Review
Clinical Neurology
Hsuan-Te Chu, Chih-Ming Cheng, Chih-Sung Liang, Wen-Han Chang, Chi-Hung Juan, Ying-Zu Huang, Jia-Shyun Jeng, Ya-Mei Bai, Shih-Jen Tsai, Mu-Hong Chen, Cheng-Ta Li
Summary: TBS is a more efficient treatment option for MD with favorable efficacy and tolerability. Research indicates that the TBS group had higher overall effect sizes, leading to improved depression response and remission rates.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Medicine, General & Internal
Lincheng Zhang, Bing Chen, Qigu Yao, Weiyan Chen, Weinan Yang, Weiji Yang, Lan He, Yuyan Zhang
Summary: The study found that acupuncture is more effective in improving post-stroke depression compared to antidepressant therapy, with significant clinical efficacy.
Review
Psychiatry
Amelia J. Scott, Louise Sharpe, Ben Colagiuri
Summary: The study found that there is little reporting on blinding in RCTs of antidepressants, with a high rate of blinding failure. Pharmaceutical company sponsorship predicted the assessment of blinding in trials, with unsponsored trials more likely to evaluate blinding.
PSYCHIATRY RESEARCH
(2022)
Review
Clinical Neurology
Min Zhang, Junjian Mo, Huiying Zhang, Yaoyin Tang, Kaiheng Guo, Xinyue OuYang, Linghua Huang, Xiaomei Zhong, Yuping Ning
Summary: The meta-analysis suggests that rTMS is an effective and well-tolerated treatment for patients with late-life depression (LLD). Further efforts are needed to improve study methodologies and increase the homogeneity of rTMS parameters to ensure comparability between studies.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Gustavo H. Vazquez, Anees Bahji, Juan Undurraga, Leonardo Tondo, Ross J. Baldessarini
Summary: The findings suggest that several modern antipsychotics and esketamine can be useful adjuncts to antidepressants for acute major depressive episodes, but lithium is slightly more effective and better tolerated.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Review
Geriatrics & Gerontology
Wa Cai, Xi-Fang Wei, Jing-Ruo Zhang, Chen Hu, Wei-Dong Shen
Summary: This systematic review and meta-analysis aimed to assess the clinical efficacy of acupuncture in late-life depression (LLD). A total of nine RCTs involving 603 participants were included. The results showed that acupuncture combined with antidepressants significantly reduced HAMD scores and had a higher cure rate compared with antidepressants alone. However, no significant difference was found between acupuncture and antidepressants in reducing HAMD scores and improving clinical outcomes. Acupuncture combined or not combined with antidepressants is an effective and safe treatment for LLD.
Review
Pharmacology & Pharmacy
Muhammad Youshay Jawad, Joshua D. Di Vincenzo, Felicia Ceban, Saja Jaberi, Leanna M. W. Lui, Emily S. Gillissie, Yazen Alnafeesi, Joshua D. Rosenblat, Roger S. McIntyre
Summary: Intranasal esketamine is a safe and effective treatment for individuals with treatment resistant depression and depression with suicidal ideation and behavior. It has been shown to decrease depressive symptoms, increase response and remission rates, and has no significant long-term side effects.
