Article
Medicine, General & Internal
Christopher C. Butler, F. D. Richard Hobbs, Oghenekome A. Gbinigie, Najib M. Rahman, Gail Hayward, Duncan B. Richards, Jienchi Dorward, David M. Lowe, Joseph F. Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S. Nguyen-Van-Tam, Mahendra G. Patel, Benjamin R. Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P. B. Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A. Detry, Christina T. Saunders, Mark Fitzgerald, Nicholas S. Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D. Jani, Nigel D. Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C. Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little
Summary: This study aimed to determine the safety, effectiveness, and cost-effectiveness of molnupiravir in vaccinated high-risk patients in the community. The results showed that molnupiravir did not reduce hospital admissions or deaths associated with COVID-19 compared to usual care in this population.
Article
Immunology
Ville Forsstroem, Laura Toivonen, Kiara Homil, Matti Waris, Casper-Emil T. Pedersen, Klaus Bonnelykke, Tuomas Jartti, Ville Peltola
Summary: This study found that genetic predisposition to childhood asthma is associated with early respiratory tract infections, particularly in the 17q21 and CDHR3 genes. Multiple asthma risk alleles are also associated with viral respiratory infections and asthma. Therefore, non-wheezing and wheezing respiratory infections and asthma may share common genetic risk factors.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Respiratory System
Kirsty L. Bradley, Clare A. Stokes, Stefan J. Marciniak, Lisa C. Parker, Alison M. Condliffe
Summary: The lungs are exposed to various environmental toxins and pathogens, leading to respiratory diseases associated with hypoxia. Endoplasmic reticulum stress can be triggered by these factors, activating the unfolded protein response. This response plays a significant role in the pathogenesis and progression of respiratory diseases, making it a potential target for therapeutic interventions.
Article
Immunology
Romina Libster, Ignacio Esteban, Alejandra Bianchi, Luciano Alva Grimaldi, Karina Duenas, Andrea Sancillo, Andrea Rodriguez, Fernando Ferrero, Katherine Stein, Patricio L. Acosta, Fausto M. Ferolla, Eduardo Bergel, Mauricio T. Caballero, Fernando P. Polack
Summary: The study found that some children infected with hMPV may develop life-threatening diseases, especially those with mothers who have asthma. This suggests that maternal asthma increases the risk of life-threatening conditions in children hospitalized for severe hMPV LRTI.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Jack L. Janetzki, Matthew J. Sykes, Michael B. Ward, Nicole L. Pratt
Summary: This study investigated 40 medicines for potential signals of chronic obstructive pulmonary disease (COPD) development or progression in real-world data. The results identified several medications with signals of COPD development or progression, but further validation is needed in large, well-controlled observational studies.
Article
Respiratory System
Josefin Eklof, Truls Sylvan Ingebrigtsen, Rikke Sorensen, Mohamad Isam Saeed, Imane Achir Alispahic, Pradeesh Sivapalan, Jonas Bredtoft Boel, Jette Bangsborg, Christian Ostergaard, Ram Benny Dessau, Ulrich Stab Jensen, Ejvind Frausing Hansen, Therese Sophie Lapperre, Howraman Meteran, Torgny Wilcke, Niels Seersholm, Jens-Ulrik Stohr Jensen
Summary: The study found a dose-dependent risk of acquiring Pseudomonas aeruginosa in COPD patients using inhaled corticosteroids. High doses of ICS were associated with a substantially increased risk of infection, caution is advised when administering them to severely ill COPD patients.
Article
Multidisciplinary Sciences
Einar M. H. Martinsen, Tomas M. L. Eagan, Elise O. Leiten, Ingvild Haaland, Gunnar R. Husebo, Kristel S. Knudsen, Christine Drengenes, Walter Sanseverino, Andreu Paytuvi-Gallart, Rune Nielsen
Summary: The study revealed differences in taxonomic composition and diversity between oral and pulmonary mycobiomes in participants with COPD and controls, with more Candida found in oral samples. Malassezia and Sarocladium were frequently found in pulmonary samples. There were no consistent differences in terms of differential abundance/distribution between study groups, but sample type affected beta diversity.
