Journal
CLINICS IN PERINATOLOGY
Volume 40, Issue 3, Pages 471-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2013.05.002
Keywords
Pain; Neonate; Postnatal development; Analgesia; Sensory processing
Categories
Funding
- British Journal of Anaesthesia/Royal College of Anaesthetists UK
- Royal College of Anaesthetists
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Nociceptive pathways are functional following birth. In addition to physiological and behavioral responses, neurophysiological measures and neuroimaging evaluate nociceptive pathway function and quantify responses to noxious stimuli in preterm and term neonates. Intensive care and surgery can expose neonates to painful stimuli when the developing nervous system is sensitive to changing input, resulting in persistent impacts into later childhood. Early pain experience has been correlated with increased sensitivity to subsequent painful stimuli, impaired neurodevelopmental outcomes, and structural changes in brain development. Parallel preclinical studies have elucidated underlying mechanisms and evaluate preventive strategies to inform future clinical trials.
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