Article
Cell Biology
Marcelo Farias-Jofre, Roberto Romero, Jose Galaz, Yi Xu, Li Tao, Catherine Demery-Poulos, Marcia Arenas-Hernandez, Gaurav Bhatti, Zhenjie Liu, Naoki Kawahara, Tomi Kanninen, Zachary Shaffer, Tinnakorn Chaiworapongsa, Kevin R. Theis, Adi L. Tarca, Nardhy Gomez-Lopez
Summary: During pregnancy, the immune responses of circulating monocytes and neutrophils to endotoxin, a Gram-negative bacterial product, are altered.
INFLAMMATION RESEARCH
(2022)
Article
Pediatrics
Sam Ebenezer Athikarisamy, Geoffrey C. Lam, Matthew N. Cooper, Tobias Strunk
Summary: Retinopathy of prematurity (ROP) is a potentially blinding vasoproliferative disease. This study aimed to assess the association between placental inflammation and the severity of ROP in premature infants. The results showed that maternal chorioamnionitis was associated with reduced odds of severe ROP, while oxygen supplementation, postnatal steroids, and platelet transfusion were strongly associated with severe ROP.
FRONTIERS IN PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Hyo Kyozuka, Tuyoshi Murata, Toma Fukuda, Erina Suzuki, Riho Yazawa, Shun Yasuda, Aya Kanno, Akiko Yamaguchi, Yuko Hashimoto, Keiya Fujimori
Summary: Labor dystocia is a risk factor for severe histological chorioamnionitis and funisitis, suggesting the need for further studies to evaluate their effects on long-term neonatal outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Medicine, General & Internal
Lijie Jia, Huimin Cao, Yuna Guo, Ying Shen, Xiaoyu Zhang, Zhou Feng, Jiangruixuan Liu, Zhongcong Xie, Zifeng Xu
Summary: This cohort study found that the use of epidural analgesia during labor in full-term nulliparous women undergoing vaginal delivery was associated with an increased risk of neonatal infection, supporting efforts to further improve safety and quality of labor and delivery care for parturient women.
Article
Developmental Biology
Irina Oltean, Jason Tran, Dorsa Mavedatnia, Sarah Lawrence, Lauren Tristani, Felipe Moretti, Dina El Demellawy
Summary: This study examined the neonatal outcomes in pregnancies complicated by placental abruption and acute chorioamnionitis. The findings showed that acute chorioamnionitis was associated with fetal death, as well as adverse Apgar scores, neonatal intensive care unit admission, and cardiac depression. The presence of funisitis, acute chorioamnionitis, and adverse neonatal outcomes were interdependent. When not considering funisitis, the aforementioned findings still held, but with smaller effect sizes. Placental abruption and acute chorioamnionitis with funisitis could affect fetal death and neonatal intensive care unit admission. Acute chorioamnionitis and placental abruption alone could impact fetal death and adverse Apgar scores.
Article
Pediatrics
Iliana Bersani, Sara De Carolis, Dirk Foell, Toni Weinhage, Cristina Garufi, Maria Pia De Carolis, Esther Diana Rossi, Giovanna Casella, Serena Antonia Rubortone, Christian Paul Speer
Summary: The study found that S100A12 could not accurately identify mothers with HCA or very preterm infants exposed to HCA. However, IL-6 and CRP levels were higher in maternal blood of the HCA group compared with controls. High concentrations of S100A12 were detected in cord and neonatal blood of some neonates exposed to HCA with advanced funisitis.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Hussein Zein, Khorshid Mohammad, Lara M. Leijser, Marie-Anne Brundler, Adam Kirton, Michael J. Esser
Summary: Placental abnormalities are associated with differential cytokine profiles in extremely pre-term infants, with the highest levels observed in the group with combined vasculopathy and inflammation. There are also sex differences between and within placental pathology groups. Sampling from cord blood may help assess the pathological status of the placenta and potentially infer outcome risks for the infant.
