Journal
CLINICS IN DERMATOLOGY
Volume 28, Issue 1, Pages 62-66Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clindermatol.2009.04.004
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The pathophysiology of atopic dermatitis is still under discussion. Although it is widely accepted that environmental factors and a genetic predisposition are essential, the role of the innate and adaptive immune system and the functional cascade of the cells involved is still unclear. A concept that integrates all immune cells as equally essential has allure. In addition, barrier abnormalities due to mutations of the gene coding for filaggrin and down-regulation of antimicrobial peptides, such as LL-37 and beta-defensins 2 and 3, were very recently found to be relevant for the pathogenesis of atopic dermatitis. (C) 2010 Elsevier Inc. All rights reserved.
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