EXPERT OPINION ON DRUG SAFETY
(2022)
Review
Rehabilitation
Ping-an Zhu, Ju-Ying Xie, Howe Liu, Youliang Wen, Yin-Jin Shao, Xiao Bao
Summary: This review systematically assessed the effectiveness of 10-Hz rTMS in fibromyalgia. The results showed that 10-Hz high-frequency rTMS significantly reduced pain and improved quality of life, but did not improve depression.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Review
Clinical Neurology
Pengpeng Cao, Yuhao Li, Bei An, Lanxian Ye, Zheng Xu
Summary: Repetitive transcranial magnetic stimulation (rTMS) combined with antidepressants improved the efficacy of antidepressant medication in adults with depression, but its effectiveness and safety in children and adolescents with depression are still controversial.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Christopher Baethge, Cora Braun, Lena Rink, Guido Schwarzer, Jonathan Henssler, Tom Bschor
Summary: The study found that increasing the dose of tricyclic antidepressants has a slightly positive effect on antidepressant efficacy, but it is not statistically significant overall. While some comparisons showed a dose gradient, it was not significant in general, and higher doses of imipramine/desipramine were significantly superior to lower doses in efficacy. Drop-out rates increased with higher doses, but not significantly.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medicine, General & Internal
Andreas S. Lappas, Bartosz Helfer, Katarzyna Henke-Ciazynska, Myrto T. Samara, Nikos Christodoulou
Summary: This systematic review and meta-analysis assessed the efficacy, tolerability, and acceptability of Clonazepam in the treatment of acute mania. The results suggested that Clonazepam may be superior to a placebo in the acute phase of treatment and comparable to Lithium and Haloperidol in terms of efficacy, both acutely and in the medium to long term. Clonazepam may be an acceptable and well-tolerated treatment for acute mania, especially when used as an augmentation strategy. However, the limited sample sizes and underpowered comparisons restrict the generalizability of the findings and hinder firm clinical conclusions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Psychology, Clinical
Taishiro Kishimoto, Katsuhiko Hagi, Shunya Kurokawa, John M. Kane, Christoph U. Correll
Summary: This study conducted a systematic review and meta-analysis on the use of antipsychotics as monotherapy and adjunctive therapy for major depressive disorder (MDD). The results suggest significant differences in treatment response and tolerability among different antipsychotics, which have important implications for clinical care.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Jessica M. de Klerk-Sluis, Marloes J. Huijbers, Stephan Locke, Jan Spijker, Philip Spinhoven, Anne E. M. Speckens, Henricus G. Ruhe
Summary: The study found that cognitive reactivity (CR) and mindfulness were associated with relapse in remitted major depressive disorder (MDD) patients before the initiation of Mindfulness-based cognitive therapy (MBCT). Higher CR and lower mindfulness were found to increase the risk of relapse, while self-compassion and rumination were not associated with relapse. Particularly, for rumination, there was a significant interaction with the use of maintenance antidepressant medication, impacting its relationship with relapse.
DEPRESSION AND ANXIETY
(2022)
Review
Neurosciences
Youjia Qiu, Longyuan Li, Aojie Duan, Menghan Wang, Minjia Xie, Zhouqing Chen, Zhong Wang
Summary: This meta-analysis examined the efficacy and tolerability of nitrous oxide (N2O) in patients with major depressive disorder (MDD), and found that N2O had a significant effect in improving depression severity and increasing response and remission rates. However, patients treated with N2O had a higher risk of experiencing nausea or vomiting.
PSYCHOPHARMACOLOGY
(2023)
Review
Psychiatry
Damien Etchecopar-Etchart, Theo Korchia, Anderson Loundou, Pierre-Michel Llorca, Pascal Auquier, Christophe Lancon, Laurent Boyer, Guillaume Fond
Summary: This study found a high prevalence of comorbid major depressive disorder in schizophrenia patients, with factors like publication year, study size, assessment tools, comorbid conditions, demographics, hospitalizations, and antidepressant use influencing the prevalence rate. Further research is needed to explore other potential factors contributing to the high prevalence of SZ-MDD.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychology, Developmental
Sayuri Nakane, Sachiko Tanaka-Mizuno, Chika Nishiyama, Kenji Kochi, Madoka Yamamoto-Sasaki, Masato Takeuchi, Yusuke Ogawa, Yuko Doi, Masaru Arai, Yosuke Fujii, Toshiyuki Matsunaga, Toshiaki A. Furukawa, Koji Kawakami
Summary: Little is known about the prescription patterns of antipsychotic drugs among children and adolescents in Japan, particularly in outpatient settings. This study investigated the prevalence and trends of antipsychotic prescription among outpatients aged <= 17 years from 2006 to 2012. The results showed that the most common prescription pattern was second-generation antipsychotic monotherapy, with risperidone being the most frequently prescribed drug.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Letter
Psychology, Clinical
Yan Luo, Toshi A. Furukawa
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yusuke Tsutsumi, Yasushi Tsujimoto, Aran Tajika, Kenji Omae, Tomoko Fujii, Akira Onishi, Yuki Kataoka, Morihiro Katsura, Hisashi Noma, Ethan Sahker, Edoardo Giuseppe Ostinelli, Toshi A. Furukawa
Summary: The study examines the magnitude and variability of contextual effects (PCE) in placebo-controlled trials across various interventions. The results show that subjective outcomes are influenced more by specific intervention effects compared to objective or semiobjective outcomes. The study highlights the importance of considering each PCE individually in different clinical settings.
