Review
Biochemistry & Molecular Biology
Katarzyna Pankiewicz, Tadeusz Issat
Summary: Chemerin is a versatile adipokine involved in various biological processes, including inflammation, angiogenesis, adipogenesis, energy metabolism, and oxidative stress. It plays a crucial role in the development of cardiovascular diseases, particularly in pre-eclampsia (PE). Elevated levels of blood chemerin and its placental expression are positively correlated with the severity of PE. This review provides an overview of the potential role of chemerin in PE development, focusing on its involvement in oxidative stress and endothelial dysfunction.
Article
Biochemistry & Molecular Biology
Sneha Damal Villivalam, Scott M. Ebert, Hee Woong Lim, Jinse Kim, Dongjoo You, Byung Chul Jung, Hector H. Palacios, Tabitha Tcheau, Christopher M. Adams, Sona Kang
Summary: Exercise can significantly increase the expression of DNMT3A in oxidative red muscle, playing a pivotal role in endurance exercise by controlling intracellular oxidative stress. Deficiency of DNMT3A leads to reduced tolerance to endurance exercise, which can be rescued by inhibiting the ALDH1L1 pathway.
Article
Obstetrics & Gynecology
Tingting Li, Sumei Wei, Conghong Fan, Dongmei Tang, Dan Luo
Summary: This study demonstrated that Nesfatin-1 promotes trophoblast cell proliferation, migration, invasion, and EMT while suppressing oxidative stress by activating the PI3K/AKT/mTOR and AKT/GSK3 beta signaling pathways, suggesting a potential therapeutic target for preeclampsia.
REPRODUCTIVE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yanli Xu, Xiaodi Kang, Hongli Jiang, Huafang Liu, Wenjing Wang
Summary: This study investigated the role of histone deacetylase 4 (HDAC4) in trophoblast invasion and migration and found that downregulation of HDAC4 impairs trophoblast proliferation, invasion, and migration, while overexpression of HDAC4 plays the opposite role. The results suggest that HDAC4 may be a promising target for the treatment of pre-eclampsia.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2023)
Review
Medicine, Research & Experimental
Wenwen Ning, Bin Wu, Yijie Chen, Jiejing Lian, Yiming Chen
Summary: Pre-eclampsia is a complex pregnancy-specific disease that is the primary cause of maternal and fetal mortality and morbidity. The underlying causes of pre-eclampsia remain unclear but involve an imbalance of molecular pathways regulating trophoblast function. Abnormal expression of certain microRNAs is associated with pre-eclampsia, with these microRNAs playing a role in regulating pregnancy-associated genes. This review discusses the role of microRNAs in trophoblast function, their impact on the pathogenesis of pre-eclampsia, and their potential use in screening, diagnosis, and treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Review
Developmental Biology
Elizabeth Bearblock, Catherine E. Aiken, Graham J. Burton
Summary: Current meta-analyses demonstrate a positive association between pre-eclampsia and exposure to PM2.5 and nitrogen dioxide, but not with ambient ozone or carbon monoxide exposure. Variability in exposure quantification, exposure period, and co-founders among studies makes comparisons complex.
Article
Biochemistry & Molecular Biology
Yunjiao Zhou, Zhenwei Yang, Hailin Zhang, Haiou Li, Meng Zhang, Haizhou Wang, Mengna Zhang, Peishan Qiu, Ruike Zhang, Jing Liu
Summary: The overexpression of DNMT3A in colorectal cancer has been found to accelerate tumor progression by regulating DAB2IP-mediated MEK/ERK activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Pei-Chi Chiang, Pei-Tzu Li, Ming-Jen Lee, Chin-Tin Chen
Summary: This study demonstrates that the reduced cellular invasion induced by photodynamic therapy (PDT) is associated with CLIC4 expression suppression through increased DNMT1 expression and promoter hypermethylation, involving the tumor suppressor p53. The findings further support that the regulation of CLIC4 expression in tumorigenesis is mediated by DNMT1-mediated hypermethylation and depends on the status of p53.
Review
Biochemistry & Molecular Biology
Mariana Andrawus, Lital Sharvit, Gil Atzmon
Summary: Epigenetic modifications such as DNA methylation can impact maternal health during pregnancy, with various risk factors contributing to long-lasting consequences. Understanding epigenetic patterns linked to poor pregnancy outcomes is crucial in recognizing the long-term effects of DNA methylation changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yang Li, Xiuli Lu, Zhihao Yu, Haozhen Wang, Bing Gao
Summary: In this study, it was found that ATP1A1 may be a key susceptibility gene involved in calcium stone formation. The down-regulation of ATP1A1 was associated with crystal deposition and activation of related signaling pathways. Overexpression of ATP1A1 or treatment with a specific inhibitor alleviated oxidative stress, inflammation, apoptosis, crystal-cell adhesion, and stone formation. These findings suggest that ATP1A1 could be a potential therapeutic target for treating calcium stones.
