Article
Endocrinology & Metabolism
Jasmin M. de Groot, Madelon L. Geurtsen, Susana Santos, Vincent W. V. Jaddoe
Summary: Prevalence of liver fat accumulation and NAFLD differs between ethnic subgroups living in the Netherlands, especially for those with a Turkish background. Early-life factors have a strong influence on these associations and may hold clues for future preventive strategies.
Article
Nutrition & Dietetics
Lauren B. Raine, Jennifer N. H. Watrous, Katherine McDonald, Nicole E. Logan, Naiman A. Khan, Arthur F. Kramer, Charles H. Hillman
Summary: There is an increasing prevalence of poor health behaviors during childhood, particularly in terms of physical activity and nutrition. This study investigated the relationship between specific aspects of nutrition, particularly B-vitamins, and related health factors on selective attention in children. The findings suggest that aspects of health, such as increased B-vitamin intake, fitness, and BMI, may have unique contributions on cognitive performance. Proper physical health and nutrition are imperative for effective cognitive functioning in preadolescent children.
Article
Endocrinology & Metabolism
Xuelian Zhou, Xiufu Lin, Jingnan Chen, Jiaqi Pu, Wei Wu, Zhaoyuan Wu, Hu Lin, Ke Huang, Li Zhang, Yangli Dai, Yan Ni, Guanping Dong, Junfen Fu
Summary: This study aims to outline the clinical characteristics of pediatric NAFLD and establish a prediction model for the disease. The results showed that NAFLD is the most common complication in children with obesity, with a higher prevalence in males compared to females and an increasing trend over the last 19 years. The nomogram based on anthropometric and laboratory indicators performed well in predicting NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Yamei Duan, Jiayou Luo, Xiongfeng Pan, Jia Wei, Xiang Xiao, Jingya Li, Miyang Luo
Summary: This study evaluated the association between inflammatory markers and NAFLD in obese children. The findings indicated that levels of IL-1 beta, IL-6, and IL-17 were significantly associated with NAFLD, suggesting that these inflammatory cytokines may serve as non-invasive markers for the development of NAFLD.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Cristina Oana Marginean, Lorena Elena Melit, Maria Oana Sasaran
Summary: Non-alcoholic fatty liver disease is now the most common chronic liver disease in children, primarily due to the rising incidence of pediatric obesity. The prevalence of MAFLD is directly related to increasing BMI, and the multiple hits theory is used to provide insights into its pathogenesis. Recent evidence suggests that the microbiome plays a crucial role in the development of MAFLD.
Article
Endocrinology & Metabolism
Denice S. Feig, Johanna Sanchez, Kellie E. Murphy, Elizabeth Asztalos, Bernard Zinman, David Simmons, Andrea M. Haqq, I. George Fantus, Lorraine Lipscombe, Anthony Armson, Jon Barrett, Lois Donovan, Paul Karanicolas, Siobhan Tobin, Kathryn Mangoff, Gail Klein, Yidi Jiang, George Tomlinson, Jill Hamilton
Summary: This study aimed to examine the impact of metformin exposure on adiposity in children of women with type 2 diabetes during pregnancy. The follow-up study found no difference in adiposity between children exposed and not exposed to metformin at 24 months.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Madelon L. Geurtsen, Rama J. Wahab, Janine F. Felix, Romy Gaillard, Vincent W. V. Jaddoe
Summary: The study found that maternal early-pregnancy glucose concentrations were only associated with offspring NAFLD among mothers of European ancestry, while this association became nonsignificant in mothers with diverse ethnic backgrounds.
Article
Gastroenterology & Hepatology
Mary Catherine Sawh, Martina Wallace, Emma Shapiro, Nidhi P. Goyal, Kimberly P. Newton, Elizabeth L. Yu, Craig Bross, Janis Durelle, Cynthia Knott, Jon A. Gangoiti, Bruce A. Barshop, Jivani M. Gengatharan, Noah Meurs, Alexandra Schlein, Michael S. Middleton, Claude B. Sirlin, Christian M. Metallo, Jeffrey B. Schwimmer
Summary: The study evaluated the association between dairy fat intake and liver fat content in children, finding an inverse correlation between dairy fat intake, plasma C15:0, and plasma iso-C17:0 with hepatic steatosis. These findings suggest potential benefits of dairy fat intake on liver health in children, warranting further clinical trials for validation and potential inclusion in dietary guidelines.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Sebastien Le Garf, Veronique Negre, Rodolphe Anty, Philippe Gual
Summary: MAFLD, formerly known as NAFLD, is a significant global cause of chronic liver disease and has become the main form of liver disease in children and adolescents, highlighting the crucial importance of early diagnosis.