FRONTIERS IN PEDIATRICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gui Liao
Summary: The study focused on the effects of artificial intelligence algorithms in magnetic resonance imaging (MRI) for diagnosing cranial nerve inflammation of placenta and exploring the correlation between cranial nerve injury with placental inflammation. The study found that the PCA artificial intelligence algorithm has high effectiveness and high accuracy in auxiliary diagnosis of premature brain nerve injury, and placental inflammation greatly increases the chance of premature infants suffering from brain nerve injury.
CONTRAST MEDIA & MOLECULAR IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Kyo Hoon Park, Kyong-No Lee, Eunji Oh, Eun Mi Im
Summary: We investigated the association between altered levels of inflammatory proteins in the cervicovaginal fluid (CVF) and acute histologic chorioamnionitis (HCA) and funisitis in women with preterm labor (PTL). The results showed significant associations between elevated CVF interleukin-8 and resistin levels and acute HCA. CVF haptoglobin, interleukin-6/8, kallistatin, MMP-8, and resistin levels were significantly higher in women with funisitis than in those without.
Article
Pediatrics
Imran Nazir Mir, Mariela Sanchez-Rosado, Jordan Reis, Naseem Uddin, L. Steven Brown, Kate Louise Mangona, David Nelson, Myra Wyckoff, Sujir Pritha Nayak, Luc Brion
Summary: This study is the first to demonstrate the association between progression and increasing severity of fetal inflammatory response (FIR) and stage of necrotizing enterocolitis (NEC).
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Hidetaka Yoshimatsu, Masanori Iwai, Yasuji Kitabatake, Keiichi Ozono, Kimitoshi Nakamura
Summary: The aim of the study was to assess the predictive value of inflammatory markers for chorioamnionitis and funisitis in extremely low gestational age neonates. It was found that procalcitonin, high-sensitivity C-reactive protein levels, and white blood cell count provide highly sensitive prediction scores for these conditions.
Article
Obstetrics & Gynecology
Gregory E. Zemtsov, Nicole Diaz, Emma Ryan, Agnes Chao, Carmen M. Avram, Matthew R. Grace, Sarah K. Dotters-Katz
Summary: Acute funisitis is associated with increased neonatal sepsis in term deliveries complicated by intraamniotic infection. However, there is no statistical association between acute funisitis and other neonatal morbidities.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Yin Ping Wong, T. Yee Khong
Summary: Neonates born with the fetal inflammatory response (FIR) are at risk of complications such as early-onset neonatal sepsis, meningitis, and pneumonia. This study evaluated the diagnostic performance of umbilical cord (UC) section in identifying FIR and investigated clinical predictors of umbilical cord FIR. The results showed that UC section diagnosis of FIR is reasonably accurate in cases with clinical chorioamnionitis, fever, and/or prolonged rupture of membrane (PROM).
Article
Medicine, General & Internal
Subeen Hong, Mina Jeong, Sohee Oh, Jeong Won Oh, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Seung Mi Lee
Summary: The study found a significant association between the presence of funisitis and adverse neonatal outcomes in twin neonates born prematurely, regardless of the presence of funisitis in the other twin.
