong, E. C. Boerma, H. Buter
Summary: This study aimed to explore the predictive value of phase angle for 1-year mortality after ICU admission. The study found that a low phase angle was significantly associated with 1-year all-cause mortality, and a low phase angle was an independent predictor of 1-year mortality. This finding is important for assessing the long-term prognosis of ICU patients and designing treatment strategies.
CLINICAL NUTRITION
(2022)
Article
Infectious Diseases
Peng Xie, Wenqiang Wang, Maolong Dong
Summary: The predictive model for 30-day mortality risk in ICU patients with fungemia constructed in this study exhibits good predictive ability, potentially offering a practical screening tool for patients with fungemia.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Medicine, General & Internal
Guoyang Dai, Xin Lu, Feng Xu, Deli Xu, Pengfei Li, Xionghui Chen, Fengbao Guo
Summary: This retrospective study analyzed clinical data of 283 acute trauma patients and found that Trauma Index (TI) performed the best in predicting early mortality risk, while different types of shock indices also had certain predictive value for early mortality risk in trauma patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Tingyu Zhang, Yuanni Liu, Ziruo Ge, Di Tian, Ling Lin, Zhenghua Zhao, Yi Shen, Xiaoli Yu, Yang Feng, Chunqian Qiang, Jianping Duan, Yanli Ma, Tianli Fan, Yongxiang Zhao, Zhihai Chen
Summary: The triglyceride-glucose index is strongly and independently associated with the risk of in-hospital death in patients with severe fever with thrombocytopenia syndrome (SFTS). It exhibits moderate-to-high strength in predicting in-hospital death and enhances the predictive value beyond baseline models.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Jian Lu, Sonia Samuel, Yasin Abdi Saed, Rongshan Li, Yafeng Li
JOURNAL OF NEPHROLOGY
(2022)
Article
Pharmacology & Pharmacy
Qingfeng Rong, Baosheng Han, Yafeng Li, Haizhen Yin, Jing Li, Yanjuan Hou
Summary: Berberine can alleviate diabetic renal tubulointerstitial injury by improving lipid metabolism, relieving lipid accumulation, and protecting mitochondria.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Lina Dong, Xiuzhao Fan, Qian Li, Jiankuan Li, Guangxin Chen, Dong Yang, Yafeng Li, Liping Zhao, Haizhen Yin, Xiaoyan Wang, Xiaojing Liu, Zhonghua Zhao, Shumei Lin
Summary: This study investigates the potential therapeutic value and mechanism of Anemone chinensis Bunge (AB) aqueous enema for ulcerative colitis (UC). The network pharmacology analysis demonstrated that AB may affect key targets and proteins related to UC. In a mouse model, AB aqueous enema alleviated colonic damage, restored tight junction proteins, and improved the diversity of gut microbiota.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jianbo Qing, Wenzhu Song, Lingling Tian, Sonia Biju Samuel, Yafeng Li
Summary: In this study, 23 hub genes closely related to interferon production and function were identified, and their expression was found to be positively correlated with immune cell infiltration in LN patients. Additionally, six small molecules were selected as potential drugs for treating lupus nephritis.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Immunology
Jian-Bo Qing, Wen-Zhu Song, Chang-Qun Li, Ya-Feng Li
Summary: This study investigates the diagnostic and predictive significance of DIRGs in IgAN, and finds that the imbalance between macrophages and CD4+ immune cells may be an important pathomechanism of IgAN.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Medicine, General & Internal
Wenzhu Song, Xiaoshuang Zhou, Qi Duan, Qian Wang, Yaheng Li, Aizhong Li, Wenjing Zhou, Lin Sun, Lixia Qiu, Rongshan Li, Yafeng Li
Summary: This study aimed to classify glomerular injury (GI) and tubular injury (TI) of chronic kidney disease (CKD) using machine learning algorithms. Through feature selection and model construction, Random Forest demonstrated superior performance in early diagnosis of GI and TI, providing potential benefits for the progression of CKD.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Hasnaa Yaigoub, Nada Fath, Hasna Tirichen, Changxin Wu, Rongshan Li, Yafeng Li
Summary: This article discusses the relationship between gut microbiota and systemic lupus erythematosus, highlighting the association between gut dysbiosis and the development of autoimmune diseases. It also proposes targeting gut microbiota as a potential therapeutic approach for SLE.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Qi Duan, Lingling Tian, Jiabing Feng, Xinbo Ping, Lihong Li, Hasnaa Yaigoub, Rongshan Li, Yafeng Li