Article
Nutrition & Dietetics
Panagiotis Varagiannis, Emmanuella Magriplis, Grigoris Risvas, Katerina Vamvouka, Adamantia Nisianaki, Anna Papageorgiou, Panagiota Pervanidou, George P. Chrousos, Antonis Zampelas
Summary: Childhood overweight and obesity prevalence has increased significantly in recent decades, prompting the need for effective interventions. This study evaluated three different family-based interventions and found that personalized interventions can successfully improve children's lifestyle and weight status, with varying effects on different outcomes such as body weight, body fat percentage, and health behaviors.
Article
Nutrition & Dietetics
Natalia Kopiczko, Anna Bobrus-Chociej, Ewa Harasim-Symbor, Eugeniusz Tarasow, Malgorzata Wojtkowska, Adrian Chabowski, Dariusz M. Lebensztejn
Summary: This study aimed to evaluate the serum FA concentration in children with obesity and NAFLD. The results showed that the total FA concentration was significantly higher in obese children and in obese children with NAFLD compared to controls. There was a significant positive correlation between total FA concentration and cholesterol, triacylglycerols, and insulin in children with NAFLD.
Article
Food Science & Technology
Albandari A. Almutairi, Waheeba E. Ahmed, Raya Algonaiman, Raghad M. Alhomaid, Mona S. Almujaydil, Sami A. Althwab, Ard ElShifa M. Elhassan, Hassan Mirghani Mousa
Summary: Obesity is a major health concern, and this study found that boiled parsley extracts have the potential to fight against obesity by reducing body weight and blood lipid levels.
Article
Pediatrics
Lu-Jie Liu, Yu-Rong Kang, Yan-Feng Xiao
Summary: The study found that serum asprosin levels were significantly elevated in obese children, especially in those with NAFLD, and were positively correlated with body mass index, waist to height ratio, fasting blood glucose, alanine aminotransferase and tumor necrosis factor-alpha. Furthermore, asprosin was independently associated with NAFLD in binary logistic regression analysis.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Ioannis A. Ziogas, Fei Ye, Zhiguo Zhao, Shu Cao, Muhammad A. Rauf, Manhal Izzy, Lea K. Matsuoka, Lynette A. Gillis, Sophoclis P. Alexopoulos
Summary: The study identified factors such as increasing bilirubin level, portal vein thrombosis, and ventilator dependence at listing associated with higher risk of waitlist mortality, while weight >= 10 kg at listing associated with lower risk. Ascites at listing was also found to be associated with a higher risk for the composite outcome.
JOURNAL OF PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Annika Mutanen, Jouko Lohi, Laura Merras-Salmio, Antti Koivusalo, Mikko P. Pakarinen
Summary: The study found that in patients with IF, 48% had active IFALD, 21% had chronic IFALD, and 31% had no IFALD. Active IFALD was mainly predicted by low serum citrulline, PN dependency, and young age, while weaning off PN and older age predicted chronic IFALD. Most patients either normalized or transformed their liver histopathology, with some progressing to active IFALD.
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhou Yuming, Tang Ruqi, Merrill Eric Gershwin, Ma Xiong
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Inbal Houri, Gideon M. Hirschfield
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Yasameen Muzahim, Ali Wakil, Mehak Bassi, Nikolaos Pyrsopoulos
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Brian H. Horwich, Douglas T. Dieterich
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Aparna Goel, Paul Kwo
Summary: The goal of autoimmune hepatitis treatment is achieving clinical and biochemical remission. Standard care involves induction treatment with corticosteroids and gradual tapering of steroids. Alternatives to standard therapy can be considered for patients with intolerance or inadequate response. Treatment withdrawal is achievable in less than 20% of patients after 2 years of sustained remission, and liver transplantation should be considered for patients with progressive disease or complications.
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Mariana Zapata, Hendrick Pagan-Torres, Marlyn J. Mayo
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Aalam Sohal, Sanya Kayani, Kris Kowdley
Summary: Primary sclerosing cholangitis (PSC) is an immune-mediated liver disease characterized by inflammation and fibrosis of bile ducts. It is commonly associated with inflammatory bowel disease, especially ulcerative colitis. The natural history of the disease varies among patients, but most will develop cirrhosis.
CLINICS IN LIVER DISEASE
(2024)