YONSEI MEDICAL JOURNAL
(2021)
Article
Obstetrics & Gynecology
Suganya Sukumaran, Vanita Pereira, Srinivas Mallur, Edwin Chandraharan
Summary: Baseline increase (>10%) during labor along with loss of cycling with or without features of tachysystole or hyperstimulation should be considered as features of ongoing chorioamnionitis. Chorioamnionitis confirmed on histopathology is associated with an increase in the rate of cesarean sections due to fetal heart rate changes, increased risk of wound infection in mothers, and increased admission of babies to SCBU.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Nutrition & Dietetics
Diana Gonzalez-Pena, Danuta Dudzik, Clara Colina-Coca, Begona de Ancos, Antonia Garcia, Coral Barbas, Concepcion Sanchez-Moreno
EUROPEAN JOURNAL OF NUTRITION
(2016)
Article
Multidisciplinary Sciences
Renata Bujak, Jesus Mateo, Isabel Blanco, Jose Luis Izquierdo-Garcia, Danuta Dudzik, Michal J. Markuszewski, Victor Ivo Peinado, Martin Laclaustra, Joan Albert Barbera, Coral Barbas, Jesus Ruiz-Cabello
Article
Biochemistry & Molecular Biology
Diana Gonzalez-Pena, Danuta Dudzik, Antonia Garcia, Begona de Ancos, Coral Barbas, Concepcion Sanchez-Moreno
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Chemistry, Analytical
Danuta Dudzik, Marcin Zorawski, Mariusz Skotnicki, Wieslaw Zarzycki, Antonia Garcia, Santiago Angulo, M. Paz Lorenzo, Coral Barbas, M. Pilar Ramos
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2017)
Review
Chemistry, Analytical
Danuta Dudzik, Cecilia Barbas-Bernardos, Antonia Garcia, Coral Barbas
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2018)
Review
Biochemistry & Molecular Biology
Luka Andrisic, Danuta Dudzik, Coral Barbas, Lidija Milkovic, Tilman Grune, Neven Zarkovic
Review
Chemistry, Analytical
Carolina Gonzalez-Riano, Danuta Dudzik, Antonia Garcia, Alberto Gil-de-la-Fuente, Ana Gradillas, Joanna Godzien, Angeles Lopez-Gonzalvez, Fernanda Rey-Stolle, David Rojo, Francisco J. Ruperez, Jorge Saiz, Coral Barbas
ANALYTICAL CHEMISTRY
(2020)
Article
Biochemical Research Methods
Paula Cuevas-Delgado, Danuta Dudzik, Veronica Miguel, Santiago Lamas, Coral Barbas
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Nutrition & Dietetics
Danuta Dudzik, Isabel Iglesias Platas, Montserrat Izquierdo Renau, Carla Balcells Esponera, Beatriz del Rey Hurtado de Mendoza, Carles Lerin, Marta Ramon-Krauel, Coral Barbas
Article
Chemistry, Analytical
Fernanda Rey-Stolle, Danuta Dudzik, Carolina Gonzalez-Riano, Miguel Fernandez-Garcia, Vanesa Alonso-Herranz, David Rojo, Coral Barbas, Antonia Garcia
Summary: This tutorial provides ready-to-use protocols for GC-MS-based metabolomics, covering sample preparation, data acquisition, and data processing strategies. Different analytical methods for various types of biological samples and cell cultures are discussed, along with considerations for obtaining semiquantitative values for metabolites. A case study presents experimental results.
ANALYTICA CHIMICA ACTA
(2022)
Review
Chemistry, Analytical
Danuta Dudzik, Szymon Macioszek, Wiktoria Struck-Lewicka, Marta Kordalewska, Magdalena Buszewska-Forajta, Malgorzata Waszczuk-Jankowska, Renata Wawrzyniak, Malgorzata Artymowicz, Joanna Raczak-Gutknecht, Danuta Siluk, Michal J. Markuszewski
Summary: The discovery of extracellular vesicles has opened up new possibilities in studying cell-to-cell communication, with potential therapeutic and diagnostic applications. However, challenges in isolating and analyzing these vesicles hinder their clinical utility, highlighting the importance of advanced analytical techniques like mass spectrometry-based metabolomics for understanding their molecular profiles.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Oncology
Szymon Macioszek, Danuta Dudzik, Rafal Bartoszewski, Tomasz Stokowy, Diether Lambrechts, Bram Boeckx, Agnieszka Wozniak, Patrick Schoffski, Michal J. Markuszewski
Summary: In this study, integrative metabolomic and transcriptomic analyses were performed to investigate the impact of imatinib treatment on tumour biochemical processes. The results revealed differential metabolite and gene expression profiles, indicating changes in pruine and pyrinridine metabolism, butanoate metabolism, as well as alanine, aspartate, and glutamate metabolism. These findings provide insights into the mechanisms of imatinib's anti-tumour activity and suggest a potentially novel approach for enhancing its efficacy or re-sensitizing imatinib-resistant tumours.
TRANSLATIONAL ONCOLOGY
(2023)
Review
Biochemical Research Methods
Vinicius Veri Hernandes, Coral Barbas, Danuta Dudzik
Meeting Abstract
Oncology
Irving W. Wainer, Danuta Dudzik, Michel Bernier, Coral Barbas