Review
Chemistry, Multidisciplinary
Jin-xuan Su, Si-jia Li, Xiao-feng Zhou, Zhi-jing Zhang, Yu Yan, Song-lin Liu, Qi Qi
Summary: Chemotherapy, the most common treatment for malignant tumors, can cause non-selective cytotoxicity and promote metastasis, reducing its clinical efficacy. Understanding the mechanisms of chemotherapy-induced metastasis is crucial for improving treatment outcomes. This review summarizes recent findings on chemotherapy-induced metastasis and discusses underlying mechanisms such as tumor-initiating cell expansion, epithelial-mesenchymal transition, extracellular vesicle involvement, and tumor microenvironment alterations. Additionally, combination treatments to overcome chemotherapy-induced metastasis are elaborated upon.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Biochemistry & Molecular Biology
Ioannis M. Koukourakis, Marios Papadimitriou, Dimitra Desse, Anna Zygogianni, Christos Papadimitriou
Summary: Neoadjuvant chemotherapy (NACT) for breast cancer (BC) can effectively reduce tumor size and improve patient survival rates. However, the immunosuppressive tumor microenvironment of certain BC subtypes hinders the efficacy of immune checkpoint inhibitors. In addition, radiotherapy (RT) has been found to enhance the anti-tumor immune response. The combination of RT, NACT, and immunotherapy may have significant therapeutic implications in BC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zhuan Feng, Yifei Qin, Fei Huo, Zhe Jian, Xiaomin Li, Jiejie Geng, Yong Li, Jiao Wu
Summary: UV irradiation-induced skin injury can lead to accumulation of lipid peroxides and iron, potentially causing ferroptosis. By mimicking iron overload, ferroptosis can be triggered in UV-irradiated keratinocytes, while NMN can enhance resistance to ferroptosis in UV-damaged skin cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Gastroenterology & Hepatology
Victor Serenon, Philippe Rouanet, Diane Charleux-Muller, Clarisse Eveno, Karine Poirot, Bertrand Trilling, Stephane Benoist, Gilles Manceau, Yves Panis, Arnaud Alves, Alex Kartheuser, Aurelien Venara, Marc Pocard, Charles Sabbagh, Anais Laforest, Zaher Lakkis, Bogdan Badic, Amelie Chau, Niki Christou, Laura Beyer-Berjot, Frederic Dumont, Adeline Germain, Alain Valverde, Emilie Duchalais, Mehdi Ouaissi, Leonor Benhaim, Maxime Collard, Jean-Jacques Tuech, Etienne Buscail, Diane Mege
Summary: This study aimed to report the incidence of iatrogenic ureteral injury (IUI) during colorectal surgery and analyze the long-term consequences of urological late complications and their impact on oncological outcomes. The results showed that IUI has few consequences if recognized early, but long-term urological sequelae can occur in a third of patients and may affect the timing of adjuvant chemotherapy in colorectal surgery.
COLORECTAL DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Strahil Strashilov, Angel Yordanov
Summary: Melanoma arises from malignant transformations of melanocytes and can occur in various parts of the body. The incidence and morbidity of cutaneous melanoma are on the rise globally, with Australia and New Zealand being leaders in this trend.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Bing Lv, Jing Chen, Xiao-Liang Liu
Summary: Anlotinib is a new tyrosine kinase inhibitor developed in China, which inhibits tumor angiogenesis and provides a new therapeutic option for lung cancer. However, one of its common adverse effects is hypertension, which can lead to discontinuation of the drug. Effective management of anlotinib-induced hypertension requires early prevention, a reasonable dosage regimen, and appropriate treatment. Moreover, anlotinib-induced hypertension may serve as a marker for predicting treatment efficacy.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Environmental Sciences
Reem S. Alruhaimi
Summary: This study investigated the role of arbutin (ARB) against cyclophosphamide (CP)-mediated oxidative and inflammatory reactions and hepatotoxicity. The results revealed that ARB exerted a protective effect on CP-induced liver injury by modulating the Nrf2/HO-1 pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Le Ma, Yan Chen, Qiang Gong, Zhuo Cheng, Congfu Ran, Kun Liu, Chunmeng Shi
Summary: Cold atmospheric plasma (CAP) alleviates radiation-induced skin injury by enhancing cell proliferation, migration, and antioxidant capacity, as well as promoting DNA damage repair. CAP also inhibits the expression of proinflammatory factors and temporarily increases the expression of pro-repair factors. In addition, it changes the polarity of macrophages, promoting skin repair. This study provides a preliminary theoretical foundation for the clinical administration of CAP in high-dose irradiated skin injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vasudevan Mani, Bander Shehail Alshammeri
Summary: Chemotherapy is a common cancer treatment, but it can lead to cognitive deficiencies and psychiatric complications. A study found that the antipsychotic drug quetiapine can improve cognitive deficits caused by chemotherapy. It works by reducing neuronal inflammation and protecting against oxidative stress, thus protecting neurons from damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