Review
Biochemistry & Molecular Biology
Orsolya Oravecz, Andrea Balogh, Roberto Romero, Yi Xu, Kata Juhasz, Zsolt Gelencser, Zhonghui Xu, Gaurav Bhatti, Roger Pique-Regi, Balint Peterfia, Petronella Hupuczi, Ilona Kovalszky, Padma Murthi, Adi L. Tarca, Zoltan Papp, Janos Matko, Nandor Gabor Than
Summary: Proteoglycan macromolecules, specifically syndecan-1, play crucial roles in various physiological processes during placenta development and healthy pregnancy. Dysregulated expression of proteoglycans, including syndecan-1, has been observed in pregnancy complications such as pre-eclampsia and fetal growth restriction. Further research is needed to explore the potential diagnostic and therapeutic applications of proteoglycans in complicated pregnancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Indrani Mukherjee, Subhrajit Biswas, Sunil Singh, Joyeeta Talukdar, Mohammed S. S. Alqahtani, Mohamed Abbas, Tapas Chandra Nag, Asit Ranjan Mridha, Surabhi Gupta, Jai Bhagwan Sharma, Supriya Kumari, Ruby Dhar, Subhradip Karmakar
Summary: The overproduction of ROS has been linked to various human diseases. Monosodium glutamate (MSG), a food additive commonly used in Asian cuisine, has been associated with ROS generation. This study found that MSG exposure influenced trophoblast invasion and differentiation, two critical functions during placenta formation, through increased ROS production. The findings suggest that long-term exposure to MSG may have adverse health effects, compromising important trophoblast functions.
Review
Pharmacology & Pharmacy
Yao Dai, Danian Chen, Tingting Xu
Summary: Atherosclerosis is a pathological process involving lipid oxidation, immune system activation, and endothelial dysfunction. DNA methylation, as one of the most important epigenetic mechanisms, plays a key role in the pathogenesis of atherosclerosis. This review discusses the abnormal changes of DNA methylation in atherosclerosis, including genome-wide hypermethylation with aging, hypermethylation linked to methyl supply and hyperhomocysteinemia, and the influence of oxidative stress on demethylation processes. The review also summarizes the current status of epigenetic treatment for atherosclerosis, providing new directions and potential therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Wenting Zhang, Lin Lyu, Zhihiong Xu, Jinjing Ni, Danni Wang, Jie Lu, Yu-Feng Yao
Summary: This study reveals the role of DNA methylation in the response of Salmonella enterica serovar Typhimurium (S. Typhimurium) to oxidative stress. The researchers found that there is no significant association between DNA methylation and transcription level in most genes, but there is a coincidence of level change between transcription and m6A GATC in certain regulatory regions. These findings provide new insights into the epigenetic regulatory mechanisms of gene expression in S. Typhimurium in the host microenvironment.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Andrea Pirkovic, Aleksandra Vilotic, Suncica Borozan, Mirjana Nacka-Aleksic, Zanka Bojic-Trbojevic, Milica Jovanovic Krivokuca, Maurizio Battino, Francesca Giampieri, Dragana Dekanski
Summary: The bioactive compound oleuropein derived from olives was evaluated for its effects on damage induced by hydrogen peroxide in human trophoblast cells in vitro. The study found that oleuropein had cytoprotective effects by improving antioxidant status, preventing protein and lipid damage, and reducing iNOS levels.
Article
Endocrinology & Metabolism
Chuan Lin, Jun Yang, Peter J. Fuller, Huan Jing, Ying Song, Wenwen He, Zhipeng Du, Ting Luo, Qingfeng Cheng, Shumin Yang, Hongman Wang, Qifu Li, Jinbo Hu, Qifu Li, Ying Song, Shumin Yang, Wenwen He, Mei Mei, Jinbo Hu, Suxin Luo, Kangla Liao, Yao Zhang, Yunfeng He, Yihong He, Ming Xiao, Bin Peng, Richa Goswami, Changhong Zhao, Zhengping Feng, Rong Li, Huacong Deng, Chun Liu, Bo Zhou, Wei Ren, Jian Long, Lilin Gong, Chuan Peng, Rufei Gao, Xiaoqiu Xiao
CLINICAL ENDOCRINOLOGY
(2020)
Meeting Abstract
Endocrinology & Metabolism
Xiaojing Lin, Xiaoling He, Xiaoqiu Xiao
Review
Endocrinology & Metabolism
Irakoze Laurent, Manirakiza Astere, Banderembako Paul, Nkengurutse Liliane, Yue Li, Qingfeng Cheng, Qifu Li, Xiaoqiu Xiao
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2020)
Article
Public, Environmental & Occupational Health
Yan Chen, Weizhi Bai, Bin Liu, Jian Huang, Irakoze Laurent, Feng Chen, Wuquan Deng, Xiaoqiu Xiao
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2020)
Article
Endocrinology & Metabolism
Renzhi Hu, Xuan Li, Chuan Peng, Ruifei Gao, Linqiang Ma, Jinbo Hu, Ting Luo, Hua Qing, Yue Wang, Qian Ge, Zhihong Wang, Chaodong Wu, Xiaoqiu Xiao, Jun Yang, Morag J. Young, Qifu Li, Shumin Yang
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Review
Endocrinology & Metabolism
Laurent Irakoze, Astere Manirakiza, Yunqi Zhang, Juncheng Liu, Jiayu Li, Liliane Nkengurutse, Shuhua Deng, Xiaoqiu Xiao
Summary: This study conducted a meta-analysis on the parent-offspring association of MetS, showing that offspring of parents with MetS have a higher risk of developing MetS. There was no differential association of MetS based on gender and/or age of the offspring.