BMJ EVIDENCE-BASED MEDICINE
(2023)
Article
Oncology
Tatsuo Akechi, Takuhiro Yamaguchi, Megumi Uchida, Fuminobu Imai, Kanae Momino, Fujika Katsuki, Naomi Sakurai, Tempei Miyaji, Tomoe Mashiko, Masaru Horikoshi, Toshi A. Furukawa, Akiyo Yoshimura, Shinji Ohno, Natsue Uehiro, Kenji Higaki, Yoshie Hasegawa, Kazuhisa Akahane, Yosuke Uchitomi, Hiroji Iwata
Summary: This study investigated the effectiveness of smartphone problem-solving therapy and behavioral activation applications in breast cancer survivors. The results showed that smartphone psychotherapy offers a promising way to reduce fear of cancer recurrence in this population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Psychiatry
Katharine A. Smith, Louise M. Howard, Simone N. Vigod, Armando D'Agostino, Andrea Cipriani
Summary: The COVID-19 pandemic has exacerbated inequalities and risk factors for mental disorders, especially in perinatal mental health. Access to services has been reduced and perinatal anxiety and depressive symptoms have increased. Telepsychiatry offers advantages, but further examination is needed. Clinicians will need expertise in navigating a hybrid model and there is a need for urgent and coordinated guidance and planning across organizations involved in perinatal mental health care.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Barry Wright, Pasco Fearon, Megan Garside, Eleni Tsappis, Elaine Amoah, Danya Glaser, Victoria Allgar, Helen Minnis, Matthew Woolgar, Rachel Churchill, Dean McMillan, Peter Fonagy, Alison O'Sullivan, Michelle McHale
Summary: Attachment is important for promoting healthy social and emotional development in infants. However, many parenting interventions currently used in practice lack sufficient evidence to determine their effectiveness. This research aimed to identify commonly used interventions in the UK, evaluate their evidence base, and provide recommendations for future research and practice.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Mathematical & Computational Biology
Orestis Efthimiou, Jeroen Hoogland, Thomas P. A. Debray, Michael Seo, Toshiaki A. Furukawa, Matthias Egger, Ian R. White
Summary: When individual patient data from a randomized trial are available, statistical and machine learning methods can be used to develop models for predicting treatment effects and guide personalized treatment choices. This article proposes measures to evaluate personalized treatment effect predictions, including discrimination and calibration. The methods are applicable to different outcome types and prediction models.
STATISTICS IN MEDICINE
(2023)
Article
Mathematical & Computational Biology
Tasnim Hamza, Konstantina Chalkou, Fabio Pellegrini, Jens Kuhle, Pascal Benkert, Johannes Lorscheider, Chiara Zecca, Cynthia P. Iglesias-Urrutia, Andrea Manca, Toshi A. Furukawa, Andrea Cipriani, Georgia Salanti
Summary: In network meta-analysis (NMA), all relevant evidence about health outcomes with competing treatments is synthesized. The evidence can come from randomized clinical trials (RCT) or non-randomized studies (NRS) as individual participant data (IPD) or aggregate data (AD). A suite of Bayesian NMA and network meta-regression (NMR) models are introduced to allow for cross-design and cross-format synthesis. The models integrate a three-level hierarchical model for synthesizing IPD and AD into four approaches, accounting for differences in design and risk of bias (RoB) in the evidence.
