4.1 Article

The Biology of Retinopathy of Prematurity How Knowledge of Pathogenesis Guides Treatment

Journal

CLINICS IN PERINATOLOGY
Volume 40, Issue 2, Pages 201-+

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2013.02.002

Keywords

Oxygen; IGF-1; Omega-3 polyunsaturated fatty acids; Postnatal weight gain; Erythropoietin

Funding

  1. Swedish Medical Research Council [2011-2432]
  2. VINNOVA [2009-00221]
  3. Research to Prevent Blindness [NEI EY017017, NEI EY022275]
  4. NIH [P01 HD18655]
  5. Lowy Medical Foundation
  6. [ALFGB-137491]

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Retinopathy of prematurity occurs because the retina of a preterm infant at birth is incompletely vascularized, and if the postnatal environment does not match the in utero environment that supported retinal development, the vessels and neural retina will not grow normally. Risk factors determined from many clinical studies and animal studies fall into 2 categories: prenatal factors and postnatal factors.

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