Article
Cell Biology
Nan Chen, Yunqi Zhang, Miaoran Wang, Xiaojing Lin, Jiayu Li, Jibin Li, Xiaoqiu Xiao
Summary: Maternal obesity can lead to offspring obesity and metabolic disorders, especially with increased endoplasmic reticulum stress during pregnancy. Offspring exposed to an obesogenic environment may exhibit higher body weight, overeating, and hypothalamic feeding circuit defects, possibly related to early postnatal induction of ER stress and proteotoxic stress. Neonatal inhibition of hypothalamic ER stress may exacerbate metabolic outcomes in the long run.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Xiaojing Lin, Yunqi Zhang, Xiaoling He, Yan Chen, Nan Chen, Juncheng Liu, Miaoran Wang, Yue Li, Hong Yang, Lei Fan, Yi Hou, Jibin Li, Chaodong Wu, Hongbo Qi, Hua Zhang, Xiaoqiu Xiao
Summary: In this study, it was found that higher levels of TMAO and the formation of abnormal NETs were associated with GDM. TMAO not only promoted the development of the placenta and fetuses but also inhibited the formation of NETs.
Article
Pharmacology & Pharmacy
Xuemei Cao, Min Mao, Junlin Diao, Yi Hou, Hong Su, Yongjun Gan, Jibin Li, Xiaoyong Tong, Chaodong Wu, Zhong Zuo, Xiaoqiu Xiao
Summary: The study showed that the partial agonist CMHX008 had a more beneficial impact on cardiac function and morphology compared to rosiglitazone, as it improved heart function without causing cardiac hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Rongfeng Huang, Jiayu Li, Maolin Liao, Li Ma, Irakoze Laurent, Xiaojing Lin, Yunqi Zhang, Rufei Gao, Yubin Ding, Xiaoqiu Xiao
Summary: The combined exposure of maternal BPA and a HFD resulted in increased urine BPA levels, precocious puberty, decreased follicle numbers, and altered hypothalamic Kiss1 methylation in F1 and F2 mice, demonstrating a trans-generational effect on female reproduction.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hong Yang, Nan Chen, Lei Fan, Xiaojing Lin, Juncheng Liu, Yuehua You, Ying Zhong, Yan Chen, Jibin Li, Xiaoqiu Xiao
Summary: Maternal high-fat diet during pregnancy and lactation has long-term effects on the pathogenesis of obesity in offspring, and the early postnatal stage is a critical window for metabolic programming.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Lei Fan, Hong Yang, Xiangnan Hu, Juncheng Liu, Yuehua You, Xinyu Li, Guangcheng Qin, Qian Ge, Yi Hou, Xiaoqiu Xiao
Summary: This study synthesized a series of vildagliptin analogs, among which ZD-2 showed moderate inhibition of DPP-4. Both ZD-2 and vildagliptin showed similar effects on improving glucose tolerance and reducing fat accumulation in high-fat-diet mice. ZD-2 also protected beta-cell function and stimulated gut hormone expression.
Article
Cell Biology
Juncheng Liu, Maolin Liao, Rongfeng Huang, Yuehua You, Xiaojing Lin, Hong Yang, Lei Fan, Ying Zhong, Xinyu Li, Jibin Li, Xiaoqiu Xiao
Summary: Simultaneous exposure of mothers to BPA and HFD during the perinatal period increases the risk of metabolic and cardiovascular abnormalities in offspring, and these synergistic effects may be transmitted to future generations.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qian Ge, Xinxin Xie, Xiangjun Chen, Rongfeng Huang, Cheng-Xue Rui, Qianna Zhen, Renzhi Hu, Min Wu, Xiaoqiu Xiao, Xi Li
Summary: This study aimed to investigate the role of circulating exosome-like vesicles (ELVs) isolated from individuals with simple obesity in the regulation of beta-cell mass. The results showed that circulating ELVs can act as negative regulators for beta-cell mass in nondiabetic obesity by inhibiting beta-cell proliferation. This effect is associated with downregulated Omentin-1 protein in ELVs.
Article
Biochemistry & Molecular Biology
Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xiao
Summary: This study investigated the effects of TREM2 overexpression on cognitive dysfunction induced by a high-fat diet. The results showed that TREM2 overexpression ameliorated cognitive impairment and promoted microglia polarization towards the anti-inflammatory phenotype in obese diabetic mice.