RESEARCH SYNTHESIS METHODS
(2023)
Article
Health Care Sciences & Services
Catherine Henshall, Zoe Davey, Cynthia Srikesavan, Liam Hart, Dan Butcher, Andrea Cipriani
Summary: This study aimed to examine the engagement and acceptability of a web-based resilience training program for nurses and to compare the levels of resilience and psychological well-being between participants who completed the program and those who did not. The results showed that the program was acceptable, engaging, and perceived as useful by the participants, suggesting the need for similar programs to be evaluated in busy healthcare settings.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychiatry
Keita Tokumitsu, Norio Yasui-Furukori, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Kazutaka Shimoda, Reiji Yoshimura
Summary: This study investigated bipolar disorder patients in psychiatric clinics in Japan and found that 3.06% of patients required hospitalization within a year. Predictors of hospitalization included bipolar I disorder, lower baseline GAF scores, unemployment, substance abuse, and baseline mood state. These findings provide valuable guidance for clinicians in preventing hospitalization for bipolar disorder.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Nariko Katayama, Atsuo Nakagawa, Satoshi Umeda, Yuri Terasawa, Kazushi Shinagawa, Toshiaki Kikuchi, Hajime Tabuchi, Takayuki Abe, Masaru Mimura
Summary: This study aimed to assess the changes in resting-state functional connectivity (rsFC) between brain regions associated with future thinking after cognitive behavioral therapy (CBT) and examine the associations with clinical improvements. The findings showed that CBT enhanced the connectivity between the frontal pole and nucleus accumbens, leading to improvements in depressive symptoms, automatic thoughts, and depression recovery process.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Mathematical & Computational Biology
Hisashi Noma, Yasuyuki Hamura, Shonosuke Sugasawa, Toshi A. Furukawa
Summary: Network meta-analysis has been widely used in evidence-based medicine to evaluate the effectiveness of multiple treatments. The prediction interval, which incorporates uncertainties and heterogeneity, is an important output of network meta-analysis. However, current standard methods based on t-distribution have been found to underestimate uncertainty in realistic situations. In this study, we propose two new methods based on bootstrap and Kenward-Roger adjustment to construct more accurate prediction intervals.
RESEARCH SYNTHESIS METHODS
(2023)
Article
Psychology, Clinical
Toshi A. Furukawa, Susumu Iwata, Masaru Horikoshi, Masatsugu Sakata, Rie Toyomoto, Yan Luo, Aran Tajika, Noriko Kudo, Eiji Aramaki
Summary: This study investigated the potential use of artificial intelligence and natural language processing to facilitate cognitive restructuring in internet cognitive-behavior therapy. The language model T5 was used to predict thoughts and feelings, and the accuracy of the predictions was validated. The results showed that correctly predicted thought-feeling pairs led to more effective reduction of negative emotions in cognitive restructuring.
COGNITIVE THERAPY AND RESEARCH
(2023)
Article
Psychiatry
Qiang Liu, Edoardo Giuseppe Ostinelli, Franco De Crescenzo, Zhenpeng Li, Anneka Tomlinson, Georgia Salanti, Andrea Cipriani, Orestis Efthimiou
Summary: When developing prediction models, researchers commonly use either an end-to-end approach or a similarity-based approach to address heterogeneity in patient characteristics. This study compared the performance of these two approaches using data from patients with depression and found that they yielded comparable results.
Article
Psychology, Clinical
Ryuhei So, Naoki Emura, Kozue Okazaki, Sakiko Takeda, Takashi Sunami, Kohei Kitagawa, Yoshitake Takebayashi, Toshi A. Furukawa
Summary: This study compared the effects of therapist-guided internet interventions with unguided ones on gambling behavior, cognition, and stage of change. The results showed that there were no significant differences between the guided and unguided groups in terms of improvement in gambling symptoms, behavior, and stage of change.
ADDICTIVE BEHAVIORS
(2024)