Review
Immunology
Jose A. Canas, Jose M. Rodrigo-Munoz, Beatriz Sastre, Marta Gil-Martinez, Natalia Redondo, Victoria del Pozo
Summary: Chronic respiratory diseases (CRDs) such as asthma and chronic obstructive pulmonary disease (COPD) are important factors in global mortality and morbidity, accounting for approximately 6% of total deaths worldwide. MicroRNAs (miRNAs) have emerged as promising diagnostic and therapeutic biomarkers for CRDs, playing crucial roles in inflammation-related pathways in asthma and COPD. Their deregulation in various biofluids and cells of patients, as well as their involvement in histopathological changes and treatment response, highlight the potential of miRNAs as prognostic tools and therapeutic targets in these respiratory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Emergency Medicine
Michael W. Tsoulis, Brianne Navetta-Modrov, Henry C. Thode, Adam J. Singer
Summary: Patients with Asthma-COPD overlap (ACO) differ demographically from patients with Asthma or COPD alone in the emergency department (ED). After adjusting for demographic differences, ACO patients show differences in several ED variables, particularly in respiratory therapies. However, clinical outcomes such as admission and mortality rates appear to be similar between groups.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Aleksandra Undrunas, Piotr Kasprzyk, Aleksandra Rajca, Krzysztof Kuziemski, Witold Rzyman, Tomasz Zdrojewski
Summary: This study aimed to determine the prevalence of chronic obstructive pulmonary disease (COPD) in the largest Polish lung cancer screening program and found that COPD is significantly under-diagnosed in this cohort. Most diagnosed cases were in the initial stage, highlighting the potential benefits of combined lung cancer and COPD screening.
Article
Medicine, General & Internal
HuanYu Long, ZhenZhen Xing, Di Chai, WeiMing Liu, YaQi Tong, YuXia Wang, YaLi Ma, MingMing Pan, Jia Cui, YanFei Guo
Summary: This study confirmed the significant burden of COPD among never-smokers and identified the risk factors for COPD in this population. Additionally, a positive association was found between solid fuel exposure and both COPD and small airway dysfunction.
FRONTIERS IN MEDICINE
(2021)
Article
Respiratory System
Hans Bisgaard, Marianne Mikkelsen, Morten Arendt Rasmussen, Astrid Sevelsted, Ann-Marie Malby Schoos, Nicklas Brustad, Anders U. Eliasen, Jonathan Thorsen, Bo Chawes, Goezde Guerdeniz, Andreanne Morin, Ken Stark, Jakob Stokholm, Carole Ober, Casper Emil Tingskov Pedersen, Klaus Bonnelykke
Summary: Fish-oil supplementation during pregnancy reduces the risk of persistent wheeze or asthma in the child. It has protective effects on non-atopic asthma and infections, but the effects on atopic asthma depend on maternal genotype and n-3 LCPUFA levels.
Article
Environmental Sciences
Vivek Vardhan Veerapaneni, Swapna Upadhyay, Tania A. Thimraj, Jayaraj Biligere Siddaiah, Chaya Sindaghatta Krishnarao, Komarla Sundararaja Lokesh, Rajesh Thimmulappa, Lena Palmberg, Koustav Ganguly, Mahesh Padukudru Anand
Summary: The study found that decreased levels of SCGB1A1 protein were associated with BMS-COPD and TS-COPD patients, positively correlated with indicators like respiratory function and exercise capacity, and decreased with severity of COPD, dyspnea, and other indicators.
Article
Microbiology
Pannathat Soontrapa, Piriyaporn Chongtrakool, Methee Chayakulkeeree
Summary: Positive culture for Aspergillus spp. from respiratory specimens, in conjunction with coexisting myeloproliferative disease, neutropenia >= 10 days, corticosteroid treatment, or positive serum galactomannan, strongly suggests the presence of invasive pulmonary aspergillosis.
Article
Critical Care Medicine
Cedric Daubin, Francois Fournel, Fabrice Thiolliere, Fabrice Daviaud, Michel Ramakers, Andrea Polito, Bernard Flocard, Xavier Valette, Damien Du Cheyron, Nicolas Terzi, Muriel Fartoukh, Stephane Allouche, Jean-Jacques Parienti
Summary: Procalcitonin levels showed limited accuracy in predicting bacterial infection in severe AECOPD patients, despite higher levels in those with bacterial infection. PCT may not be reliable as a standalone marker for initiating antibiotic treatment in this population.
ANNALS OF INTENSIVE CARE
(2021)
