Article
Pediatrics
Xiaowei Sun, Fenqin Xue, Jialin Wen, Limin Gao, Yang Li, Qianqian Jiang, Lijun Yang, Hong Cui
Summary: This study investigated the characteristics of acute seizures and background electrical activity in neonatal rats with perinatal hypoxic-ischemic encephalopathy (HIE). The results showed that all neonatal rats in the HIE group experienced frequent seizures during hypoxia, and the seizure frequency and duration decreased with increasing age. The background electrical activity was significantly inhibited during and immediately after hypoxia, and gradually recovered after 72 hours. This study suggests that the neonatal rat model can simulate seizures caused by HIE in premature infants.
FRONTIERS IN PEDIATRICS
(2022)
Review
Pharmacology & Pharmacy
Ferenc Domoki
Summary: Hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in term neonates. Recent studies have shown that molecular hydrogen may have neuroprotective effects in combating the deleterious consequences of hypoxic-ischemic insults. However, further research is needed to explore the potential synergistic effect of hydrogen with therapeutic hypothermia for the treatment of HIE.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Pediatrics
Mohamed El-Dib, Nicholas S. J. Abend, Topun Austin, Geraldine Boylan, Valerie Chock, M. Roberta Cilio, Gorm Greisen, Lena Hellstroem-Westas, Petra Lemmers, Adelina Pellicer, Ronit Pressler, Arnold Sansevere, Tammy Tsuchida, Sampsa Vanhatalo, Courtney J. Wusthoff
Summary: The development of neonatal neurocritical care in the past decade has shown significant progress in neuromonitoring and neuroprotection. Commonly used brain monitoring tools in the neonatal intensive care unit (NICU) include amplitude integrated EEG (aEEG), full multichannel continuous EEG (cEEG), and near-infrared spectroscopy (NIRS). However, there is no consensus on the consistent and efficient use of these modalities in common NICU scenarios. This review summarizes current evidence for the best utilization of neuromonitoring modalities in neonates with encephalopathy or possible seizures.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Jana Krystofova Mike, Yasmine White, Rachel S. Hutchings, Christian Vento, Janica Ha, Ariana Iranmahboub, Hadiya Manzoor, Anya Gunewardena, Cheryl Cheah, Aijun Wang, Brian D. Goudy, Satyan Lakshminrusimha, Janel Long-Boyle, Jeffrey R. Fineman, Donna M. Ferriero, Emin Maltepe
Summary: Clemastine shows promise in treating demyelinating diseases but has no effect on neurodevelopmental outcomes following global ischemic insult.
Article
Pediatrics
Alexa C. Stone, Kyle C. Strickland, David T. Tanaka, Jennifer B. Gilner, Monica E. Lemmon, Jeffrey B. Russ
Summary: This study examines the impact of chorioamnionitis on outcomes in neonates with hypoxic-ischemic encephalopathy (HIE) and finds that chorioamnionitis is associated with an increased risk of abnormal EEG patterns and post-neonatal epilepsy, highlighting the crucial role of placental pathology in neuroprognostication for HIE patients.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Kelly Harvey-Jones, Frederic Lange, Vinita Verma, Gemma Bale, Christopher Meehan, Adnan Avdic-Belltheus, Mariya Hristova, Magdalena Sokolska, Francisco Torrealdea, Xavier Golay, Veronika Parfentyeva, Turgut Durduran, Alan Bainbridge, Ilias Tachtsidis, Nicola J. Robertson, Subhabrata Mitra
Summary: Using optical markers to measure mitochondrial metabolism, oxygenation, and cerebral blood flow, this study found that these markers can predict injury severity and outcome in neonates with encephalopathy just 1 hour after hypoxia-ischemia.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Wievineke M. J. Apers, Linda S. de Vries, Floris Groenendaal, Mona C. Toet, Lauren C. Weeke
Summary: Neonatal seizures are common and can cause further brain damage. This study aimed to investigate the time interval between confirmation of seizures through aEEG and administration of AEDs. The results showed that only 32.1% of seizures were treated within 1 hour, with clinical recognition or SDA-identified seizures more likely to receive timely treatment.
