Journal
CLINICS IN PERINATOLOGY
Volume 41, Issue 1, Pages 229-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2013.10.007
Keywords
Preterm birth; Neurogenesis; Neonatal brain injury; Cognitive delay
Categories
Funding
- Fonds de Recherche en Sante du Quebec
- Canadian Institute of Health Research
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The incidence of preterm birth is on the rise. The outcome of premature birth can vary widely, spanning completely normal development to severe neurologic deficits, with most children showing mild to moderate cognitive delay and increased incidence of neuropsychiatric conditions such as anxiety, attention deficit hyperactivity, and autism spectrum disorders. Several animal models have been employed to study the consequences of prematurity, one of the most promising being chronic perinatal hypoxia in mouse, which recapitulates the cognitive impairments, partial recovery over time and enhanced recovery with environmental enrichment.
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