Summary: This study aimed to investigate the protective effects of Trametenolic acid (TA) on diabetic nephropathy (DN) and its underlying mechanism. The results showed that TA administration significantly alleviated renal histopathological changes and improved renal function in DN mice. Furthermore, TA activated the Nrf2/HO-1 signaling pathway, inhibited NF-kappa B signaling, and reduced inflammation. These findings suggest that TA exhibits renoprotective effects by ameliorating oxidative stress and inflammation.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jianbo Qing, Fang Zheng, Huiwen Zhi, Hasnaa Yaigoub, Hasna Tirichen, Yaheng Li, Juanjuan Zhao, Yan Qiang, Yafeng Li
Summary: This study identified 274 common up-regulated or down-regulated immune-related genes (DIRGs) in the glomeruli and tubulointerstitium of various glomerulonephritis (GN) subtypes. These DIRGs are mainly involved in T-cell differentiation, the RAS signaling pathway, and the MAPK signaling pathway. Single-sample gene set enrichment analysis (ssGSEA) showed significant increases in dendritic cells (DC) and macrophages in glomeruli, and significant decreases in neutrophils and NKT cells. A nomogram model based on 7 DIRGs was constructed to predict GN, and 20 DIRGs for each GN subtype in glomeruli and tubulointerstitium were identified as characteristic genes.
Review
Medicine, General & Internal
Ting Cheng, Huiwen Zhi, Yunxiao Liu, Shengxiao Zhang, Ziyi Song, Yafeng Li
Summary: This study reports a case of rapidly progressive glomerulonephritis (RPGN) in a patient with concurrent rheumatoid arthritis (RA) and Sjogren's syndrome (SS), characterized by double positivity in anti-glomerular basement membrane (anti-GBM) antibodies and perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA). The patient showed significant improvement and renal function recovery after aggressive treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Wenqiang Zhi, Xiaoli Yuan, Wenzhu Song, Guorong Jin, Yafeng Li
Summary: This is the first report of fecal microbiota transplantation (FMT) in patients with chronic kidney disease. The patient experienced abnormal renal function and no proteinuria after medication, but FMT treatment stabilized renal function and reduced proteinuria. Additionally, FMT improved the patient's lipid profile.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Huimin Han, Yasin Abdi Saed, Wenzhu Song, Ming Wang, Yafeng Li
Summary: This study investigated the prevalence of respiratory pathogens and co-infection with SARS-CoV-2 in the early stage of the COVID-19 epidemic. The results showed that human rhinovirus was the most common infectious pathogen in November, while human respiratory syncytial virus appeared most frequently in December and January. Among the patients in Wuhan, 18.7% were infected with SARS-CoV-2, and only two children were coinfected with other respiratory pathogens. In Taiyuan, there was no detection of SARS-CoV-2 infection, but influenza A virus was detected most frequently in December and January.
Article
Mathematical & Computational Biology
Wenzhu Song, Lixia Qiu, Jianbo Qing, Wenqiang Zhi, Zhijian Zha, Xueli Hu, Zhiqi Qin, Hao Gong, Yafeng Li
Summary: This study used Bayesian Network model and algorithm to explore the risk factors for stroke, and found that age, fasting plasma glucose, systolic blood pressure, and family history of stroke are direct risk factors, while sex, educational levels, high density lipoprotein cholesterol, diastolic blood pressure, and urinary albumin-to-creatinine ratio are indirect risk factors.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Review
Chemistry, Multidisciplinary
Lingling Tian, Yi Wang, Jianbo Qing, Wenjing Zhou, Lin Sun, Rongshan Li, Yafeng Li
Summary: Kidney diseases are common worldwide, and triterpenes from Inonotus obliquus may have potential for treating and protecting against these diseases.
Article
Cell Biology
Hasnaa Yaigoub, Hasna Tirichen, Xiaohong Xin, Shuhong Shi, Changxin Wu, Rongshan Li, Yafeng Li
Summary: The study developed an efficient method for preparing single cell suspension from human kidney tissue puncture using digestive enzymes, achieving high purity and viability of cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