Article
Clinical Neurology
Bjorn Welzel, Ricardo Schmidt, Marie Johne, Wolfgang Loescher
Summary: In a rat model of birth asphyxia, midazolam not only prevented seizures but also reduced neuroinflammation, behavioral and cognitive abnormalities, and neurodegeneration following asphyxia. These findings suggest that midazolam has potential as an intervention to improve the treatment and outcome of birth asphyxia.
ANNALS OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liam M. Koehn, Kevin Nguyen, Xiaodi Chen, Andre Santoso, Richard Tucker, Yow-Pin Lim, Barbara S. Stonestreet
Summary: Targeting hypoxia-ischemia (HI)-related brain injury can effectively alleviate behavioral deficits and brain infarct volume in newborns, with no significant differences found in the efficacy of hIAIPs at different doses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Xiaowei Sun, Fenqin Xue, Jialin Wen, Limin Gao, Yang Li, Lijun Yang, Hong Cui
Summary: This study investigated the pathological response of sleep-wake states in neonatal rats with hypoxic-ischemic encephalopathy (HIE). The results showed that HIE caused changes in the sleep-wake states, but they gradually returned to normal levels over time.
NATURE AND SCIENCE OF SLEEP
(2022)
Review
Medicine, General & Internal
Amaresh K. Ranjan, Anil Gulati
Summary: Neonatal hypoxic-ischemic encephalopathy (HIE) is a condition that leads to brain damage in newborns due to insufficient blood and oxygen supply during or after birth. HIE is a major cause of neurological disability and mortality in newborns, and its severity depends on several factors. The pathophysiology of HIE involves different phases, and understanding the cellular and molecular aspects of these phases is crucial for developing new interventions and therapeutics.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jason Sutin, Rutvi Vyas, Henry A. Feldman, Silvina Ferradal, Chuan-Heng Hsiao, Lucca Zampolli, Lara J. Pierce, Charles A. Nelson, Sarah U. Morton, Susanne Hay, Mohamed El-Dib, Janet S. Soul, Pei-Yi Lin, Patricia E. Grant
Summary: The objective of this study was to evaluate the association between cerebral oxygen metabolism (CMRO2) and neurodevelopmental outcomes at 18 months in neonates with hypoxic ischemic encephalopathy (HIE), and to assess CMRO2 as a potential diagnostic for HIE. The study found that CMRO2 was significantly associated with cognitive and motor outcomes and outperformed conventional clinical evaluations in predicting these outcomes in mild to moderate HIE. This provides a promising, objective, physiologically-based diagnostic for HIE.
Article
Pediatrics
Emma Macdonald-Laurs, Cynthia Sharpe, Mark Nespeca, Neggy Rismanchi, Jeffrey J. Gold, Rachel Kuperman, Sonya Wang, Ngoc Minh D. Lee, David J. Michelson, Richard Haas, Peter Reed, Suzanne L. Davis
Summary: The first hour of cEEG in at-risk neonates can predict subsequent seizures, aiding in the identification of high-risk newborns.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)
Article
Multidisciplinary Sciences
Tim Hermans, Katherine Carkeek, Anneleen Dereymaeker, Katrien Jansen, Gunnar Naulaers, Sabine Van Huffel, Maarten De Vos
Summary: In neonates with hypoxic ischemic encephalopathy, the use of wavelet coherence between EEG power and rSO2 is a promising method for assessing neurovascular coupling. However, fluctuations in SpO2 limit the reliability of previous methods. To address this issue, partial wavelet coherence is proposed to eliminate the influence of SpO2. Furthermore, the study investigates the additional value of novel NVC biomarkers compared to traditional EEG and NIRS biomarkers for identifying brain injury.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ewelina Bratek-Gerej, Apolonia Ziembowicz, Elzbieta Salinska
Summary: This study found that activation of group II mGlu receptors can prevent brain damage and regulate apoptosis and neuroprotective mechanisms in experimental birth asphyxia. Agonists LY379268 and NAAG can inhibit excessive glutamate release and apoptotic damage, and restore the concentration of neurotrophins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