A. Floreani, D. Bizzaro, S. Shalaby, G. Taliani, P. Burra
Summary: Drug-induced liver injury (DILI) is a serious clinical condition with varying incidences and a higher vulnerability in females. Sex differences in pharmacokinetics and pharmacodynamics, hormonal effects, immune response, and the use of herbal and dietary supplements contribute to the risk. A novel phenotype of autoimmune-mediated DILI has been described. Assessments of DILI and its associated factors are important for patient safety and drug development.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Multidisciplinary Sciences
Ritesh K. Srivastava, Yong Wang, Jasim Khan, Suhail Muzaffar, Madison B. Lee, Zhiping Weng, Claire Croutch, Anupam Agarwal, Jessy Deshane, Mohammad Athar
Summary: This study investigated the pathobiology of arsenical compounds in two mouse models and found that they caused skin inflammation, blistering, and necrosis, accompanied by increased cytokines and proinflammatory mediators. The presence or absence of hair follicles did not significantly affect the qualitative inflammatory response, but the levels of cytokines and chemokines differed between the two strains. The mechanisms of inflammation were similar, involving reactive oxygen species induction and unfolded protein response signaling.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Cell Biology
Yuan Fang, Yang Liu, Yu Yan, Yiyu Shen, Zenan Li, Xu Li, Yufang Zhang, Zhigang Xue, Cong Peng, Xiang Chen, Ke Cao, Jianda Zhou
Summary: Ultraviolet radiation is a significant environmental factor contributing to skin damage, and tRNA-derived small RNAs play a role in UV-induced skin injury. The study suggests that tRF-Gly-CCC-019 may be involved in acute skin injury induced by UVB radiation by regulating the Rac1 gene in the WNT signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Fantian Zeng, Sureya Nijiati, Yangtengyu Liu, Qinqin Yang, Xiaomin Liu, Qianyu Zhang, Shi Chen, Anqi Su, Hehe Xiong, Changrong Shi, Congbo Cai, Zhongning Lin, Xiaoyuan Chen, Zijian Zhou
Summary: An artemisinin-based probe (Art-Gd) was developed for contrast-enhanced magnetic resonance imaging of ferroptosis (feMRI) in anticancer drug-induced acute cardiac/kidney injuries (ACI/AKI). The probe showed great feasibility in early diagnosis of ACI/AKI, providing imaging evidence for the different mechanisms of action of ferroptosis-targeted agents. This study presents a feMRI strategy with simple chemistry and robust efficacy for early evaluation of anticancer drug-induced ACI/AKI.
Review
Medicine, General & Internal
Matteo Marchetti, Maxime G. Zermatten, Debora Bertaggia Calderara, Alessandro Aliotta, Lorenzo Alberio
Summary: Knowledge on heparin-induced thrombocytopenia is expanding with recent advancements in diagnosis, management, and discoveries on its pathogenesis. However, many aspects of the condition remain unclear, and further research is needed to fully understand and apply these new insights.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Tanja Eichkorn, Jonathan W. Lischalk, Elisabetta Sandrini, Eva Meixner, Sebastian Regnery, Thomas Held, Julia Bauer, Emanuel Bahn, Semi Harrabi, Juliane Hoerner-Rieber, Klaus Herfarth, Juergen Debus, Laila Koenig
Summary: Radiation-induced contrast enhancements (RICE) are a common side effect following radiotherapy for gliomas, and correct diagnosis and treatment decisions for RICE are challenging. Research shows that different treatments result in varying outcomes for RICE, emphasizing the importance of making the right treatment decisions.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Dermatology
Ahmed K. Alomari, Earl J. Glusac, Jennifer Choi, Pei Hui, Erin H. Seeley, Richard M. Caprioli, Kalman L. Watsky, Jennifer Urban, Rossitza Lazova
JOURNAL OF CUTANEOUS PATHOLOGY
(2015)
Letter
Dermatology
Evelyn Lilly, Matthew Burke, Harriet Kluger, Jennifer Choi
Letter
Dermatology
Mariam B. Totonchy, Harib H. Ezaldein, Christine J. Ko, Jennifer N. Choi
Editorial Material
Dermatology
Joshua W. Trufant, Sean R. Christensen, Jennifer M. McNiff, Jennifer Nam Choi
ARCHIVES OF DERMATOLOGY
(2010)
Article
Oncology
Jennifer Nam Choi, Allison Hanlon, David Leffell
CURRENT PROBLEMS IN CANCER
(2011)
Article
Dermatology
Anjela Galan, Jennifer M. McNiff, Jennifer Nam Choi, Rossitza Lazova
JOURNAL OF CUTANEOUS PATHOLOGY
(2010)
Letter
Dermatology
Jasmine Ahmadi, Jennifer N. Choi
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2011)
Letter
Dermatology
Christopher G. Bunick, David Leffell, Marcus Bosenberg, Joachim Yahalom, Jennifer N. Choi
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2012)
Article
Dermatology
Christine J. Ko, Jennifer M. McNiff, Angelika Iftner, Thomas Iftner, Jennifer Nam Choi
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2013)
Article
Oncology
Viswanath Reddy Belum, Alyssa Fischer, Jennifer Nam Choi, Mario E. Lacouture
CURRENT ONCOLOGY REPORTS
(2013)
Article
Dermatology
Nika Cyrus, Robert Stavert, Ashley R. Mason, Christine J. Ko, Jennifer Nam Choi
Article
Dermatology
Lauren E. Wiznia, Antonio Subtil, Jennifer N. Choi
Article
Oncology
Trisha Kaundinya, Salma El-Behaedi, Jennifer N. Choi
JOURNAL OF CANCER EDUCATION
(2023)
